Clinical trials: in Guadeloupe
Non-inferiority, in Terms of Extubation Failure, Continuation of Enteral Nutrition Before Extubation Versus Gastric Vacuity Peri-extubation
Non-inferiority Study of the Pursuit of Enteral Nutrition Compared to a Strategy of Gastric Emptiness Peri-extubation. Cluster Randomized Trial
Approximately 50 to 60% of ICU patients are subjected to invasive mechanical ventilation-through a tracheal tube. Extubation consists of a key moment for the patient on the road to recovery (1).
- Trial name
- AMBROISIE (NCT03335345)
- Testing
- maintaining calorie intake, maximum gastric vacuity
- Where
- 22 sites in France, Guadeloupe
- Volunteers
- 1,148 people
- Sponsor
- Centre Hospitalier le Mans
Coronavirus Infections, Severe Acute Respiratory Syndrome
Household Transmission Investigation Study for COVID-19 in Tropical Regions
This study is a interventional study that present minimal risks and constraints to evaluate the presence of novel coronavirus (SARS-CoV-2) or antibodies among individuals living in households where there is a confirmed…
- Conditions
- Coronavirus Infections, Severe Acute Respiratory Syndrome, SARS-CoV Infection
- Trial name
- EPI-COVID-19 (NCT04328129)
- Testing
- Human biological samples
- Where
- 4 sites in French Guiana, Guadeloupe and 1 more
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Cancer of Prostate
Prostatic Cancer Versus Androgen Deficiency
Open study to make a comparison between hypogonadism and euogonadism patients regarding the severity of prostate cancer. The purpose of this study is to determine the importance of the relationship between the hormonal status and…
- Trial name
- AndroCan (NCT02235142)
- Testing
- Blood sample
- Where
- 8 sites in France, Guadeloupe and 1 more
- Volunteers
- 1,614 people
- Sponsor
- Hopital Foch
Blood Donors, Dengue
Dengue Seroprevalence Study in Blood Donors in the French West Indies
Dengue is an infectious disease most prevalent in the world. This disease is endemic in the Caribbean, with an increase in seasonal rains.
- Trial name
- DengSeroprevAn (NCT01104740)
- Testing
- Biological sample collection
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang, Martinique
Renal Replacement Therapy for Acute Kidney Injury in ICU
The Artificial Kidney Initiation in Kidney Injury 2
The timing of renal replacement therapy (RRT) in the context of severe acute kidney injury (AKI) is one the most debated issues in critical care medicine.
- Trial name
- AKIKI2 (NCT03396757)
- Testing
- Standard strategy, Delayed strategy
- Where
- 41 sites in France, Guadeloupe
- Volunteers
- 768 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
T-cell Lymphoma, Leukaemia
High Risk Adult T-cell Leukemia/Lymphoma (ATLL-HR) and Allogeneic Transplant
Patients are recruited at diagnosis or at relapse of ATLL-HR in French Caribbean islands and Guyana. They all receive Zidovudine and Pegylated Interferon (ZPI).
- Trial name
- ATLL-HR-01 (NCT01941680)
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 20 people
- Sponsor
- University Hospital Center of Martinique
Mother to Child Transmission of HIV
National Cohort of Children Born to HIV-positive Mothers
The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children…
- Trial name
- EPF (NCT03306251)
- Where
- 52 sites in France, French Guiana and 2 more
- Volunteers
- 5,200 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Sickle Cell Disease
Sickle Cell Disease, Neurocognitive Disorders, Social Participation
This project will promote the development of transdisciplinary analyses. Neuropsychological disorders will be explored with the usual appropriate tests done by psychologists and neuropsychologists regularly involved in the…
- Trial name
- SOCIODREP (NCT04793854)
- Testing
- Measure of the Life habits (MHAVIE)
- Where
- Guadeloupe
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Geriatric Syndromes
KArukera Study of Aging in Nursing Homes
Nursing homes are a recent occurrence in Guadeloupe, and little is known about the characteristics of their residents. In Guadeloupe, in the French West Indies, nearly 1200 dependent older people are cared for in nursing homes.
- Trial name
- KASEHPAD (NCT04587466)
- Where
- 11 sites in Guadeloupe, Saint Martin
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Geriatric Syndromes
KArukera Study of Ageing in Foster Families
Foster care for dependent older people could be a viable alternative to nursing homes. While this type of accommodation appears to be less expensive than living in a geriatric institution, few scientific studies have been able to…
- Trial name
- KASAF (NCT04545775)
- Where
- Guadeloupe
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Suicide Attempt
Suicide Prevention Algorithm in the French Overseas Territories
In France, suicide behaviours are a major public health concern that triggered the creation in 2013 of a National Observatory of Suicide.
