Clinical trials: in Finland
Prostate Cancer, Prostate Adenocarcinoma
A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer
Men with localized, intermediate risk prostate cancer will be randomized to undergo either radical prostatectomy or the TULSA procedure, with a follow-up of 10 years in this multi-centered randomized control trial.
- Trial name
- CAPTAIN (NCT05027477)
- Testing
- Radical Prostatectomy, TULSA Procedure
- Where
- 22 sites in United States, Canada and 1 more
- Volunteers
- 201 people
- Sponsor
- Profound Medical Inc.
Skin Transplantation
Post-market Clinical Follow-up Study for a CE Marked Wound Care Product (FibDex®)
FibDex® 2-2022 is a sponsored, post-marketing clinical follow-up (PMCF) study to monitor the clinical performance and safety of the CE marked product nanofibrillar cellulose (NFC) wound dressing, FibDex®, when used according to…
- Trial name
- NCT05666999
- Testing
- FibDex®, Suprathel, Aquacel Foam
- Where
- Finland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- UPM-Kymmene Corporation
Metastatic Non Small Cell Lung Cancer
Pembrolizumab/Vibostolimab Coformulation (MK-7684A) or Pembrolizumab/Vibostolimab Coformulation Plus Docetaxel Versus Docetaxel for Metastatic Non Small Cell Lung Cancer (NSCLC) With Progressive Disease After Platinum Doublet Chemotherapy and Immunotherapy (MK-7684A-002, KEYVIBE-002)
The main purpose of this study is to compare pembrolizumab/vibostolimab coformulation (MK-7684A) plus docetaxel or pembrolizumab/vibostolimab coformulation to normal saline placebo plus docetaxel.
- Trial name
- NCT04725188
- Testing
- Pembrolizumab/Vibostolimab coformulation, Docetaxel
- Where
- 95 sites in United States, Argentina and 18 more
- Volunteers
- 255 people
- Sponsor
- Merck Sharp & Dohme LLC
AI-assisted Documentation
Effect of AI Assisted Documentation in Primary Health Care on Time Saving, Patient Satisfaction and Health Care Provider Satisfaction
Background There is currently no research evidence from randomized trial settings on the effectiveness of AI-assisted documentation.
- Trial name
- NCT06836258
- Testing
- AI assisted documentation
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Advanced Solid Tumors Cancer
A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors
This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combination with osimertinib, erlotinib, and nivolumab in participants with advanced…
- Trial name
- NCT02099058
- Testing
- Osimertinib, Nivolumab, Telisotuzumab vedotin
- Where
- 36 sites in United States, Belgium and 7 more
- Volunteers
- 237 people
- Sponsor
- AbbVie
Polycystic Ovary Syndrome (PCOS)
Optimizing Metformin Use in Polycystic Ovary Syndrome
The goal of this clinical trial is to learn if a metformin dose of 1500 mg or 2250 mg per day is better to treat polycystic ovary syndrome (PCOS) in adults. It will also learn about the adverse effects of metformin.
- Trial name
- MET-PCOS (NCT07120815)
- Testing
- Metformin 1500 mg daily, Metformin 2250 mg daily
- Where
- Finland
- Volunteers
- 184 people
- Sponsor
- Helsinki University Central Hospital
Obstructive Sleep Apnea
Lifestyle and Physical Activity as Part Of Obstructive Sleep Apnea Treatment
The goal of this clinical trial is to investigate the effects of an individually tailored lifestyle intervention on symptoms and severity of obstructive sleep apnea (OSA), physical activity (PA) levels and sedentary behavior…
- Trial name
- ELO (NCT06382883)
- Testing
- Individually tailored lifestyle and physical activity intervention, Individually tailored lifestyle and physical activity intervention combined with enhanced behavioral support -intervention (EBS)
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Filha ry
Aortic Rupture
Prediction of Aortic Dilatation and Rupture
Aortic aneurysm is a very common incidental finding in the diagnostic imaging of the chest. It is especially common in middle aged men (up to 40 %).
- Trial name
- DilAo (NCT05065996)
- Testing
- Aortic MRI + 4D flow MRI
- Where
- Finland
- Volunteers
- 170 people
- Sponsor
- Kuopio University Hospital
Myocardial Infarction, Coronary Artery Disease
Arrhythmias in Post-Myocardial Infarction Patients
Patients are screened for significant arrhythmias and other possibly significant ECG-patterns directly after discharge and two weeks after myocardial infarction using wearable devices.
