Clinical trials: in Colombia
Cardiac Arrest, Out-Of-Hospital
New Information and Communication Technologies (ICT´s) in Basic Life Support Training for Non-medical Students: Educational Trial
With the increase in life expectancy of the general population and advances in medicine, there is now a population with a higher amount of cardiovascular diseases that lead to an increased risk of sudden cardiac arrest.
- Trial name
- NCT04286204
- Testing
- Basic Life Support training based on ICTs, Classic Basic Life Support training
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Systemic Lupus Erythematosus
A Study of the Safety and Efficacy of GDC-0853 in Participants With Moderate to Severe Active Systemic Lupus Erythematosus
This is a study to evaluate the safety and efficacy of GDC-0853 in combination with standard of care therapy in participants with moderate to severe active systemic lupus erythematosus (SLE).
- Trial name
- NCT02908100
- Testing
- GDC-0853
- Where
- 70 sites in United States, Argentina and 10 more
- Volunteers
- 260 people
- Sponsor
- Genentech, Inc.
Major Depressive Disorder, Generalized Anxiety Disorder
Internet-delivered Cognitive Behavioral Treatment of Depression and Anxiety in Latin American College Students
The aim is to evaluate short term and longer term treatment effects of internet-delivered cognitive behavioral therapy compared to treatment as usual for college students with anxiety and/or depression in low-middle income…
- Trial name
- NCT04780542
- Testing
- Yo Puedo Sentirme Bien- Clinician-Guided version, Yo Puedo Sentirme Bien- Self-Guided version
- Where
- 8 sites in Colombia, Mexico
- Volunteers
- 1,500 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Covid19, SARS-CoV-2
A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older
The primary objective of the randomized observer-blinded phase 2b/3 part of this trial is to demonstrate the efficacy of a 2-dose schedule of CVnCoV in the prevention of first episodes of virologically-confirmed cases of COVID-19…
- Trial name
- NCT04652102
- Testing
- CVnCoV, Authorized/licensed vaccines for preventing COVID-19 (AV) as standard of care through their national vaccination program
- Where
- 46 sites in Argentina, Belgium and 8 more
- Volunteers
- 39,680 people, healthy volunteers welcome
- Sponsor
- CureVac
Microtia, Microtia-Anotia
Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology
The CAUSE study is a multicenter study, with domestic (n=4) and international (n=6) study sites. Children and young adults (ages 0-18) who have microtia and/or craniofacial microsomia and their parents are invited to participate.
- Conditions
- Microtia, Microtia-Anotia, Craniofacial Microsomia, Goldenhar Syndrome
- Trial name
- CAUSE (NCT04351893)
- Where
- 10 sites in United States, Colombia and 2 more
- Volunteers
- 935 people
- Sponsor
- Seattle Children's Hospital
COVID-19, SARS-CoV-2
LatInamerican Vaccine Effectiveness Against Hospitalizations Due to Circulating COVID-19 VoC RWE Study
COVID-19 is the infectious disease caused by the novel coronavirus known as SARS-CoV-2, that appeared in 2019. The World Health Organisation (WHO) declared the novel coronavirus a pandemic on 11 March 2020.
- Trial name
- LIVE (NCT05282017)
- Where
- 9 sites in Brazil, Colombia and 3 more
- Volunteers
- 792 people
- Sponsor
- AstraZeneca
Alcohol Use Disorder
Scale-up of Prevention and Management of Alcohol Use Disorders and Comorbid Depression in Latin America
A quasi-experimental study will compare primary health care-based prevention and management of alcohol use disorder, operationalized by heavy drinking, in three intervention cities from Colombia, Mexico and Peru with three…
- Trial name
- SCALA (NCT03524599)
- Testing
- Intervention municipality
- Where
- Colombia
- Volunteers
- 690 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Premature Ejaculation
TPTNS for Treating Patients With Premature Ejaculation
Background: Transcutaneous posterior tibial nerve stimulation is an effective therapy for controlling urinary incontinence. Premature ejaculation (PE) and urinary incontinence are anatomically and physio-pathologically similar.
- Trial name
- NCT03204890
- Testing
- Transcutaneous Posterior Tibial Nerve Stimulation
- Where
- Colombia
- Volunteers
- 26 people
- Sponsor
- Boston Medical Group
Systemic Sclerosis Pulmonary, Pulmonary Hypertension
Infusion of Allogeneic Mesenchymal Stem Cells in Patients With Diffuse Cutaneous Systemic Sclerosis With Refractory Pulmonary Involvement
Progressive SSc is an entity with limited therapeutic alternatives and with asurvival rate of less than 45% in the first 3 to 5 years.
- Conditions
- Systemic Sclerosis Pulmonary, Pulmonary Hypertension, Pulmonary Fibrosis
- Trial name
- NCT04432545
- Testing
- Mesenchymal Stem Cells from Wharton ́s jellyintravenous infusion of Mesenchymal Stem Cells from Wharton ́s jelly
- Where
- Colombia
- Sponsor
- Universidad de la Sabana
Aneurysms Saccular, Aneurysm, Ruptured
Pre-SEAL™IT: Saccular Endovascular Aneurysm Lattice System First In Human Interventional Trial
To establish the preliminary safety and effectiveness of the SEAL™ Endovascular Aneurysm Lattice System for the treatment of saccular intracranial aneurysms. The data from this study will be used to support: 1.
