Clinical trials: in Honduras
Gastroenteritis
Efficacy and Safety of Two Doses of HIL-214 in Children
This is a randomized, placebo-controlled study that is being done to evaluate the safety and effectiveness of two doses of the HIL-214 vaccine compared to a placebo.
- Trial name
- NCT05281094
- Testing
- HIL-214
- Where
- 17 sites in United States, Colombia and 5 more
- Volunteers
- 3,084 people, healthy volunteers welcome
- Sponsor
- HilleVax
Severe Traumatic Brain Injury
Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics
Narrative: Worldwide, traumatic brain injury (TBI) is a leading cause of death and disability among children and adolescents. The Investigators aim to test whether pediatric TBI treatment guided by invasive intracranial pressure…
- Trial name
- BELA TRIPP (NCT05566431)
- Testing
- ICP, CREVICE
- Where
- 11 sites in United States, Colombia and 4 more
- Volunteers
- 428 people
- Sponsor
- University of Washington
Diarrhoea;Acute, Diarrhea Travelers
Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct
The purpose of this study is to compare a single dose of rifaximin with loperamide to the current standard approach of single dose azithromycin with loperamide for the treatment of acute watery traveler's diarrhea (TD).
- Trial name
- TrEAT_TD2 (NCT05677282)
- Testing
- Rifaximin 550 MG, Azithromycin 500 MG, Loperamide
- Where
- 4 sites in Djibouti, Honduras and 2 more
- Volunteers
- 150 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Covid19
Home-based Care and Hand Hygiene Interventions in Honduras
This study aims to enroll patients with acute infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) who do not meet criteria for hospital admission according to protocols developed by the Honduras Ministry…
- Trial name
- NCT04886414
- Testing
- Phone-based monitoring, Oxygen saturation monitoring, Alcohol-based hand sanitizer
- Where
- Honduras
- Volunteers
- 1,821 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Acute Heart Failure (AHF)
American Registry of Ambulatory or Acutely Decompensated Heart Failure
The purpose of this study is to better characterize and understand the population of patients with ambulatory or acutely decompensated heart failure in the American continent, getting to know their sociodemographic, clinical and…
- Conditions
- Heart Failure, Acute Heart Failure (AHF), Chronic Heart Failure
- Trial name
- AMERICCAASS (NCT05295641)
- Where
- 119 sites in United States, Argentina and 19 more
- Volunteers
- 6,732 people
- Sponsor
- Fundacion Clinica Valle del Lili
Blood Pressure, Inflammation
Community-Engaged Research: A Tool to Advance Cookstove Interventions
Nearly 3 billion people rely on biomass combustion to meet basic domestic energy needs. Many households use traditional cookstoves to meet these energy needs, which can result in extremely high indoor air pollution…
- Conditions
- Blood Pressure, Inflammation, Glycated Hemoglobin (HbA1c)
- Trial name
- NCT02658383
- Testing
- Cleaner cookstove received after visit 2, Cleaner cookstove received after visit 4
- Where
- Honduras
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Influenza, Human
Efficacy Study With QIVc in Pediatric Subjects
This phase 3 clinical study is a randomized, observer-blind, multicenter study of QIVc versus a non-influenza vaccine in subjects 6 months though 47 months of age.
- Trial name
- NCT03932682
- Testing
- QIVc, Comparator
- Where
- 74 sites in Bangladesh, Bulgaria and 13 more
- Volunteers
- 5,723 people, healthy volunteers welcome
- Sponsor
- Seqirus
Respiratory Syncytial Virus Infections
A Phase III, Double-blind Study to Assess Safety and Efficacy of an RSV Maternal Unadjuvanted Vaccine, in Pregnant Women and Infants Born to Vaccinated Mothers
The purpose of this study was to evaluate the ability of a single dose of the investigational RSV Maternal vaccine, administered intramuscularly (IM) to pregnant women aged 18-49 years, in good general maternal health, in…
- Trial name
- GRACE (NCT04605159)
- Testing
- RSV MAT
- Where
- 159 sites in United States, Argentina and 22 more
- Volunteers
- 11,194 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Preterm Birth, Distress Respiratory Syndrome
Adverse Neonatal Outcomes With a Shortened Clinical Regimen of Dexamethasone.
Respiratory morbidity, including respiratory distress syndrome (RDS), is a serious complication of preterm birth and the leading cause of early neonatal mortality and disability.
- Trial name
- UNODEXA (NCT06569251)
- Testing
- Dexamethasone 12 mg QD, Dexamethasone 6 mg BID
- Where
- Honduras
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
COPD, Respiratory Insufficiency
Use of Autologous Stem/Stromal Cells In Chronic Lung Disorders: Obstructive (COPD) & Restrictive (RLD)
Pulmonary Disorders are often categorized as Obstructive or Restrictive disorders. This study will establish two channels of investigation, one group within each type of pulmonary dysfunction.