- Conditions
- Myocardial Infarction, Coronary Artery Disease, Arrythmia, ECG Electrical Alternans
- Trial name
- NCT03231826
- Where
- Finland
- Volunteers
- 445 people
- Sponsor
- Tampere University
Aortic Dissection
Scandinavian Trial of Uncomplicated Aortic Dissection Therapy
The introduction of thoracic endovascular aortic repair (TEVAR) in 1994 has radically changed the treatment of thoracic aortic pathology, and TEVAR is now the recommended therapy for "complicated" TBADs and other thoracic aorta…
- Trial name
- SUNDAY (NCT05215587)
- Testing
- TEVAR
- Where
- 28 sites in Denmark, Finland and 4 more
- Volunteers
- 554 people
- Sponsor
- University of Aarhus
Metastatic Breast Cancer
A Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC)
This study will evaluate the efficacy, safety and patient-reported outcomes of trastuzumab emtansine plus atezolizumab compared with trastuzumab emtansine plus placebo in participants with HER2-positive and PD-L1-positive LABC or…
- Trial name
- KATE3 (NCT04740918)
- Testing
- Trastuzumab Emtansine, Atezolizumab
- Where
- 51 sites in United States, Australia and 17 more
- Volunteers
- 96 people
- Sponsor
- Hoffmann-La Roche
Sjogren Syndrome, Xerostomia
Photodynamic Treatment as Part of Oral Healthcare on Persons With Sjögren's Syndrome
This thesis study will investigate whether the regular use of antibacterial photodynamic therapy can alleviate dry mouth symptoms in patients with Sjogren's syndrome and thus be a potential addition to regular oral self-care…
- Trial name
- NCT06877546
- Testing
- Lumoral treatment
- Where
- Finland
- Volunteers
- 16 people
- Sponsor
- Koite Health Oy
Dental Plaque, Bleeding of Subgingival Space
Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons
On average, the dental condition of elderly people is poor due to various reasons. The importance of oral health maintenance of the ageing population has been recognized by the World Health Organization (WHO), as oral health…
- Conditions
- Dental Plaque, Bleeding of Subgingival Space, Oral Complication
- Trial name
- NCT06576063
- Testing
- Lumoral Treatment, Standard oral hygiene methods
- Where
- 3 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Koite Health Oy
Intracranial Aneurysm
International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach
IMPACT is an observational, post market study designed to provide an ongoing safety and performance evaluation of Stryker Neurovascular devices used for the treatment of intracranial aneurysms with an endovascular approach.
- Trial name
- IMPACT (NCT04572230)
- Testing
- Endovascular treatment of intracranial aneurysms using a flow-diverting stent
- Where
- 32 sites in Austria, Finland and 5 more
- Volunteers
- 405 people
- Sponsor
- Stryker Neurovascular
Heart Failure
AQT90 FLEX NTproBNP2 Test Kit - 23004 - Reference Interval Study
The purpose of this study is to establish the overall (age- and sex independent) at least 95th percentile upper reference limit (URL) of the NTproBNP2 Test Kit on the AQT90 FLEX analyzer.
- Trial name
- RI (NCT06834880)
- Testing
- No intervention; Observational study
- Where
- Finland
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Radiometer Medical ApS
Psoriatic Arthritis
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
The purpose of this study is to compare the safety and efficacy of risankizumab versus placebo in participants with moderately to severely active psoriatic arthritis (PsA).
- Trial name
- KEEPsAKE 1 (NCT03675308)
- Testing
- Risankizumab
- Where
- 256 sites in United States, Argentina and 37 more
- Volunteers
- 964 people
- Sponsor
- AbbVie
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Lymphoma, Non-Hodgkin
A Study to Compare the Efficacy and Safety of JCAR017 to Standard of Care in Adult Subjects With High-risk, Transplant-eligible Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphomas
The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory…
- Trial name
- TRANSFORM (NCT03575351)
- Testing
- Standard of Care, JCAR017
- Where
- 54 sites in United States, Belgium and 10 more
- Volunteers
- 184 people
- Sponsor
- Celgene
Locally Advanced Solid Tumors, Metastatic Solid Tumors
A Phase 1 Study of INCMGA00012 in Patients With Advanced Solid Tumors
The primary goal of this Phase 1 study is to characterize the safety and tolerability of INCMGA00012 and establish the maximum tolerated dose (MTD) of INCMGA00012 administered on either every two week or every four week schedules…
- Trial name
- NCT03059823
- Testing
- retifanlimab
- Where
- 80 sites in United States, Australia and 14 more
- Volunteers
- 325 people
- Sponsor
- Incyte Corporation
Positron Emission Tomography, Pancreatic Cancer
Pancreatic Cancer Diagnosis With FAPI-PET Imaging
Staging pancreatic cancer (PC) presents a clinical challenge. Triphasic whole body CT is the primary imaging method in diagnosing, staging and during follow up.
- Conditions
- Positron Emission Tomography, Pancreatic Cancer, FAPI, Diagnostics
- Trial name
- NCT07098598
- Testing
- PET/CT
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
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