Clinical trials: in Croatia
Burning Mouth Syndrome
The Efficacy of N-acetyl-cysteine in the Treatment of Burning Mouth Syndrome
The purpose of this study was to examine the efficacy of N-acetyl cysteine in the treatment of burning mouth syndrome. A control group of patients with burning mouth syndrome will receive a placebo.
- Trial name
- NCT05309070
- Testing
- N-acetyl cysteine
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- University of Zagreb
Larynx Neoplasm, Laryngectomy; Status
Validation and Cross-cultural Adaptation of Croatian SECEL Questionnaire
Self-Evaluation of Communication Experiences after Laryngectomy (SECEL) questionnaire has been developed, with the aim of evaluating rehabilitation needs and the psychosocial care for patients with laryngeal cancer.
- Conditions
- Larynx Neoplasm, Laryngectomy; Status, Communication, Quality of Life
- Trial name
- NCT05346237
- Testing
- Quality of life questionnaire
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Osijek University Hospital
Solid Tumors, Colorectal Cancer
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
The main purpose of this 3-part study is to evaluate the safety and efficacy of the study drug known as LY2880070 in participants with advanced or metastatic solid tumors.
- Conditions
- Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT02632448
- Testing
- LY2880070, Gemcitabine
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 229 people
- Sponsor
- Esperas Pharma Inc.
Dry Eye Disease, Dry Eye
Efficacy of Lipid-containing Artificial Tears in the Treatment of Dry Eye
This clinical study involves patients with Dry Eye Disease (DED) who are visiting an ophthalmology outpatient clinic. Eligible participants must have an Ocular Surface Disease Index (OSDI) score ≥14 and <50, and at least one…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eye, Evaporative
- Trial name
- NCT06955585
- Testing
- Proluxx Artificial Tear Spray
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Sestre Milosrdnice
Schizophrenia
An Efficacy, Safety And Tolerability Study of Flexibly Dosed Paliperidone Extended Release (ER) in Participants With Schizophrenia
The purpose of this study is to explore tolerability, safety and effectiveness of flexibly dosed paliperidone extended release (ER) in participants with schizophrenia (psychiatric disorder with symptoms of emotional instability…
- Trial name
- PERFlexS (NCT00460512)
- Testing
- Paliperidone ER
- Where
- 231 sites in Belgium, Bulgaria and 20 more
- Volunteers
- 1,814 people
- Sponsor
- Janssen-Cilag International NV
Schizophrenia
A Study of Transition to the Paliperidone Palmitate 3-Month Formulation In Participants With Schizophrenia Previously Stabilized on the Paliperidone Palmitate 1-Month Formulation
The purpose of this study is to estimate the proportion of participants fulfilling criteria for symptomatic remission following a transition to 12 months treatment with flexible-dose paliperidone palmitate 3 month formulation…
- Trial name
- NCT02713282
- Testing
- Paliperidone palmitate 3 month formulation (PP3M)
- Where
- 46 sites in Croatia, Denmark and 13 more
- Volunteers
- 306 people
- Sponsor
- Janssen-Cilag Ltd.
Alzheimer Disease
ASURE: Alzheimer Study Using oRal Edaravone
This is a multi-center, Phase IIa, randomized, double-blind, placebo-controlled study in patients with Alzheimer's Disease (AD).
- Trial name
- NCT05323812
- Testing
- TW001
- Where
- 6 sites in Croatia, Netherlands
- Volunteers
- 61 people
- Sponsor
- Treeway B.V.
Colorectal Carcinoma, Analgesia, Postoperative
Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery
Effective pain management after abdominal surgery is essential for recovery. This study compares two pain relief methods-intrathecal morphine (a single spinal injection) and continuous epidural analgesia-for patients undergoing…
- Conditions
- Colorectal Carcinoma, Analgesia, Postoperative, Laparotomy
- Trial name
- NCT06935708
- Testing
- Intrathecal Morphine, Epidural Analgesia
- Where
- Croatia
- Volunteers
- 98 people
- Sponsor
- Meri Mirceta
Endometriosis, Probiotics
The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial
ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis.
- Trial name
- ProMetrioS (NCT06929364)
- Testing
- Omni Biotic Stress
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- The Gut Microbiome Center (Centar za crijevni mikrobiom)
Pregnancy, Autoimmune Thyroid Disease
Changes in Natural Immunity in Pregnant Women With Autoimmune Thyroid Disease
Autoimmune thyroid disease (AITD) is the most common endocrine disorder in women of reproductive age, including during pregnancy. It encompasses two clinical conditions: autoimmune hyperthyroidism and hypothyroidism.
