Clinical trials: in Georgia
Glioblastoma, Anaplastic Astrocytoma
Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma
In this multinational dose finding Phase IIb study the efficacy and safety of two doses of AP 12009 compared to standard chemotherapy (temozolomide or PCV) is investigated in adult patients with confirmed recurrent high-grade…
- Trial name
- NCT00431561
- Testing
- AP 12009 10 µM, AP 12009 80 µM, temozolomide or PCV
- Where
- 36 sites in Austria, Georgia and 4 more
- Volunteers
- 141 people
- Sponsor
- Isarna Therapeutics GmbH
Relapsing Remitting Multiple Sclerosis
Phase 3 Study to Evaluate Efficacy and Safety of NU100 in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
The purpose of this study is to evaluate the safety and efficacy of NU100 in patients with relapsing remitting multiple sclerosis (RRMS) as compared to placebo and an active comparator.
- Trial name
- NCT01464905
- Testing
- NU100, rhIFN beta-1b
- Where
- 12 sites in Belarus, Bulgaria and 10 more
- Volunteers
- 500 people
- Sponsor
- Nuron Biotech Inc.
Heart Failure
Evaluation of CLP in Heart Failure Patients With Chronic Kidney Disease
The purpose of this study is to determine the effects of CLP on serum potassium and signs and symptoms of fluid overload in heart failure patients with chronic kidney disease.
- Trial name
- NCT01265524
- Testing
- CLP
- Where
- 3 sites in Armenia, Georgia and 1 more
- Volunteers
- 113 people
- Sponsor
- Sorbent Therapeutics
Heart Failure
Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure
This study is designed to understand the pharmacokinetics of different oral formulations of CK-1827452 being considered for future studies in patients with heart failure.
- Trial name
- NCT00941681
- Testing
- CK-1827452
- Where
- 3 sites in Georgia
- Volunteers
- 35 people
- Sponsor
- Cytokinetics
Acute Coronary Syndrome
VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome
The objective of this study is to evaluate the safety and efficacy of short-term A-002 treatment on morbidity and mortality when added to atorvastatin and standard of care in subjects with an acute coronary syndrome (ACS).
- Trial name
- VISTA-16 (NCT01130246)
- Testing
- A-002, varespladib methyl
- Where
- 362 sites in United States, Australia and 15 more
- Volunteers
- 5,189 people
- Sponsor
- Anthera Pharmaceuticals
Medical Abortion
The Extended Gestational Age Medical Abortion Study
This open-label, comparative study will compare the efficacy, safety, and acceptability of 200 mg mifepristone followed in 24-48 hours by 800mcg buccal misoprostol or 400mcg sublingual misoprostol for termination of pregnancy in…
- Trial name
- NCT00997347
- Testing
- Mifepristone and misoprostol
- Where
- 12 sites in United States, Georgia and 3 more
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Acute Coronary Syndrome
A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome
Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots.
- Trial name
- PLATO (NCT00391872)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 672 sites in United States, Argentina and 42 more
- Volunteers
- 18,624 people
- Sponsor
- AstraZeneca
Hepatitis C
Pilot Trial of Bavituximab Combined With Ribavirin for Initial Treatment of Chronic HepC Virus Genotype 1 Infection
This will be a randomized, open-label, active-control Phase II pilot trial of bavituximab combined with ribavirin for initial treatment of chronic HCV genotype 1 infection.
- Trial name
- NCT01273948
- Testing
- Bavituximab, Pegylated interferon (PEG-IFN)
- Where
- Georgia
- Volunteers
- 66 people
- Sponsor
- Peregrine Pharmaceuticals
Leukemia, T-Cell
Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia
BCX-1777 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. The Phase II trial is designed to study the effectiveness of BCX-1777 in treating patients who have recurrent or refractory advanced…
- Trial name
- NCT00095381
- Testing
- forodesine hydrochloride (BCX-1777)
- Where
- 24 sites in United States, Georgia
- Volunteers
- 20 people
- Sponsor
- BioCryst Pharmaceuticals
Partner HIV Testing, Couple HIV Counseling
Couple-oriented Prenatal HIV Counseling in Low and Medium HIV Prevalence Countries
ANRS 12127 Prenahtest is an intervention trial conducted in four countries (Cameroon, Dominican Republic, Georgia and India), where pregnant women are randomized during prenatal care to receive either standard post-test HIV…
- Conditions
- Partner HIV Testing, Couple HIV Counseling, Couple Communication, HIV Incidence
- Trial name
- Prenahtest (NCT01494961)
- Testing
- Couple-oriented post-test HIV counseling
- Where
- 4 sites in Cameroon, Dominican Republic and 2 more
- Volunteers
- 1,943 people, healthy volunteers welcome
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Hysterectomy
Study to Evaluate the Efficacy, Safety and Tolerability of N1539
To determine the analgesic efficacy, duration of effect, and safety of single doses of N1539 in subjects undergoing open abdominal hysterectomy
- Trial name
- NCT01084161
- Testing
- N1539, Morphine
- Where
- 12 sites in Georgia, Poland and 1 more
- Volunteers
- 486 people
- Sponsor
- Alkermes, Inc.