- Trial name
- cSVF-Lung (NCT03909750)
- Testing
- Lipoaspiration, AD-cSVF, Normal Saline IV
- Where
- 2 sites in United States, Honduras
- Volunteers
- 50 people
- Sponsor
- Healeon Medical Inc
Respiratory Syncytial Virus Infections
Prospective Surveillance of Respiratory Syncytial Virus Disease in Infants and Toddlers
The study is a multi-center, multi-national, prospective surveillance study in which the study participants will not receive a study vaccine but will provide a baseline blood sample and be followed for acute respiratory disease…
- Trial name
- NCT05964582
- Where
- 15 sites in United States, Finland and 5 more
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Surgical Wound Infection, Cesarean Wound; Dehiscence
Sucrose as a Standard in Cesarean Section Surgical Wound Healing to Reduce Hospital Time
It is a randomized, single-blind clinical trial, whose population to be studied will be randomized patients with a diagnosis of dehiscence and infection of a cesarean surgical wound who meet the inclusion and exclusion criteria.
- Trial name
- SAGRA (NCT06477770)
- Testing
- Clorhexidine soap, Sucrose
- Where
- Honduras
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Fever
Clinical Evaluation of the FilmArray® Global Fever (GF) Panel
This study will evaluate the clinical sensitivity and specificity of the FilmArray Global Fever (GF) Panel.
- Trial name
- NCT02968355
- Testing
- Observational study
- Where
- 11 sites in United States, Cambodia and 8 more
- Volunteers
- 2,084 people
- Sponsor
- BioFire Defense LLC
Mycoses, Candidiasis, Invasive
Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis
The purpose of this study is to compare the safety, pharmacokinetics, and efficacy of oral SCY-078 vs. standard-of-care following initial intravenous echinocandin therapy in the treatment of invasive candidiasis.
- Conditions
- Mycoses, Candidiasis, Invasive, Candidemia
- Trial name
- NCT02244606
- Testing
- SCY-078, Fluconazole, Micafungin
- Where
- 30 sites in United States, El Salvador and 3 more
- Volunteers
- 27 people
- Sponsor
- Scynexis, Inc.
Nutrition in Cancer Survival and Treatment
Nutrition in Pediatric Oncology in Central America
This study investigates nutritional status, at predefined points in therapy, and the association with outcomes in children and adolescents undergoing treatment for cancer in institutions under Asociación de Hemato-Oncología…
- Trial name
- NCT03976830
- Where
- Honduras
- Volunteers
- 126 people
- Sponsor
- Columbia University
Substance Use Disorders, Substance Withdrawal
Reducing Readmissions: BNI Trial in Substance Use Disorder
The aim of this clinical trial is to assess the effectiveness of Brief Negotiated Interview (BNI) in comparison to Narrative Therapy and Standard Care in reducing readmissions among male patients aged 18 and above with a history…
- Trial name
- NCT06223191
- Testing
- Brief Negotiated Interview, Narrative Interview
- Where
- Honduras
- Volunteers
- 150 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Frailty, Aging
Phase I: Safety and Efficacy of an Injectable Follistatin Plasmid Gene Therapy in Humans
This study examines the safety and effects of an injectable plasmid gene therapy. Plasmids are circular pieces of DNA which have been widely studied as a non-permanent \& non-heritable method for transferring genes and inducing…
- Trial name
- NCT06411366
- Testing
- Follistatin plasmid
- Where
- Honduras
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Minicircle
Advanced Cancer, Advanced Solid Tumor
Effect and Safety of Ocoxin Oral Solution on the Quality of Life of Paediatric Patients With Advanced Stage Solid Tumours
Exploratory study to evaluate the effect and safety of the use of Ocoxin® oral solution on the quality of life of paediatric patients with advanced stage solid tumours.
- Conditions
- Advanced Cancer, Advanced Solid Tumor, Lymphoma, Hodgkin, Central Nervous System Tumor
- Trial name
- NCT06363201
- Testing
- Ocoxin Oral solution
- Where
- Honduras
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Gastric Cancer
Novel Screening Modality for Early Gastric Cancer
Potential patients will be recruited at participating sites based on routine care with clinical indications for upper endoscopy.
- Trial name
- NCT04114006
- Where
- Honduras
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Preterm Delivery, Hypothermia
Randomized Controlled Trial of Social Network Targeting in Honduras
Social network targeting strategies can be used to improve the delivery and uptake of health interventions. We will enroll approximately 30,000 individuals into a randomized controlled trial of different targeting algorithms in…
- Conditions
- Preterm Delivery, Hypothermia, Diarrhea, Upper Respiratory Infection
- Trial name
- NCT02694679
- Testing
- CBNH
- Where
- 2 sites in United States, Honduras
- Volunteers
- 31,195 people, healthy volunteers welcome
- Sponsor
- Yale University