Clinical trials: in Brazil
Chronic Obstructive Pulmonary Disease
Clinical and Hemodynamic Correlates of Different Polarities of HD-tDCS in COPD
The aim of this pilot randomized clinical trial is to identify the acute effects of HD-tDCS in the diaphragm cortex on cerebral hemodynamics in individuals with COPD.
- Trial name
- NCT07831629
- Testing
- High-definition Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Paraíba
Bone Loss, Osteoclastic, Bone Loss, Alveolar
Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting
This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated…
- Conditions
- Bone Loss, Osteoclastic, Bone Loss, Alveolar, Alveolar Bone Loss, Alveolar Bone Atrophy
- Trial name
- NCT04998058
- Testing
- Maxillary sinus floor elevation grafting with synthetic bone substitute.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Dental Caries, Restoration Defects
Repair Versus Replacement of Failed Restorations in Primary Teeth
Dental caries affect approximately 573 million children globally, and the management of failed restorations is a frequent clinical issue in pediatric dentistry.
- Conditions
- Dental Caries, Restoration Defects, Primary Teeth
- Trial name
- NCT07813065
- Testing
- Repair of Failed Restoration, Replacement of Failed Restoration
- Where
- Brazil
- Volunteers
- 382 people
- Sponsor
- University of Sao Paulo
Low Back Pain
Pilates Method vs. Kinesiotherapy for Occupational Low Back Pain
Occupational low back pain is a prevalent cause of functional disability. This randomized clinical trial aims to compare the effects of the Pilates Method and conventional kinesiotherapy on functional disability (Oswestry Index)…
- Trial name
- NCT07829354
- Testing
- Pilates Method, Conventional Kinesiotherapy
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Federal do Triangulo Mineiro
Asthma
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with asthma who have previously completed the parent studies.
- Trial name
- AIRPHRODITE (NCT06609239)
- Testing
- Lunsekimig
- Where
- 150 sites in United States, Argentina and 18 more
- Volunteers
- 900 people
- Sponsor
- Sanofi
Critical Illness, Family Satisfaction
Patient Characterization Panel to Improve Satisfaction With the Intensive Care Unit Stay (CONNECT)
Intensive care units (ICUs) present unique challenges to humanized, person-centered care. The severity of illness and the demands of complex technical management can displace attention from patients as individuals, making it…
- Conditions
- Critical Illness, Family Satisfaction, Critical Care, Intensive Care
- Trial name
- CONNECT (NCT07830043)
- Testing
- Patient-as-a-Person Characterization Panel with Staff Training, Standard ICU Care
- Where
- 2 sites in Brazil
- Volunteers
- 966 people
- Sponsor
- University of Sao Paulo General Hospital
Fibromyalgia (FM) OR Fibromyalgia Syndrome
Effects of Reiki Therapy in Women With Fibromyalgia
The goal of this randomized clinical trial is to evaluate the effects of a 4-week Reiki therapy program in women with fibromyalgia.
- Trial name
- NCT07821034
- Testing
- Reiki Intervention
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Venous Thromboembolism
Computerized Registry of Patients With Venous Thromboembolism (RIETE)
The Computerized Registry of Patients with Venous Thromboembolism (RIETE) is a multidisciplinary Project initiated in march 2001 and consisting in obtaining an extensive data registry of consecutive patients with venous…
- Trial name
- RIETE (NCT02832245)
- Where
- 305 sites in United States, Argentina and 27 more
- Volunteers
- 120,000 people
- Sponsor
- Manuel Monreal
Severe Hypertriglyceridemia
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study will evaluate the efficacy and safety of plozasiran in approximately 288 adult participants with severe hypertriglyceridemia (SHTG) and history of at least two prior acute pancreatitis (AP) events not attributed to…
- Trial name
- SHASTA-5 (NCT06880770)
- Testing
- Plozasiran
- Where
- 140 sites in United States, Argentina and 25 more
- Volunteers
- 288 people
- Sponsor
- Arrowhead Pharmaceuticals
Coronary Artery Disease, Chronic Coronary Syndrome
Same-Day Discharge After Elective Transradial Percutaneous Coronary Intervention: A Pilot Randomized Trial
This single-center pilot randomized trial evaluated the safety and feasibility of same-day discharge (within 6 hours) compared with conventional overnight hospitalization (≥24 hours) in patients with chronic coronary artery…
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Elective Percutaneous Coronary Intervention
- Trial name
- SDD-PROCAPE (NCT07830784)
- Testing
- same day discharge, Conventional Hospitalization