- Conditions
- Aneurysms Saccular, Aneurysm, Ruptured, Aneurysm
- Trial name
- Pre-SEAL™IT (NCT05686733)
- Testing
- SEAL Device
- Where
- Colombia
- Volunteers
- 26 people
- Sponsor
- Galaxy Therapeutics INC
Urinary Tract Cancer
A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
This Phase IIIb, multicenter study will assess the safety of atezolizumab as second- to fourth-line treatment for participants with locally advanced or metastatic urothelial or non-urothelial cancer of the urinary tract in…
- Trial name
- NCT02928406
- Testing
- Atezolizumab
- Where
- 175 sites in Argentina, Australia and 30 more
- Volunteers
- 1,004 people
- Sponsor
- Hoffmann-La Roche
Anaemia
Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)
The purpose of this multi-center event-driven study in non-dialysis (ND) participants with anemia associated with chronic kidney disease (CKD) is to evaluate the safety and efficacy of daprodustat compared to darbepoetin alfa.
- Trial name
- NCT02876835
- Testing
- Daprodustat, Darbepoetin alfa, Iron Therapy
- Where
- 574 sites in United States, Argentina and 37 more
- Volunteers
- 3,872 people
- Sponsor
- GlaxoSmithKline
Triple-Negative Breast Cancer
A Study of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced or Metastatic Triple-Negative Breast Cancer
This study evaluated the efficacy and safety of ipatasertib in combination with atezolizumab and paclitaxel in locally advanced or metastatic Triple-Negative Breast Cancer (TNBC) previously untreated in this setting.
- Trial name
- NCT04177108
- Testing
- Atezolizumab, Ipatasertib, Paclitaxel
- Where
- 182 sites in United States, Argentina and 35 more
- Volunteers
- 242 people
- Sponsor
- Hoffmann-La Roche
Community Acquired Pneumonia, Complicated Skin and Soft Tissue Infection
Retrospective Chart Review Study to Assess Characteristics, Treatment Outcomes and Resource Use of Adults Hospitalized for CAP and CSSTi Treated With Zinforo in Multiple Countries
MULTINATIONAL Retrospective Chart Review Study to Assess the Characteristics, Treatment Outcomes and Resource Use Among Adult Patients Hospitalized for Community-Acquired Pneumonia (CAP) or Complicated Skin and Soft Tissue…
- Trial name
- NCT04198571
- Testing
- Zinforo (ceftaroline fosamil)
- Where
- 26 sites in Brazil, Colombia and 5 more
- Volunteers
- 317 people
- Sponsor
- Pfizer
Macular Holes, Macular Hole of Left Eye (Disorder)
Autologous Platelet-rich Plasma as a Treatment for Macular Holes
For a series of patients with full-thickness macular hole, an autologous plasma rich in growth factors was developed in the form of a clot and applied to the retinal defect.
- Conditions
- Macular Holes, Macular Hole of Left Eye (Disorder), Macular Hole of Right Eye (Disorder)
- Trial name
- NCT06323902
- Testing
- Pars plana vitrectomy, with or without epiretinal membrane peeling, plus PRGF membrane implantation
- Where
- Colombia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinica Oftalmologica Paredes
Alzheimer Disease
Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease
This substudy will evaluate the effect of crenezumab on the longitudinal tau burden in a subgroup of preclinical Presenilin1 (PSEN1) E280A mutation carriers and non-carriers, who were enrolled in study NCT01998841 (GN28352).
- Trial name
- NCT03977584
- Testing
- Crenezumab, [^18F]GTP1
- Where
- Colombia
- Volunteers
- 114 people
- Sponsor
- Hoffmann-La Roche
Heart Failure, Caregiver Burden
Effect of the PLAN CUIDARTE on the Caregiving Competence of People With Heart Failure
According to the World Health Organization (WHO), by 2021 cardiovascular diseases (CVD) will be a public health problem, among them heart failure (HF), since this is a chronic disease, patients should be competent in their care.
- Conditions
- Heart Failure, Caregiver Burden, Discharge Plan, Care Transitions
- Trial name
- PLANCUIDARTE (NCT06309875)
- Testing
- PLAN CUIDARTE, Conventional care
- Where
- Colombia
- Volunteers
- 84 people
- Sponsor
- Universidad de la Sabana
Toxicity, Safety Issues
Safety Assessment of P2Et Extract in Healthy Voluntary Subjects in Colombia
Caesalpinia spinosa extract is rich in gallotannins and other well characterized polyphenols and has a major antioxidant activity.
- Trial name
- NCT03663881
- Testing
- P2Et extract
- Where
- Colombia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario San Ignacio
Congenital Urogenital Anomaly
Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis
Non-conspicuous penis (congenital megaprepuce, occult penis) is a symptomatic malformation that includes phimosis and excessively baggy, urine-filled prepuce with alteration of the appearance of the penis.
- Trial name
- DISMUD (NCT03295175)
- Testing
- Hematoxylin-eosin and smooth muscle actin markers
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital Universitario San Ignacio
Risk Behavior
Effectiveness of Counseling Interventions to Modify Risk Behaviors in Patients at the Hospital San Ignacio.
Randomized clinical trial that aims to determine the effectiveness of a counseling intervention to modify the stage of behavioral change in risk behaviors (smoking and risky alcohol consumption) in patients candidates for…
- Trial name
- EFICO (NCT03521622)
- Testing
- brief counseling
- Where
- Colombia
- Volunteers
- 440 people
- Sponsor
- Hospital Universitario San Ignacio