Clinical trials: completed, in Bolivia
Respiration, Artificial, Acute Hypoxemic Respiratory Failure
Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure
The goal of this observational study is to estimate the prevalence of the use of protective ventilation with low tidal volume ventilation in the transition of spontaneous ventilation modes in patients with hypoxemic acute…
- Conditions
- Respiration, Artificial, Acute Hypoxemic Respiratory Failure, Respiratory Insufficiency
- Trial name
- SPIRAL (NCT06042036)
- Testing
- Spontaneous mode of mechanical ventilation
- Where
- 10 sites in Argentina, Bolivia and 8 more
- Volunteers
- 431 people
- Sponsor
- University of Sao Paulo General Hospital
Critically Ill Children, Nutritional Support
Relationship of Nutritional Support for Critically Ill Children With Clinical Outcomes in a Pediatric Hospital in Bolivia (NutPeBol)
The aim of this observational study is to learn about the characteristics of nutritional support in critically ill children. The primary question to be answered is Is there an association between nutritional support of the…
- Trial name
- NutPeBol (NCT06716229)
- Where
- 2 sites in Bolivia
- Volunteers
- 56 people
- Sponsor
- MPH D Raul Copana-Olmos
Gallstone Disease, Gallbladder Malignant Neoplasm
Validation of Serum Metabolite Differences in Patients With Gallstones and Gallbladder Cancer
We have observed that the serum levels of certain metabolites differ between Chilean patients with gallbladder cancer and those with gallstone disease.
- Trial name
- NCT07744477
- Testing
- serum samples
- Where
- 33 sites in Bolivia, Chile and 2 more
- Volunteers
- 230 people
- Sponsor
- Centre Paul Strauss
Gallbladder Malignant Neoplasm
Validation of Differential Serum Levels for Five Minerals in South American Gallstone Patients With and Without Gallbladder Cancer
We have previously observed that serum concentrations of five minerals - aluminium, copper, sulphur, zinc, and bromine - differ between South American patients with gallbladder cancer and those with gallstones.
- Trial name
- METALS (NCT07642817)
- Testing
- Research of gallbladder cancer
- Where
- 33 sites in Bolivia, Chile and 2 more
- Volunteers
- 230 people
- Sponsor
- Centre Paul Strauss
Gallbladder Malignant Neoplasm
Validation of the Association Between the Abundance of Three Bacterial Genera in Stool Samples and the Risk of Gallbladder Cancer in South American Patients With Gallstones
In our previous work, we found three types of bacteria in stool samples from South American patients with gallstones linked to a higher risk of gallbladder cancer.
- Trial name
- NCT07635745
- Where
- 4 sites in Bolivia, Chile and 2 more
- Volunteers
- 120 people
- Sponsor
- Centre Paul Strauss
Alzheimer Disease
LatAm-FINGERS Initiative for Cognitive Change
Currently, 40% of global dementia cases can be prevented through lifestyle changes, with Latin America having a 56% potential reduction due to its high-risk factors.
- Trial name
- LatAmFINGERS (NCT06492967)
- Testing
- Systematic Lifestyle Intervention, Flexible Lifestyle Intervention
- Where
- 13 sites in Argentina, Bolivia and 10 more
- Volunteers
- 1,065 people
- Sponsor
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Cutaneous Leishmaniases
Combination, Miltefosine Monotherapy for Cutaneous Leishmaniasis in New World
This study evaluates if the combination of thermotherapy (one application, 50⁰C for 30") and 3 weeks of miltefosine is safe and have a comparable cure rate with the current recommended first line treatments comprising meglumine…
- Trial name
- NCT04515186
- Testing
- Meglumine Antimoniate, Miltefosine, Thermotherapy machine
- Where
- 6 sites in Bolivia, Brazil and 2 more
- Volunteers
- 184 people
- Sponsor
- Drugs for Neglected Diseases
Heart Failure, Acute Heart Failure (AHF)
American Registry of Ambulatory or Acutely Decompensated Heart Failure
The purpose of this study is to better characterize and understand the population of patients with ambulatory or acutely decompensated heart failure in the American continent, getting to know their sociodemographic, clinical and…
- Conditions
- Heart Failure, Acute Heart Failure (AHF), Chronic Heart Failure
- Trial name
- AMERICCAASS (NCT05295641)
- Where
- 119 sites in United States, Argentina and 19 more
- Volunteers
- 6,732 people
- Sponsor
- Fundacion Clinica Valle del Lili
Acute Kidney Injury
Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients With AKI
Animal and human studies have shown that the administration of vitamin B3 (niacin) improves renal ischemia; helping to recover from acute kidney injury (AKI) more effectively; Therefore, its use in patients with AKI could improve…
- Trial name
- VIBAKI (NCT04893733)
- Testing
- Vitamin B Complex, STOP AKI protocol
- Where
- Bolivia
- Volunteers
- 260 people
- Sponsor
- Caja Nacional de Salud
Covid19
Validation of Laboratory Techniques, Strategies, and Types of Samples for Epidemiological Control in the Covid-19 Pandemic
This is a study of validation for diagnostic techniques used on epidemiological control in the COVID-19 pandemic. It will be carried out in accredited public, private and university clinical laboratories of the collaborator…
- Trial name
- NCT04581083
- Testing
- RT-PCR, LAMP, POOL RT-PCR
- Where
- Bolivia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Chagas Disease
A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi
Researchers are looking for a better way to treat children who have an infectious disease caused by the parasite Trypanosoma cruzi (Chagas' disease).
