Clinical trials: tuberculosis
Tuberculosis, Pulmonary, Helminthiasis
Tuberculosis - Learning the Effect of Parasites and Reinforcing Diets
The objectives of this research are to determine: the burden of intestinal parasitic infections among persons living with pulmonary tuberculosis (TB) whether intestinal parasitic infections alter TB treatment outcomes, including…
- Conditions
- Tuberculosis, Pulmonary, Helminthiasis, Malnutrition
- Trial name
- TB-LEOPARD (NCT05048485)
- Where
- 2 sites in United States, India
- Volunteers
- 141 people
- Sponsor
- Boston Medical Center
Pulmonary Multi-drug Resistant Tuberculosis
A Prospective Patient Registry of Patients Exposed to Bedaquiline
The purpose of this study is to describe the medical indication and utilization of expert medical consultation among participants treated with bedaquiline (BDQ), BDQ susceptibility based on minimum inhibitory concentrations…
- Trial name
- NCT02274389
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Janssen Research & Development, LLC
Tuberculosis
Latent Tuberculosis in Healthcare Workers - the Reality of a Portuguese Tertiary Hospital
Prospective, descriptive study to assess latent tuberculosis infection (LTBI) among healthcare worker (HCW) in a tertiary hospital in a low-risk area.
- Trial name
- NCT05847491
- Testing
- IGRA/Tuberculin skin test
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar do Oeste
Tuberculosis
Food Incentives for TB Treatment Compliance in East Timor (FITTCET)
This study will examine whether food is a cost-effective method for improving treatment compliance for TB patients in Timor Leste.
- Trial name
- NCT00192556
- Testing
- food
- Where
- Australia
- Volunteers
- 270 people
- Sponsor
- Menzies School of Health Research
Tuberculosis
Tuberculosis (TB) Screening for the Diagnosis of Latent TB in Immunocompromised Populations
The tuberculin skin test (TST) has been the gold standard for diagnosing latent tuberculosis for almost 100 years. While this test performs reasonably well in healthy, non-bacille Calmette-Guerin (BCG) vaccinated populations, it…
- Trial name
- NCT00134342
- Testing
- T-SPOT TB ELISPOT test
- Where
- 2 sites in Canada
- Volunteers
- 203 people
- Sponsor
- University Health Network, Toronto
Latent Tuberculosis Infection, Tuberculosis
Clinical Trial to Investigate the Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI® Following One Month of Isoniazid Treatment in Subjects With Latent Tuberculosis Infection
The aim of the trial is to assess the safety, tolerability and immunogenicity of two doses of RUTI® vaccine administered four weeks apart after one month pre-treatment with INH.
- Trial name
- NCT01136161
- Testing
- RUTI
- Where
- 3 sites in South Africa
- Volunteers
- 95 people
- Sponsor
- Archivel Farma S.L.
Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
- Trial name
- CPE (NCT00468104)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Pulmonary and Critical Care
Tuberculosis
Epidemiological Study In Tuberculosis-Endemic Urban Area in Senegal
A cross-sectional childhood M. tuberculosis infection survey of age-specific rates (defined by positivity to the test QuantiFERON-TB Gold Plus) will be conducted in Senegal to collect information on the local TB endemic to inform…
- Trial name
- MTBVAC-EPI (NCT03767946)
- Testing
- Quantiferon Gold Plus Test
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Biomedical Research Center EPLS
Tuberculosis, Pulmonary
TuBerculosis Viability Interregional Study and Agreement on Biological Tests
The objective of the present study is to confirm in a multicentric study the utility of our viability test in large cohort of smear-positive pulmonary tuberculosis patients under treatment and to determine if the test could help…
- Trial name
- TBVISA (NCT04968886)
- Testing
- Diagnostic Test: viability test on sputum and comparision with culture results (reference test)
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Neoplasm, Pulmonary Tuberculosis
Could the Stroke Volume Variation Predict a Fluid Responsiveness in Thoracotomy?
There are some risks of pulmonary edema in patients undergoing pulmonary lobectomy with one lung ventilation. The overloading of fluid administration could be related to the development of pulmonary edema in patents after…
- Trial name
- NCT02331056
- Testing
- fluid loading, thoracoscopic pulmonary lobectomy, thoracotomy
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Samsung Medical Center
Tuberculosis
Safety and Risk of Sensitisation of the rdESAT-6 + rCFP-10 Skin Test Following Repeated Intradermal Administration
The primary objective is to assess the safety of three dose levels (0.01, 0.1 and 1.0 µg) of the rdESAT-6 + rCFP-10 skin test reagent when injected into healthy adults.
