Clinical trials: in Croatia
Crohn's Disease
A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy
The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and severely active Crohn's disease (CD).
- Trial name
- NCT03345836
- Testing
- Upadacitinib
- Where
- 428 sites in United States, Argentina and 46 more
- Volunteers
- 624 people
- Sponsor
- AbbVie
Appendicitis in Pregnancy
A Novel Appendicitis TriMOdal Prediction Score (ATMOS) for Acute Appendicitis in Pregnancy: a Retrospective Observational Study
Acute appendicitis (AA) is a disease of younger age, but it occurs in 1 out of 500-2000 pregnancies. The current treatment of choice for AA in pregnancy is surgical.
- Trial name
- ATMOS (NCT05202483)
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Low-Grade Squamous Intraepithelial Lesions
Effect of Alpha-lipoic Acid on Regression of Low-grade Squamous Intraepithelial Lesions (LSIL)
Low-grade squamous intraepithelial lesions (LSIL) are premalignant changes on the cervix that can lead to malignant changes, i. e. cervical cancer.
- Trial name
- NCT05485259
- Testing
- DL-alpha lipoic acid
- Where
- 2 sites in Bosnia and Herzegovina, Croatia
- Volunteers
- 100 people
- Sponsor
- University of Zagreb
Hip Fractures
Fascia Iliaca Compartment Block for Pain Management in Hip Fracture Patients
BLOCKPAIN is a randomized controlled study, 80 participants. The participants will be hip fracture patients in Emergency Medicine Department in Clinical Hospital "Sveti Duh", Zagreb, Croatia.
- Trial name
- BLOCKPAIN (NCT04837924)
- Testing
- fascia iliaca compartment block, (FICB) (levobupivacaine hydrochloride 0,25% 40 ml), paracetamol 1 gram IV, Rescue analgesic tramadol 100 mg IV if needed
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- General Hospital Sveti Duh
Cardiac Disease
Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease
A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment.
- Trial name
- NCT03395639
- Testing
- Edoxaban, Standard of Care (SOC)
- Where
- 48 sites in United States, Austria and 12 more
- Volunteers
- 168 people
- Sponsor
- Daiichi Sankyo
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus
This trial is conducted globally. The aim of this trial is to investigate efficacy and safety of oral Semaglutide versus Liraglutide and versus Placebo in Subjects with Type 2 Diabetes Mellitus.
- Trial name
- PIONEER 4 (NCT02863419)
- Testing
- semaglutide, liraglutide
- Where
- 108 sites in United States, Croatia and 11 more
- Volunteers
- 711 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus
This trial is conducted globally. The aim of this trial is to investigate Efficacy and Safety of Oral Semaglutide versus Empagliflozin in Subjects with Type 2 Diabetes Mellitus.
- Trial name
- PIONEER 2 (NCT02863328)
- Testing
- semaglutide, empagliflozin
- Where
- 106 sites in United States, Argentina and 10 more
- Volunteers
- 822 people
- Sponsor
- Novo Nordisk A/S
Appendicitis Acute
Evaluation of One Day Discharge After Laparoscopic Appendectomy for Uncomplicated Appendicitis in Children.
The aim of this study was to evaluate the value and safety of discharge of a child to home care within 24 hours after laparoscopic appendectomy for uncomplicated appendicitis to reduce the impact on the child's psyche and need…
- Trial name
- NCT05095987
- Testing
- Laparoscopic Appendectomy
- Where
- Croatia
- Volunteers
- 180 people
- Sponsor
- Miro Jukić
Efficacy of a 21-Day Wear Period for the Cascade CGM
Glucomen Day Cascade CGM System 21-Day Wear Study
Assessment of 21-day CGM wear period
- Trial name
- GLUCODAY21 (NCT05460260)
- Testing
- Cascade CGM
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 10 people
- Sponsor
- WaveForm Technologies Inc.
Multiple Sclerosis, Spasticity, Muscle
A Study to Investigate the Safety and Effectiveness of Arbaclofen Extended-Release Tablets for Patients With MS
Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disease of the central nervous system (CNS) that is regarded as the foremost cause of non-traumatic neurologic disability in adults in North America.
- Trial name
- OS440-3004 (NCT03290131)
- Testing
- Arbaclofen
- Where
- 30 sites in Belarus, Bosnia and Herzegovina and 5 more
- Volunteers
- 536 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Crohn's Disease
A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
The purpose of this study is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active Crohn's disease (CD).