- Trial name
- APSOM (NCT03427190)
- Testing
- APSOM vs Control
- Where
- 9 sites in French Guiana, Guadeloupe and 2 more
- Volunteers
- 259 people
- Sponsor
- University Hospital Center of Martinique
Bradycardia, Sick Sinus Syndrome
Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing
This study shall evaluate in daily medical practice the clinical results of the AV delay hysteresis search algorithm in patients with a INSIGNIA ULTRA or AVT pacemaker implanted for one of the three following indications: sinus…
- Conditions
- Bradycardia, Sick Sinus Syndrome, Heart Block
- Trial name
- NCT00286858
- Testing
- Insignia Ultra and Insignia AVT
- Where
- 40 sites in France, Guadeloupe
- Volunteers
- 903 people
- Sponsor
- Boston Scientific Corporation
Cardiac Amyloidosis
Cardiac Amyloidosis : Diagnostic Using Red Flag Signals
Cardiac amyloidosis is an increasingly contributor of degenerative cardiac diseases. However, its frequency remains underestimated, and diagnosis is often realized at late stages of the disease.
- Trial name
- TEAM Red Flags (NCT04459169)
- Testing
- diagnostic algorithm
- Where
- 3 sites in Guadeloupe, Martinique
- Volunteers
- 424 people
- Sponsor
- University Hospital Center of Martinique
Viruses
Pilot Study to Detect Zika Virus in Sperm
The purpose of this study is to seek the presence of ZIKV in semen, to determine its localization and to assess the efficiency of spermatozoa processing methods to obtain virus free spermatozoa.
- Trial name
- ZIKSPERM (NCT02874456)
- Testing
- virus detection
- Where
- Guadeloupe
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Chikungunya Virus Infection
Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults
This is a multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety and immunogenicity of a 2-injection vaccine Chikungunya virus (CHIKV) virus-like particle vaccine (CHIKV VLP) in healthy adults.
- Trial name
- NCT02562482
- Testing
- VRC-CHKVLP059-00-VP, VRC-PBSPLA043-00-VP
- Where
- 6 sites in Dominican Republic, Guadeloupe and 3 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 2, Thyroid Nodule (Benign)
Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules in Type 2 Diabetes
A 2-years prospective, randomized and multicentric study will be performed to assess the efficacy of metformin compared to sitagliptin on benign thyroid nodules size ≥ 2 cm, in newly diagnosed patients with type 2 diabetes.
- Trial name
- METNODTHYR (NCT04298684)
- Testing
- METFORMIN, Sitagliptin
- Where
- 4 sites in France, Guadeloupe and 1 more
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Chikungunya Virus Infection
Yoga for Chronic Chikungunya
The purpose of this study is to assess the benefits of a 8-week yoga program on quality of life in patients suffering from chronic chikungunya.
- Trial name
- YOCHIK (NCT04455919)
- Testing
- Wait-list group, Yoga group
- Where
- Guadeloupe
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Sickle Cell Disease
European Sickle Cell Disease Cohort - Hydroxyurea
In the context of the Risk Management Plan (RMP), as requested from Addmedica by the EMEA, to collect information about long-term safety of Siklos® (hydroxycarbamide) when used in patients with Sickle Cell Disease.
- Trial name
- ESCORT-HU (NCT02516579)
- Testing
- Siklos
- Where
- 60 sites in France, French Guiana and 5 more
- Volunteers
- 1,906 people
- Sponsor
- Theravia
Multiple Myeloma
Multiple Myeloma and Environmental Exposure to Pesticides in the French West Indies: A Population Based Case-control Study.
Multiple myeloma (MM) is a malignancy of plasma cells engaging in monoclonal immunoglobulin production. A strong presumption was established between exposure to pesticides and the risk of MM.
- Trial name
- MYELODOM (NCT04260490)
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Prostate Cancer
Structural Network on Prostate Cancer in the French Greater West Region
The project aims at developing and structuring a network of clinicians, pathologists, and scientists, from the "Grand Ouest" area, most of them already involved in prostate cancer management and research.
- Trial name
- RESCAP (NCT03214315)
- Testing
- Visceral adipose tissue specimen
- Where
- 7 sites in France, Guadeloupe
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Tours