- Trial name
- NCT00793702
- Testing
- rdESAT-6 + rCFP-10
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Statens Serum Institut
Tuberculosis
Biodistribution and Pharmacokinetics of Pretomanid in Tuberculosis Patients Using 18F-Pretomanid PET
This is an observational study that will examine the pretomanid pharmacokinetics (PK) in tuberculosis (TB) patients. Dynamic 18F-pretomanid PET/CT will be performed after intravenous injection of 18F-pretomanid to determine…
- Trial name
- NCT05609552
- Testing
- 18F-Pretomanid PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tuberculosis, Drug-resistant Tuberculosis
Brief Bactericidal Activity of Anti-Tuberculosis Drugs
The investigators will determine the bactericidal activity of high-dose isoniazid against M. tuberculosis isolates that are (1) susceptible to isoniazid at 2.0 mcg/ml but resistant at 0.1 and 0.4 mcg/ml or (2) susceptible at 0.4…
- Conditions
- Tuberculosis, Drug-resistant Tuberculosis, Isoniazid Resistant Tuberculosis (Disorder)
- Trial name
- BBA (NCT02236078)
- Testing
- High dose isoniazid
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Centers for Disease Control and Prevention
MDR-TB
Saliva and Dried Blood Spot Therapeutic Drug Monitoring for MDR-TB in Tanzania
Dried blood spot and saliva samples are collected during multidrug resistant tuberculosis (MDR-TB) treatment to measure the drug concentration of levofloxacin.
- Trial name
- NCT04124055
- Testing
- Therapeutic drug monitoring (TDM)
- Where
- Tanzania
- Volunteers
- 51 people
- Sponsor
- Jan-Willem C Alffenaar
Tuberculosis
Evaluation and Demonstration of New Tuberculosis Diagnostics for Indonesia
The goal of this cluster-randomised controlled trial (CRCT) is to learn whether the use of new non-sputum-based diagnostic tests and other intervention components for tuberculosis (TB) diagnosis in healthcare facilities (HCF) can…
- Trial name
- EVIDENT (NCT07293455)
- Testing
- nPOC Testing Intervention Package
- Where
- Indonesia
- Volunteers
- 40,000 people
- Sponsor
- Universitas Padjadjaran
Efficacy and Safety
A Study on the Short-course Treatment Regimen Containing Pretomanid for Drug-resistant Tuberculosis
Rifampicin-resistant tuberculosis (RR-TB) is characterized by a long treatment course, high incidence of adverse reactions, low cure rate and high recurrence rate.
- Trial name
- BPaLM (NCT07126639)
- Testing
- bedaquiline, Pretomanid (Pa), linezolid
- Volunteers
- 200 people
- Sponsor
- Wuhan Pulmonary Hospital
Tuberculosis
TB Case-Finding, Treatment and Prevention Intervention in Thailand
The project aimed to test a strategy for the early detection and prevention of tuberculosis in household contacts of tuberculosis patients in order to reduce the morbidity, mortality and transmission of this disease in Thailand.
- Trial name
- CaPThai (NCT05581212)
- Testing
- Tuberculosis Case-Finding, Treatment and Prevention Public Health Pack
- Where
- 20 sites in Thailand
- Volunteers
- 7,455 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Tuberculosis
PPD Size and Mycobacteria Tuberculosis ELISPOT in Children Who Have Received BCG in Neonate Period
To investigate the size of PPD and TB specific ELISPOT among children between 3m/o and 15 y/o . Calculate the normal range of age specific PPD size in children who recieved BCG at new-born period.
- Trial name
- NCT00172783
- Where
- Taiwan
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tuberculosis
Evaluation of the QuantiFERON-TB Test.
To compare the results of the investigational test to the currently approved QuantiFERON-TB Gold In-Tube test.
- Trial name
- NCT02253537
- Testing
- CST001
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- QIAGEN Gaithersburg, Inc
Tuberculosis
Results of an Interferon-Gamma Release Assay After Treatment for Tuberculosis
New blood tests have become available to detect either latent or active tuberculosis. These tests - which according to the CDC can replace the tuberculin skin test - measure the production of gamma-interferon (a cytokine) by…
- Trial name
- NCT00595907
- Where
- Switzerland
- Volunteers
- 89 people
- Sponsor
- University Hospital, Geneva
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