Clinical trials: tuberculosis
Tuberculosis, Multidrug-Resistant
Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis
Resistance to anti-tuberculosis drugs is a continually growing problem. Multidrug-resistant tuberculosis (MDRTB) is resistance to at least rifampicin and isoniazid, and extensively drug-resistant TB is additional resistance to a…
- Trial name
- T3-RCT (NCT05007795)
- Testing
- Targeted sequencing using the GenoScreen Deeplex assay
- Where
- South Africa
- Volunteers
- 280 people
- Sponsor
- University of Cape Town
Tuberculosis, Pulmonary, Physical Disability
Cardiopulmonary Function and Quality of Life in Pulmonary Tuberculosis
This work aims to assess cardiopulmonary function and quality of life in people with sequelae of pulmonary tuberculosis undergoing rehabilitation.
- Conditions
- Tuberculosis, Pulmonary, Physical Disability, Quality of Life
- Trial name
- NCT04844502
- Testing
- Physical rehabilitation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Tuberculosis
Effect of Mycobacterial Infection on Immune Status
This study, titled "Effect of Mycobacterial Infection on Immune Status" (EMIIS), investigates the immune-driven mechanisms of mycobacterial infections, focusing on the dynamic immune characteristics of multidrug-resistant…
- Trial name
- EMIIS (NCT07638670)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Tuberculosis
BCG Revaccination Study in Diabetic and Non-Diabetic Adults
The purpose of this study is to: 1. explore whether investigators can make BCG more effective by giving it in a different way. For this, aerosol inhaled BCG will be compared against the conventional BCG injection. 2.
- Trial name
- NCT06246851
- Testing
- BCG Danish
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Non-invasive TB Triage and Patient Mapping Platform Using Breath Via Low-Cost Titanium Dioxide Nanotube Sensor
The purpose of this pilot study is to evaluate the sensitivity and specificity of a nanotube-based point-of-care breath-based tuberculosis screening test as compared to the current standards of care including sputum microscopy…
- Trial name
- NCT02681445
- Testing
- Breath Collection
- Where
- India
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tuberculous Meningitis
Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation
Tuberculous (TB) meningitis is the most severe manifestation of TB infection, leaving up to 50% of patients dead or neurologically disabled.
- Trial name
- REMOVER (NCT01802502)
- Testing
- Rifampicin intravenous, Oral rifampicin
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Padjadjaran
Tuberculosis, Tuberculosis, Pulmonary
Study to Evaluate Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects
A Phase 1, Partially-Blinded, Placebo-Controlled, Randomized, Multiple Ascending Dose Study to Include A Single Dose Food-Effect Study to Evaluate the Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects
- Trial name
- NCT04865536
- Testing
- TBI-223 1800 mg, TBI-223 2400mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Tuberculosis, HIV
Pharmacokinetics of Anti-TB Drugs in HIV/TB Co-infected Children in Ghana
Tuberculosis (also known as TB) is a common infection and a major cause of death in children. Effective treatment using a combination of anti-tuberculosis (anti-TB) medications saves lives, but dosages of these medications are…
- Trial name
- NCT01687504
- Where
- Ghana
- Volunteers
- 106 people
- Sponsor
- The Miriam Hospital
HIV, Tuberculosis
Rifampin and Efavirenz Interactions in Older Children
Efavirenz is an essential component of HIV treatment in children aged 3 years or older on anti-tuberculosis (anti-TB) treatment. However, the appropriate efavirenz dose during anti-TB treatment remains unclear.
- Trial name
- NCT01704144
- Where
- Ghana
- Volunteers
- 160 people
- Sponsor
- The Miriam Hospital
Tuberculosis
Phase 2a Study of PBTZ169
Multicenter, open, randomized study with active control (isoniazid) to evaluate the early antibacterial activity, safety and pharmacokinetics of the drug PBTZ169 (capsules 80 mg) when used in patients with first-diagnosed…
- Trial name
- NCT03334734
- Testing
- PBTZ169, Isoniazid
- Volunteers
- 16 people
- Sponsor
- Nearmedic Plus LLC
Tuberculosis
Prospective Evaluation of Novel Diagnostics for Tuberculosis in KwaZulu-Natal, South Africa
Tuberculosis (TB) infects nearly two billion people and has become the leading infectious cause of mortality worldwide, due in part to inadequate diagnostic and prognostic tests.
