Clinical trials: tuberculosis
Colonoscopy
Patient-posture and Ileal-intubation During Colonoscopy
During colonoscopy, the colonoscopist employs various maneuvers, including changing the patient's posture to left-lateral decubitus or supine, to achieve complete colonoscopic examination.
- Trial name
- PIC (NCT01159886)
- Testing
- Ileal intubation
- Where
- India
- Volunteers
- 216 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Tuberculosis
Safety Study Investigating if Concomitant Injections of C-Tb and 2 T.U Tuberculin Affect Induration Responses
A new, more specific skin test to detect tuberculosis has been developed by Statens Serum Institut in Denmark. The new skin test is named C-Tb and like the current Tuberculin a positive test result will show as redness and/or…
- Trial name
- TESEC-07 (NCT01779102)
- Testing
- C-Tb, Tuberculin PPD RT 23 SSI, C-Tb / Tuberculin PPD RT 23 SSI
- Where
- 7 sites in South Africa
- Volunteers
- 456 people
- Sponsor
- Statens Serum Institut
Tuberculosis
Intensive Smoking-cessation Intervention Versus Smoking-cessation Advice in Smear-positive Patients With Pulmonary Tuberculosis
The aim of the study is to determine the impact of a package of smoking-cessation interventions on a composite measure of Tuberculosis (TB) treatment-related outcomes.
- Trial name
- NCT01517022
- Testing
- nicotine replacement therapy
- Where
- India
- Volunteers
- 800 people
- Sponsor
- All India Institute of Medical Sciences
Tuberculosis (TB), Human Immunodeficiency Virus (HIV) Prophylaxis
Integrating HIV Prevention With TB Household Contact Evaluation in Uganda
This household randomized implementation study assesses the implementation and effectiveness of home-based HIV self- testing and PrEP initiation versus standard clinic referral for PrEP initiation during modified standard-of-care…
- Trial name
- TB PrEP (NCT07119359)
- Testing
- Home-based HIV self-testing, Home-based initiation of PrEP
- Where
- Uganda
- Volunteers
- 2,480 people, healthy volunteers welcome
- Sponsor
- University of Washington
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices
We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Lung Cancer, Tuberculosis; Tracheitis
- Trial name
- NCT04850742
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Tuberculosis
Evaluation of Somatostatin Receptor Imaging Using PET/MRI as a Novel Approach to Detecting Pathology in Pulmonary TB
Imaging using 68Ga-DOTANOC PET (positron emission tomography) has the potential to detect granulomas in pulmonary tuberculosis, leading to previously unexplored indications for this PET tracer, including identification of…
- Trial name
- NCT02845570
- Testing
- 68Ga-DOTANOC PET/MRI, 18F-FDG PET/MRI
- Where
- 2 sites in Singapore
- Volunteers
- 8 people
- Sponsor
- National University Hospital, Singapore
Tuberculosis
Wirelessly Observed Therapy in Comparison to Directly Observed Therapy for the Treatment of Tuberculosis
This study uses an ingestion sensor and a wearable sensor (worn as a patch on the skin), which are new Proteus Digital Health (PDH) technologies approved by the FDA, to collect information about patients taking their TB…
- Trial name
- NCT01960257
- Testing
- Digital Health Feedback System, SOC DOT
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of California, San Diego
Central Nervous System Tuberculosis
A Retrospective Study of Treatment Patterns and Clinical Outcomes in Patients With Central Nervous System Tuberculosis
This is a retrospective clinical study to analyze the clinical characteristics, complications, and effects of different treatment options on long-term prognosis in patients with central nervous system tuberculosis.
- Trial name
- NCT06011915
- Where
- 2 sites in China
- Volunteers
- 638 people
- Sponsor
- Tongji Hospital
Active Tuberculosis
Characterization and Evaluation of Diagnostic Biomarkers for Tuberculosis
There was no sensitive and specific biomarker for tuberculosis infection, disease progression and predicting the prognosis of treatment.
