Clinical trials: in Finland
Carpal Tunnel Syndrome (CTS), Carpal Tunnel Surgery
Carpal Tunnel Release Efficacy Trial
Background Carpal tunnel syndrome (CTS) is a prevalent condition that affects 2.7% of the population, especially women. It arises due to compression of the median nerve in the wrist and is linked to factors like diabetes…
- Trial name
- FOCUS (NCT06934187)
- Testing
- Carpal tunnel release
- Where
- Finland
- Volunteers
- 96 people
- Sponsor
- Kuopio University Hospital
Depression, Depressive Disorder
Follow-up Study With Clinical Vitamin D Supplementation Trial on Patients With Depression (DepFuD)
Depression affects 350 million people worldwide. In the light of the global disease burden statistics, the efficacy of current treatments for depression appears insufficient.
- Trial name
- DepFuD (NCT02521012)
- Testing
- Vitamin D 10 micrograms, Vitamin D 100 micrograms
- Where
- Finland
- Volunteers
- 319 people
- Sponsor
- Kuopio University Hospital
Carpal Tunnel Syndrome
Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block
Carpal tunnel syndrome (CTS) is the most commonly appearing entrapment neuropathy of the upper extremity. Treatment options include both non-operative and operative methods.
- Trial name
- PERSONNEL (NCT05372393)
- Testing
- Local infiltration anaesthesia in carpal tunnel release, Distal median nerve block with local infiltration anaesthesia in carpal tunnel release
- Where
- Finland
- Volunteers
- 118 people
- Sponsor
- Kuopio University Hospital
Migraine Headache
A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache
Study 20170703 is a phase 4, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of erenumab against placebo in participants with chronic migraine (CM) who have a history of at…
- Trial name
- NCT03971071
- Testing
- Erenumab 70 mg, Erenumab 140 mg
- Where
- 94 sites in United States, Australia and 10 more
- Volunteers
- 620 people
- Sponsor
- Amgen
Depression
Motivational Multicomponent Lifestyle Interventions as a Supportive Treatment for Depression in Primary Health Care
The investigators aim to examine whether a motivational multicomponent lifestyle intervention as a supportive treatment for depression has a beneficial effect on recovery from depression in a primary health care setting.
- Trial name
- DEPKuopio (NCT05681767)
- Testing
- Motivational multicomponent lifestyle intervention + Treatment as usual, Treatment as usual
- Where
- Finland
- Volunteers
- 210 people
- Sponsor
- Kuopio University Hospital
Dental Caries, Child Neglect
Improving Family's Adherence to Dental Care After DGA (HECC-CAN-study)
Early childhood caries (ECC) is a common disease. Its prevalence is highest in poor, socially disadvantaged, and minority groups. Dental treatment under General Anaesthesia (DGA) is common, especially among the youngest patients.
- Trial name
- HECC-CAN (NCT04898465)
- Testing
- Social Paediatric Intervention
- Where
- Finland
- Volunteers
- 89 people
- Sponsor
- Helsinki University Central Hospital
Depressive Disorder, Major
A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment
The primary purpose of this study is to assess the long-term safety and tolerability of esketamine nasal spray in combination with a selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor (SSRI/SNRI)…
- Trial name
- ESCAPE-LTE (NCT04829318)
- Testing
- Esketamine, SSRI/SNRI
- Where
- 59 sites in Argentina, Belgium and 12 more
- Volunteers
- 183 people
- Sponsor
- Janssen-Cilag Ltd.
Proximal Humeral Fracture, Shoulder Fractures
Surgical Versus Non-surgical Treatment of Displaced Proximal Humerus Fracture in Adults Aged 50 to 65 Years
The goal of this clinical trial is to study whether surgery results in better functional outcomes than non-surgical treatment among patients aged 50-65 with a displaced proximal humerus fracture.
