Clinical trials: in Cameroon
Cryptococcal Meningitis
Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS
The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce morbidity and mortality due to AIDS…
- Trial name
- PreCASA (NCT02624453)
- Testing
- Fluconazole, Antiretroviral therapy
- Where
- Cameroon
- Volunteers
- 186 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Virus Diseases
A Study to Evaluate the Safety and Immunogenicity of a Candidate Ebola Vaccine in Adults
The purpose of this study is to assess the safety and immunogenicity of the investigational ChAd3-EBO-Z vaccine administered to approximately 3 000 adults in Africa as a single IM dose Considering the risk of exposure to Ebola…
- Trial name
- NCT02485301
- Testing
- GlaxoSmithKline (GSK) Biologicals' investigational recombinant chimpanzee adenovirus Type 3-vectored Ebola Zaire vaccine (ChAd3-EBO-Z) (GSK3390107A)
- Where
- 5 sites in Cameroon, Mali and 2 more
- Volunteers
- 3,024 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
Short Term Effect of Liraglutide Versus Vildagliptine on Insulin Secretion and Insulin Sensitivity in Type 2 Diabetes
This is a single blind randomised controlled clinical trial in uncontrolled type 2 Diabetes mellitus patients on oral glucose lowering agents, and naive to incretinomimetic.
- Trial name
- LIRAVIS (NCT02832999)
- Testing
- sub cutaneous liraglutide, Oral Vildagliptin
- Where
- Cameroon
- Volunteers
- 14 people
- Sponsor
- Yaounde Central Hospital
Hepatitis C, HIV Infection
Feasibility, Tolerance and Efficacy of Interferon-free, Antiviral Treatment With Sofosbuvir + Ribavirin for the Treatment of Genotype 2 and Sofosbuvir/Ledipasvir for the Treatment of Genotype 1 and 4 Hepatitis C Virus-infected Patients in West and Central Africa
Primary Objective: To evaluate the efficacy (sustained virological response 12 weeks after end-of-treatment [SVR12]) of 12-week course of an interferon-free regimen combining sofosbuvir and weight-dosed ribavirin (genotype 2), or…
- Trial name
- TAC (NCT02405013)
- Testing
- Sofosbuvir, Ribavirin, Ledipasvir
- Where
- 4 sites in Cameroon, Côte d’Ivoire and 1 more
- Volunteers
- 120 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
Evaluation of a Maintenance Strategy With Protease Inhibitors With or Without Lamivudine in Virologically Suppressed HIV Patients on Second Line Antiretroviral Treatment in Africa
Multicenter, randomized, superiority trial to evaluate efficacy of a mono or bi-therapy of protease inhibitors with or without lamivudine over a period of 96 weeks. The primary outcome will be the failure rate at 96 weeks.
- Trial name
- MOBIDIP (NCT01905059)
- Testing
- monoPI - boosted lopinavir or boosted darunavir, bi therapy - (boosted lopinavir or boosted darunavir) + lamivudine
- Where
- 5 sites in Burkina Faso, Cameroon and 1 more
- Volunteers
- 265 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV, HIV Infections
Evaluation of Three Strategies of Second-line Antiretroviral Treatment in Africa (Dakar - Bobo-Dioulasso - Yaoundé)
Since the first line antiretroviral (ARV) treatment is now largely accessible in the Sub-Saharian Africa countries, documentation of virological failure, drug resistance patterns and second line treatment evaluation are still to…
- Trial name
- 2LADY (NCT00928187)
- Testing
- emtricitabine/tenofovir + lopinavir/ritonavir (WHO recommended second line), abacavir + didanosine + lopinavir/ritonavir (WHO recommended second line), emtricitabine/tenofovir + darunavir + ritonavir (Second line strategy under evaluation)
- Where
- 3 sites in Burkina Faso, Cameroon and 1 more
- Volunteers
- 454 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Surgery, Surgery- Complications
African Surgical Outcomes Study (ASOS)
STUDY OBJECTIVE To confirm the incidence of in-hospital postoperative complications in adult surgical patients in Africa. STUDY DESIGN Seven day, African national multi-centre prospective observational cohort study of adult (≥18…
- Conditions
- Surgery, Surgery- Complications, Mortality
- Trial name
- ASOS (NCT03044899)
- Testing
- All surgeries in adult patients
- Where
- 25 sites in Algeria, Benin and 23 more
- Volunteers
- 11,422 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Pediatric HIV Infection
Active Search for Pediatric HIV/AIDS (ASPA)
The Active Search for Pediatric HIV/AIDS (ASPA) aims at assessing the acceptability, feasibility and effectiveness of the targeted provider-initiated-testing and counseling (tPITC) in comparison with the blanket…
- Trial name
- ASPA (NCT03024762)
- Testing
- targeted Provider-Initiated-Testing and Counseling (tPITC)
- Where
- 3 sites in Cameroon
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- Research for Development International
Diabetes Mellitus
Metabolic Effects of Stevia in Type 2 Diabetic Patients
The main aim of the study is to assess the short term and 1-month metabolic effects of Stevia rebaudiana bertoni in patients with type 2 diabetes.
- Trial name
- STEDIA1 (NCT02834715)
- Testing
- Stevia rebaudiana liquid extract
- Where
- Cameroon
- Volunteers
- 22 people
- Sponsor
- Yaounde Central Hospital
HIV Infections
Molecular Diversity of HIV-1 Group O Strains and Treatment Management in Cameroon
Infections with HIV-1 group O are found in 1 to 3 % of persons living with HIV in Cameroon. The natural history and treatment response is not well understood.
