Clinical trials: tuberculosis
Tuberculosis, Pulmonary, Interferon-gamma Release Tests
IGRA and Mantoux Response in Children With Suspected Latent or Active TB Infection
The aim of this project is to analyze the potential contribution of IGRA test QuantiFERON-TB Gold In Tube test (QTF-GIT, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent)…
- Conditions
- Tuberculosis, Pulmonary, Interferon-gamma Release Tests, Tuberculin Test
- Trial name
- TBTubercolar (NCT02653404)
- Testing
- IGRA test (QTF-GIT)
- Where
- 3 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Siena
Tuberculosis
Clinical Trial to Evaluate the Efficacy and Safety of EEC for the Diagnosis of Mycobacterium Tuberculosis Infection in People Aged 3 Years and Above
This study is a randomized, blinded, active-controlled clinical trial to evaluate the effectiveness and safety of EEC in the diagnosis of Mycobacterium tuberculosis infection in people aged 3 years and above.
- Trial name
- NCT07152639
- Testing
- 5μg/ml EEC, 5 unit（U） EC, 5 IU TB-PPD
- Where
- 8 sites in China
- Volunteers
- 1,784 people, healthy volunteers welcome
- Sponsor
- Chengdu CoenBiotech Co., Ltd
Acquired Immunodeficiency Syndrome, Tuberculosis
Optimal Time to Initiate Antiretroviral Therapy in HIV & TB Coinfected Adults Being Treated for Tuberculosis
Aim of the study is to determine optimal time to initiate anti-retroviral therapy in HIV/TB co-infected patients who recently started treatment for Tuberculosis by comparing immediate versus deferred initiation of HAART.
- Trial name
- TB-HAART (NCT01315301)
- Testing
- Comparison of different treatment strategies
- Where
- Ethiopia
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis
Efficacy of Anti-Tubercular Vaccination in Multiple Sclerosis
The frequency of auto-immune diseases (including multiple sclerosis) is increasing in industrialised countries. According to an hypothesis which is receiving a wide international credit, this may be due to the fact that the…
- Trial name
- NCT00202410
- Testing
- Bacille of Calmette-Guerin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- S. Andrea Hospital
Tuberculosis
Vitamin D in Active Tuberculosis (TB) Study
Tuberculosis is a disease caused by a bacterium (a germ) that can cause illness in any organ of the body, but most frequently causes disease of the lungs. TB is short for tuberculosis.
- Trial name
- NCT00788320
- Testing
- Vitamin D3
- Where
- United States
- Sponsor
- Atlanta VA Medical Center
Tuberculosis, Latent Tuberculosis
Use TST and QFT-RD1 Test to Monitor the Tuberculous Infection in Patients, Close Contact People and Health Care Workers
Tuberculosis is still the most common infectious disease in Taiwan. The infants in Taiwan have been vaccinated at birth with BCG -Tokyo 171 strain since 1951.
- Conditions
- Tuberculosis, Latent Tuberculosis, Tuberculosis Contact, Elderly
- Trial name
- NCT00311220
- Testing
- tuberculin for skin test
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Tuberculosis, Malnutrition
Tuberculosis - Learning the Impact of Nutrition
The proposed work is based on the finding that one-third of the world is infected with the bacteria Mycobacterium tuberculosis (Mtb) and only 10% of these individuals develop TB.
- Conditions
- Tuberculosis, Malnutrition, Helminth Infection
- Trial name
- TB-LION (NCT03598842)
- Testing
- Nutritional Supplementation Meal, Multivitamin, Anti-parasitic medications
- Where
- India
- Volunteers
- 786 people
- Sponsor
- Boston Medical Center
Tuberculosis, Acute Coronary Syndrome
Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis
Tuberculosis (TB) is a global pandemic that despite successful treatment and bacterial eradication can cause chronic ill health, such as pulmonary impairment after tuberculosis (PIAT) and cardiovascular disease (CVD).
- Conditions
- Tuberculosis, Acute Coronary Syndrome, Pulmonary Hypertension (Diagnosis)
- Trial name
- Doxy-TB (NCT05473520)
- Testing
- Doxycycline
- Where
- 6 sites in Malaysia, Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Tuberculosis
Bacille Calmette Guerin (BCG) Revaccination of Healthy Adolescents for the Prevention of Mycobacterium Tuberculosis Sustained Infection
The purpose of this study is to demonstrate the efficacy of Bacille Calmette Guerin (BCG) revaccination against sustained Mycobacterium tuberculosis infection versus placebo in previously BCG vaccinated QuantiFERON®-TB Gold Plus…
- Trial name
- NCT04152161
- Testing
- BCG vaccine SSI
- Where
- 5 sites in South Africa
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Tuberculosis
A Study to Evaluate the Safety and Immunogenicity of Ad5-105K in Adults Aged 18 to 49 Years
This is a randomized, observer-blind, positive-controlled study. There will be 2 treatment groups (Group A and B). In each treatment group, 18 participants will be randomly assigned to receive either the investigational vaccine…
- Trial name
- NCT06732583
- Testing
- Tuberculosis (TB) vaccine (Ad5-105K), Ad5-105K
- Where
- Indonesia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Lung Cancer, Tuberculosis
Epidemiology and Diagnosis of Haemoptysis: a Multicenter Study
Haemoptysis is the coughing up of blood originating from the respiratory tract. It is a common and worrying clinical symptom which can be due to different aetiologies including lung cancer, tuberculosis, COPD, bronchiectasis…
- Conditions
- Lung Cancer, Tuberculosis, Bronchiectasis, Pneumonia
- Trial name
- NCT02045394
- Testing
- Chest X-ray, computed tomography of the chest, Bronchoscopy
- Where
- 6 sites in Italy
- Volunteers
- 610 people
- Sponsor
- University of Milan
Human Immunodeficiency Virus, Tuberculosis
Preventive Therapy for Tuberculosis in HIV Infected Persons
Title: Evaluation of efficacy of two different preventive therapy regimens for tuberculosis in HIV infected persons Phase: Phase III trial Population: 650 HIV positive patients without tuberculosis Number of sites: Three 1.
