Clinical trials: in Croatia
Diabetes Mellitus, Type 2
A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes
This study will compare the effect of semaglutide once weekly to insulin aspart 3 times daily as add on to metformin and insulin glargine in people with type 2 diabetes.
- Trial name
- SUSTAIN 11 (NCT03689374)
- Testing
- Semaglutide, Insulin aspart, Insulin glargine U100
- Where
- 210 sites in Bosnia and Herzegovina, Bulgaria and 19 more
- Volunteers
- 2,274 people
- Sponsor
- Novo Nordisk A/S
Hypotension During Surgery
Use of Hypotension Prediction Index to Reduce Intraoperative Hypotension in Major Thoracic Surgery
Intraoperative hypotension is linked to increased incidence of perioperative adverse events such as myocardial and cerebrovascular infarction and acute kidney injury.
- Trial name
- NCT05615168
- Testing
- "Acumen IQ" guided hemodynamic optimization, "Flotrac" guided hemodynamic optimization
- Where
- Croatia
- Volunteers
- 34 people
- Sponsor
- University Hospital Dubrava
Elective Surgical Procedures, Laparoscopy
Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery
Addition of nitrous oxide N2O towards the end of prolonged isoflurane anesthesia hastens patients recovery. The hypothesis is that the addition of N2O at the end of prolonged sevoflurane anaesthesia also hastens early recovery…
- Conditions
- Elective Surgical Procedures, Laparoscopy, Laparotomy, Anesthesia, General
- Trial name
- SEVONATE (NCT03420586)
- Testing
- Nitrous Oxide
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- General Hospital Zadar
Wound, Biofilm
Clinical Implications of Biofilm in Chronic Wound
Chronic wounds are important economic and health-care problem. Biofilm has been recognized as a major factor in wound chronicity, delayed healing, and persistent infections, increasing the need for frequent dressing changes…
- Conditions
- Wound, Biofilm, Chronic Pain, Quality of Life
- Trial name
- NCT05054244
- Testing
- standard wound treatment, Hyperbaric oxygenation (HBOT)
- Where
- Croatia
- Volunteers
- 140 people
- Sponsor
- University of Rijeka
Sepsis, Acute Respiratory Distress Syndrome
European Registry for Hemadsorption in Sepsis With the Seraph Filter
Although new techniques like extracorporeal blood purification have lately emerged, septic patients still have very high hospital mortality rates. Sepsis can be induced by either viremia, bacteriemia or in some cases both.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Infections - Pathogen Unspecified, Disease
- Trial name
- NCT05608096
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Croatian Society for Organ Support
Herniated Disc, Low Back Pain
Efficacy of PLDD Versus ESI in the Treatment of Lumbar Radicular Pain
The most common cause of lumbar radicular pain is intervertebral disc herniation with or without pressure on the nerve root, which leads to inflammation and pain.
- Trial name
- NCT05601791
- Testing
- Epidural Steroid Injection, Percutaneous Laser Disc Decompression
- Where
- Croatia
- Volunteers
- 116 people
- Sponsor
- Osijek University Hospital
Smoking Cessation
Varenicline Versus Cytisine for Smoking Cessation in Primary Care Setting
The overall goals of this study are to 1) assess awareness of interest in the use of pharmacotherapy for smoking cessation in Croatia and Slovenia, countries in Central Europe with very high smoking prevalence, and 2) investigate…
- Trial name
- NCT04015414
- Testing
- Varenicline, Cytisine
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 352 people
- Sponsor
- University of Zagreb
Pterygium of Conjunctiva and Cornea
Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery
Pterygium is a noncancerous growth of the conjunctival tissue over the cornea. It is a progressive disease that may lead to visual impairment in advanced stages, as well as restriction of ocular motility, chronic inflammation and…
- Trial name
- NCT03321201
- Testing
- Cauterization, Fibrin glue
- Where
- Croatia
- Volunteers
- 164 people
- Sponsor
- University of Split, School of Medicine
Mental Illness, Stigmatization
European Study on the Attitude of Psychiatrists Towards Their Patients
Background: Many people think that people with mental disorders might be dangerous or unpredictable. These patients face various sources of disadvantages and experience discrimination on job interviews, in education, and housing.
- Trial name
- Eustigma (NCT04644978)
- Testing
- anonymous online survey
- Where
- 31 sites in Albania, Austria and 29 more
- Volunteers
- 4,245 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
DNA Damage
Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa
The remarkable therapeutic anticaries effect of fluoride is well recognized, but in recent years, toxic effects on the oral mucosa have been discussed.
- Trial name
- NCT05596149
- Testing
- Toothpaste without fluoride, Toothpaste with sodium fluoride, Toothpaste with sodium monofluorophosphate
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Epilepsy
A Clinical Study to Investigate the Efficacy and Safety of Lacosamide as an Add on Therapy in Children With Epilepsy With Partial-onset Seizures
The purpose of this study is to evaluate the long-term safety, tolerability and efficacy of lacosamide (LCM) in pediatric subjects.
