Clinical trials: active, in Cyprus
Charcot Marie Tooth Disease
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C…
- Trial name
- INC-6601 (NCT01193075)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Michael Shy
Aortic Valve Stenosis
Impact of Beta Blockers on TAVI (BETA-TAVI)
The BETA-TAVI trial is a prospective, investigator-initiated, multicenter, randomized, open-label, non-inferiority trial designed to evaluate the safety of continuing versus temporarily interrupting chronic beta-blocker therapy…
- Trial name
- BETA-TAVI (NCT05721170)
- Testing
- Beta blocker
- Where
- 2 sites in Cyprus, Greece
- Volunteers
- 348 people
- Sponsor
- National and Kapodistrian University of Athens
Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
- Trial name
- INC-6602 (NCT01193088)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Ankle Fractures, Ankle Injuries
Turkish Version of the Ankle Fracture Outcome of Rehabilitation Measure (A-FORM-TR): A Multi-Centre Validation Study
Ankle fractures are common injuries that can affect a patient's mobility, mood, sleep, and everyday life for months. The Ankle Fracture Outcome of Rehabilitation Measure (A-FORM) is an English-language patient-reported outcome…
- Trial name
- A-FORM-TR (NCT07620015)
- Where
- 3 sites in Cyprus, Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Utku Gürhan
Myositis, Active Idiopathic Inflammatory Myopathy
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
The main purpose of this study is to measure the long-term safety and tolerability of efgartigimod PH20 SC in adult participants with Idiopathic Inflammatory Myopathy (IIM) who previously participated in ARGX-113-2007.
- Conditions
- Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis, Polymyositis
- Trial name
- ALKIVIA+ (NCT05979441)
- Testing
- Efgartigimod PH20 SC
- Where
- 92 sites in United States, Argentina and 27 more
- Volunteers
- 240 people
- Sponsor
- argenx
Postural Balance
Balance Training Versus Traditional Physical Education in High School Students
This study will compare the effects of an 8-week balance-focused exercise program and traditional physical education on static and dynamic balance performance in high school students.
- Trial name
- NCT07805421
- Testing
- Balance-Focused Exercise Program, Traditional Physical Education
- Where
- Cyprus
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Arthroplasty, Replacement, Hip, Patient Education
Early Mobilization and Postoperative Complications in Hip Arthroplast
Orthopedic surgical procedures, particularly total hip replacement, are of great importance in the older population in terms of regaining functional independence, reducing pain, and improving quality of life.
- Conditions
- Arthroplasty, Replacement, Hip, Patient Education, Patient Education and Early Mobilization After Total Hip Arthroplasty
- Trial name
- NCT07867717
- Testing
- Early Mobilization Education, Routine Postoperative Care
- Where
- Cyprus
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cyprus Aydin University
Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, hATTR-PN
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
The purpose of this study is to: Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional status, disability, and gait speed Demonstrate…
- Trial name
- TRITON-PN (NCT07223203)
- Testing
- Nucresiran, Vutrisiran
- Where
- 61 sites in United States, Argentina and 20 more
- Volunteers
- 125 people
- Sponsor
- Alnylam Pharmaceuticals
ER-positive Breast Cancer, HER2-negative Breast Cancer
Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)
This is an international, multi-center, randomised, open label, superiority phase III trial of elacestrant vs standard endocrine therapy in patients with ER+/HER2- breast cancer and ctDNA relapse.
- Conditions
- ER-positive Breast Cancer, HER2-negative Breast Cancer, Stage IIB Breast Cancer, Stage III Breast Cancer
- Trial name
- TREAT ctDNA (NCT05512364)
- Testing
- Elacestrant, Tamoxifen, Letrozole 2.5mg
- Where
- 113 sites in Belgium, Cyprus and 10 more
- Volunteers
- 220 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Retroperitoneal Sarcoma, Liposarcoma
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS…
- Conditions
- Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
- Trial name
- STRASS2 (NCT04031677)
- Testing
- Surgery, Preoperative chemotherapy
- Where
- 176 sites in United States, Australia and 13 more
- Volunteers
- 250 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Empowerment, Patient, Mobile Application
Patient Empowerment Via Mobile Health Applications (MHAs)
The goal of this observational study is to learn if myAria MHA can help adult oncology patients better manage their health and participate in medical research.
