Clinical trials: in Croatia
Hypertension, Portal
A Study to Test Whether Two Different Doses of Avenciguat Help People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)
This study is open to adults with liver cirrhosis and high blood pressure in the portal vein (main vessel going to the liver). The purpose of this study is to find out whether a medicine called Avenciguat helps people with this…
- Trial name
- NCT05161481
- Testing
- Avenciguat (BI 685509)
- Where
- 45 sites in United States, Argentina and 20 more
- Volunteers
- 80 people
- Sponsor
- Boehringer Ingelheim
Obesity, Abdominal, Surgery
Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery
Surgical stress after major abdominal surgery in perioperative period causes neuroendocrine, metabolic and imunologic changes in organism with production of proinfflamatory citokines and results with appearance of systemic…
- Conditions
- Obesity, Abdominal, Surgery, Systemic Inflammatory Response Syndrome, Postoperative Complications
- Trial name
- ADIPOS (NCT06057207)
- Testing
- serum levels of adiponectin, IL-6, Postoperative systemic infflamation
- Where
- 2 sites in Croatia
- Volunteers
- 58 people
- Sponsor
- Osijek University Hospital
Schizophrenia
Extension Study of Pimavanserin for the Adjunctive Treatment of Schizophrenia
To evaluate the long-term safety and tolerability of pimavanserin after 52 weeks of adjunctive treatment in subjects with schizophrenia
- Trial name
- NCT03121586
- Testing
- Pimavanserin
- Where
- 161 sites in United States, Argentina and 12 more
- Volunteers
- 995 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Conduction Defect
Pilot evaluatIon Of NovEl tEmpoRary ExtraVascular PACING (PIONEER EV PACING) Study
The PIONEER EV PACING Study is prospective, multi-center, acute (in-hospital), single-arm, pilot study. The study objective is to characterize preliminary safety and performance of the AtaCor EV Temporary Pacing Lead System when…
- Trial name
- NCT05610033
- Testing
- AtaCor StealthTrac Lead
- Where
- Croatia
- Volunteers
- 12 people
- Sponsor
- AtaCor Medical, Inc.
Non-Metastatic Breast Cancer
Effectiveness of Original vs. AI-Generated Plain Language Summaries of Systematic Reviews
The study explores how patients with non-metastatic breast cancer perceive and comprehend original Plain Language Summary and AI-generated Plain Language Summary (PLS) of two systematic reviews from the Cochrane Library.
- Trial name
- NCT07140107
- Testing
- AI-generated PLS, Original PLS
- Where
- Croatia
- Volunteers
- 130 people
- Sponsor
- University of Split, School of Medicine
Multiple Myeloma
A Study of Combination of Daratumumab and Velcade (Bortezomib) Melphalan-Prednisone (DVMP) Compared to Velcade Melphalan-Prednisone (VMP) in Participants With Previously Untreated Multiple Myeloma
The purpose of this study is to determine if the addition of daratumumab to velcade (bortezomib) melphalan-prednisone (VMP) will prolong progression-free survival (PFS) compared with VMP alone in participants with previously…
- Trial name
- NCT02195479
- Testing
- Velcade, Melphalan, Prednisone
- Where
- 160 sites in United States, Argentina and 22 more
- Volunteers
- 706 people
- Sponsor
- Janssen Research & Development, LLC
Schizophrenia
Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia
To evaluate the efficacy and safety of adjunctive pimavanserin compared with adjunctive placebo in the treatment of negative symptoms of schizophrenia
- Trial name
- ADVANCE-2 (NCT04531982)
- Testing
- Pimavanserin
- Where
- 102 sites in Argentina, Bulgaria and 10 more
- Volunteers
- 454 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Ulcerative Colitis
Safety and Efficacy Study of PTG-100 in the Treatment of Moderate to Severe Ulcerative Colitis
The main objectives of this study are to evaluate the efficacy, safety, and tolerability of daily doses of PTG-100 in subjects with moderate to severe ulcerative colitis (UC).
- Trial name
- NCT02895100
- Testing
- PTG-100
- Where
- 98 sites in United States, Australia and 15 more
- Volunteers
- 98 people
- Sponsor
- Protagonist Therapeutics, Inc.
Anesthesia
Evaluation of Regional Blocks Efficacy in Orthognathic Surgery
The proposed study, which will be carried out on 72 male and female patients, who have reached bone maturity, are younger than 50 years and underwent orthognathic surgical procedures.
- Trial name
- NCT07133048
- Testing
- Levobupivakain 0.25 %, NaCl 0.9 %
- Where
- Croatia
- Volunteers
- 72 people
- Sponsor
- Clinical Hospital Center Rijeka
Voice Disorder Due to Iatrogenic Factor, Endotracheal Intubation During Surgery
Objective and Perceptual Characteristics of the Voice After Endotracheal Intubation in Head and Neck Surgery
Introduction: Possible consequences of endotracheal intubation are post-intubation voice changes. Hypothesis: Endotracheal intubation during head and neck surgery is associated with objective and perceptual voice disorders.