- Trial name
- PROVE-TB (NCT04583904)
- Where
- South Africa
- Volunteers
- 843 people
- Sponsor
- University of Washington
Tuberculosis
ID93/GLA-SE Vaccination + BCG Challenge
The purpose of this study is to: 1. Demonstrate the safety of a novel TB vaccine (ID93/GLA-SE) when given to both BCG-vaccinated and BCG-naïve volunteers. 2.
- Trial name
- NCT06670755
- Testing
- ID93/GLA-SE, BCG Danish
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis, Tuberculosis Infection
Immunological Biomarkers in Tuberculosis Management
Tuberculosis (TB) is the leading cause of death by infectious disease in the world, responsible for 1.6 million deaths in 2017. The treatment of active TB requires at least a 6-month combined antibiotic regimen and can cause…
- Trial name
- OPTI-4TB (NCT04271397)
- Testing
- Multiple blood samples, Single blood sample
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Tuberculosis; Pulmonary, Confirmed, Unspecified Means
Delayed Diagnosis of Bacteriologically Positive Pulmonary Tuberculosis and Relative Optimized Suggestions in China
The purpose of the study is to collect health-seeking pathways, sociodemographic characteristics and symptoms of 400 newly diagnosed patients with bacteriologically confirmed pulmonary tuberculosis(TB).
- Trial name
- NCT04434976
- Where
- 20 sites in China
- Volunteers
- 400 people
- Sponsor
- Huashan Hospital
Tuberculosis
First Time in Human (FTIH) Safety and Pharmacokinetics (PK) Study of GSK3036656 in Healthy Subjects
GSK3036656 is being developed by GSK for the treatment of tuberculosis (TB). This is the FTIH study for GSK3036656 to evaluate the safety, tolerability and PK of single ascending and repeat oral doses of GSK3036656 in healthy…
- Trial name
- NCT03075410
- Testing
- GSK3036656
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
Drug Interaction Study Between Rifabutin And Lersivirine (UK-453,061)
Approximately 1/3 of persons living with HIV infection are co-infected with tuberculosis (TB). Rifabutin, used in the treatment of TB, is an inducer of drug metabolism thus may decrease concentrations of lersivirine if…
- Trial name
- NCT00925535
- Testing
- Lersivirine, Rifabutin
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tuberculosis
Gene Xpert Diagnosis of TB Using Tracheal Aspirates From Intensive Care Unit (ICU) Patients
Aim: To evaluate the diagnostic utility and impact on patient outcomes of an automated PCR (Gene Xpert® MTB/RIF), in a group of patients with suspected pulmonary TB who are mechanically ventilated in ICU, using tracheal…
- Trial name
- NCT01530568
- Testing
- Xpert, Smear
- Where
- South Africa
- Volunteers
- 341 people
- Sponsor
- University of Cape Town
Tuberculosis
Development of a Rapid and Accurate Diagnostic Assay for Tuberculosis
This study evaluates new technique for diagnosis of tuberculosis. Among patients who are suspected with tuberculosis, participants will be tested conventional method including Xpert TB/RIF assay, and new diagnostic technique…
- Trial name
- NCT03423550
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Tuberculosis Identification.
Equivalence Study of Tuberculin Purified Protein Derivative in Comparison With a Reference Standard (PPD-S2)
A study to determine bioequivalence of PPD material versus Reference Standard.
- Trial name
- 02 (NCT01798121)
- Testing
- To compare new PPD to reference standard material, Reference standard
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- JHP Pharmaceuticals LLC
Tuberculosis
TB PCR in BAL and EBUS-TBNA
This prospective observational multi-centre UK study will evaluate Xpert MTB/RIF Ultra for the detection of Mycobacterium tuberculosis (MTB) in bronchoalveolar lavage (BAL) samples for pulmonary TB and endobronchial ultrasound…
- Trial name
- TRiBE (NCT04909385)
- Where
- United Kingdom
- Volunteers
- 394 people
- Sponsor
- Imperial College Healthcare NHS Trust
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.