Clinical trials: tuberculosis
Tuberculosis, Tuberculosis (TB)
Questioning the Epidemiology of Asymptomatic TB
Tuberculosis (TB) remains one of the world's leading causes of morbidity and mortality. Current TB control strategies focus largely on the binary paradigm of TB, which tackle Mtb infection and the symptomatic stages of the…
- Conditions
- Tuberculosis, Tuberculosis (TB), HIV, HIV (Human Immunodeficiency Virus)
- Trial name
- TB QUEST (NCT07312266)
- Where
- Mozambique
- Volunteers
- 6,770 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Tuberculosis, Pulmonary, Antibiotic Prophylaxis
Prevention of Tuberculosis in Prisons
The purpose of this study is to determine if the isoniazid is effective in the prevention of tuberculosis in a prison population, exposed to the high endemicity of the disease.
- Trial name
- NCT03028129
- Testing
- Isoniazid 900 milligrams
- Where
- Brazil
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Tuberculosis, Tuberculosis, Pulmonary
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Ex-vivo Antitubercular Activity of PBTZ169 Formulation
This is a randomized, double-blind, placebo-controlled, single ascending dose study conducted at one study center in Switzerland.
- Trial name
- NCT03423030
- Testing
- PBTZ169 Formulation, PBTZ169 NCP
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Innovative Medicines for Tuberculosis
Tuberculosis (TB)
A Confirmatory Trial of Adjunctive NAC to Prevent Post Tuberculosis Lung Disease
The goal of this clinical trial is to evaluate if N-acetylcysteine (NAC) works to prevent post-tuberculosis lung disease (PTLD) in patients with severe pulmonary impairment. It also aims to assess the safety of NAC.
- Trial name
- NAC-PTLD (NCT06909799)
- Testing
- N-Acetyl Cysteine (NAC), Standard TB treatment
- Where
- The Gambia
- Volunteers
- 242 people
- Sponsor
- The Aurum Institute NPC
Pulmonary Tuberculosis
Induced Sputum Versus Bronchoscopy in Smear Negative Pulmonary Tuberculosis
This is a randomised study that compares different diagnostic approaches for diagnosing pulmonary tuberculosis in patients suspected of pulmonary tuberculosis in whom the three classic (non-induced) sputum samples didn't show…
- Trial name
- NCT01011543
- Testing
- Diagnostic techniques in pulmonary tuberculosis
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Latent Tuberculosis, Persistent Infection
New Strategies for Assessment of the Persistence of Viable Bacilli in Latent and Active Tuberculosis
Current diagnostic tools such as interferon gamma release assay (IGRA) and purified protein derivative (PPD) can not distinguish patients with latent tuberculosis infection (LTBI) and persistence of live mycobacteria.
- Conditions
- Latent Tuberculosis, Persistent Infection, Mycobacterium Tuberculosis
- Trial name
- TB-LIVE (NCT05621343)
- Where
- Sweden
- Volunteers
- 89 people
- Sponsor
- Region Skane
Pulmonary Tuberculosis
Homeopathy as an Adjuvant to Chemotherapy Improves Clinical Outcome in Relapsed Pulmonary Tuberculosis
The purpose of the study is to evaluate the effect of homeopathy as an adjuvant to Anti tuberculosis treatment on sputum conversion, hematological, clinical sign and symptoms of relapsed Pulmonary TB.
- Trial name
- NCT01242592
- Testing
- Anti-Tuberculosis Treatment
- Where
- India
- Volunteers
- 56 people
- Sponsor
- NMP Medical Research Institute
Multidrug Resistant Tuberculosis, Pediatric
Pharmacokinetic and Safety Trial to Determine the Appropriate Dose for Pediatric Patients With Multidrug Resistant Tuberculosis
The purpose of this trial is to determine the pediatric dose of delamanid that is equivalent to the adult dose already shown to be effective against multidrug-resistant tuberculosis.
- Trial name
- NCT01856634
- Testing
- 100 mg Delamanid, 50 mg Delamanid, 25 mg Pediatric Formulation Delamanid
- Where
- 2 sites in Philippines, South Africa
- Volunteers
- 37 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome
Mentor Mothers: A Sustainable Family Intervention in South African Townships
The purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with Mothers Living with HIV (MLH)in South Africa.