- Trial name
- NCT00658346
- Testing
- Treatment initiation for HIV-1 group O infected patients, Treatment initiation for HIV-1 group M infected patients
- Where
- 2 sites in Cameroon
- Volunteers
- 141 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Pain
Face Validity and Cross-Cultural Acceptability of the FPS-R in Cameroon
This study evaluates the face validity and cultural acceptability of the Faces Pain Scale - Revised in pediatric patients treated at Mbingo Baptist Hospital, Northwest Province, Cameroon.
- Trial name
- FPS-RCam (NCT02571933)
- Testing
- Pre-treatment Faces Pain Scale - Revised, Post-treatment Faces Pain Scale - Revised, Cognitive interview
- Where
- Cameroon
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cameroon Baptist Convention Health
Drug Resistant Malaria Due to Plasmodium Falciparum
Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa
The antimalarial drugs efficacy and safety study will be conducted in the Clinics and hospital of the Cameroon Development Corporation (CDC) Estates, Tiko Health District, located in a typical forest and rainfall area in the…
- Trial name
- NCT02974348
- Testing
- Arthemeter-lumefantrine, Artesunate mefloquine, Dihydroartemisinin piperaquine
- Where
- Cameroon
- Volunteers
- 300 people
- Sponsor
- University of Bamenda
Loiasis
Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis
Background: Loa loa is a small worm that infects people in West and Central Africa. It is spread by the bite of a fly. Adult worms live under the skin and can cause swelling in the arms, legs, and face.
- Trial name
- NCT01593722
- Testing
- Diethylcarbamazine, Ivermectin
- Where
- Cameroon
- Volunteers
- 155 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer, Anxiety
Watching Live VIA/VILI Examinations on a Digital Screen May Reduce Patients' Anxiety
The purpose of this study is to assess whether the degree of anxiety experienced by women undergoing visual inspection with acetic acid (VIA) and Lugol's iodine (VILI) can be reduced by watching the procedure in real-time on a…
- Trial name
- NCT02945111
- Testing
- Real-time view, No visual support
- Where
- Cameroon
- Volunteers
- 122 people
- Sponsor
- Prof. Patrick Petignat
Malaria
Research on the Economics of Artemisinin Combination Therapy (ACTs) for the Treatment of Malaria
The objective of the REACT project is to evaluate the effectiveness and cost-effectiveness implications of interventions designed to improve health worker practice in providing treatment for uncomplicated malaria to febrile…
- Trial name
- REACT (NCT01350752)
- Testing
- RDTs & Provider Training on Malaria Diagnosis and Treatment, Extended provider training (Cameroon only), School based malaria education (Nigeria only)
- Where
- 3 sites in Cameroon, Nigeria
- Volunteers
- 6,513 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections, AIDS
Antiretroviral Treatment Simplified Follow-up Management Assessment (ANRS 12110 STRATALL)
Access to antiretroviral therapy (ART) is still limited in Africa (11% of patients in immediate need in June 2005). Face to the scope of the need and the constraints (unavailability and cost of viral load and CD4 cell count, lack…
- Trial name
- NCT00301561
- Testing
- Simplified follow-up approach of ARV treatment, Standard follow-up approach of ARV treatment
- Where
- 9 sites in Cameroon
- Volunteers
- 459 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Periodontitis, Diabetes
Effect of Non Surgical Treatment of Periodontitis on Diabetes Control
The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients.
- Trial name
- PARODIA1 (NCT02745015)
- Testing
- non-surgical periodontal treatment
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- Yaounde Central Hospital
HIV, HIV-uninfected Children
A Cross Sectional Evaluation of the Development in Children Age 4 to 7 Infected or Exposed to HIV From the ANRS 12140 Cohort (Pediacam)
This study aims to perform a comprehensive neuro-cognitive evaluation of the 4-7 year old children from the Pediacam cohort (ANRS 12140 /12225, NCT02043418).
- Conditions
- HIV, HIV-uninfected Children, Children Exposed to HIV
- Trial name
- PediacamDEV (NCT02570334)
- Testing
- HIV-infected children initiated antiretroviral treatment within the first 7 months of life
- Where
- 3 sites in Cameroon
- Volunteers
- 400 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV, Reproductive Health
Disability and HIV: Vulnerability of People With Disabilities to HIV Infection in Sub-Saharan Africa
According to the recent World Report on Disability, around 15% of the world population lives with a disability and 80% of people with disabilities (PWD) live in developing countries.
- Conditions
- HIV, Reproductive Health, Disability
- Trial name
- HandiVIH (NCT02192658)
- Where
- Cameroon
- Volunteers
- 1,610 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Diabetes Mellitus
Improving Access to HbA1c in Sub Saharan Africa
Glycated haemoglobin (HbA1c) is the best surrogate of average blood glucose control in diabetic patients. Large-scale studies in the USA and UK have demonstrated that lowering HbA1c significantly reduces diabetes complications.
- Trial name
- IA3 (NCT01460095)
- Testing
- HbA1c measurement and education
- Where
- 9 sites in Cameroon, Guinea
- Volunteers
- 1,349 people
- Sponsor
- Yaounde Central Hospital