Clinical trials: open to volunteers, in Cameroon
Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement
Low INR to Minimize Bleeding With Mechanical Valves Trial
This study evaluates the use of a lower INR target (1.5 to 2.5) in patients with a mechanical bileaflet heart valve in the aortic position.
- Trial name
- LIMIT (NCT03636295)
- Testing
- Warfarin
- Where
- 45 sites in Belgium, Botswana and 16 more
- Volunteers
- 2,625 people
- Sponsor
- Population Health Research Institute
Cervical Cancers
Use Misoprostol to Optimize Prevention of Cervical Cancer
This is a double-blind randomized controlled trial of 420 non-pregnant women undergoing cancer screening by visual inspection with acetic acid (VIA) who have Type 3 transformation zone (TZ) and randomized to receive either…
- Trial name
- MISOPCx (NCT06669533)
- Testing
- Misoprostol
- Where
- Cameroon
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV-1-infection
DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection
Phase III trial evaluating doravirine as an alternative to dolutegravir in treatment naïve people living with HIV-1 infection.
- Trial name
- ELDORADO (NCT06203132)
- Testing
- Doravirine + tenofovir DF + lamivudine, Dolutegravir + tenofovir DF + lamivudine or emtricitabine
- Where
- 19 sites in Brazil, Cameroon and 4 more
- Volunteers
- 610 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Alcohol Use Disorder, Alcohol-Related Injury
Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon
Brief Summary Alcohol use is a major contributor to injury burden in Cameroon, particularly among trauma patients presenting to emergency departments.
- Conditions
- Alcohol Use Disorder, Alcohol-Related Injury, Trauma
- Trial name
- NCT07677449
- Testing
- Cameroon-Adapted SBIRT, Usual Care
- Where
- Cameroon
- Volunteers
- 690 people
- Sponsor
- University of Buea
Chronic Respiratory Conditions
Pulmonary Rehabilitation in African Countries
Chronic Respiratory Diseases (CRDs) are common disabling conditions worldwide with high prevalence, morbidity and mortality. More than half of the CRD patients live in low- and middle-income countries (LMICs) where resources for…
- Trial name
- NCT07602673
- Testing
- Centre-based Pulmonary Rehabilitation, Community-based Pulmonary Rehabilitation
- Where
- 3 sites in Cameroon, Nigeria and 1 more
- Volunteers
- 150 people
- Sponsor
- University of Edinburgh
Trauma, Injury
Data-Driven Lay First Responder Program in Cameroon
Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system.
- Trial name
- K-LFR Project (NCT07581327)
- Testing
- Lay First Responder (LFR) training
- Where
- Cameroon
- Volunteers
- 1,812 people
- Sponsor
- Sabrinah Christie
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
Digital Telecytology for Triage of HPV-Positive Women in Cameroon
This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecytology triage among HPV-positive women in Cameroon.
- Conditions
- Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia Grade 2 (CIN2), Cervical Cancer Screening Methods
- Trial name
- NCT07550010
- Testing
- HPV testing (self-sampling), Digital telecytology, AI-assisted telecytology
- Where
- 2 sites in Cameroon
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Effects of Menstrual Products on the Vaginal Microbiome
Improving Menstrual and VAginal Health for All
A three-period crossover trial will study the effects of short-term use of 3 menstrual products (menstrual pad, tampon, menstrual cup) on the bacterial composition of the vaginal microbiome in three countries (Peru, Cameroon, and…
- Trial name
- IMVAHA (NCT06646185)
- Testing
- Menstrual Pads, Menstrual Cups, Tampons
- Where
- 3 sites in Cameroon, Peru and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Cervical Cancer Screening, HIV
Optimization of Cervical Cancer Screening Strategies Among Women Living With HIV: Effectiveness and Implementation of Decentralized Approach Using a Mobile Team With HPV Testing in the Western Region of Cameroon
Context. Cervical cancer (CC) is a leading cause of death among women living with HIV (WLHIV) in resource-limited settings. Yet, effective methods for screening and preventing CC are available.
- Trial name
- OptiTri_MT (NCT07181278)
- Testing
- Mobile unit with quasi point of care HPV testing and immediate triage + treatment, Centralized screening
- Where
- 6 sites in Cameroon
- Volunteers
- 1,180 people
- Sponsor
- Institut de Recherche pour le Developpement
Cardiac Disease, Metabolic Disease
Cardiometabolic Disease Risk Factors in Cameroon
Cardiometabolic diseases (CMDs) are a major public health concern in sub-Saharan Africa, including Cameroon. Studies have shown a significant increase in the prevalence of hypertension, diabetes, and obesity in recent years.
- Trial name
- URBACAM-D (NCT06957548)
- Testing
- Cardiometabolic disease
- Where
- Cameroon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pediatric Cancer
Hospital Based Registry of Childhood Cancer in Pediatric Oncology Units in French Speaking Africa
The ultimate aim of this registry is to collect precise information concerning the children coming to oncology units working with the French African Oncology Group.
- Trial name
- RFAOP (NCT03803735)
- Where
- 14 sites in Burkina Faso, Cameroon and 10 more
- Volunteers
- 10,000 people
- Sponsor
- French Africa Pediatric Oncology Group
Simian Foamy Virus Infection (Disorder)
Simian Foamy Virus Transmission to Humans
About three quarters of the viral agents that have emerged recently in humans are considered to originate from other animals. These viruses have often evolved and spread into the human population through various mechanisms after…
- Trial name
- NCT03225794
- Testing
- Simian foamy virus Infection
- Where
- Cameroon
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Cervical Cancer Screening, HIV
Impact of a Single Versus Multiple Visits on the Cervical Cancer Screening Completeness, Feasibility and Acceptability Among Women Living With HIV in Cameroon
Context. Cervical cancer (CC) is a leading cause of death among women living with HIV (WLHIV) in resource-limited settings. Yet, effective methods for screening and preventing CC are available.
- Trial name
- OptiTri_GC (NCT07177170)
- Testing
- Differentiated screening delivery, Single visit
- Where
- Cameroon
- Volunteers
- 1,422 people
- Sponsor
- Institut de Recherche pour le Developpement
Cervical Cancer, HPV
Automated Cervical Cancer Screening Using a Smartphone-based Artificial Intelligence Classifier
Cervical cancer remains a major public health challenge in low- and middle-income countries (LMICs) due to financial and logistical issues.
- Trial name
- NCT04859530
- Testing
- AVC test
- Where
- Cameroon
- Volunteers
- 5,886 people, healthy volunteers welcome
- Sponsor
- Prof. Patrick Petignat