Clinical trials: in Ghana
Malaria, Anaemia
Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana
In areas of Africa where malaria is only a problem during a short rainy season, monthly courses of antimalarial drugs can provide very effective prevention of malaria in children.
- Trial name
- NCT01651416
- Testing
- Artemether-lumefantrine combination, Dihydroartemisinin Piperaquine combination, Amodiaquine plus sulphadoxine-pyrimethamine combination
- Where
- Ghana
- Volunteers
- 2,400 people
- Sponsor
- Centre for Global Health Research, Ghana
Bladder Cancer, Diabetes
BLADDER CANCER SCREENING AMONG DIABETIC PATIENTS
patients om metformin from diabetic clinic were checked for bladder cancer
- Trial name
- NCT02505516
- Testing
- metformin
- Where
- Ghana
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- UFUOMA MILLER FAKPOR
Rotavirus Gastroenteritis
Evaluation of the Human Rotavirus Vaccine at Varying Schedules and Doses in Rural Ghana
The purpose of this study is to determine whether giving the Human Rotavirus Vaccine on alternate dosing schedules will enhance the immune response to the vaccine in a low-resource, high-burden country in Africa.
- Trial name
- NCT01575197
- Testing
- Human Rotavirus Vaccine
- Where
- Ghana
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
Introduction of Eurartesim® in Burkina Faso, Mozambique, Ghana and Tanzania
WHO recommends the use of artemisinin-based combination therapies (ACTs) in the treatment of uncomplicated malaria to stem falciparum malaria drug resistance.
- Trial name
- NCT02199951
- Testing
- Dihydroartemisinin and piperaquine
- Where
- 7 sites in Burkina Faso, Ghana and 2 more
- Volunteers
- 10,000 people
- Sponsor
- INDEPTH Network
Malaria, Falciparum
Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa
The primary objective is to confirm the hypothesis that azithromycin used in combination with chloroquine is non-inferior to artemether- Lumefantrine for the treatment of symptomatic, uncomplicated malaria due to P.
- Trial name
- NCT00677833
- Testing
- Azithromycin plus Chloroquine, Artemether-lumefantrine
- Where
- 7 sites in Burkina Faso, Côte d’Ivoire and 3 more
- Volunteers
- 361 people
- Sponsor
- Pfizer
Malaria, Pregnancy
Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy
The incidence of malaria, including the incidence in pregnant women, is declining in many African countries. Thus, there is a need to re-examine the efficacy and cost effectiveness of giving intermittent preventive treatment with…
- Conditions
- Malaria, Pregnancy, Anaemia
- Trial name
- IPTp_IST (NCT01084213)
- Testing
- Intermittent screening and treatment of malaria in pregnancy (IST), SP-IPTp
- Where
- 4 sites in Burkina Faso, Ghana and 2 more
- Volunteers
- 5,354 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Preserving ACTs - Text Reminders to Increase Adherence to ACT Treatment
A randomized controlled trial was conducted to assess the effectiveness of text reminders sent to ACT users through an automated text messaging system short-message-system.
- Trial name
- PACT (NCT01722734)
- Testing
- Text message reminders
- Where
- Ghana
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Glaucoma
The Ghana Primary Tube Versus Trabeculectomy Study
Medical treatment of glaucoma in West Africa is often unsuccessful because of the cost of medications, disease severity and poor compliance. Surgical treatment is likely to be a more practical solution.
- Trial name
- GPTVT (NCT02088528)
- Testing
- Aurolab glaucoma drainage device, Trabeculectomy with mitomycin-c
- Where
- Ghana
- Volunteers
- 298 people
- Sponsor
- Tema Christian Eye Center
Glaucoma
Incidence and Progression of Glaucoma in the Tema Eye Survey Cohort
Aim 1: To determine the incidence of glaucoma in Ghana in subjects previously found to be non-glaucomatous in the Tema Eye Survey.