- Conditions
- Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome, Tuberculosis
- Trial name
- NCT00972699
- Testing
- Peer support and mentoring
- Where
- South Africa
- Volunteers
- 1,200 people
- Sponsor
- University of California, Los Angeles
Tuberculosis
Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults
This study will evaluate two different ways to give rifapentine (RPT), a drug that may help shorten treatment duration for tuberculosis (TB) disease.
- Trial name
- NCT01574638
- Testing
- Rifapentine (RPT)
- Where
- 4 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculous Lymphadenitis, Cervical
Steroids vs Placebo in Treatment of Tuberculous Lymphadenitis
This study will be conducted as a single blinded randomized control trial. The goal of this clinical trial is to learn about the role of low dose steroids in the resolution of tuberculous lymphadenitis.
- Trial name
- NCT06236152
- Testing
- Ferrous sulfate, Deltacortril
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Fahad Javed Awan
Pleural Effusion, Pleural Diseases
Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy
The aim of this study is to compare the rigid thoracoscopy with CT-guided pleural needle biopsy by the diagnostic efficacy and safety in patients with pleural effusion.
- Trial name
- NCT00720954
- Testing
- Ct-guided pleural needle biopsy, Thoracoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Eskisehir Osmangazi University
Non-Tuberculous Mycobacteria Pulmonary Disease, Bronchiectasis
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly as a chronic lung infection in people with long-term lung problems such…
- Trial name
- NCT07192705
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
HIV/AIDS, Tuberculosis
Prevent TB: Choice Architecture for TPT Delivery
Background: Clinical guidelines and policies often fail to achieve high levels of delivery of intended clinical interventions. The difference in what the investigators know works and what is actually delivered at the clinic-level…
- Trial name
- NCT04466488
- Testing
- Choice Architecture
- Where
- South Africa
- Volunteers
- 50,798 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tuberculosis, Alcohol Use Disorders
Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, Russia
The primary goal of this study is to assess the effectiveness of two alcohol interventions administered singly or in combination as an integrated component of TB care provided to patients with co-occurring TB and AUDs in Tomsk…
- Trial name
- IMPACT (NCT00675961)
- Testing
- Brief Counseling Intervention (BCI), Naltrexone, BCI + Naltrexone
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Tuberculosis, Pulmonary
Impact of Malnutrition on Pharmacokinetic of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children (TB-Speed TB-PK)
TB-Speed TB-PK is a cross-sectional PK study of anti-TB treatment nested in the TB-Speed HIV and TB-Speed SAM studies aiming at assessing the impact of malnutrition on PK of rifampicin, isoniazid, pyrazinamide, and ethambutol in…
- Trial name
- NCT04972903
- Where
- 4 sites in Uganda, Zambia
- Volunteers
- 85 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Tuberculosis
Safety and Risk of Sensitisation of the rdESAT-6 + rCFP-10 Skin Test Following Repeated Intradermal Administration
The primary objective is to assess the safety of three dose levels (0.01, 0.1 and 1.0 µg) of the rdESAT-6 + rCFP-10 skin test reagent when injected into healthy adults.
- Trial name
- NCT00793702
- Testing
- rdESAT-6 + rCFP-10
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Statens Serum Institut
Pharmaceutical Care, HIV/AIDS
The Impact of Pharmacists' Interventions on the Quality of Life of HIV-TB Co-infection Outpatients in Indonesia
Rationale: The co-infection of human immunodeficiency virus (HIV) and tuberculosis (TB) diseases presents further problems to patient's adherence due to high pill burden and adverse effects in the drug combination therapy.
- Conditions
- Pharmaceutical Care, HIV/AIDS, Tuberculosis
- Trial name
- NCT04325438
- Testing
- Pharmaceutical Care
- Where
- 3 sites in Indonesia
- Volunteers
- 25 people
- Sponsor
- Bekasi City Public Hospital
Tuberculosis
Reactogenicity, Safety and Immunogenicity of a TB/FLU-01L Tuberculosis Vaccine
The study is a single centre, phase I, open, randomized, by intranasal and sublingual application trial that explored the safety and immunogenicity of 2 doses (Day 1 and Day 21) TB/FLU-01L tuberculosis vaccine in BCG-vaccinated…
- Trial name
- NCT03017378
- Testing
- TB/FLU-01L
- Where
- Kazakhstan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
Tuberculosis
TMC207 +/- Rifabutin/Rifampin
Evaluation of effect of rifampin or rifabutin on single dose PK of TMC207 in healthy volunteers
- Trial name
- NCT01341184
- Testing
- Rifabutin, Rifampin, TMC207
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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