Clinical trials: tuberculosis
Tuberculosis, Pulmonary
Evaluation of 11C-acetate PET Imaging as a Novel Approach to Detecting Pathology in Pulmonary TB
Imaging using 11C-acetate PET (positron emission tomography) in patients with tuberculosis (TB) may be able to detect non-replicating persister bacilli.
- Trial name
- NCT02972697
- Testing
- 11C-acetate ligand, FDG ligand
- Where
- 2 sites in Singapore
- Volunteers
- 5 people
- Sponsor
- National University Hospital, Singapore
Cystic Fibrosis
Epidemiology and Clinical Characteristics of Non-Tuberculous Mycobacteria Infections in Cystic Fibrosis Patients.
An increase in the prevalence of infections due to non-tuberculous mycobacteria (NTM) is observed in many countries and recent data suggest the circulation of dominant clones with a possibility of human-to-human contamination.
- Trial name
- CIMENT (NCT03312075)
- Testing
- Sputum and blood samples
- Where
- 14 sites in France
- Volunteers
- 848 people
- Sponsor
- University Hospital, Brest
Latent Tuberculosis Infection
Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness
On a global scale, tuberculosis (TB) is the single most important infectious cause of morbidity and mortality. The World Health Organization has estimated that one-third of the entire world's population carries latent TB…
- Trial name
- NCT00931736
- Testing
- Isoniazid, Rifampin
- Where
- 12 sites in Australia, Benin and 7 more
- Volunteers
- 6,031 people
- Sponsor
- McGill University
Malignant Pleural Effusion, Tuberculous Pleural Effusion
Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions
This prospective observational analytical study aims to assess the diagnostic value of Cancer Ratio and Cancer Ratio Plus in differentiating malignant pleural effusion from tuberculous pleural effusion.
- Trial name
- CRPLUS-MPE-TPE (NCT07766876)
- Testing
- Cancer Ratio and Cancer Ratio Plus
- Volunteers
- 120 people
- Sponsor
- Sohag University
Tuberculous Meningitis
Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis
Tuberculous meningitis (TBM) is the most serious form of Mycobacterium tuberculosis infection, causing mortality and disability in more than half of the patients.
- Trial name
- NCT03898635
- Testing
- Linezolid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Huashan Hospital
Healthy Volunteers
Drug Interaction Study Between Rifabutin And Lersivirine (UK-453,061)
Approximately 1/3 of persons living with HIV infection are co-infected with tuberculosis (TB). Rifabutin, used in the treatment of TB, is an inducer of drug metabolism thus may decrease concentrations of lersivirine if…
- Trial name
- NCT00925535
- Testing
- Lersivirine, Rifabutin
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Extrapulmonary Tuberculosis, Tuberculosis, Pulmonary
POC Strategies to Improve TB Care in Advanced HIV Disease
Tuberculosis (TB) remains the major cause of morbidity and mortality among patients with HIV. Sub-optimal diagnostics contributes towards poor patient outcome and there is an urgent need to identify non-sputum-based point-of-care…
- Conditions
- Extrapulmonary Tuberculosis, Tuberculosis, Pulmonary, Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome
- Trial name
- TBPOC (NCT04122404)
- Testing
- LF-LAM
- Where
- 3 sites in Ghana
- Volunteers
- 425 people
- Sponsor
- University of Southern Denmark
Tuberculosis
Influence of Filarial Infections on Tuberculosis Disease and Tuberculosis Vaccination in Cameroon
Filarial nematodes modulate the host immune response to promote regulatory and T helper type 2 immune responses, which were shown to influence concomitant infections.
- Trial name
- MAP-TB (NCT04547738)
- Testing
- TB treatment according to national guidelines
- Where
- Cameroon
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Tuberculosis
Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis (TB) in Elderly Residents of Nursing Homes?
In face of the increased rates of tuberculosis in residents of long term care facilities, annual screening for latent tuberculosis is recommended.
- Trial name
- NCT00756808
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Tuberculosis, HIV Infections
Pharmacokinetics of Emtricitabine/Tenofovir/Efavirenz in HIV-infected Patients With Tuberculosis
In this pilot study the pharmacokinetics and safety of the antiretroviral combination of co-formulated emtricitabine/tenofovir/efavirenz will be studied in HIV-positive patients with pulmonary tuberculosis (TB) who are…
- Trial name
- PETE (NCT00474435)
- Testing
- Emtricitabine/tenofovir/efavirenz
- Where
- Tanzania
- Volunteers
- 30 people
- Sponsor
- African Poverty Related Infection Oriented Research Initiative
Tuberculosis, Illicit Drug Use
Transmission of Tuberculosis Among Illicit Drug Use Linkages
Tuberculosis (TB) is the leading infectious disease killer globally and leading cause of death in persons with HIV. The most effective way to reduce TB incidence and mortality is to interrupt transmission.
