Clinical trials: tuberculosis
Tuberculosis
PPD Size and Mycobacteria Tuberculosis ELISPOT in Children Who Have Received BCG in Neonate Period
To investigate the size of PPD and TB specific ELISPOT among children between 3m/o and 15 y/o . Calculate the normal range of age specific PPD size in children who recieved BCG at new-born period.
- Trial name
- NCT00172783
- Where
- Taiwan
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tuberculosis, Respiratory Tract Infections
Accuracy and Consequences of Using Trial-of-antibiotics for TB Diagnosis (ACT-TB Study)
This is a three-arm, open-label individually randomised controlled clinical trial investigating the benefits of the diagnostic use of broad-spectrum antimicrobials during the diagnostic process for tuberculosis (TB) and the risk…
- Conditions
- Tuberculosis, Respiratory Tract Infections, Pneumonia
- Trial name
- ACT-TB (NCT03545373)
- Testing
- Azithromycin, Amoxicillin
- Where
- Malawi
- Volunteers
- 1,583 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diabetes Mellitus, Tuberculin (Skin Test) Positive
Efficacy, Security, Adherence, Tolerability and Cost Effectiveness of Latent TB Treatment in Patients With TB/DM2 (TBL)
Researchers will evaluate the efficacy, toxicity, adherence and cost effectiveness of treatment with isoniazid or rifampicin in patients with diabetes mellitus type two (DM2) and latent TB (LTB).
- Trial name
- TBL (NCT03278483)
- Testing
- Isoniazid 300 mg Oral Tablet, Rifampin 600 mg Oral Tablet
- Where
- Mexico
- Volunteers
- 396 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Pregnancy Related, Tuberculosis Infection
Effects of Tuberculosis Infection on Development and Function of the Placenta
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on…
- Conditions
- Pregnancy Related, Tuberculosis Infection, Placenta Diseases
- Trial name
- NCT06352970
- Testing
- TB infection
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Lund University
Therapeutic Drug Monitoring (TDM), Tuberculosis
Collect Data From Patients Receiving Standardized Anti-tuberculosis Therapy, Collect Monitoring Data, and Evaluate Treatment Efficacy and Potential Adverse Reactions.
The purpose of this clinical trial is to investigate the correlation between anti-tuberculosis drug concentration monitoring and treatment efficacy and safety through analytical studies.The main questions it aims to answer…
- Trial name
- Tuberculosis (NCT07607288)
- Testing
- Antituberculosis drugs Group
- Where
- China
- Volunteers
- 2,215 people
- Sponsor
- Beijing Chest Hospital
Pulmonary Tuberculosis, Rifampicin-resistant Tuberculosis
Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis：Contezolid, Delamanid and Bedaquiline Cohort
The goal of this clinical trial is to compare the efficacy and safety of a Contezolid and Delamanid-Containing short regimen to standard longer regimen in Rifampicin-resistant pulmonary tuberculosis (RR-TB).
- Trial name
- INSPIRE-CODA (NCT06081361)
- Testing
- Bedaquiline, Delamanid, Contezolid
- Where
- 39 sites in China
- Volunteers
- 186 people
- Sponsor
- Beijing Chest Hospital
HIV, Tuberculosis
Medical and Economical Impact of IGRAs Diagnosis of Latent Tuberculosis in HIV-infected Patients
Tuberculosis is a current infection during HIV infection. After infectious contact, some patients will develop tuberculosis some will only be infected without symptoms, they have Latent Tuberculosis Infection (LTBI) which can…
- Conditions
- HIV, Tuberculosis, Latent Tuberculosis Infection
- Trial name
- IGRAVIH (NCT00805272)
- Testing
- QTF-TB Gold and T-SPOT TB
- Where
- France
- Volunteers
- 536 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis Infection
1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam
Introduction: Tuberculosis (TB) infection is a key driver of the TB pandemic, with over 10.6 million people fell ill with TB disease in 2022.
- Trial name
- NCT06191692
- Testing
- Isoniazid, Rifapentine, Rifampicin
- Where
- 2 sites in Vietnam
- Sponsor
- Freundeskreis Für Internationale Tuberkulosehilfe e.V
Tuberculosis, TB Infection
A Phase I Study of Lipovaxin Tuberculosis Vaccine in Adult Healthy Populations
A Phase I, Double-Blind, Randomized, Placebo Controlled Trial to Evaluate Safety and Immunogenicity of Lipovaxin Tuberculosis Vaccine (Bio Farma) in Healthy Populations Aged 18-40 Years in Indonesia
- Trial name
- NCT07647107
- Testing
- LipovaxinS4-EAH (Middle Dose), LipovaksinS4-EAH (High Dose)
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Tuberculosis, Pulmonary
Diagnosis Test of Real-time Polymerase Chain Reaction (RT-PCR) for Pulmonary Tuberculosis
BACKGROUND: Pulmonary tuberculosis remains the leading cause of morbidity and mortality in Thailand. The microbiological detection of TB is important because of early and correct diagnosis, drug resistance testing and ensures…
- Trial name
- NCT06284187
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Khon Kaen Hospital
HIV Infection, Tuberculosis
Early vs Late Introduction of Antiretroviral Therapy in HIV-infected Patients With Tuberculosis (ANRS 1295 CAMELIA)
In Cambodia the prevalence of both tuberculosis (TB) and Human Immunodeficiency Virus (HIV) infection is high. Data suggest that aggressive management of HIV infection, which includes Anti-Retroviral Therapy (HAART) during…
- Trial name
- NCT00226434
- Testing
- Early antiretroviral treatment, Late antiretroviral treatment
- Where
- 5 sites in Cambodia
- Volunteers
- 661 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Tuberculosis
Trial of Point-of-treatment Xpert MTB/RIF Assay
Xpert MTB/RIF assay is a novel automated molecular tool for the diagnosis of TB. Xpert can detect TB genetic material in sputum samples as well as test for genetic resistance to rifampicin providing results within 2 hours.
