Clinical trials: in Belarus
Ulcerative Colitis
Etrasimod Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to determine whether oral etrasimod is a safe and effective treatment for moderately to severely active ulcerative colitis.
- Trial name
- ELEVATE UC 52 (NCT03945188)
- Testing
- Etrasimod
- Where
- 315 sites in United States, Argentina and 38 more
- Volunteers
- 433 people
- Sponsor
- Arena Pharmaceuticals
Severe Hypertriglyceridemia
Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Normal Renal Function
The purpose of this study is to evaluate the efficacy and safety of K-877 in adult patients with fasting high triglyceride levels ≥500 mg/dL and <2000 mg/dL and normal renal function.
- Trial name
- NCT03001817
- Testing
- K-877, Fenofibrate
- Where
- 220 sites in United States, Belarus and 7 more
- Volunteers
- 551 people
- Sponsor
- Kowa Research Institute, Inc.
Ulcerative Colitis
Study of the Efficacy and Safety of AMT-101 in Subjects With Ulcerative Colitis (LOMBARD)
Randomized, Placebo-controlled, Double-blind, Parallel-group, Multicenter, Phase 2a Study of the Efficacy and Safety of Oral AMT-101 in Subjects with Moderate to Severe Ulcerative Colitis.
- Trial name
- NCT04583358
- Testing
- AMT-101 (oral)
- Where
- 59 sites in United States, Belarus and 12 more
- Volunteers
- 105 people
- Sponsor
- Applied Molecular Transport
Severe Hypertriglyceridemia
Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Mild or Moderate Renal Impairment
The purpose of this study is to evaluate the efficacy and safety of K-877 in adult patients With Fasting High Triglyceride Levels ≥500 mg/dL and <2000 mg/dL and Mild or Moderate Renal Impairment.
- Trial name
- NCT03011450
- Testing
- K-877, Fenofibrate
- Where
- 241 sites in United States, Belarus and 7 more
- Volunteers
- 471 people
- Sponsor
- Kowa Research Institute, Inc.
Mental Illness, Stigmatization
European Study on the Attitude of Psychiatrists Towards Their Patients
Background: Many people think that people with mental disorders might be dangerous or unpredictable. These patients face various sources of disadvantages and experience discrimination on job interviews, in education, and housing.
- Trial name
- Eustigma (NCT04644978)
- Testing
- anonymous online survey
- Where
- 31 sites in Albania, Austria and 29 more
- Volunteers
- 4,245 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
HER2-positive Breast Cancer, Early-stage Breast Cancer
Extension Study to Provide Adjuvant Treatment Following Neoadjuvant Treatment and Surgical Resection in Protocol TX05-03
This is an extension study to provide adjuvant treatment with single agent Herceptin or TX05 and assess continued safety and immunogenicity in subjects with HER2-positive early breast cancer following neoadjuvant treatment and…
- Conditions
- HER2-positive Breast Cancer, Early-stage Breast Cancer, Breast Cancer, Breast Neoplasms
- Trial name
- NCT04109391
- Testing
- TX05 (trastuzumab), Herceptin (trastuzumab)
- Where
- 86 sites in Belarus, Chile and 8 more
- Volunteers
- 338 people
- Sponsor
- Tanvex BioPharma USA, Inc.
Metabolic Acidosis, Chronic Kidney Disease
Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis
The purpose of this study is to evaluate the effect of TRC101 on the progression of chronic kidney disease (CKD) and to evaluate the safety profile of TRC101 in CKD patients with metabolic acidosis.
- Trial name
- VALOR-CKD (NCT03710291)
- Testing
- TRC101
- Where
- 203 sites in United States, Albania and 32 more
- Volunteers
- 1,480 people
- Sponsor
- Tricida, Inc.
Age-Related Macular Degeneration
Treatment of Age-related Macular Degeneration Using Retinal Stem and Progenitor Cells
Treatment of age-related macular degeneration using retinal stem and progenitor cells
- Trial name
- NCT05187104
- Testing
- Cultured retinal stem and progenitor cells, Standard treatment according to the clinical protocols
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Systemic Sclerosis
Treatment of Systemic Sclerosis With Autologous Regulatory Т-cells
Treatment of patients with systemic sclerosis with autologous regulatory Т-cells
- Trial name
- NCT05214014
- Testing
- Autologous Regulatory Т-cells, Standard treatment according to the clinical protocols
- Where
- Belarus
- Volunteers
- 30 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Tracheal Stenosis, Laryngeal Stenosis
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
- Trial name
- NCT05535803
- Testing
- Olfactory mucosa-derived mesenchymal stem cells, Patients treated according to current clinical protocols
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Multiple Myeloma, Pneumococcal Infection
Pneumococcal Vaccination of Multiple Myeloma Patients on Novel Agents
Multiple myeloma is an incurable blood cancer of plasma cells that occurs in older individuals. Novel agents (proteasome inhibitors, immunomodulatory agents) have substantially improved the overall response rates…
- Conditions
- Multiple Myeloma, Pneumococcal Infection, Febrile Neutropenia, Pneumococcal Pneumonia
- Trial name
- NCT03619252
- Testing
- Vaccination with pneumococcal conjugate vaccine (PCV13), Standard Antibacterial Prophylaxis
- Where
- Belarus
- Volunteers
- 36 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Transplantation Infection, Kidney Transplant; Complications
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells…
- Conditions
- Transplantation Infection, Kidney Transplant; Complications, Stem Cell Transplant Complications, Liver Transplant; Complications
- Trial name
- NCT04281797
- Testing
- Intestinal microbiome new generation sequencing
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Recurrent Pregnancy Loss
Treatment of Recurrent Pregnancy Loss Using Mesenchymal Stem Cells
Treatment of Recurrent pregnancy loss using mesenchymal stem cells capable of differentiation in the endometrial-decidual direction.
