Clinical trials: tuberculosis
Tuberculosis
A Controlled Trial of a 4-Month Quinolone-Containing Regimen for the Treatment of Pulmonary Tuberculosis
Tuberculosis is currently treated with a 6-month course regimen. During this time many patients might fail to adhere to treatment and default, increasing the risk of recurrent disease which might be multidrug resistant.
- Trial name
- NCT00216385
- Testing
- Gatifloxacin combined regimen
- Where
- 5 sites in Benin, Guinea and 3 more
- Volunteers
- 2,070 people
- Sponsor
- Institut de Recherche pour le Developpement
Monitoring, Immunologic, Active Tuberculosis
New Generation IGRA in Immunocompromised Individuals
Evaluation of a new ELISA based interferon-gamma release assay (QuantiFERON TB plus In-tube test) in immunocompromized patients
- Conditions
- Monitoring, Immunologic, Active Tuberculosis, Tuberculosis in Solid Organ Transplant Recipients, Tuberculosis in Marrow Transplant Recipients
- Trial name
- TBnet#54 (NCT02639936)
- Where
- 16 sites in Denmark, Germany and 8 more
- Volunteers
- 2,663 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Network European Trialsgroup
Pulmonary Disease, Tuberculosis, Pulmonary
Evaluate Safety, Tolerability, PK of TBAJ-876 in Healthy Adults
A Phase 1, Partially Blind, Placebo Controlled, Randomized, Combined Single Ascending Dose (SAD) with a Food Effect Cohort (Part 1), Multiple Ascending Dose (MAD) (Part 2), and Relative Bioavailability (rBA) (Part 3) Study to…
- Conditions
- Pulmonary Disease, Tuberculosis, Pulmonary, Tuberculosis, Multi Drug Resistant Tuberculosis
- Trial name
- NCT04493671
- Testing
- TBAJ-876 suspension, TBAJ-876 100 mg tablet, TBAJ-876 25 mg tablet
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
MDR TB
Study of Adjunctive Recombinant Human Interleukin-2 Therapy in Patients With MDR-TB
Multidrug-resistant tuberculosis (MDR-TB) has emerged as a challenge worldwide. Few studies have prospectively reported outcomes in patients with pulmonary MDR-TB treated with adjunctive immunotherapy combined to standard…
- Trial name
- rhIL-2 (NCT03069534)
- Testing
- RhIL-2
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Tuberculosis, Pulmonary
Novel Triple-dose Tuberculosis Retreatment Regimens: How to Overcome Resistance Without Creating More
Drug-resistance is a major challenge for tuberculosis (TB) care programs. The new WHO guideline recommends adding levofloxacin in previously treated patients with isoniazid-resistant rifampicin-susceptible TB.
- Trial name
- TriDoRe (NCT03862248)
- Testing
- 6EH³RZ, 6EHR³Z, 6EHRZLfx
- Where
- Bangladesh
- Sponsor
- Institute of Tropical Medicine, Belgium
Latent Tuberculosis, TB Infection
Evaluating the Accuracy of New Tests for TB Infection Diagnosis
Introduction: The large reservoir of tuberculosis infections is a key driver of sustained tuberculosis (TB) incidence. Accurate diagnostic tests are crucial to correctly identify and treat people with TB infection, which is vital…
- Conditions
- Latent Tuberculosis, TB Infection, Tuberculosis
- Trial name
- TB infection (NCT06221735)
- Testing
- Cy-TB test, STANDARD F TB-Feron FIA test
- Where
- Vietnam
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Freundeskreis Für Internationale Tuberkulosehilfe e.V
Tuberculosis
Heterologous Effects of BCG in Healthy UK Adults
TB038 is a clinical study to assess the non-specific effects of BCG vaccination and gain a better understanding of how the body's immune system reacts to BCG and in turn potentially prevents infection from other bacteria.
- Trial name
- NCT02380508
- Testing
- BCG SSI, No vaccination, BCG Sii
- Where
- 3 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Deworming Against Tuberculosis
The purpose of this study is to investigate whether treatment against intestinal helminths in patients with pulmonary tuberculosis undergoing chemotherapy could improve the clinical outcome by enhancing host immunity.
- Trial name
- NCT00857116
- Testing
- Albendazole
- Where
- Ethiopia
- Volunteers
- 140 people
- Sponsor
- Linkoeping University
Tuberculosis, Multidrug-Resistant
Hotspots, Households and Hospitals: Enhanced Drug-resistant Tuberculosis Case Finding in Namibia
Poor case management, pharmacokinetic variability and on-going transmission have fostered the drug-resistant tuberculosis (DR-TB) epidemic leading to a global estimated number of >500,000 new multidrug resistant (MDR) TB cases…
- Trial name
- H3TB (NCT05022238)
- Where
- Namibia
- Volunteers
- 2,100 people
- Sponsor
- University of Namibia
Tuberculosis
TBTC Study 25: Study of the Tolerability of Higher Doses of Rifapentine in the Treatment of Tuberculosis
Randomized, double-blind study of the tolerability of three different doses of rifapentine
- Trial name
- NCT00023426
- Testing
- rifapentine
- Where
- 23 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Centers for Disease Control and Prevention
MDR-TB
Saliva and Dried Blood Spot Therapeutic Drug Monitoring for MDR-TB in Tanzania
Dried blood spot and saliva samples are collected during multidrug resistant tuberculosis (MDR-TB) treatment to measure the drug concentration of levofloxacin.