- Conditions
- Empowerment, Patient, Mobile Application, Prostate CA
- Trial name
- MyAria (NCT07828951)
- Testing
- Digital health application engagement and empowerment
- Where
- Cyprus
- Volunteers
- 50 people
- Sponsor
- Constantinos Zamboglou
Prostate Adenocarcinoma, Radiation Toxicity
Hypo-Combi Trial: Hypofractionated EBRT Plus HDR-BT Boost for Prostate Cancer
Hypo-Combi Trial: A Prospective Phase I/II Study of Combined Hypofractionated External Beam Radiation Therapy (EBRT) plus Interstitial High-Dose-Rate Brachytherapy (HDR-BT) for Intermediate/High Risk Prostate Cancer
- Trial name
- Hypo-Combi (NCT05003752)
- Testing
- External beam radiation therapy, High-dose-rate brachytherapy, Goserelin 10.8 mg
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- German Oncology Center, Cyprus
Prostate Cancer
Artificial Intelligence to Personalize Prostate Cancer Treatment (the HypoElect Trial)
A prospective, single-arm phase II study is the individualization of RT for patients with high-risk localized PCa based on multimodal artificial intelligence (MMAI).
- Trial name
- HypoElect (NCT06582446)
- Testing
- Androgen Deprivation Therapy (ADT) - Goserelin, High-Dose-Rate Interstitial Brachytherapy (HDR BRT), radiotherapy
- Where
- Cyprus
- Volunteers
- 30 people
- Sponsor
- German Oncology Center, Cyprus
Prostate Cancer
Artificial Intelligence Driven Personalisation of Radiotherapy and Concomitant Androgen Deprivation Therapy for Prostate Cancer Patients (the HypoPro Trial)
The aim of this prospective, single-arm phase II study is the individualization of both radiotherapy (RT) and androgen deprivation therapy (ADT) duration for patients with high-risk localized prostate cancer (PCa) according to…
- Trial name
- HypoPro (NCT06772441)
- Testing
- Androgen deprivation therapy (ADT)
- Where
- Cyprus
- Volunteers
- 30 people
- Sponsor
- German Oncology Center, Cyprus
Cardiomyopathy, Secondary, Arrhythmias, Cardiac
Pacing Advancements With Cost and Experience VALuation for Unified Patient-Led Clinical Evidence - the PACEVALUE Study
The PACEVALUE study is a large, international observational study aiming to improve the treatment of patients receiving cardiac implantable electronic devices (CIEDs) such as pacemakers, implantable cardioverter-defibrillators…
- Conditions
- Cardiomyopathy, Secondary, Arrhythmias, Cardiac, Heart Failure, Pacing Induced Cardiomyopathy
- Trial name
- PACEVALUE (NCT07276139)
- Where
- 13 sites in Australia, Bulgaria and 5 more
- Volunteers
- 4,500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Irriversible Pulpitis
Postoperative Pain After Root Canal Treatment Using Different Root Canal Sealers
This prospective randomized clinical trial aims to compare the effects of three different root canal sealers-AH Plus, ProRoot Bio Sealer, and BC Sealer ion+-on postoperative pain following root canal treatment in patients…
- Trial name
- PO-Pain (NCT07608939)
- Testing
- AH Plus Root Canal Sealer, ProRoot Bio Sealer, BC Sealer ion+ Sealer
- Where
- Cyprus
- Volunteers
- 135 people
- Sponsor
- European University of Lefke
Breath Exercise, State Anxiety
The Effect of Diaphragmatic Breathing Exercises Before Gastroscopy on Anxiety, Fear, and Vital Signs
Gastroscopy, performed as an invasive procedure for the diagnosis and treatment of upper gastrointestinal tract diseases, is often perceived by patients as an unpleasant and frightening experience, leading to anxiety (Hua et al.…
- Conditions
- Breath Exercise, State Anxiety, Adult Patients, Vital Signs Monitoring
- Trial name
- NCT07781943
- Testing
- Diaphragmatic Breathing Exercises
- Where
- Cyprus
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Supportive Care, Exercise Adaptations
Intradialytic Exercise and Cognitive Function
Exercise training may improve global and domain-specific cognitive function, mental health, psychological well-being, dialysis efficacy, and health-related quality of life in people with end-stage kidney disease receiving…
- Conditions
- Supportive Care, Exercise Adaptations, Exercise Training Therapy, Clinical Exercise
- Trial name
- EXCOG-HD (NCT07780175)
- Testing
- Resistance Training, Aerobic training, Combination Training
- Where
- Cyprus
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Heart Failure
Snapshot Study on Patients With Heart Failure
The goal of this observational study is to provide a better understanding of medical practice for heart failure management based on real-world data, collected both across Europe and the rest of the world, using robust methodology…
- Trial name
- GRASP-HF (NCT06469814)
- Where
- 63 sites in Armenia, Austria and 9 more
- Volunteers
- 4,000 people
- Sponsor
- European Society of Cardiology
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
BPH Global Registry
Benign prostatic hyperplasia (BPH) is one of the most common performed surgical procedures in urology. Over the past few decades there have been an increasing development of newer surgical treatment options.
- Trial name
- NCT05543200
- Where
- 30 sites in United States, Canada and 19 more
- Volunteers
- 7,500 people
- Sponsor
- Société Internationale d'Urologie