- Trial name
- TOTAL (NCT04151602)
- Testing
- Smoked illicit drug use
- Where
- South Africa
- Volunteers
- 802 people
- Sponsor
- Boston Medical Center
Tuberculosis
Impact of Vitamin D Supplementation on Host Immunity to Mycobacterium Tuberculosis and Response to Treatment
Tuberculosis bacterium (TB) is a germ that can infect any part of the human body, especially the lungs. Vitamin D is a hormone present in humans that regulates blood electrolytes such as calcium and phosphate.
- Trial name
- NCT00918086
- Testing
- Vitamin D pill
- Where
- Georgia
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Emory University
Autoimmune Rheumatic Diseases, Prevention
Incidence of Tuberculosis in Patients With Autoimmune Rheumatic Diseases
This is a prospective, randomized, controlled study designed to evaluate the effectiveness of annual re-screening for tuberculosis infection (TBI) (previous) in patients with autoimmune rheumatic diseases (ARDs) receiving…
- Trial name
- TB-RESCREEN (NCT07731672)
- Testing
- re-screening, No Rescreening
- Where
- Brazil
- Volunteers
- 1,660 people
- Sponsor
- University of Sao Paulo General Hospital
Tuberculosis, Pleural, Pleural Biopsy
Diagnostic Utility of Mycobacterium Tuberculosis Cell-free DNA in Hong Kong
Tuberculosis (TB) is an endemic infectious disease in Hong Kong and a global health threat. Tuberculous pleuritis (TBP) is the most common form of extrapulmonary tuberculosis in China.
- Trial name
- MYDNITE-3 (NCT06646237)
- Where
- Hong Kong
- Volunteers
- 350 people
- Sponsor
- Chinese University of Hong Kong
Lymphadenopathy, Tuberculosis
Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples
The purpose of this study is to compare the diagnostic efficacy of nested and realtime polymerase chain reaction for Mycobacterium tuberculosis using EBUS-TBNA samples in patients with isolated intrathoracic lymphadenopathy.
- Conditions
- Lymphadenopathy, Tuberculosis, Sarcoidosis
- Trial name
- NCT02497079
- Testing
- Nested PCR for formalin-fixed tissues, Nested PCR for fresh tissues, Real-time PCR for fresh tissues
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pusan National University Hospital
Hepatitis, Tuberculosis, Pulmonary
Reintroduction Regimens After Hepatitis During Anti-tuberculosis Treatment
Despite the availability of effective anti-tuberculosis agents that exist to treat this illness, hepatotoxicity during first-line drugs anti-tuberculosis medications (ATT) such as isoniazid (INH), rifampin (RIF), and pyrazinamide…
- Trial name
- NCT01395654
- Testing
- isoniazid, rifampin, pyrazinamide
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Mycobacterium Infections, Atypical
Special Investigation of Clarith/Klaricid in Patients With Non-tuberculous Mycobacterial Pulmonary Infections
To evaluate the efficacy and safety of long-term treatment with clarithromycin in patients with Non-tuberculous Mycobacterial Pulmonary Infections.
- Trial name
- NCT01097005
- Where
- 59 sites in Japan
- Volunteers
- 466 people
- Sponsor
- Mylan Inc.
Tuberculosis
Local Anesthesia and Tuberculin Skin Test in Infants and Children
The use of local anaesthesia efficiently reduces pain due to needle puncture. However, when tuberculin skin test is performed it is the skin reaction to tuberculin injection that is studied.
- Trial name
- NCT00309673
- Testing
- lidocaine / Prilocaine
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis
Potential Role of Microbiome in Tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a deadly infectious disease and major global public health problem.
- Trial name
- Micro-STOP (NCT04985994)
- Where
- 2 sites in Pakistan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
HIV Infections, Tuberculosis
Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO)
The Temprano trial is based on the following assumptions: ART initiation at CD4 counts <800/mm3 could significantly reduce the probability of severe HIV-related morbidity or death in the medium term.
- Trial name
- TEMPRANO (NCT00495651)
- Testing
- Antiretroviral medications, Antiretroviral medications+Isoniazid prophylaxis
- Where
- 9 sites in Côte d’Ivoire
- Volunteers
- 2,073 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
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