- Trial name
- NCT04124055
- Testing
- Therapeutic drug monitoring (TDM)
- Where
- Tanzania
- Volunteers
- 51 people
- Sponsor
- Jan-Willem C Alffenaar
Tuberculosis
Validation of Artificial Intelligence Enabled TB Screening and Diagnosis in Zambia
Tuberculosis (TB) is a global epidemic and for many years has remained a major cause of death throughout the developing world. Zambia is among the top 30 TB/HIV high burden countries.
- Trial name
- NCT05139940
- Where
- 3 sites in Zambia
- Volunteers
- 2,432 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
Rheumatoid Arthritis, Tuberculosis
Comparison of the Tuberculin Skin Test (TST) and QuantiFERON ®-TB Gold Test (QFT-G) In Patients With Rheumatoid Arthritis Being Considered for Anti-TNF-Alpha Therapy
This research will help doctors interested in the usefulness of a new test to discover hidden tuberculosis infections in patients diagnosed with rheumatoid arthritis (RA). This new test is called Quantiferon-Gold (QFT-G).
- Trial name
- NCT00925249
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant
Xpert MTB/XDR Clinical Evaluation Trial
FIND and partners intend to address the need for a multi- and extensively drug-resistant tuberculosis (M/XDR-TB) diagnostic solution for patients in settings with a high burden of drug-resistant tuberculosis (DR-TB) though the…
- Trial name
- NCT03728725
- Testing
- Cepheid Gene Xpert MTB/XDR
- Where
- Moldova
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis
Evaluation of Non-Inferiority of Two Fast Follower Nucleic Acid Amplification Tests
Assess sensitivity and specificity of two nucleic acid amplification tests, namely Epistem Genedrive® and MolbioTruenat™ in raw sputum compared to the WHO-endorsed GeneXpert® MTB/RIF assay using a gold standard of four cultures
- Trial name
- FIND (NCT02252198)
- Testing
- Epistem Genedrive® and MolBio Truenat™
- Where
- United States
- Volunteers
- 504 people
- Sponsor
- Johns Hopkins University
Tuberculous Meningitis
Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis
Tuberculous meningitis (TBM) is the most serious form of Mycobacterium tuberculosis infection, causing mortality and disability in more than half of the patients.
- Trial name
- NCT03898635
- Testing
- Linezolid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Huashan Hospital
Tuberculosis, Human Immunodeficiency Virus Infections
Safety and Efficacy of Two Once Daily Anti Retroviral Treatment Regimens Along With Anti-tuberculosis Treatment
Protocol Summary Title: Evaluation of safety and efficacy of two different once daily anti-retroviral treatment regimens along with anti-tuberculosis treatment in patients with HIV-1 and tuberculosis - Randomized Controlled…
- Trial name
- NCT00332306
- Testing
- Didanosine, Lamivudine, Efavirenz, Didanosine, Lamivudine, Nevirapine
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Tuberculosis Research Centre, India
HIV, Hepatitis C
Strategic Screening for Infectious Diseases (Tuberculosis, HIV, HBV, HCV) Amongst Migrants in France
To evaluate the efficacy of a new screening for infectious diseases: tuberculosis, HIV, HBV and HCV, based on risk factors questionnaires (TB screen for tuberculosis and TROD screen for HIV and hepatitis) amongst a population of…
- Conditions
- HIV, Hepatitis C, Hepatitis B, Tuberculosis
- Trial name
- STRADA (NCT02959684)
- Where
- 18 sites in France
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- University Paris 7 - Denis Diderot
Rheumatoid Arthritis, Spondylarthritis
Quantiferon-TB Gold in the Assessment of Latent TB in Patients Candidate to Treatment or Treated With TNFα Antagonists
The purpose of this study is to evaluate the value of Quantiferon-TB Gold (QFT-G) assay in the screening for latent tuberculosis infection (LTBI) in rheumatologic patients due to start or on treatment with TNFα antagonists.
- Conditions
- Rheumatoid Arthritis, Spondylarthritis, Tuberculosis
- Trial name
- TNFTB (NCT00491933)
- Testing
- Quantiferon-TB Gold assay, Tuberculin skin test
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Fatebenefratelli Sacco
Capacity Building, Support for Midlevel Health Professionals
Integrated Infectious Disease Capacity-Building Evaluation
This evaluation aim is to investigate a cost-effective way to build capacity for the care and prevention of infectious diseases among mid-level practitioners (MLP) in sub-Saharan Africa.
- Conditions
- Capacity Building, Support for Midlevel Health Professionals, Diagnostic Training
- Trial name
- IDCAP (NCT01190540)
- Testing
- Training and supervision, Integrated Management of Infectious Disease (IMID)
- Where
- Uganda
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Washington
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