Clinical trials: tuberculosis
Tuberculosis, Pulmonary
Sorfequiline-based Regimens in Adults With Newly Diagnosed Drug-sensitive Pulmonary TB
The goal of this interventional trial is to evaluate the safety and efficacy of the loading dose regimen 200/100SPaL-4/13 weeks, and the 100SPaL -17 weeks regimen in adults with newly diagnosed, drug-sensitive, smear-positive…
- Trial name
- NCT07672405
- Testing
- sorfequiline, Pretomanid, Linezolid
- Where
- 12 sites in South Africa, Tanzania
- Volunteers
- 100 people
- Sponsor
- Global Alliance for TB Drug Development
Patients With Moderate-to-severe COPD With Destroyed Lung by Tuberculosis
Indacaterol EfectIveness In COPD Patients With Tuberculosis History
This clinical study will assess efficacy and safety of indacaterol (150㎍ o.d.) in patients with Chronic Obstructive Pulmonary Disease (COPD) with destroyed lung by tuberculosis.
- Trial name
- INFINITY (NCT01778062)
- Testing
- Indacaterol, Control
- Where
- 13 sites in South Korea
- Volunteers
- 136 people
- Sponsor
- Novartis Pharmaceuticals
Tuberculosis Diagnosis, HIV
Optimizing Clinical Outcomes in HIV-Infected Adults & Children
This is a study to evaluate Xpert MTB/RIF as the first-line TB diagnostic test in HIV-infected adults and pediatric patients as a means to obtain faster, more accurate TB diagnosis.
- Trial name
- NCT02043080
- Testing
- Xpert MTB/RIF Tuberculosis diagnostic tool
- Where
- Zambia
- Volunteers
- 1,436 people
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis
Clinical Study of BCG Vaccine for Intradermal Injection
The study used a randomized, dose-escalation, blinded, placebo-controlled trial design. In this trial, 160 subjects were enrolled.
- Trial name
- NCT04563273
- Testing
- BCG vaccine 1（0.025mg/0.1ml/person）, BCG vaccine 2 （0.05mg/0.1ml/person）, BCG vaccine 3（0.075mg/0.1ml/person）
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Pleural Diseases
Outcome of Patients Undiagnosed Under Medical Thoracoscopy
Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases.
- Trial name
- NCT01356979
- Testing
- Medical thoracoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 355 people
- Sponsor
- Eskisehir Osmangazi University
HIV Infections, Tuberculosis
Evaluation of 2 Interferon γ Assays in the Diagnosis of Latent Tuberculosis in HIV-infected Patients.ANRS EP 40 QUANTI SPOT
The aim of this study is to estimate the usefulness of QuantiFERON TB Gold In-Tube® and T-SPOT.TB® for the diagnosis of latent tuberculosis in HIV infected antiretroviral naive patients: 80 originated from low TB prevalence…
- Trial name
- NCT00647205
- Testing
- QuantiFERON TB Gold In-Tube, T-SPOT.TB®
- Where
- France
- Volunteers
- 240 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Tuberculosis
Biodistribution and Pharmacokinetics of Pretomanid in Tuberculosis Patients Using 18F-Pretomanid PET
This is an observational study that will examine the pretomanid pharmacokinetics (PK) in tuberculosis (TB) patients. Dynamic 18F-pretomanid PET/CT will be performed after intravenous injection of 18F-pretomanid to determine…
- Trial name
- NCT05609552
- Testing
- 18F-Pretomanid PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pulmonary Tuberculosis
Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)
Vitamin D exerts its effects via the Vitamin D Receptor (VDR) present in activated macrophages and induces expression and release of the cathelicidin, LL-37, a human antimicrobial peptide involved in killing of MTB.
- Trial name
- NCT01580007
- Testing
- Active Sodium Phenylbutyrate and active cholecalciferol
- Where
- Bangladesh
- Volunteers
- 288 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Multi-drug Resistant Tuberculosis
A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis
The purpose of this study is to provide safety and efficacy data for TMC207 and to demonstrate that TMC207 added to a background regimen (BR) is superior to treatment with the BR plus placebo.