- Trial name
- NCT02625974
- Testing
- Nifurtimox (Lampit, BAYA2502)
- Where
- 25 sites in Argentina, Bolivia and 1 more
- Volunteers
- 330 people
- Sponsor
- Bayer
Trypanosoma Cruzi Infection, Chagas Disease
New Therapies and Biomarkers for Chagas Infection
Chagas disease (CD) is an endemic zoonotic disease with a significant global impact. Current approved treatments for CD (benznidazole (BZN) and nifurtimox (NFX)) were developed in the 1970s with regimens and dosing intervals…
- Trial name
- TESEO (NCT03981523)
- Testing
- Benznidazole, Nifurtimox
- Where
- 3 sites in Bolivia
- Volunteers
- 450 people
- Sponsor
- University of Texas, El Paso
Dental Caries in Children
Efficacy of the Use of Silver Diamine Fluoride and Sodium Fluoride Varnish for the Treatment of Caries in Children
The goal of this observational study is to identify the efficacy of silver diamine fluoride 38% followed by sodium fluoride varnish 5% in a population with untreated dental caries age range 4 to 12 years old.
- Trial name
- NCT05638217
- Testing
- Silver diamine fluoride 38% followed by Sodium fluoride varnish 5%
- Where
- Bolivia
- Volunteers
- 199 people
- Sponsor
- Universidad Mayor de San Simón
Zika Virus, Pregnancy Related
ZIKAlliance Pregnant Women Cohort
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAlliancePW (NCT03188731)
- Where
- 14 sites in Bolivia, Brazil and 5 more
- Volunteers
- 3,852 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Zika Virus
ZIKAlliance Children Cohort (ZIKAllianceCH)
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAllianceCH (NCT03393286)
- Where
- 10 sites in Bolivia, Brazil and 5 more
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Cutaneous Leishmaniasis, American
Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis
Cure rate for L braziliensis bolivian CL has been 70%-80% for standard systemic and local monotherapies. It would benefit patients if cure rates could be consistently >90%, so testing a combination of two treatments is proposed.
- Trial name
- NCT03829917
- Testing
- Miltefosine and Paromomycin, miltefosine, paromomycin
- Where
- Bolivia
- Volunteers
- 120 people
- Sponsor
- Fundacion Nacional de Dermatologia
Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex
Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia
This protocol will compare topical paromomycin to standard intralesional (IL) antimony (Sb) to placebo for L braziliensis in Bolivia.
- Conditions
- Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex, Leishmaniasis, American, Leishmaniasis; American, Cutaneous
- Trial name
- NCT03096457
- Testing
- Paromomycin Sulfate, Pentamidine Isethionate
- Where
- 2 sites in Bolivia
- Volunteers
- 80 people
- Sponsor
- Fundacion Nacional de Dermatologia
Leishmaniasis, Cutaneous Leishmaniasis
Intralesional Antimony for Bolivian Cutaneous Leishmaniasis
Intralesional injection of antimony has been used for L major from Iran with a modest cure rate [56%: Asilian 2004]. However, this therapeutic approach has been used for L braziliensis from Brazil, with an attractive cure rate…
- Trial name
- NCT01300975
- Testing
- pentavalent antimony, cryotherapy
- Where
- 2 sites in Bolivia
- Volunteers
- 90 people
- Sponsor
- Fundacion Nacional de Dermatologia
Mucocutaneous Leishmaniasis
Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis
This study is a Phase 4, open-label, single group study in which at least 40 adult patients undergoing miltefosine treatment for mucocutaneous leishmaniasis (CL and ML) will be assessed by 12-lead ECG for prolongation of the…
- Trial name
- NCT02429518
- Testing
- Miltefosine
- Where
- Bolivia
- Volunteers
- 42 people
- Sponsor
- Knight Therapeutics (USA) Inc
Acute Kidney Injury
Detection and Management of Acute Kidney Injury (AKI) in Low and Low Middle Income Countries: A Pilot Feasibility Project
This feasibility study will be conducted at 4 international sites located in Asia (Dhahran, Nepal); Africa (Blantyre, Malawi and Kilimanjaro, Tanzania) and Latin America (Cochabamba, Bolivia).
- Trial name
- NCT02912611
- Testing
- Education and Protocol based management
- Where
- 3 sites in Bolivia, Malawi and 1 more
- Volunteers
- 2,101 people
- Sponsor
- University of California, San Diego