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- PAULO CASTRO CHERPAK
HIV-1-infection
Dolutegravir/Lamivudine in Treatment-Naïve Pregnant Women
Protocol Number: FH-94 Study Objetives: Primary: To evaluate the virological response to Dolutegravir/Lamivudine in naive pregnant women with HIV who are starting antiretroviral therapy and vertical transmission in exposed…
- Trial name
- PREDUAL (NCT07616739)
- Testing
- Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO], TDF/XTC or TAF/FTC plus Dolutegravir (XTC stand for lamivudine OR emtricitabine)
- Where
- 10 sites in Argentina, Brazil
- Volunteers
- 210 people
- Sponsor
- Fundación Huésped
Heterozygous or Homozygous Familial Hypercholesterolemia
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
The purpose of this open-label, single arm, multicenter extension study is to evaluate the long-term safety and tolerability of inclisiran in participants with HeFH or HoFH who have completed the ORION-16 (CKJX839C12301)…
- Trial name
- V-PEDS-OLE (NCT05682378)
- Testing
- Inclisiran
- Where
- 52 sites in United States, Argentina and 24 more
- Volunteers
- 195 people
- Sponsor
- Novartis Pharmaceuticals
Premature Newborns, Cranial Asymmetry
Effects of Tummy Time Associated With Therapeutic Positioning in Premature Newborns With Cranial Asymmetry
Deformational plagiocephaly is an alteration in the shape of a baby's head caused by pressure exerted on the skull. This condition can begin during gestation and worsen after birth, especially when the baby spends a lot of time…
- Trial name
- plagiocephaly (NCT07758426)
- Testing
- Tummy Time Protocol
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Febrile Neutropenia
Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing Pathogens
The study proposes a planned, double-blind, non-inferiority clinical trial involving patients with febrile neutropenia and risk of extended-spectrum beta-lactamase (ESBL) infection.
- Trial name
- CLEMENT (NCT06342115)
- Testing
- Ceftolozane-Tazobactam, Meropenem
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- Beneficência Portuguesa de São Paulo
Hypertrophy, Muscle Strength
Applicability of Tissue Flossing for Blood Flow Restriction in the Upper Limb: Reliability and Performance Analysis
Blood flow restriction (BFR) is a widely studied technique that combines low-intensity exercise with vascular occlusion, resulting in muscular benefits.
- Trial name
- NCT06512961
- Testing
- Tissue Flossing, Blood Flow Restriction Cuff, Training Protocol
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Paulista University
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection as well as or…
- Trial name
- NCT07044297
- Testing
- MK-8527, FTC/TDF
- Where
- 81 sites in United States, Argentina and 14 more
- Volunteers
- 4,390 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Fall Risk
EFFECT OF A PHYSICAL EXERCISE PROGRAM ON FUNCTIONAL CAPACITY AND FALL PREVENTION IN PSYCHIATRIC INPATIENT CARE
Falls are an important health problem, especially among adults and older people who are hospitalized, because they can cause injuries, increase the length of hospital stay, and make it more difficult to perform daily activities.
- Trial name
- NCT07827547
- Testing
- Intervention
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiomyopathy, Hypertrophic
A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy
The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).
- Trial name
- ODYSSEY-HCM (NCT05582395)
- Testing
- Mavacamten
- Where
- 224 sites in United States, Australia and 21 more
- Volunteers
- 580 people
- Sponsor
- Bristol-Myers Squibb
Chronic Obstructive Pulmonary Disease
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
This is a parallel, double blind, Phase 3, 2-arm study that is designed to provide additional safety information, assess the durability of treatment response, and provide additional PK and immunogenicity assessments.
- Trial name
- AERIFY-4 (NCT06208306)
- Testing
- Itepekimab (SAR440340)
- Where
- 223 sites in United States, Argentina and 30 more
- Volunteers
- 669 people
- Sponsor
- Sanofi
Non-small Cell Lung Cancer
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
The goal of this study is to evaluate intismeran autogene plus pembrolizumab versus placebo plus pembrolizumab for the adjuvant treatment of margin negative, completely resected Stage II, IIIA, IIIB (with nodal involvement [N2])…
- Trial name
- INTerpath-002 (NCT06077760)
- Testing
- Intismeran autogene, Pembrolizumab
- Where
- 229 sites in United States, Argentina and 31 more
- Volunteers
- 868 people
- Sponsor
- Merck Sharp & Dohme LLC
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