Clinical trials: in Guadeloupe
Sickle Cell Trait, Environmental Exposure
Sickle Cell Trait and Exercise, Effect of Hot Environment
The heterozygous form of sickle cell disease is clinically asymptomatic. Nevertheless, it was observed that, the sickle cell trait is associated with serious medical complications especially during intense physical efforts.
- Conditions
- Sickle Cell Trait, Environmental Exposure, Adverse Effect
- Trial name
- TDex (NCT04028791)
- Testing
- Exercise on ergocycle
- Where
- Guadeloupe
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of the French West Indies and French Guiana
Cardiac Arrest
Therapeutic Hypothermia After Cardiac Arrest in Non Shockable Rhythm
Cardiac arrest is at present a major cause of mortality as well as a cause of disability for the surviving victims.In Europe, every year counts as 300,000 cardiac arrests responsible for 250,000 deaths.
- Trial name
- HYPERION (NCT01994772)
- Testing
- Targeted controlled temperature between 32.5 and 33.5°C, Targeted controlled temperature between 36.5 and 37.5°C
- Where
- 26 sites in France, Guadeloupe
- Volunteers
- 584 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Ventilator-associated Pneumonia
Medico-economic Study of the Subglottic Secretions Drainage in Prevention of Ventilator-associated Pneumonia (DEMETER)
In France, despite the implementation of bundles to prevent Ventilator-Associated Pneumonia (VAP) in the last decades, the VAP incidence remains high above 10 per cent.
- Trial name
- DEMETER (NCT02515617)
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- 25 sites in Belgium, France and 2 more
- Volunteers
- 2,577 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Fibrosis, Liver
Impact of Chlordecone on Active Chronic Hepatitis
Chlordecone is known to induce liver damage in rat and mice but no data exists in human being. However chlordecone was used until 1993 in French West Indies for banana fields, it is important to test what damage can be induced…
- Trial name
- HEPATOCHLORD (NCT03373396)
- Testing
- Blood samples
- Where
- Guadeloupe
- Volunteers
- 283 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Hypertension Arterial
Hypertension and Cardiovascular Risk Associated With Obstructive Sleep Apnea in Adult in Guadeloupe (French West Indies)
The MAPA is the reference method to estimate the PA during the SAHOS. The MAPA can be recommended over 48 hours: indeed, the PA falls at the beginning of every apnea then increases gradually up to a pressif peak arising at the…
- Trial name
- HTA-SAHOS (NCT03373357)
- Testing
- Patient not SAHOS, Patient SAHOS sailed by the ventilation in PPC and not sailed
- Where
- Guadeloupe
- Volunteers
- 220 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Sickle Cell Disease
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:
Despite important advances in the current understanding of sickle cell vaso-occlusion, the basis of its control and prevention remain partially unknown.
- Trial name
- STRESS (NCT03368924)
- Testing
- SCA patients (SS genotype)
- Where
- Guadeloupe
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Amyotrophic Lateral Sclerosis
Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies
The diagnosis and the follow-up of the patients reached of SLA is centralized, since a few years, at the the Caribbean Reference center of the rare neurological diseases (CERCA labélisé in 2006) in Martinique and at the Unity of…
- Trial name
- SLA-DOM (NCT03367650)
- Testing
- Blood sample and environmental survey
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Type 2 Diabetes Treated With Insulin
Characteristics of Type 2 Diabetes Patients, Treated With Insulin and Their Follow up Care in Guadeloupe
Type 2 diabetes is a major problem of public health in the French West Indies, with an estimated prevalence of 8%, twice more than in France.
- Trial name
- DT2IT (NCT03362762)
- Testing
- Description of plans insuliniques used in Guadeloupe in the type 2 diabetes and the characteristics of the handled patients:
- Where
- Guadeloupe
- Volunteers
- 205 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Left Ventricular Hypertrophy
Frequency of Cardiac Amyloidosis in the Caribbean's. (TEAM Amylose)
The frequency of cardiac amyloidosis among patients presenting with a so-called left ventricular hypertrophy remains unknown. This problem is especially relevant in the Caribbean's, where an amyloidosis-prone mutation of…
- Trial name
- NCT03322319
- Testing
- Tissue biopsies
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 175 people
- Sponsor
- University Hospital Center of Martinique
Cardiovascular Disease
Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions
Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function…
- Trial name
- ACT (NCT01939080)
- Testing
- Exercise training with supervised sessions
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 308 people
- Sponsor
- University Hospital Center of Martinique
Vascular Diseases, Embolism and Thrombosis
Epidemiology of Thromboembolism Disease: A Cohort Study
The purpose of this study is to determine different risk factors of thromboembolic disease. Different points will be studied 1. do different types of thromboembolic disease (distal Deep Vein Thrombosis (DVT), proximal DVT…
- Conditions
- Vascular Diseases, Embolism and Thrombosis, Phlebitis, Venous Insufficiency
- Trial name
- OPTIMEV (NCT00670540)
- Testing
- procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosis
- Where
- 231 sites in Belgium, France and 1 more
- Volunteers
- 8,256 people
- Sponsor
- University Hospital, Grenoble
Head and Neck Neoplasms, Neoplasm Recurrence, Local
Taxotere (Docetaxel) in 1st Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
The purpose of the study is to compare time to progression and overall survival after treatment with Taxotere plus cisplatin versus cisplatin plus 5-FU (PF treatment group) in the first line treatment of patients with recurrent…
- Conditions
- Head and Neck Neoplasms, Neoplasm Recurrence, Local, Neoplasm Metastasis
- Trial name
- NCT00401323
- Testing
- docetaxel (XRP6976), cisplatin, 5-fluorouracil (5-FU)
- Where
- 20 sites in United States, Argentina and 18 more
- Volunteers
- 568 people
- Sponsor
- Sanofi