- Trial name
- TBNEATXpert (NCT01554384)
- Testing
- Xpert MTB/RIF assay, Smear microscopy
- Where
- 4 sites in South Africa, Zambia and 1 more
- Volunteers
- 1,472 people
- Sponsor
- University of Cape Town
Tuberculosis
The Efficacy of Silymarin on the Prevention of Hepatotoxicity From Antituberculosis Drugs
Hepatitis is one of the most common adverse effect from anti-tuberculosis. Silymarin showed its efficacy to decreased serum alanine transaminase enzyme in animal models from recent study.
- Trial name
- NCT01800487
- Testing
- silymarin
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Ramathibodi Hospital
Latent Tuberculosis Infection
Enhancing the Public Health Impact of Latent Tuberculosis (TB) Infection Diagnosis and Treatment
The study is a pragmatic cluster randomized trial that is being conducted in 5 countries, with sites in 4 cities in Canada, Benin, Ghana, Indonesia and Vietnam.
- Trial name
- ACT4 (NCT02810678)
- Testing
- Latent Tuberculosis Infection program evaluation & diagnosis
- Where
- 8 sites in Benin, Canada and 3 more
- Volunteers
- 24 people
- Sponsor
- McGill University
Rifampicin-resistant Tuberculosis
French National Cohort of Patients With Rifampicin-Resistant Tuberculosis
A major obstacle in the fight against multidrug-resistant tuberculosis is its treatment. In 2021, only 60% of patients with MDR/RR tuberculosis who received treatment globally were successfully cured, while 12% succumbed to the…
- Trial name
- CONTRol-TB (NCT06565806)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis
TMC207-C202: Study to Evaluate Bactericidal Activity of Multiple Oral Doses of TMC207 in Subjects With Sputum-Smear Positive Tuberculosis
The purpose of this study is to assess the effects of 3 different oral doses of TMC207 administered over a 7 day period on the organism that causes tuberculosis
- Trial name
- NCT00523926
- Testing
- TMC207
- Volunteers
- 75 people
- Sponsor
- Tibotec BVBA
Tuberculosis
Evaluation of Point-of-care Ultrasound in Children From 6 Months to 15 Years With Presumptive Tuberculosis
Diagnosis of tuberculosis (TB) in children is particularly challenging in low and middle-income countries (LMIC), and a high number of children remain undiagnosed and untreated.
- Trial name
- NCT05364593
- Where
- 2 sites in Guinea-Bissau, South Sudan
- Volunteers
- 576 people
- Sponsor
- Medecins Sans Frontieres, Spain
Tuberculosis Infection, Tuberculosis Infection, Latent
Isoniazid-Related Hepatotoxicity in Clinical Practice: Incidence and Predictors
The objective of this observational study is to determine how frequently isoniazid (INH) causes liver injury (hepatotoxicity) in adults treated for tuberculosis (TB) or latent tuberculosis infection (LTBI) and to understand which…
- Trial name
- INH-DILI (NCT07472348)
- Testing
- Standard isoniazid-based TB/LTBI therapy
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- ASST Fatebenefratelli Sacco
Tuberculosis, Psoriasis
Sensitivity and Specificity of QuantiFeron -TB Gold Test (QFT-G)in Patients With Psoriasis
The purpose of this study is to determine the level of agreement between QuantiFeron -TB Gold test (QFT-G)and Tubeculin skin test (TST)for screening of latent tuberculosis in patients suffering from psoriasis.
- Trial name
- NCT01223976
- Testing
- Tuberculin skin test and Quantiferon -TB Gold test
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tuberculosis, Pulmonary
EBA, Safety and Tolerability of Sanfetrinem Cilexetil
To evaluate the 2-week bactericidal activity, pharmacokinetics, safety and tolerability of sanfetrinem cilexetil in participants with rifampicin-susceptible pulmonary tuberculosis.
- Trial name
- NCT05388448
- Testing
- Sanfetrinem Cilexetil, Rifampicin
- Where
- South Africa
- Volunteers
- 54 people
- Sponsor
- TASK Applied Science
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