- Trial name
- NCT01269268
- Where
- South Korea
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Tuberculosis, Resistance Bacterial
TB-CAPT MTB/XDR Study
The Cepheid Xpert MTB/XDR cartridge, which runs on the same platform as Xpert MTB/RIF Ultra, has been developed to detect additional resistance to isoniazid, fluoroquinolones and second-line injectable anti-tuberculosis drugs and…
- Conditions
- Tuberculosis, Resistance Bacterial, Diagnoses Disease
- Trial name
- NCT04567368
- Testing
- Xpert MTB/XDR
- Where
- 2 sites in South Africa
- Volunteers
- 753 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis
Evaluation of the VOT Among Tuberculosis Patients From Lambaréné
This pilot study aimed to assess the feasibility of using an instant messenger to monitor drug intake in tuberculosis patients and to assess cash incentive to improve adherence to drug intake
- Trial name
- dotsapp (NCT05865626)
- Testing
- VOT with and without cash incentive
- Where
- Gabon
- Volunteers
- 30 people
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Pulmonary Tuberculosis
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (TMC207-CL001)
The trial will evaluate the extended bactericidal activity of 14 consecutive days of oral administration of TMC207 at multiple doses as determined by the rate of change of log10 colony forming units (CFU) per ml sputum over the…
- Trial name
- NCT01215110
- Testing
- TMC207, Rifafour e-275 mg
- Where
- South Africa
- Volunteers
- 68 people
- Sponsor
- Global Alliance for TB Drug Development
Tuberculosis, HIV
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
This cluster-randomized trial in Uganda will evaluate the effectiveness and implementation of a novel, peer-led TB education and counseling strategy to improve outcomes among persons with tuberculosis (TB) with and without…
- Trial name
- TEACH (NCT05917210)
- Testing
- Peer-Navigaton TB-EC Strategy, Usual TB-EC Strategy
- Where
- Uganda
- Volunteers
- 1,920 people
- Sponsor
- Yale University
Pulmonary Tuberculosis
Efficacy and Safety of Qinbudan as an Adjunct Therapy for Retreatment Pulmonary Tuberculosis
The purpose of this study is to assess the efficacy and safety of Chinese medicine Qinbudan in Patients Receiving Standard Combination Therapy for Retreatment Pulmonary Tuberculosis.
- Trial name
- NCT02313610
- Testing
- Qinbudan
- Where
- 12 sites in China
- Volunteers
- 253 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Tuberculosis
TBTC Study 26 PK: Rifapentine Pharmacokinetics in Children During Treatment of Latent TB Infection
Compared to adults, children appear to require higher weight-based doses of rifapentine to acheive comparable drug levels. TBTC Study 26, a study of the effectiveness and tolerability of weekly rifapentine/isoniazid for three…
- Trial name
- NCT00164450
- Testing
- Isoniazid, Rifapentine
- Where
- 24 sites in United States, Brazil and 2 more
- Volunteers
- 158 people
- Sponsor
- Centers for Disease Control and Prevention
Latent Tuberculosis, Diabetes Mellitus, Type 2
Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation
This study will be investigating the effect of latent tuberculosis infection (LTBI) treatment on glucose tolerance and low-grade inflammation.
- Trial name
- NCT04830462
- Testing
- Rifampicin 300 Mg Oral Capsule, Isoniazid 300 Mg ORAL TABLET
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Herlev and Gentofte Hospital
Latent Tuberculosis
Prevalence of Latent Tuberculosis in High Risk Children
identify the prevalence of latent tuberculosis (according to new guideline ;NICE tuberculosis) among these high risk groups of children and notify ministry of health
- Trial name
- NCT03910946
- Testing
- Tuberculin, Purified Protein 5Unt/0.1 mL Solution
- Volunteers
- 100 people
- Sponsor
- Assiut University
Tuberculosis
Latent Tuberculosis Infection in Bone Marrow Transplant Recipients
The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients.
- Trial name
- NCT01021124
- Where
- South Korea
- Volunteers
- 409 people
- Sponsor
- Asan Medical Center
Tuberculosis
Cali Sin Tos Aim 2
The overall objective of this Aim is to design and iteratively adapt a home-based, mHealth- and oral testing facilitated strategy for implementing tuberculosis (TB) contact tracing in Cali, Colombia.
- Trial name
- NCT06338462
- Testing
- Chatbot, Oral testing
- Where
- Colombia
- Volunteers
- 269 people
- Sponsor
- Yale University
Latent Tuberculosis Infection, End Stage Renal Disease (ESRD)
Prevalence of Latent Tuberculosis Infection Among Hemodialysis Patients
This observational cross-sectional study aims to determine the prevalence of latent tuberculosis infection (LTBI) among patients undergoing regular hemodialysis at Sohag University Hospital, using the tuberculin skin test (TST).
- Conditions
- Latent Tuberculosis Infection, End Stage Renal Disease (ESRD), Hemodialysis
- Trial name
- NCT07210970
- Testing
- Tuberculin Skin Test (TST)
- Volunteers
- 200 people
- Sponsor
- Sohag University
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