- Trial name
- NCT01600963
- Testing
- Arm A Double-blind Phase: TMC207, Treatment Failure During Double-blind Phase: TMC207, Treatment Failure During Follow-up Phase: TMC207
- Where
- 44 sites in Brazil, Cambodia and 15 more
- Sponsor
- Janssen Infectious Diseases BVBA
Tuberculous Meningitis, HIV I Infection
Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis
Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis drugs and corticosteroids) in HIV patients with tuberculosis…
- Trial name
- TIMPANI (NCT05590455)
- Testing
- Adalimumab Injection
- Where
- 3 sites in Brazil, Mozambique and 1 more
- Volunteers
- 130 people
- Sponsor
- ANRS, Emerging Infectious Diseases
IPF, Sarcoidosis
Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases
Nasal, tracheal and bronchial sampling of MLF in patients with idiopathic pulmonary fibrosis(IPF), sarcoidosis, tuberculosis(TB), asthma and COPD. Similar sampling from healthy controls for comparative data.
- Conditions
- IPF, Sarcoidosis, Tuberculosis, Asthma
- Trial name
- RESPI-SAM (NCT02807025)
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Healthy
Clinical Trial to Investigate the Pharmacokinetics of Second-Line Anti-Tuberculosis Agents
This study aims to investigate the pharmacokinetic characteristics of second-line anti-tuberculosis agents after oral/intramuscular administration in healthy male volunteers.
- Trial name
- NCT02128308
- Testing
- Levofloxacin and Streptomycin added, Moxifloxacin and Kanamycin added
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Tuberculosis
Phenotyping of High Dose Rifampicin
Higher doses of rifampicin as a means of more efficient use of this pivotal TB drug has shown promising results and might become standard in future.
- Trial name
- PHENORIF (NCT04525235)
- Testing
- phenotyping cocktail, rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Tuberculosis
Quantitative Measurement of Plasma and Urine MTB Cell-free DNA Level
Tuberculosis (TB) is one of the leading causes of infectious disease worldwide. The diagnosis of TB typically relies on microbiological evidence of the presence of Mycobacterium tuberculosis (MTB) or histological features of the…
- Trial name
- LIQUID-TB (NCT07170735)
- Testing
- Plasma MTB cfDNA assay, Urine MTB cfDNA assay
- Where
- 2 sites in Hong Kong
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Tuberculosis
Sputum-free Diagnostis of TB
The aim of this study is to identify new biomarkers that enable reliable, non-invasive diagnosis of tuberculosis (TB), including in patients who are unable to produce sputum.
- Trial name
- TB_Diagnostics (NCT07125274)
- Testing
- Biomarker-guided diagnostic tests
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Research Center Borstel
HIV Infections, Tuberculosis
Early Versus Standard Start of Anti-HIV Therapy for Treatment-Naive Adults in Haiti
Anti-HIV treatment consisting of lamivudine/zidovudine (3TC/ZDV) and efavirenz (EFV) is the current standard of care for initial treatment of HIV in most areas of the world.
- Trial name
- NCT00120510
- Testing
- Efavirenz, Lamivudine/Zidovudine
- Where
- Haiti
- Volunteers
- 816 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Pulmonary
Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis
A phase 2, two-part, multicentre, open label, controlled, randomised clinical trial in adult participants with newly diagnosed, sputum-positive pulmonary drug-sensitive tuberculosis (DSTB).
- Trial name
- SYNERGY (NCT07773610)
- Testing
- TBAJ-587 50 mg, Pretomanid 200mg, Linezolid 600Mg Tab
- Where
- South Africa
- Volunteers
- 135 people
- Sponsor
- TASK Applied Science
Non-tuberculous Mycobacterial Infections
Linezolid for Treatment of Nontuberculous Mycobacterial Diseases
A prospective open study to determine the efficacy and tolerability of oral linezolid 600mg./day for the treatment of 40 patients with nontuberculous mycobacterial diseases will be conducted at Siriraj Hospital, Mahidol…
- Trial name
- NCT03220074
- Testing
- Oral Tablet
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Tuberculosis (TB), Tuberculosis Infection, Latent
Burden of Tuberculosis Among Pregnant and Postpartum Women in Guinea-Bissau
This study aims to address critical diagnostic and data gaps in tuberculosis (TB) care among pregnant and postpartum women in Guinea-Bissau, a high-burden, resource-limited setting.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, Pregnancy, Tuberculosis Diagnosis
- Trial name
- TIPP (NCT07419568)
- Testing
- Enhanced protocol
- Where
- Guinea-Bissau
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Tuberculosis
The Correlate of Risk Targeted Intervention Study
Effective tuberculosis (TB) control requires that people who progress from latent Mycobacterium tuberculosis (MTB) infection (LTBI) to TB disease are identified and treated before they infect others.
- Trial name
- CORTIS (NCT02735590)
- Testing
- Isoniazid, Rifapentine
- Where
- 5 sites in South Africa
- Volunteers
- 2,927 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
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