Clinical trials: suspended, in France
Neuropsychological Tests, Memory
Adaptation and Normalization of a Verbal Episodic Memory Test in French Sign Language
To date, neuropsychological assessment of deaf signing persons is complicated by a lack of resources, especially the absence of tools available in French Sign Language (LSF).
- Conditions
- Neuropsychological Tests, Memory, Alzheimer Disease, Deafness
- Trial name
- RL-RI-LSF (NCT06902753)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Solid Tumors
A Study to Test Different Doses of BI 1831169 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)
This study is open to adults with different types of advanced cancer (solid tumors) that are accessible for injection and/or biopsy.
- Trial name
- NCT05155332
- Testing
- BI 1831169, anti-PD-1 antibody
- Where
- 33 sites in United States, Australia and 8 more
- Volunteers
- 190 people
- Sponsor
- Boehringer Ingelheim
Rheumatoid Arthritis
Microbiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitor
Personalized medicine in which each patient would receive the ideal personalized treatment and regimen, holds great promise to improve patient's care.
- Trial name
- MARAJA (NCT04530305)
- Testing
- Upadacitinib <15 MG [Rinvoq]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Malignant Biliary Stenosis
Hot AXIOS™ for Bile Duct Drainage in Malignant Stenosis
The study is designed to highlight the effectiveness of the Hot AXIOS™ stent when used in accordance with standard medical practice on the evolution of the quality of life of patients with malignant biliary stenosis requiring…
- Trial name
- RAINBOW (NCT06750146)
- Testing
- Hot AXIOS™ Stent and Electrocautery Enhanced Delivery System
- Where
- 18 sites in France
- Volunteers
- 162 people
- Sponsor
- Boston Scientific Corporation
Total Hip Replacement
Mpact Cup Performance After Total Hip Arthroplasty
The main objective of this study is to evaluate the 10 year performances of Mpact cup in total hip arthroplasty.
- Trial name
- NCT02846636
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Medacta International SA
Acute Myeloid Leukemia
Evaluation of DASATINIB Monotherapy Efficacy in Acute Myeloid Leukemia Patients Refractory to VENETOCLAX-AZACITIDINE
The goal of this clinical trial is to learn about the efficacy of DASATINIB monotherapy in acute myeloid leukemia patients refractory to VENETOCLAX-AZACITIDINE.
- Trial name
- VEN-R DASA (NCT06055621)
- Testing
- Dasatinib
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Institut Paoli-Calmettes
Acute Ischemia
REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts
The main objective is to evaluate the efficacy of IV administration of the P2Y12 inhibitor (cangrelor) in addition to mecanich thrombectomy and WMD versus mecanich thrombectomy and WMD alone on the functional prognosis at 3…
- Trial name
- REPERFUSE (NCT04667078)
- Testing
- Cangrelor, best medical management
- Where
- 13 sites in France
- Volunteers
- 368 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Atrial Fibrillation, Stroke
The CONFORM Pivotal Trial
The CLAAS® device will be evaluated for safety and efficacy by establishing its performance is non-inferior to the commercially available WATCHMAN® and Amulet™ left atrial appendage closure devices in patients with non-valvular…
- Trial name
- NCT05147792
- Testing
- CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
- Where
- 94 sites in United States, Czechia and 4 more
- Volunteers
- 1,600 people
- Sponsor
- Conformal Medical, Inc
Non-Resectable Pancreas Carcinoma
Evaluation of the High Intensity Focused Ultrasound (HIFU) Technique for Patients With Unresectable Pancreatic Tumor Treatment (PULS)
This is a phase I/II, multicenter trial for patients with locally advanced and unresectable pancreatic tumours : A Phase I evaluating the tolerance of intraoperative High Intensity Focused Ultrasound (HIFU) intervention on the…
- Trial name
- PULS (NCT06211933)
- Testing
- HIFU intervention
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Leon Berard
Breast Cancer, Aromatase Inhibitors
Assessment of Cryotherapy's Analgesic Impact in Anti-aromatase-induced Arthralgia
The first aim of this comparative, randomized, prospective, multicenter study is to evaluate the analgesic effect at 6 weeks of whole-body cryotherapy, compared to placebo cryotherapy, in patients suffering from arthralgia under…
- Trial name
- CRYOMATASE (NCT05315011)
- Testing
- Whole-body cryotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Brain Injuries
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients
Impaired gastrointestinal transit (IGT) especially constipation, is common among patients under mechanical ventilation, occurring in up to 80 % of the patients during the first week, and has been associated with worse outcome in…
- Trial name
- NIPA (NCT05008926)
- Testing
- Naloxegol
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Brest
Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction…
- Trial name
- NCT04331769
- Testing
- AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
- Where
- 122 sites in United States, Belarus and 8 more
- Volunteers
- 400 people
- Sponsor
- Ancora Heart, Inc.