- Conditions
- Voice Disorder Due to Iatrogenic Factor, Endotracheal Intubation During Surgery, Thyroid Surgery, Head and Neck Surgery
- Trial name
- VOICE (NCT07131800)
- Where
- Croatia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Centre Zagreb
Fractures, Hip, Femoral Neck Fractures
Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures
The goal of this clinical trial is to explore the effects of different peripheral nerve blocks in older adults with hip fractures. It will also explore the safety of preoperative administration of peripheral nerve blocks.
- Conditions
- Fractures, Hip, Femoral Neck Fractures, Intertrochanteric Fractures, Subtrochanteric Fractures
- Trial name
- NCT07130006
- Testing
- PENG and LFCN peripheral nerve blocks with spinal anesthesia, FN and LFCN peripheral nerve blocks with spinal anesthesia, FIC peripheral nerve block with spinal anesthesia
- Where
- Croatia
- Volunteers
- 256 people
- Sponsor
- University Hospital of Split
Nasal Patency, Breathing Disorder During Sleeping
Investingation on Outcomes After Combining Septoplasty With Additional Procedures.
The aim of this study will be to compare postoperative nasal airflow and symptom improvement using a NOSE form in patients after different types of surgical treatment.
- Conditions
- Nasal Patency, Breathing Disorder During Sleeping, Breathing Mechanics
- Trial name
- NOSEjob (NCT07127848)
- Testing
- Septoplasty with Mucotomy, Septoplasty with Turbinectomy, Septoplasty with Valvuloplasty
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- University Hospital Sestre Milosrdnice
Keratoconus
The K-Map Study, Global Prevalence of KC
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss.
- Trial name
- NCT03115710
- Testing
- Rotating Scheimpflug camera (Pentacam HR)
- Where
- 12 sites in United States, China and 10 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Metastatic Breast Cancer
A Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC)
This study will evaluate the efficacy, safety and patient-reported outcomes of trastuzumab emtansine plus atezolizumab compared with trastuzumab emtansine plus placebo in participants with HER2-positive and PD-L1-positive LABC or…
- Trial name
- KATE3 (NCT04740918)
- Testing
- Trastuzumab Emtansine, Atezolizumab
- Where
- 51 sites in United States, Australia and 17 more
- Volunteers
- 96 people
- Sponsor
- Hoffmann-La Roche
Arrhythmias, Cardiac, Atrial Fibrillation
Future Cardia™ Insertable Cardiac Monitor in Subjects With Paroxysmal Atrial Fibrillation (First-in-Human Study)
This study is a first-in-human, prospective, multi-center, pre-market single-arm clinical trial to evaluate the Future Cardia™ ICM.
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation, Bradycardia, Ventricular Tachycardia
- Trial name
- NCT06167434
- Testing
- Future Cardia™ Insertable Cardiac Monitoring (ICM) System
- Where
- Croatia
- Volunteers
- 30 people
- Sponsor
- Future Cardia, Inc
Cardiac Surgery
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.
To date, no pharmacological agents are proven efficacious in treating perioperative AKI. There is a strong biological rationale for the administration of amino acid in the management of patients at risk of AKI with increases in…
- Trial name
- PROTection (NCT03709264)
- Testing
- Amino Acids
- Where
- 22 sites in Croatia, Italy and 1 more
- Volunteers
- 3,511 people
- Sponsor
- Università Vita-Salute San Raffaele
Antibiotic Resistant Infection, Critical Illness
Bolus Versus Continuous Infusion of Meropenem
This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units.
- Trial name
- MERCY (NCT03452839)
- Testing
- Meropenem
- Where
- 26 sites in Croatia, Italy and 2 more
- Volunteers
- 607 people
- Sponsor
- Università Vita-Salute San Raffaele
Shock
Renin-guided Hemodynamic Management in Patients With Shock
Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant…
- Trial name
- RENIN (NCT05898126)
- Testing
- Renin-guided hemodynamic management, Usual care
- Where
- 3 sites in Croatia, Italy
- Volunteers
- 800 people
- Sponsor
- Università Vita-Salute San Raffaele
Psoriatic Arthritis
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
The purpose of this study is to compare the safety and efficacy of risankizumab versus placebo in participants with moderately to severely active psoriatic arthritis (PsA).
- Trial name
- KEEPsAKE 1 (NCT03675308)
- Testing
- Risankizumab
- Where
- 256 sites in United States, Argentina and 37 more
- Volunteers
- 964 people
- Sponsor
- AbbVie
Neovascular Age-related Macular Degeneration
OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)
A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.
- Trial name
- COAST (NCT04757636)
- Testing
- 2.0 mg OPT-302, 2.0 aflibercept
- Where
- 209 sites in United States, Argentina and 28 more
- Volunteers
- 998 people
- Sponsor
- Opthea Limited
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