- Trial name
- CIPAT (NCT06925399)
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- University of Rijeka
HIV-1-infection, Inflammation
The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events
MISTRAL (Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications, antimicrobial drug resistance, and unresponsiveness to therapeutic HIV-1 vaccination) is a 5-year EU Horizon…
- Conditions
- HIV-1-infection, Inflammation, AIDS
- Trial name
- MISTRAL (NCT05421286)
- Where
- 22 sites in Belgium, Croatia and 9 more
- Volunteers
- 991 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Community-acquired Pneumonia, Bacterial Pneumonia
Omadacycline vs. Moxifloxacin for the Treatment of Community-Acquired Bacterial Pneumonia
The purpose of this study is to evaluate the safety and efficacy of omadacycline as compared to moxifloxacin in the treatment of adults with community-acquired bacterial pneumonia.
- Trial name
- NCT04779242
- Testing
- Omadacycline, Moxifloxacin
- Where
- 55 sites in Bulgaria, Croatia and 6 more
- Volunteers
- 670 people
- Sponsor
- Paratek Pharmaceuticals Inc
Hereditary Angioedema
C1 Inhibitor Registry in the Treatment of Hereditary Angioedema (HAE) Attacks
This is a non-interventional treatment Registry of Hereditary Angioedema (HAE) patients treated with C1 inhibitor, either plasma-derived (pdC1INH) or the recombinant human form (rhC1INH / Ruconest), to observe adverse events and…
- Trial name
- NCT01397864
- Testing
- rhC1INH or pdC1INH
- Where
- 17 sites in Bulgaria, Croatia and 11 more
- Volunteers
- 181 people
- Sponsor
- Pharming Technologies B.V.
Atrial Fibrillation
Cryoablation System FIM/CE Mark Study
Multi-center, open label, prospective clinical study to establish the acute safety and performance of the Cryterion Cardiac Cryoablation System
- Trial name
- NCT03723070
- Testing
- The Cryterion Cardiac Cryoablation System
- Where
- 4 sites in Croatia, Netherlands and 1 more
- Volunteers
- 88 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
POLARx Cardiac Cryoablation System Study
This is a Post Market Clinical Follow-up (PMCF) study designed to establish the continued safety and effectiveness profile of the Boston Scientific Cardiac Cryoablation System after receiving CE mark.
- Trial name
- POLAR ICE (NCT04250714)
- Testing
- Boston Scientific Cardiac Cryoablation System
- Where
- 19 sites in Belgium, Croatia and 5 more
- Volunteers
- 400 people
- Sponsor
- Boston Scientific Corporation
Colitis, Ulcerative, Crohn's Disease
A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
The main aim of the study is to check for long-term side effects of Vedolizumab Subcutaneous (also known as Vedolizumab SC) in people with ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- NCT02620046
- Testing
- Vedolizumab SC
- Where
- 301 sites in United States, Argentina and 31 more
- Volunteers
- 746 people
- Sponsor
- Takeda
Paravertebral Block, Pectoralis and Serratus Plane Nerve Blocks
The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks
The use of regional anesthesia in breast surgery improves the postoperative outcome, reduces the development of infection, and weakens the perioperative immunosuppressive response associated with the response to surgical stress.
- Conditions
- Paravertebral Block, Pectoralis and Serratus Plane Nerve Blocks, Breast Cancer, Immunologic Suppression
- Trial name
- NCT05816538
- Testing
- Paravertebral nerve block (PVB), Pectoralis and Serratus Plane Nerve Blocks (PECS 2), Regional anesthetic technique with ultrasound guidance
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University of Rijeka
Vitreomacular Traction Syndrome
Pneumovitreolysis for Vitreomacular Traction
In this prospective, non-randomized, single-arm pilot study, conducted at the Eye Clinic of the University Hospital Split, the investigators are going to evaluate the utility of a single intravitreal injection of sulfur…
- Trial name
- NCT03945695
- Testing
- Pneumatic Vitreolysis in combination with "Drinking-Bird-Technique"
- Where
- Croatia
- Volunteers
- 12 people
- Sponsor
- University of Split, School of Medicine
AF, Ablation of Atrial Fibrillation
Comparison of Different Electroporation Systems in the Ablation Treatment of Atrial Fibrillation
The participant is invited to participate in a clinical study comparing three different techniques for treating atrial fibrillation (AF) called electroporation systems.
- Trial name
- PFA Champion (NCT06646887)
- Testing
- Electroporation
- Where
- 2 sites in Croatia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Systemic Inflammatory Response, Aortic Valve Stenosis
Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement
Aim of this randomized prospective study is to investigate the immunomodulatory effects of dexmedetomidine on outcomes in patients with isolated aortic stenosis after surgical aortic valve replacement.
- Trial name
- NCT05641064
- Testing
- Dexmedetomidine 0.5mcg/kg/h, Dexmedetomidine 1 mcg/kg/h
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Dubrava
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