- Trial name
- NCT05520112
- Testing
- Mesenchymal stem cells capable of differentiation in the endometrial-decidual direction, Standard treatment according to the clinical protocols
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Segmental Fracture - Bone Loss
Treatment of Patients With Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles
Treatment of patients with segmental bone tissue defects using mesenchymal stem cells enriched by extracellular vesicles
- Trial name
- NCT05520125
- Testing
- Mesenchymal stem cells enriched by extracellular vesicles, Standard treatment of bone defects
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Nerve Block, Efficiency
Ultrasound-guided Femoral Nerve Block Without Electrical Stimulation of Peripheral Nerves
There is little work comparing the effectiveness of a femoral nerve block performed only under US guidance or US plus electrical stimulation of the peripheral nerve (EPN).
- Conditions
- Nerve Block, Efficiency, Femoral Nerve, Ultrasonography
- Trial name
- USvsUSEPN (NCT05209490)
- Testing
- Femoral nerve blockade under ultrasound control with a peripheral nerve stimulator, femoral nerve blockade under ultrasound control without a peripheral nerve stimulator
- Where
- Belarus
- Volunteers
- 40 people
- Sponsor
- Mogilev Regional Clinical Hospital
Nerve Block, Efficiency
Femoral Nerve Blockade 7.5 ml of 1% Lidocaine: US Guidance Versus US Guidance With Electrical Stimulation of Peripheral Nerves (Influence of the Femoral Nerve Blockade on the Effectiveness of Small Doses of Local Anesthetic.). (EPBwEPN)
In modern anesthesiology, peripheral nerve blocks are performed using ultrasound control and electrical stimulation of peripheral nerves (PEN), or only ultrasound control or only EPN.
- Conditions
- Nerve Block, Efficiency, Femoral Nerve, Ultrasonography
- Trial name
- NCT05209711
- Testing
- Femoral nerve block under ultrasound control with a electrostimulator peripheral nerves 7.5 ml 1% lidocaine, Femoral nerve blockade under ultrasound control without a peripheral nerve stimulator 7.5 ml 1% lidocaine
- Where
- Belarus
- Volunteers
- 40 people
- Sponsor
- Mogilev Regional Clinical Hospital
Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Soft Palate
Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity
The purpose of this study was to determine whether LI administered in combination with cyclophosphamide, indomethacin and zinc in a multivitamin (CIZ) combination prior to standard of care therapy (surgery followed by…
- Trial name
- IT-MATTERS (NCT01265849)
- Testing
- LI, Cyclophosphamide, Indomethacin
- Where
- 102 sites in United States, Austria and 21 more
- Volunteers
- 928 people
- Sponsor
- CEL-SCI Corporation
Non-Hodgkin's B-cell Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell
Safety, PD & Efficacy of MT-3724 for the Treatment of Patients With Relapsed or Refractory DLBCL
The purpose of this study is to evaluate the safety and tolerability of MT-3724 in subjects with relapsed or refractory B-Cell NHL or relapsed and refractory CLL (Part 1 only) and relapsed and refractory DLBCL (Part 2 and Part…
- Conditions
- Non-Hodgkin's B-cell Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell, Small Lymphocytic Leukemia, Diffuse Large B Cell Lymphoma
- Trial name
- MT-3724NHL001 (NCT02361346)
- Testing
- MT-3724 Phase 1, MT-3724 Phase 2
- Where
- 41 sites in United States, Belarus and 8 more
- Volunteers
- 38 people
- Sponsor
- Molecular Templates, Inc.
Common Variable Immunodeficiency (CVID), APDS / PASLI
Study of Efficacy of CDZ173 in Patients With APDS/PASLI
This study was designed to explore CDZ173, a selective PI3Kδ inhibitor, in patients with genetically activated PI3Kδ, i.e., patients with Activated phosphoinositide 3-kinase delta syndrome/ p110δ-activating mutation causing…
- Trial name
- NCT02435173
- Testing
- CDZ173
- Where
- 10 sites in United States, Belarus and 7 more
- Volunteers
- 37 people
- Sponsor
- Novartis Pharmaceuticals
Nerve Block, Efficiency
Effectiveness of Peripheral Blocks Under Ultrasound Control With and Without Electrical Nerve Stimulation
In modern anesthesiology, peripheral nerve blocks are performed using ultrasound control and electrical stimulation of peripheral nerves (PEN), or only ultrasound control or only PEN.
- Conditions
- Nerve Block, Efficiency, Sciatic Nerve, Ultrasonography
- Trial name
- EPBwEPN (NCT05054881)
- Testing
- sciatic nerve blockade under ultrasound control with a peripheral nerve stimulator, sciatic nerve blockade under ultrasound control without a peripheral nerve stimulator
- Where
- Belarus
- Volunteers
- 40 people
- Sponsor
- Mogilev Regional Clinical Hospital