HIV-1 Patients
Multicountry, Multicenter Post-Marketing Observational Study of Clinical, Biological and Virological Outcomes, Compliance and Tolerability of Kaletra® in Routine Clinical Use
KaleEAST is a non-interventional, post-marketing observational study (PMOS) in which lopinavir/ritonavir is prescribed in the usual manner in accordance with the terms of the local marketing authorization with regards to dose…
- Trial name
- KaleEAST (NCT01379703)
- Where
- 103 sites in Czechia, Georgia and 10 more
- Volunteers
- 2,288 people
- Sponsor
- Abbott
Acute Myeloid Leukemia
A Pharmacokinetic and Efficacy Study of Amonafide L-malate (AS1413) in Combination With Cytarabine in Patients With Acute Myeloid Leukemia (AML)
A phase IIa study to evaluate the pharmacokinetic and efficacy of amonafide L-malate (AS1413) in combination with cytarabine in treating patients with acute myeloid leukemia (AML)
- Trial name
- NCT01066494
- Testing
- Amonafide + cytarabine
- Where
- 6 sites in Georgia, Ukraine
- Volunteers
- 20 people
- Sponsor
- Antisoma Research
Induced Abortion
Study of 400mcg Versus 800mcg Buccal Misoprostol Following Mifepristone 200mg for Abortion up to 63 Days Gestation
This double-blind, randomized study will compare the efficacy and acceptability of mifepristone 200mg followed in 36-48 hours by 400mcg or 800mcg of buccal misoprostol (i.e., in the cheeks) for termination of pregnancy in women…
- Trial name
- NCT00482209
- Testing
- Mifepristone, misoprostol
- Where
- 4 sites in Georgia, Vietnam
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Rheumatoid Arthritis
Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to Methotrexate
The primary objective of this study is to evaluate the efficacy (ACR20) of Rob 803 administered orally once daily for 12 weeks in combination with a stable dose of methotrexate in subjects with moderate or severe active RA.
- Trial name
- ROBUST (NCT00525213)
- Testing
- Rob 803
- Where
- 34 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 224 people
- Sponsor
- OxyPharma
Lupus Erythematosus, Systemic, Lupus Nephritis
Study of LJP 394 in Lupus Patients With History of Renal Disease
The primary purpose of this study is to determine whether abetimus sodium is more effective than placebo in delaying time to renal flare in SLE patients with a history of renal disease.
- Trial name
- ASPEN (NCT00089804)
- Testing
- abetimus sodium (LJP 394), Phosphate-buffered saline
- Where
- 201 sites in United States, Argentina and 28 more
- Volunteers
- 943 people
- Sponsor
- La Jolla Pharmaceutical Company
Bronchial Asthma
Study of Efficacy of Phenytoin in Therapy of Children With Bronchial Asthma
The purpose of this study was to determine whether antiepileptic drug phenytoin is effective in the treatment of chronic asthma in children.
- Trial name
- NCT00366067
- Testing
- Phenytoin
- Where
- Georgia
- Volunteers
- 50 people
- Sponsor
- Centre of Chinese Medicine, Georgia
Diabetes
ANDES-AGI-1067 as a Novel Antidiabetic Agent Evaluation Study
This double-blind, placebo-controlled, dose-finding study is designed to identify the lowest AGI-1067 dose that improves glycemic control as measured by HbA1c and fasting glucose in subjects with Type 2 diabetes mellitus.
- Trial name
- ANDES (NCT00525577)
- Testing
- AGI-1067
- Where
- 90 sites in United States, Bosnia and Herzegovina and 6 more
- Volunteers
- 1,012 people
- Sponsor
- AtheroGenics