- Trial name
- NCT03105128
- Testing
- risankizumab IV, risankizumab SC
- Where
- 475 sites in United States, Argentina and 42 more
- Volunteers
- 931 people
- Sponsor
- AbbVie
Ulcerative Colitis (UC)
A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
This study was comprised of three substudies. The objective of Substudy 1 was to characterize the dose-response, efficacy, and safety of upadacitinib compared to placebo in inducing clinical remission to identify the induction…
- Trial name
- NCT02819635
- Testing
- Upadacitinib
- Where
- 496 sites in United States, Argentina and 44 more
- Volunteers
- 1,302 people
- Sponsor
- AbbVie
Plaque Psoriasis
CF101 Therapy in Patients With Moderate-to-severe Plaque Psoriasis
This trial will test the hypothesis that the administration of CF101, a novel anti-inflammatory agent, to patients with moderate to severe plaque psoriasis will relieve signs and symptoms of the disease.
- Trial name
- NCT03168256
- Testing
- CF101 2mg, CF101 3mg, Apremilast 30mg
- Where
- 30 sites in Bosnia and Herzegovina, Bulgaria and 7 more
- Volunteers
- 528 people
- Sponsor
- Can-Fite BioPharma
Smoking, Excessive Drinking
WHO-HPH Recognition Project on Fast-Track Implementation of Clinical Health Promotion
The project's background is the notion that patient centred clinical health promotion has been shown to significantly improve both outcomes and patient safety.
- Conditions
- Smoking, Excessive Drinking, Lack of Physical Activity, Malnutrition
- Trial name
- RP (NCT01563575)
- Testing
- fast-track implementation process
- Where
- 11 sites in Canada, Croatia and 9 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Crohn's Disease
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
The objective of Study M15-991 is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active CD.
- Trial name
- NCT03104413
- Testing
- risankizumab SC, risankizumab IV
- Where
- 403 sites in United States, Argentina and 41 more
- Volunteers
- 618 people
- Sponsor
- AbbVie
Enteric Hyperoxaluria
Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria
The purpose of this study is to determine the efficacy, durability and long-term safety of reloxaliase in patients with enteric hyperoxaluria.
- Trial name
- URIROX-2 (NCT03847090)
- Testing
- Reloxaliase
- Where
- 113 sites in United States, Austria and 14 more
- Volunteers
- 92 people
- Sponsor
- Allena Pharmaceuticals
Malocclusion, Angle Class II
Predictors Associated With Seeking Orthodontic Treatment, Compliance and Treatment Success
Aim: to search for reasons for seeking orthodontic treatment, compliance during orthodontic treatment, drop-out from orthodontic treatment and success of orthodontic treatment.
- Trial name
- PONCOS (NCT03455634)
- Testing
- Twin Block, Sander bite jumping appliance
- Where
- Croatia
- Volunteers
- 110 people
- Sponsor
- Visnja Katic
Caries; Enamel, Gingivitis
Immunological and Regenerative Implications of Corrosion of Dental Materials
During orthodontic treatment intraoral corrosion results with release of nickel and titanium ions from orthodontic appliances in surrounding tissues.
- Trial name
- IMUNODENT (NCT03334461)
- Testing
- Exposure to oral antiseptics or enamel remineralisation agent
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Burning Mouth Syndrome, Melatonin
Salivary Melatonin Levels and Sleep Quality in Patients With Burning Mouth Syndrome
Burning mouth syndrome is an idiopathic condition characterized by symptoms burning and / or pain of the oral mucosa with an orderly clinical finding. So far not found a unique way of treatment.
- Trial name
- NCT05309681
- Testing
- Epworth's sleepiness scale; unstimulated saliva sample
- Where
- Croatia
- Volunteers
- 45 people
- Sponsor
- University of Zagreb
Colitis, Ulcerative
Efficacy and Safety of Vedolizumab Subcutaneously (SC) as Maintenance Therapy in Ulcerative Colitis
The purpose of this study is to assess the effect of vedolizumab subcutaneous (vedolizumab SC) maintenance treatment on clinical remission at Week 52 in participants with moderately to severely active ulcerative colitis (UC) who…
- Trial name
- NCT02611830
- Testing
- Vedolizumab 300 mg IV, Vedolizumab 108 mg SC
- Where
- 174 sites in United States, Argentina and 29 more
- Volunteers
- 383 people
- Sponsor
- Takeda
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