Osteoarticular Infection, Intensive Care Patients
OsteoArticular Sepsis in Intensive Care unitS
This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses).
- Conditions
- Osteoarticular Infection, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS (NCT06627842)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Cancer
Evolution of the Therapeutic Care in Ovarian Cancer From 2011
The ESME Ovarian Cancer database is a multi-center real life database using a retrospective data collection process in 18 French Comprehensive Cancer Center (FCCC) over 20 sites).
- Trial name
- ESME OC (NCT03275298)
- Where
- 20 sites in France
- Volunteers
- 13,331 people
- Sponsor
- UNICANCER
Oxaliplatin-induced Peripheral Neuropathy
Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.
It is a phase II trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. The trial population is composed of patients ≥18 years old that have developed stage II/III colorectal cancer and are…
- Trial name
- RILUZOX-01 (NCT03722680)
- Testing
- Riluzole
- Where
- 16 sites in France
- Volunteers
- 80 people
- Sponsor
- UNICANCER
PTEN Gene Mutation
Cancer Risk Assessment in Patients With a Constitutional Alteration of the PTEN Gene
This is a multicentric, observational, retrospective and prospective study, aiming to estimate the risk of cancer occurrence in subjects carrying a PTEN mutation, based on the constitution of a national cohort.
- Trial name
- COCO (NCT05630105)
- Where
- 45 sites in France
- Volunteers
- 430 people
- Sponsor
- Institut Bergonié
Diabetes, Type 2, Non-Insulin Dependent
Comparative Effectiveness of Prescribed Adapted Physical Activity (APA), Either Practiced Independently After Training, or Supervised by an APA Teacher, on Glycemic Regulation in People With Unbalanced Type 2 Diabetes.
Comparative effectiveness on glycemic balance of a non-pharmacological treatment, Adapted Physical Activity (APA), either supervised by a qualified APA instructor or unsupervised in autonomy, in individuals with inadequately…
- Conditions
- Diabetes, Type 2, Non-Insulin Dependent, Poorly Controlled Diabetes Mellitus
- Trial name
- ACTIDIAB (NCT06598865)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes Mellitus, Type 2
Subjects With T2D or at Risk of T2D Cohort Follow-up
The main objective of this study is to prospectively follow the subjects included in "Descendance" cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the…
- Trial name
- DESCENDANCE (NCT05567692)
- Testing
- OGTT, HbA1c, Questionnaire
- Where
- France
- Volunteers
- 837 people, healthy volunteers welcome
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes Type 1
Development of Artificial Intelligence Tools for the Detection of Stress Markers and Consideration of Stress States in the Monitoring of Subjects With Type 1 Diabetes
Stress refers to all the reactions of an organism subjected to exogenous or endogenous stress. In the context of diabetes, stress plays a critical role.
- Trial name
- SMART-T1D (NCT06985862)
- Testing
- Voice recording 4 times a day
- Where
- 5 sites in France
- Volunteers
- 35 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes Type 1
Multicenter Study Evaluating the Relationship Between Perceived Daily Stress Level and Glycemic Level in Subjects With Type 1 Diabetes
Type 1 diabetes (T1D) affects around 200,000 people in France. The only treatment is insulin, administered either by multiple injections, by pump alone or, more recently, by automated insulin delivery systems (AIDs), which have…
- Trial name
- EVASTRESS (NCT06896045)
- Testing
- Assess stress levels 4 times a day before meals (morning, noon and evening and at bedtime) using a visual analogue scale
- Where
- 14 sites in France
- Volunteers
- 125 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète