Clinical trials: in Croatia
Periodontitis
Change in Gingival Volume and Quality of Life Due to Initial Periodontal Therapy in Smokers
The aim of this study is to compare the dimensional changes of the gingiva due to initial periodontal therapy in non-smokers and cigarette smokers and to compare the oral health related quality of life of non-smokers and…
- Trial name
- NCT05719519
- Testing
- Initial periodontal therapy and 3D intraoral scanning
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Carpal Tunnel Syndrome Bilateral
Neurological Outcomes Following Carpal Tunnel Wound-closure Techniques
single-centre randomised prospective trial will conducted at the University Hospital of Split in Croatia. The investigators plan to enrol 100 patients, randomly assigned to suture-based wound closure (n=50) or tissue…
- Trial name
- NCT05808855
- Testing
- two-component skin adhesive Glubran Tiss 2®, skin stitched with transcutaneous nylon suture
- Where
- 2 sites in Croatia
- Volunteers
- 100 people
- Sponsor
- University of Split, School of Medicine
Carpal Tunnel Syndrome
A Comparison of Tissue Adhesive Material and Suture as Wound-closure Techniques Following Carpal Tunnel Decompression
Participants will be randomly assigned to suture-based wound closure (n=50) or tissue adhesive-based wound closure (n=50) with two-component skin adhesive Glubran Tiss 2®.
- Trial name
- NCT05747989
- Testing
- two-component skin adhesive, Glubran Tiss 2, skin is stitched with transcutaneous nylon sutures
- Where
- Croatia
- Volunteers
- 98 people
- Sponsor
- University of Split, School of Medicine
Atrial Fibrillation
Cryoballoon Isolation of Superior Vena Cava in Paroxysmal Atrial Fibrillation
There is still unresolved question whether isolation of superior vena cava (SVC) in conjunction to conventional pulmonary vein isolation (PVI) improves outcomes in the treatment of paroxysmal atrial fibrillation.
- Trial name
- CISPAF (NCT05081310)
- Testing
- superior vena cava isolation, pulmonary vein isolation
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University of Zagreb
Atrial Fibrillation
Rotational Angiography in Cryoballoon Ablation
There is still unresolved question weather preprocedural imaging of left atrium and pulmonary veins is needed before the pulmonary vein isolation procedure for the treatment of atrial fibrillation.
- Trial name
- NCT04293757
- Testing
- Rotational angiography
- Where
- Croatia
- Volunteers
- 128 people
- Sponsor
- University of Zagreb
Total Hip Arthroplasty, Functional Recovery
Comparison of Three Different Surgical Approaches on the Functional Outcome After Total Hip Arthroplasty
This study aimed to determine differences in functional recovery after total hip arthroplasty between a group of patients operated on using a direct lateral approach, an anterolateral minimally invasive approach, and a posterior…
- Trial name
- NCT06141928
- Testing
- Functional recovery analysis
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clinic for Orthopedics Lovran
Gastrointestinal Microbiome
Benefits of Alcoholic Hangover Medicine
Myrkl is advertised as a dietary supplement for use before alcohol consumption that is effective in prevention of side effects during the next day.
- Trial name
- BLAM (NCT06126094)
- Testing
- Myrkl, dextrin
- Where
- Croatia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Gut Microbiome Center (Centar za crijevni mikrobiom)
Inflammatory Bowel Diseases, Crohn Disease
Real World Data on Vedolizumab Concentration and Outcomes in Inflammatory Bowel Disease (IBD) Patients Switching From Intravenous (IV) to Subcutaneous (SC) Vedolizumab in University Hospital Center Osijek
Inflammatory bowel disease consists of ulcerative colitis (UC) or Crohn's disease (CD). The main aim of this study is to describe real-world data on vedolizumab serum concentration and treatment outcomes in cohort of patients…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative
- Trial name
- NCT05504915
- Where
- Croatia
- Volunteers
- 31 people
- Sponsor
- Osijek University Hospital
Acute Limb Ischemia
Evaluation of Acute Lower Limb Ischemia
The primary objective of this study is to evaluate the effect of different treatment modalities on clinical outcome of patients suffering from acute lower limb ischemia (ALI).
