Clinical trials: in Bolivia
Trypanosoma Cruzi Infection, Chagas Disease
New Therapies and Biomarkers for Chagas Infection
Chagas disease (CD) is an endemic zoonotic disease with a significant global impact. Current approved treatments for CD (benznidazole (BZN) and nifurtimox (NFX)) were developed in the 1970s with regimens and dosing intervals…
- Trial name
- TESEO (NCT03981523)
- Testing
- Benznidazole, Nifurtimox
- Where
- 3 sites in Bolivia
- Volunteers
- 450 people
- Sponsor
- University of Texas, El Paso
Sepsis
Early Resuscitation in Paediatric Sepsis Using Inotropes
Septic shock in children still carries substantial mortality and morbidity. While resuscitation with 40-60 mL/kg intravenous fluid boluses remains a cornerstone of initial resuscitation, an increasing body of evidence indicates…
- Trial name
- ANDES-CHILD (NCT06478797)
- Testing
- Fluid, Adrenalin
- Where
- 4 sites in Argentina, Bolivia and 1 more
- Volunteers
- 40 people
- Sponsor
- NATALIA LOPERA MUNERA
Mucosal Leishmaniasis
Treatment of Mucosal Bolivian Leishmaniasis
The purpose of this protocol is to conduct a randomized comparison of the efficacy and tolerance of miltefosine, LAMB, and pentavalent antimony for the treatment of mucosal leishmaniasis.
- Trial name
- NCT04799236
- Testing
- Group 1: Miltefosine, Group 2: Pentavalent Antimony, Group 3: Liposomal amphotericin B
- Where
- Bolivia
- Volunteers
- 120 people
- Sponsor
- Fundacion Nacional de Dermatologia
Dental Caries in Children
Efficacy of the Use of Silver Diamine Fluoride and Sodium Fluoride Varnish for the Treatment of Caries in Children
The goal of this observational study is to identify the efficacy of silver diamine fluoride 38% followed by sodium fluoride varnish 5% in a population with untreated dental caries age range 4 to 12 years old.
- Trial name
- NCT05638217
- Testing
- Silver diamine fluoride 38% followed by Sodium fluoride varnish 5%
- Where
- Bolivia
- Volunteers
- 199 people
- Sponsor
- Universidad Mayor de San Simón
CIN3, CIN2
Cervical Cancer Screening With Human Papillomavirus Testing
HPV testing for primary cervical cancer screening of women over 30 years of age is likely to become the standard of care in the near future in many areas of the world.
- Conditions
- CIN3, CIN2, Cervical Cancer
- Trial name
- ESTAMPA (NCT01881659)
- Testing
- HPV screening
- Where
- 12 sites in Argentina, Bolivia and 7 more
- Volunteers
- 50,000 people
- Sponsor
- International Agency for Research on Cancer
Zika Virus, Pregnancy Related
ZIKAlliance Pregnant Women Cohort
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAlliancePW (NCT03188731)
- Where
- 14 sites in Bolivia, Brazil and 5 more
- Volunteers
- 3,852 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Zika Virus
ZIKAlliance Children Cohort (ZIKAllianceCH)
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAllianceCH (NCT03393286)
- Where
- 10 sites in Bolivia, Brazil and 5 more
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Covid19
Clinical Trial to "Study the Efficacy and Therapeutic Safety of Ivermectin: (SAINTBO)
Coronavirus disease (COVID-19) is an infectious disease caused by a new virus. The disease causes a respiratory illness (such as the flu) with symptoms such as cough, fever, and, in more severe cases, respiratory distress, even…
- Trial name
- SAINTBO (NCT04836299)
- Testing
- Ivermectin
- Where
- Bolivia
- Volunteers
- 90 people
- Sponsor
- Universidad Mayor de San Simón
Covid-19, Mental Health Disorder
The Covid-19 HEalth caRe wOrkErS (HEROES) Study
Since December 2019 the world has been shaken with an enormous global threat: the Covid-19 pandemic. This new kind of coronavirus is generating an unprecedented impact both on the general population and on the healthcare systems…
- Conditions
- Covid-19, Mental Health Disorder, Stress Disorder, Anxiety
- Trial name
- HEROES (NCT04352634)
- Testing
- Exposure to the SARS-CoV-2 and its consequences
- Where
- 22 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Chile
Cutaneous Leishmaniasis, American
Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis
Cure rate for L braziliensis bolivian CL has been 70%-80% for standard systemic and local monotherapies. It would benefit patients if cure rates could be consistently >90%, so testing a combination of two treatments is proposed.