- Trial name
- NCT01964560
- Testing
- Lacosamide
- Where
- 141 sites in United States, Argentina and 33 more
- Volunteers
- 540 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Rheumatoid Arthritis
Study To Evaluate The Safety And Efficacy Of ILV-094 In Subjects With Rheumatoid Arthritis
The primary objective of this study is to assess the safety and efficacy of different dose regimens of ILV-094 compared with placebo, administered subcutaneously to subjects with active rheumatoid arthritis who are taking…
- Trial name
- NCT00883896
- Testing
- ILV-094
- Where
- 52 sites in United States, Belgium and 9 more
- Volunteers
- 195 people
- Sponsor
- Pfizer
Myelodysplastic Syndrome, MDS
Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA
The study's primary objective [in a population of patients with MDS after failure of treatment with azacitidine (AZA) or decitabine (DAC)], is to compare the overall survival (OS) of patients in the rigosertib group vs the…
- Conditions
- Myelodysplastic Syndrome, MDS, Refractory Anemia With Excess Blasts, RAEB
- Trial name
- INSPIRE (NCT02562443)
- Testing
- rigosertib, Any approved or standard-of-care therapy, best supportive care (BSC)
- Where
- 158 sites in United States, Australia and 20 more
- Volunteers
- 372 people
- Sponsor
- Traws Pharma, Inc.
Diabetes Mellitus, Type 2
Secondary Care - Continuous Glucose Monitoring
Introduction and objective: The current state of glucose monitoring includes the use of A1C, self-monitoring of blood glucose (SMBG), and continuous glucose monitoring (CGM).
- Trial name
- SC-COSMO (NCT03487887)
- Testing
- continuous glucose monitoring (CGM) iPro™2 Medtronic
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Croatian Society for Endocrinology and Diabology
Cushing Syndrome
Observational Registry on Patients With Endogenous CS to Document Safety and Effectiveness of Ketoconazole.
This is a non-interventional, prospective, multinational, multicentre, observational study, in which data collected are those derived from routine clinical practice via an European registry on CS: ERCUSYN.
- Trial name
- KetoPASS (NCT04872920)
- Where
- 6 sites in Croatia, France and 2 more
- Volunteers
- 200 people
- Sponsor
- HRA Pharma
Kidney Transplantation, Glomerular Filtration Rate
Estimating Glomerular Filtration Rate in Kidney Transplant Recipients
Accurate estimation of the glomerular filtration rate (GFR) is crucial for the management of kidney recipients, since it is the most predictive parameter of allograft failure that drives patient monitoring and decision-making.
- Trial name
- NCT05229939
- Testing
- No intervention
- Where
- 10 sites in United States, Croatia and 2 more
- Volunteers
- 11,412 people, healthy volunteers welcome
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients
The purpose of this study is to determine whether eculizumab long-term use is safe and effective in patients with relapsing NMO.
- Trial name
- NCT02003144
- Testing
- eculizumab
- Where
- 69 sites in United States, Argentina and 18 more
- Volunteers
- 119 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Atrial Fibrillation
Safety & Clinical Performance Study of Catheter Ablation With the Centauri System for Patients With Atrial Fibrillation
This study is a prospective, single-arm, open-label study following patients to 1 year, to evaluate the safety and performance of the Centauri System for catheter ablation of atrial fibrillation (AF).
- Trial name
- ECLIPSE AF (NCT04523545)
- Testing
- cardiac ablation
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Galaxy Medical, Inc.
Hodgkin Lymphoma
Brentuximab Vedotin Associated With Chemotherapy in Untreated Patients With Hodgkin Lymphoma.
This study aims to evaluate the efficacy of brentuximab vedotin + AVD combination (doxorubicine, vinblastine, dacarbazine) in patients with Hodgkin lymphoma stage I / II with an unfavorable diagnosis, assessed by the negativity…
- Trial name
- BREACH (NCT02292979)
- Testing
- Doxorubicin, Bleomycin, Vinblastine
- Where
- 65 sites in Belgium, Croatia and 3 more
- Volunteers
- 170 people
- Sponsor
- The Lymphoma Academic Research Organisation
Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Soft Palate
Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity
The purpose of this study was to determine whether LI administered in combination with cyclophosphamide, indomethacin and zinc in a multivitamin (CIZ) combination prior to standard of care therapy (surgery followed by…
- Trial name
- IT-MATTERS (NCT01265849)
- Testing
- LI, Cyclophosphamide, Indomethacin
- Where
- 102 sites in United States, Austria and 21 more
- Volunteers
- 928 people
- Sponsor
- CEL-SCI Corporation
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