- Trial name
- PROMOTE-ALI (NCT05138679)
- Testing
- Revascularization, Primary major amputation, Best medical treatment
- Where
- 37 sites in Austria, Croatia and 8 more
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Multiple Sclerosis (MS)
Long-Term Outcomes and Durability of Effect Following Treatment With Cladribine Tablets for MS (CLASSIC-MS)
The objective of this study was to collect data both retrospectively and prospectively in order to evaluate the long-term outcomes, durability of effect, and real-world treatment patterns following treatment with Cladribine…
- Trial name
- NCT03961204
- Testing
- Data Collection
- Where
- 99 sites in United States, Australia and 27 more
- Volunteers
- 662 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Diffuse Large B-Cell Lymphoma
MabionCD20 Compared to MabThera in Lymphoma Patients
The aim of the study is to demonstrate the high level of biosimilarity between MabionCD20 (MABION SA) and the reference product: MabThera (rituximab by Hoffman-La Roche) in patients with CD20-positive diffuse large B-cell…
- Trial name
- MADILYM (NCT02617485)
- Testing
- Rituximab, Doxorubicin, Vincristine
- Where
- 35 sites in Bosnia and Herzegovina, Croatia and 5 more
- Volunteers
- 143 people
- Sponsor
- Mabion SA
Von Willebrand Diseases
Clinical Study to Investigate the Efficacy and Safety of Wilate During Prophylaxis in Previously Treated Patients With VWD
This is a prospective, non-controlled, international, multi-center phase 3 study investigating the efficacy and safety of Wilate in previously treated adult patients with VWD, to obtain additional data on the safety and efficacy…
- Trial name
- NCT04052698
- Testing
- Wilate
- Where
- 14 sites in United States, Belarus and 6 more
- Volunteers
- 43 people
- Sponsor
- Octapharma
Crohn's Disease
CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Crohn's Disease (LIBERTY-CD)
This is Phase 3, Randomized, Placebo-controlled study to demonstrate superiority of CT-P13 SC over Placebo SC in Patients With Moderately to Severely Active Crohn's Disease
- Trial name
- NCT03945019
- Testing
- CT-P13 SC (Infliximab)
- Where
- 29 sites in United States, Belarus and 24 more
- Volunteers
- 396 people
- Sponsor
- Celltrion
Giant Cell Arteritis
KPL-301 for Subjects With Giant Cell Arteritis
The primary objective of the study is to evaluate the efficacy of mavrilimumab (KPL-301) versus placebo, co-administered with a 26-week corticosteroid taper, for maintaining sustained remission for 26 weeks in subjects with new…
- Trial name
- NCT03827018
- Testing
- mavrilimumab, prednisone
- Where
- 49 sites in United States, Australia and 13 more
- Volunteers
- 70 people
- Sponsor
- Kiniksa Pharmaceuticals, Ltd.
Schizophrenia, Schizoaffective Disorder
Pharmacokinetic, Safety, and Tolerability Study of Risperidone ISM® at Different Dose Strengths
This clinical trial is designed to evaluate different dosages of risperidone ISM, a new long-acting injectable form.
- Trial name
- PRISMA-1 (NCT01788774)
- Testing
- Risperidone ISM 50 mg, Risperidone ISM 75 mg, Risperidone ISM 100 mg
- Where
- 5 sites in Croatia, Russia and 2 more
- Volunteers
- 36 people
- Sponsor
- Rovi Pharmaceuticals Laboratories
Multiple Myeloma (MM)
Study to Evaluate t(11;14) Status and BCL2 Expression in Adult Participants With Multiple Myeloma (MM)
Multiple myeloma (MM) is a rare cancer caused by abnormal survival of plasma cells (blood cells). Most trial participants with MM relapse (cancer has come back) or become non- responsive to treatment and remission gets shorter…
- Trial name
- MEDICI (NCT04721002)
- Where
- 40 sites in United States, Argentina and 20 more
- Volunteers
- 514 people
- Sponsor
- AbbVie
Atrium; Beat, Echocardiography
Chronic Ibrutinib Therapy Effect on Left Atrial Function
Ibrutinib is an irreversible Bruton tyrosine-kinase inhibitor. In prospective studies, the ibrutinib efficacy in the treatment of various B-cell malignancies was established.
- Conditions
- Atrium; Beat, Echocardiography, Physiology, Therapy Adverse Effect
- Trial name
- CITE-LA (NCT03751410)
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University Hospital Sestre Milosrdnice
Atrial Fibrillation Paroxysmal, Recurrence
Early Recurrences of Atrial Arrhythmias and Their Impact on Late Recurrence After Pulmonary Vein Isolation With Pulsed Field Ablation of Paroxysmal Atrial Fibrillation
This is a prospective, single-arm study conducted in University Hospital of Split, Department of Cardiology. Patients treated with PFA for symptomatic paroxysmal atrial fibrillation will be asked to participate in the study.
- Trial name
- NCT05328882
- Testing
- Monitoring of paroxysmal atrial fibrillation recurrence after pulsed field catheter ablation
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University of Split, School of Medicine
Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis
Investigation of Subclinical Markers of Multiple Sclerosis
Transcranial magnetic stimulation (TMS) studies reported consistent and substantial impairments in the central nervous system (CNS) in multiple sclerosis (MS).
- Trial name
- SUBCLIN-MS (NCT04604041)
- Testing
- 1. Clinical testing; 2. Neurophysiological examination (TMS, EMNG); 3. Psychomotor examination; 4. Neuropsychological evaluation; 5. Flow cytometry; 6. ELISA
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University of Split, School of Medicine
Laryngeal Dystonia, Spasmodic Dysphonia
Cortical Silent Period in Laryngeal Dystonia
The goal of this observational study is to evaluate the cortical silent period (cSP) in cricothyroid muscle (CT) in laryngeal dystonia and control healthy subjects.
- Trial name
- cSPDystonia (NCT05580302)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Croatia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
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