- Trial name
- PHF50-65 (NCT06416618)
- Testing
- Surgical, Non surgical
- Where
- 2 sites in Denmark, Finland
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Infant Development
Assessment of Motor Development With a Wearable in Rural and Low-income Settings
The MaMa study aims to assess feasibility and validity of an infant wearable in a rural settings. Altogether N~100 infants will be recruited and measured multiple times at homes from age 6 months to age 18 months.
- Trial name
- MaMa (NCT05782673)
- Testing
- wearable MAIJU for motor assessment
- Where
- 4 sites in Finland, Malawi
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Influenza (Healthy Volunteers)
Study to Evaluate the Effectiveness of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Adults 65 Years of Age and Older
Primary Objective: To demonstrate the superior relative effectiveness of QIV-HD as compared to QIV-SD among persons 65 years of age and older for the prevention of cardiovascular and/or respiratory hospitalizations.
- Trial name
- NCT04137887
- Testing
- Quadrivalent Influenza Vaccine (split virion, inactivated) High-Dose (QIV-HD), Standard-Dose Inactivated Influenza Vaccine Quadrivalent, Northern Hemisphere strains (QIV-SD)
- Where
- Finland
- Volunteers
- 33,096 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Celiac Disease, Dermatitis Herpetiformis
Background of Different Phenotypes of Coeliac Disease
The main purpose of this study is to investigate genetic, serological, immunological and microbiata diversities between different coeliac disease phenotypes and to discover applicable prognostic markers for specific phenotypes.
- Trial name
- NCT05597904
- Testing
- Genetic predisposition
- Where
- Finland
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Crohn Disease
An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease
This is an extension study to evaluate safety and efficacy of ozanimod in participants with moderately to severely active Crohn's Disease.
- Trial name
- NCT03467958
- Testing
- Ozanimod
- Where
- 766 sites in United States, Argentina and 47 more
- Volunteers
- 854 people
- Sponsor
- Celgene
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART D (NCT05658640)
- Testing
- Trametinib, Dexamethasone, Cyclophosphamide
- Where
- 36 sites in Austria, Belgium and 13 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART B (NCT05751044)
- Testing
- Dasatinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART C (NCT05745714)
- Testing
- Ruxolitinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Factor VIII Deficiency, Factor IX Deficiency
The European Paediatric Network for Haemophilia Management ( PedNet Registry)
Rationale: Haemophilia is a rare disease; to improve knowledge international collaboration is needed. Well-defined clinical data will be collected from complete cohorts in order to prevent selection bias.
- Trial name
- PedNet (NCT02979119)
- Where
- 39 sites in Austria, Belgium and 17 more
- Volunteers
- 4,000 people
- Sponsor
- PedNet Haemophilia Research Foundation
Carpal Tunnel Syndrome
aDjunct bicarbonatE in Local anaesthesIa for CarpAl Tunnel rElease (DELICATE)
Introduction Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment syndrome in Finland and worldwide. Nowadays carpal tunnel release (CTR) surgery is often done in local anaesthesia.
- Trial name
- DELICATE (NCT05328180)
- Testing
- Sodium bicarbonate, Control arm
- Where
- Finland
- Volunteers
- 116 people
- Sponsor
- Kuopio University Hospital
Neuromuscular Blockade
Reversal of Neuromuscular Blockade During the General Anaesthesia
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe…
- Trial name
- NCT04048655
- Testing
- Neostigmine, Combinations
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Carpal Tunnel Syndrome, Median Nerve Entrapment
An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial
The study compares two widely used treatments in closing the wound after open carpal tunnel release surgery: absorbable and non-absorbable sutures.
- Trial name
- SUPER (NCT05503719)
- Testing
- Surgical wound closed with an absorbable suture, Surgical wound closed with a non-absorbable suture
- Where
- Finland
- Volunteers
- 116 people
- Sponsor
- Kuopio University Hospital
Pain, Chronic, Sleep
Sleep, Pain and Stress in Adolescents With Persistent Pain
The main aim is the gain information of sleep structures in adolescents with persistent pain. Also to study simple interventions to support their sleep and pain management.
- Trial name
- PedPainSleep (NCT05677412)
- Testing
- suggestive relaxation, Neutral story
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
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