- Trial name
- NCT00351702
- Testing
- Isoniazid with Ethambutol
- Where
- India
- Volunteers
- 683 people
- Sponsor
- Tuberculosis Research Centre, India
Tuberculosis, HIV
Start TB Patients on ART and Retain on Treatment (START Study)
The purpose of the START Study is to identify an effective, cost-effective, acceptable intervention that addresses programmatic, structural and psychosocial barriers to ART initiation and retention during TB treatment, with the…
- Trial name
- START (NCT01872390)
- Testing
- Combination Intervention Package, Standard of Care
- Where
- 12 sites in Lesotho
- Volunteers
- 415 people
- Sponsor
- Columbia University
TB - Tuberculosis, PTLD
Intergrated Service Delivery for Lung Health Conditions
The Advancing Lung Health in Zambia project aims to improve access to integrated screening, diagnosis, and management of tuberculosis (TB) and other priority respiratory diseases at community and primary healthcare levels.
- Conditions
- TB - Tuberculosis, PTLD, COPD (Chronic Obstructive Pulmonary Disease), Computer Aided Diagnosis
- Trial name
- TB REACH W11 (NCT07816523)
- Testing
- Intergrated lung health screening, AI-Enabled Cough Sound Screening for Tuberculosis, Post-TB Lung Disease evaluation
- Where
- Zambia
- Volunteers
- 20,300 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Tuberculosis
Effectiveness of Active Case Finding of Household Contacts in a Routine Tuberculosis (TB) Control Program
The purpose of this study is to determine the effectiveness and cost-effectiveness of a new population-based active case-finding program among adult household contacts of new infectious TB cases to detect active TB cases in the…
- Trial name
- NCT02174380
- Testing
- Active Household Contact Evaluation
- Where
- Peru
- Volunteers
- 1,900 people
- Sponsor
- Lena Shah
Pulmonary Tuberculosis, Treatment Adherence
Effectiveness of Psychosocial Counseling in Patients With a New Tuberculosis Diagnosis
Introduction: Newly diagnosed TB patients frequently experience psychological distress, stigma, and concerns regarding treatment duration, side effects, and social consequences, which may negatively affect adherence.
- Conditions
- Pulmonary Tuberculosis, Treatment Adherence, Mental Health
- Trial name
- NCT07703696
- Testing
- psychosocial counseling
- Where
- Indonesia
- Volunteers
- 108 people
- Sponsor
- Universitas Diponegoro
Tuberculosis
Local Anesthesia and Tuberculin Skin Test in Infants and Children
The use of local anaesthesia efficiently reduces pain due to needle puncture. However, when tuberculin skin test is performed it is the skin reaction to tuberculin injection that is studied.
- Trial name
- NCT00309673
- Testing
- lidocaine / Prilocaine
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis
Real-time Tuberculosis Medication Adherence Intervention in Rural Southwestern Uganda
With an estimated 60,000 people diagnosed with TB (Tuberculosis) annually, Uganda holds the 16th position of the 22 countries with highest cases of TB in the world.
- Trial name
- MAT K43 (NCT03800888)
- Testing
- Daily SMS reminders for TB patients, SMS Notifications for social supporters, Weekly SMS remiders
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- Mbarara University of Science and Technology
Tuberculosis
Phase 2a Clinical Trial of ID93+GLA-SE Vaccine in BCG-vaccinated Healthy Healthcare Workers
The purpose of this study is to evaluate the experimental tuberculosis (TB) vaccine called ID93+GLA-SE. The safety, immunogenicity, and efficacy of ID93+GLA-SE will be compared to placebo, after three intramuscular (IM)…
- Trial name
- NCT03806686
- Testing
- ID93+GLA-SE
- Where
- 3 sites in South Korea
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Quratis Inc.
Tuberculosis
Gene Expression in HIV and Tuberculosis Co-infection
Background: Tuberculosis (TB) infection is particularly deadly when it happens in people who are also infected with the human immunodeficiency virus (HIV).
- Trial name
- NCT01611402
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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