- Trial name
- NCT03829917
- Testing
- Miltefosine and Paromomycin, miltefosine, paromomycin
- Where
- Bolivia
- Volunteers
- 120 people
- Sponsor
- Fundacion Nacional de Dermatologia
Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex
Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia
This protocol will compare topical paromomycin to standard intralesional (IL) antimony (Sb) to placebo for L braziliensis in Bolivia.
- Conditions
- Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex, Leishmaniasis, American, Leishmaniasis; American, Cutaneous
- Trial name
- NCT03096457
- Testing
- Paromomycin Sulfate, Pentamidine Isethionate
- Where
- 2 sites in Bolivia
- Volunteers
- 80 people
- Sponsor
- Fundacion Nacional de Dermatologia
Leishmaniasis, Cutaneous Leishmaniasis
Intralesional Antimony for Bolivian Cutaneous Leishmaniasis
Intralesional injection of antimony has been used for L major from Iran with a modest cure rate [56%: Asilian 2004]. However, this therapeutic approach has been used for L braziliensis from Brazil, with an attractive cure rate…
- Trial name
- NCT01300975
- Testing
- pentavalent antimony, cryotherapy
- Where
- 2 sites in Bolivia
- Volunteers
- 90 people
- Sponsor
- Fundacion Nacional de Dermatologia
Mucocutaneous Leishmaniasis
Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis
This study is a Phase 4, open-label, single group study in which at least 40 adult patients undergoing miltefosine treatment for mucocutaneous leishmaniasis (CL and ML) will be assessed by 12-lead ECG for prolongation of the…
- Trial name
- NCT02429518
- Testing
- Miltefosine
- Where
- Bolivia
- Volunteers
- 42 people
- Sponsor
- Knight Therapeutics (USA) Inc
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
Acute Kidney Injury
Detection and Management of Acute Kidney Injury (AKI) in Low and Low Middle Income Countries: A Pilot Feasibility Project
This feasibility study will be conducted at 4 international sites located in Asia (Dhahran, Nepal); Africa (Blantyre, Malawi and Kilimanjaro, Tanzania) and Latin America (Cochabamba, Bolivia).
- Trial name
- NCT02912611
- Testing
- Education and Protocol based management
- Where
- 3 sites in Bolivia, Malawi and 1 more
- Volunteers
- 2,101 people
- Sponsor
- University of California, San Diego
Mountain Sickness, Chronic
Chronic Mountain Sickness, Systemic Vascular Function
Diseases associated with chronic hypoxemia like chronic obstructive pulmonary disease (COPD) or emphysema, represent major medical and socio-economical problems and one of the leading cause of morbidity and mortality in the…
- Trial name
- CMS (NCT01182792)
- Testing
- Vitamin C and E
- Where
- 2 sites in Bolivia, Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Diabetic Retinopathy
The Santa Cruz Diabetic Retinopathy Utilizing Artificial Intelligence Study
In this clinical trial, we plan to evaluate the usefulness of artificial intelligence (AI) software paired with a handheld retinal camera to compare diabetic retinopathy status in Bolivian patients as read by retina specialists…
- Trial name
- SC-DRAI (NCT03912961)
- Testing
- Picture of the retina with a handheld retinal camera
- Where
- 3 sites in Bolivia
- Volunteers
- 1,034 people
- Sponsor
- Retina Global
Chagas Disease, Trypanosomiasis
BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease
Evaluate if benznidazole, an antiparasite drug, given at a dose calculated as 5mg/kg/day for 60 days, now administered as a fixed daily dose of 300mg during 40 to 80 days of treatment - period adjusted according to the patient's…
- Conditions
- Chagas Disease, Trypanosomiasis, Heart Disease
- Trial name
- BENEFIT (NCT00123916)
- Testing
- Benznidazole
- Where
- 47 sites in Argentina, Bolivia and 3 more
- Volunteers
- 2,854 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Non-Small-Cell Lung Carcinoma
Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung Cancer
Background: Research has shown that the Epidermal Growth Factor Receptor (EGFR) gene is an important target for personalized lung cancer treatment.
- Trial name
- NCT01255150
- Where
- 12 sites in United States, Bolivia and 3 more
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Spirometry, Respiratory Function Tests
Spirometric Predicted Values in Bolivia
There is no local predicted values for spirometry available in Bolivia. The aim of the present study is to establish moderne predicted values for healthy non-smokers recruited in a major city of Bolivia, Santa Cruz De La Sierra.
- Trial name
- SPIROBOLIVIA (NCT03660111)
- Testing
- spirometry
- Where
- Bolivia
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain