Clinical trials: in India
Gingival Recessions
Influence of Keratinized Tissue Width and Attached Gingiva Width on Root Coverage in Patients With Recession Defects: A Prospective Clinical Study
To evaluate the association between the width of keratinized tissue and attached gingiva with root coverage outcomes in RT1 gingival recession defects of maxillary and mandibular anterior teeth treated with subepithelial…
- Trial name
- NCT07576439
- Testing
- Vestibular incision subperiosteal tunnel access with connective tissue graft in treating RT 1 gingival recession defects
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Obstructive Pulmonary Disease
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
This is a parallel, double blind, Phase 3, 2-arm study that is designed to provide additional safety information, assess the durability of treatment response, and provide additional PK and immunogenicity assessments.
- Trial name
- AERIFY-4 (NCT06208306)
- Testing
- Itepekimab (SAR440340)
- Where
- 223 sites in United States, Argentina and 30 more
- Volunteers
- 669 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
Evaluate Safety and Effectiveness of MBX-102 in Type 2 Diabetes Patients With Poor Glycemic Control on Metformin
To define the relative efficacy, safety and tolerability profiles of oral daily MBX-102 at daily doses of 400 and 600 mg vs. placebo and Actos® 30 mg (up-titrated to 45 mg after 8 weeks) when administered for up to 24 weeks in…
- Trial name
- NCT00814372
- Testing
- MBX-102, Actos, Metformin
- Where
- 26 sites in United States, India
- Volunteers
- 242 people
- Sponsor
- Gilead Sciences
Haemophilia A and B With and Without Inhibitors
A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors
This study will test how well a new medicine called concizumab works for participants who have haemophilia A or B with or without inhibitors. The purpose is to show that concizumab can prevent bleeds and is safe to use.
- Trial name
- Explorer10 (NCT05135559)
- Testing
- Concizumab
- Where
- 91 sites in United States, Algeria and 22 more
- Volunteers
- 153 people
- Sponsor
- Novo Nordisk A/S
Decompensated Cirrhosis
To Develop and Validate an Equation for Determination of Major Adverse Kidney Events in Patients With Decompensated Cirrhosis and Ascites.
Acute kidney injury (AKI) is the sudden loss of kidney function that occurs frequently in hospitalised patients with cirrhosis. It develops in up to 53% and is independently associated with high short-term mortality.
- Trial name
- NCT07794787
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sickle Cell Disease
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle…
- Trial name
- Hibiscus 2 (NCT06612268)
- Testing
- Etavopivat
- Where
- 175 sites in United States, Australia and 19 more
- Volunteers
- 510 people
- Sponsor
- Novo Nordisk A/S
Periapical Diseases, Periapical Periodontitis
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma
- Trial name
- NCT06643676
- Testing
- Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data, Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
- Where
- India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Ulcerative Colitis
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
The primary objective of this study is to observe the long-term safety of filgotinib in adults who have completed or met protocol specified efficacy discontinuation criteria in a prior filgotinib treatment study in ulcerative…
- Trial name
- SELECTIONLTE (NCT02914535)
- Testing
- Filgotinib
- Where
- 323 sites in United States, Argentina and 37 more
- Volunteers
- 1,173 people
- Sponsor
- Alfasigma S.p.A.
Fucosidosis
A Long-Term Observational Study of Patients With Fucosidosis
The purpose of this observational research study is to learn more about the natural history of fucosidosis, its symptoms, and how it develops over time.
- Trial name
- NCT07615400
- Where
- 16 sites in United States, India and 4 more
- Volunteers
- 57 people
- Sponsor
- JCR Pharmaceuticals Co., Ltd.
Myelodysplastic Syndrome, Anemia in Myelodysplastic Syndromes
A Phase 2a Study of HT-6184 in Subjects With IPSS-R Very Low, Low or Intermediate Risk MDS and Anemia
This research is being conducted to asses if HT-6184 is effective in the treatment of Very Low, Low, or Intermediate Risk Myelodysplastic Syndrome (MDS) and Symptomatic Anemia.
- Trial name
- NCT07052006
- Testing
- HT-6184
- Where
- 10 sites in India
- Volunteers
- 37 people
- Sponsor
- Halia Therapeutics, Inc.
Hypovolemic Shock
A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients
This is a prospective, multi-centric, open-labeled, phase-IV clinical study to evaluate the safety and efficacy of centhaquine citrate (LYFAQUIN™), a first-in-class drug for treating hypovolemic shock, a life-threatening…
- Trial name
- NCT05956418
- Testing
- Centhaquine
- Where
- 17 sites in India
- Volunteers
- 400 people
- Sponsor
- Pharmazz, Inc.
Multiple Myeloma
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma…
- Trial name
- NCT05827016
- Testing
- Iberdomide, Lenalidomide
- Where
- 269 sites in United States, Argentina and 32 more
- Volunteers
- 1,230 people
- Sponsor
- Bristol-Myers Squibb
Schizophrenia
Prucalopride for Cognitive Functioning in Schizophrenia
A core component of schizophrenia is neurocognitive impairment. The cognitive deficits are prominently seen in memory, attention, working memory, problem solving, processing speed and social cognition.
- Trial name
- NCT06474286
- Testing
- Prucalopride 1 MG
- Where
- India
- Volunteers
- 34 people
- Sponsor
- University of Pittsburgh
Relapsing Multiple Sclerosis
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
A study to evaluate the efficacy and safety of fenebrutinib on disability progression and relapse rate in adult participants with RMS.
- Trial name
- FENhance 2 (NCT04586023)
- Testing
- Fenebrutinib, Teriflunomide
- Where
- 106 sites in United States, Austria and 15 more
- Volunteers
- 751 people
- Sponsor
- Hoffmann-La Roche
Lung Neoplasms, Non-Small-Cell Lung Carcinoma
Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)
Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. Metastatic means cancer that has spread to other parts of the body.
- Trial name
- NCT04738487
- Testing
- Pembrolizumab/Vibostolimab, Pembrolizumab
- Where
- 188 sites in United States, Brazil and 21 more
- Volunteers
- 1,264 people
- Sponsor
- Merck Sharp & Dohme LLC
Moderate Severe Pulpitis, Extremely Deep Caries
"The Relationship Between Pulpal Inflammatory Marker Levels in Moderate and Severe Pulpitis and Outcome of Full Pulpotomy in Mandibular Molars With Extremely Deep Caries: A Prospective Cohort Study."
Study Title: - The Relationship between pulpal inflammatory marker levels in moderate and severe pulpitis and outcome of full pulpotomy in mandibular molars with extremely deep caries: A prospective cohort study." RATIONALE: …
- Trial name
- NCT07825415
- Testing
- full pulpotomy
- Where
- India
- Volunteers
- 86 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Schizophrenia, Schizo Affective Disorder
Feasibility and Acceptability of Mobile Mental Health App for SZ and SZA
A new mental health application will be developed for persons with schizophrenia and schizoaffective disorder. The aim is to look at whether it is feasible to use a mobile health application for improving medication adherence in…
- Trial name
- NCT06474325
- Testing
- Intervention via mobile application
- Where
- India
- Volunteers
- 44 people
- Sponsor
- University of Pittsburgh
Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
This study will test how well a new medicine called concizumab works in the body of people with haemophilia A or B without inhibitors. The purpose is to show that concizumab can prevent bleeds in the body and is safe to use.
- Trial name
- explorer8 (NCT04082429)
- Testing
- Concizumab
- Where
- 113 sites in United States, Algeria and 31 more
- Volunteers
- 156 people
- Sponsor
- Novo Nordisk A/S
Temporomandibular Joint Disorders
Alloplastic Total Temporomandibular Joint (TMJ) Replacement Registry
Prospective data will be collected in approximately 200 patients treated with an TMJ replacement. Patients will be followed up according to the standard (routine) for up to 5 years after the treatment.
- Trial name
- NCT03991728
- Where
- 23 sites in Brazil, Colombia and 13 more
- Volunteers
- 200 people
- Sponsor
- AO Innovation Translation Center
Schizophrenia
Evaluate Pharmacokinetics, Safety, and Tolerability of AX251 LAI in Patients With Schizophrenia
The purpose of this study is to assess the pharmacokinetics (PK), safety, and tolerability of AX251 long-acting injectable (LAI) administered as a single dose in patients with schizophrenia.
- Trial name
- NCT07484204
- Testing
- AX251 LAI 45 mg, AX251 LAI 90 mg, AX251 LAI 135 mg
- Where
- 4 sites in India
- Volunteers
- 48 people
- Sponsor
- Anxo Pharmaceutical Co., Ltd.
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