- Trial name
- NCT02085850
- Where
- Ghana
- Volunteers
- 1,375 people, healthy volunteers welcome
- Sponsor
- Tema Christian Eye Center
Plasmodium Falciparum Malaria
Superiority of ArTiMist Versus Quinine in Children With Severe Malaria
The purpose of this study is to demonstrate that ArTiMist (sublingual artemether spray) is better than intravenous quinine in reducing parasite counts by >= 90% within 24 hours after the start of treatment in children with severe…
- Trial name
- NCT01258049
- Testing
- Artemether Sublingual Spray, Quinine
- Where
- 3 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 151 people
- Sponsor
- Proto Pharma Ltd
Malaria
The Role of Rapid Diagnostic Tests for Malaria for Targeting of ACTs at Community Level
This study aims to test directly by means of a cluster randomized controlled trial, the impact of the introduction of RDTs for malaria on dispensing behaviour of chemical sellers, the main non-formal outlet for drugs locally, at…
- Trial name
- GhanaCommRDT (NCT01907672)
- Testing
- Rapid Diagnostic Test
- Where
- Ghana
- Volunteers
- 4,748 people
- Sponsor
- Ghana Health Services
Postpartum Hemorrhage
Effect of Prophylactic Administration of Oxytocin in Uniject™ on Postpartum Hemorrhage at Home Births in Ghana
This study is designed to test the hypothesis that the intramuscular administration of 10 IU of oxytocin in Uniject™ during the third stage of labor by a Community Health Officer (CHO) at home births in Ghana will reduce the risk…
- Trial name
- NCT01108289
- Testing
- Oxytocin in Uniject
- Where
- Ghana
- Volunteers
- 1,586 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Plasmodium Falciparum Malaria
EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune Adults
Malaria is caused by a germ that people get from the bites of some mosquitoes. It kills over 2 million people each year. Many of the drugs used to treat malaria do not work as well as they used to and researchers are exploring…
- Trial name
- NCT01026246
- Testing
- EBA-175 RII-NG Malaria Vaccine
- Where
- Ghana
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Malnutrition
Evaluation of Vitamin A and Zinc Supplementation on Malarial Morbidity
The purpose of this study was to determine whether young children receiving Vitamin A and Zinc supplements will have a lower incidence of symptomatic malaria than similar children receiving vitamin A supplements alone.
- Trial name
- NCT01782001
- Testing
- vitamin A, vitamin A and zinc
- Where
- Ghana
- Volunteers
- 200 people
- Sponsor
- Kintampo Health Research Centre, Ghana
Malaria
Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial
Effective use of Rapid Diagnostic Test (RDT) and artemisinin-based combination therapy (ACT) depends on the accuracy and safety of RDT based treatment practices and on factors related to the health delivery system.
- Trial name
- RDT-ACT (NCT00832754)
- Testing
- RDT, Clinical Judgement as basis for treatment of malaria with ACT
- Where
- Ghana
- Volunteers
- 3,063 people
- Sponsor
- Kintampo Health Research Centre, Ghana
Malnutrition
Effects of Fortified Complementary Foods on Vitamin A Status and Body Pool Size in Ghanaian Infants.
This study tried to prove that children given food supplements containing vitamin A would have better liver vitamin A stores than children given food supplements without vitamin A over a 5 month period.
- Trial name
- vitapool (NCT01751009)
- Testing
- Vitamin A supplements, Sprinkles without Vitamin A
- Where
- Ghana
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Kintampo Health Research Centre, Ghana
Infections, Papillomavirus, Cervical Cancer
Type Distribution of Human Papillomavirus in Adult African Women Diagnosed With Invasive Cervical Cancer
The aim of the study is to assess the distribution of the most frequent types of human papillomavirus in African women diagnosed with invasive cervical cancer.
- Trial name
- NCT01207999
- Testing
- Collection of cervical cancer tissue samples, Data collection
- Where
- 5 sites in Ghana, Nigeria and 1 more
- Volunteers
- 591 people
- Sponsor
- GlaxoSmithKline
HIV, Tuberculosis
Rifampin and Efavirenz Interactions in Older Children
Efavirenz is an essential component of HIV treatment in children aged 3 years or older on anti-tuberculosis (anti-TB) treatment. However, the appropriate efavirenz dose during anti-TB treatment remains unclear.
- Trial name
- NCT01704144
- Where
- Ghana
- Volunteers
- 160 people
- Sponsor
- The Miriam Hospital
Tuberculosis, HIV
Rifampin and Nevirapine Interactions in Young Children
Nevirapine is the preferred nonnucleoside reverse transcriptase inhibitor (NNRTI) for treatment of HIV in children younger than 3 years old who have tuberculosis (TB) coinfection.
- Trial name
- NCT01699633
- Where
- Ghana
- Volunteers
- 58 people
- Sponsor
- The Miriam Hospital
Tuberculosis, HIV
Pharmacokinetics of Anti-TB Drugs in HIV/TB Co-infected Children in Ghana
Tuberculosis (also known as TB) is a common infection and a major cause of death in children. Effective treatment using a combination of anti-tuberculosis (anti-TB) medications saves lives, but dosages of these medications are…
- Trial name
- NCT01687504
- Where
- Ghana
- Volunteers
- 106 people
- Sponsor
- The Miriam Hospital