Clinical trials: in India
Non Small Cell Lung Cancer (Stage III)
A Global Study to Assess the Effects of Osimertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer (LAURA)
A global study to assess the efficacy and safety of osimertinib following chemoradiation in patients with stage III unresectable Epidermal Growth Factor Receptor Mutation Positive non-small cell lung cancer
- Trial name
- LAURA (NCT03521154)
- Testing
- Osimertinib 80mg/40mg
- Where
- 118 sites in United States, Argentina and 15 more
- Volunteers
- 216 people
- Sponsor
- AstraZeneca
Mild Cognitive Impairment
Mild Cognitive Impairment and Multidomain Intervention Package
The state of Kerala, India has the highest proportion of older adults and the burden of lifestyle diseases causes great concern.
- Trial name
- NCT06488430
- Testing
- Multidomain intervention package for preventing cognitive decline
- Where
- India
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis
Study of WAL0921 in Patients With Glomerular Kidney Diseases
This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and…
- Conditions
- Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis, Minimal Change Disease, Primary Immunoglobulin A Nephropathy
- Trial name
- NCT06466135
- Testing
- WAL0921
- Where
- 50 sites in United States, Australia and 5 more
- Volunteers
- 96 people
- Sponsor
- Walden Biosciences
Mental Health Issue
Implementation Science to Improve School Ethos for Mental Health
The objective of the study is to identify the challenges and opportunities existing within the school ethos in implementing evidence-based interventions to improve youth mental health and to identify the most appropriate…
- Trial name
- NCT06488404
- Where
- India
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetic Macular Edema
Extension Study of MYL-1701P-3001 for Safety and Efficacy
This Study (AFIL-IJZ-3002) is designed to evaluate the safety, efficacy and immunogenicity of MYL-1701P among a group of participants successfully completing MYL-1701P-3001 (NCT03610646) study.
- Trial name
- NCT04674800
- Testing
- MYL-1701P, a proposed biosimilar to Eylea
- Where
- 15 sites in India
- Volunteers
- 52 people
- Sponsor
- Mylan Pharmaceuticals Inc
HIV Infections
Evaluating the Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and Their Infants
The purpose of this study was to compare the virologic efficacy and safety of three antiretroviral (ARV) regimens, dolutegravir plus emtricitabine/tenofovir alafenamide, dolutegravir plus emtricitabine/tenofovir disoproxil…
- Trial name
- VESTED (NCT03048422)
- Testing
- Dolutegravir, Emtricitabine/tenofovir alafenamide, Emtricitabine/tenofovir disoproxil fumarate
- Where
- 21 sites in United States, Botswana and 7 more
- Volunteers
- 643 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Irritable Bowel Syndrome
A Clinical Study to Determine the Safety and Efficacy of An Oral Probiotic Supplementation in the Management of Irritable Bowel Syndrome With Protein Digestion.
This is an open-label, two-arm, prospective, interventional, in-use safety and efficacy study of an oral probiotic supplementation in adult subjects having irritable bowel syndrome.
- Trial name
- NCT06687720
- Testing
- MetBroma
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease
Fibrosis Lessens After Metabolic Surgery
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity, diabetes, and dyslipidemia.
- Conditions
- Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis
- Trial name
- FLAMES (NCT06374875)
- Testing
- Metabolic surgery, Incretin-Based Therapy
- Where
- 22 sites in United States, Brazil and 11 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cervical Cancer, Human Papillomavirus (HPV) Infection
Secondary Cervical Cancer Prevention of Vulnerable Women With HPV and HIV Co-infection in India
Cervical cancer (CC) remains one of the most common malignancies among women in India, with nearly 100,000 women diagnosed annually and over 60,000 preventable deaths annually.
- Conditions
- Cervical Cancer, Human Papillomavirus (HPV) Infection, Human Immunodeficiency Virus (HIV) Infection
- Trial name
- SAKHI (NCT07209917)
- Testing
- SAKHI HPV Intervention, Enhanced Standard of Care (SOC+)
- Where
- 4 sites in India
- Volunteers
- 348 people
- Sponsor
- University of California, Irvine
Androgenic Alopecia
A Clinical Study to Assess Safety, Efficacy and In-use Tolerability of Different Dosages of Hair Growth Products in Patients With Mild to Moderate Androgenic Alopecia (Grade I to III).
This is a prospective, interventional, exploratory, four-arm - dose response study, comparative, double-blind, randomized, placebo-control, proof of concept, safety, efficacy and in-use tolerability study of three different…
- Trial name
- NCT06551818
- Testing
- SesZen-Bio Low Dose 1 (350 mg extract), SesZen-Bio Low Dose 1 (150 mg liposomal), SesZen-Bio High Dose 1 (500 mg extract)
- Where
- India
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Thinning Hair
A Clinical Study to Evaluate the Safety, Effectiveness and In-Use Tolerability of Hair Growth and Scalp Health Serum in Subjects With Mild to Moderate Hair Thinning.
This is a Prospective, Interventional, Randomized, Double-Blind, Placebo-Controlled, Single-Centre, Clinical Study to Evaluate the Safety, Efficacy and In-Use Tolerability of Fermented Extract Hair Growth and Scalp Health Serum.
- Trial name
- NCT07195487
- Testing
- Fermented Extract Hair Growth and Scalp Health Serum
- Where
- India
- Volunteers
- 34 people
- Sponsor
- NovoBliss Research Pvt Ltd
Type 2 Diabetes, Obesity
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-2 (NCT05929079)
- Testing
- Retatrutide
- Where
- 98 sites in United States, Argentina and 6 more
- Volunteers
- 1,152 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis (RA)
Impact of Optimised Protein Intake on Household Work Limitations and Disability in Rheumatoid Arthritis
The goal of this clinical trial is to learn if optimised protein intake improves household work capacity and overall functional status in women with rheumatoid arthritis.
- Trial name
- NCT07737119
- Testing
- Protein Optimisation through Dietary Counselling and Supplementation
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Satguru Partap Singh Hospitals
Neuroblastoma
Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow
Children and adults diagnosed with high-risk neuroblastoma patients with primary refractory disease or incomplete response to salvage treatment in bone and/or bone marrow will be treated for up to 101 weeks with naxitamab and…
- Trial name
- NCT03363373
- Testing
- GM-CSF + Naxitamab
- Where
- 20 sites in United States, Canada and 7 more
- Volunteers
- 122 people
- Sponsor
- Y-mAbs Therapeutics
Non-Small Cell Lung Cancer
A Study Comparing Savolitinib Plus Osimertinib vs Savolitinib Plus Placebo in Patients With EGFRm+ and MET Amplified Advanced NSCLC
This study will compare the activity of the combination of savolitinib and osimertinib against the combination of savolitinib with placebo to osimertinib in patients with Epidermal Growth Factor Receptor Mutation Positive and MET…
- Trial name
- CoC (NCT04606771)
- Testing
- Osimertinib + Savolitinib
- Where
- 21 sites in United States, Argentina and 4 more
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Wound Healing, Bone Regeneration
Fucoidan(Seaweed) Based Gel Around Immediate Implants
The current study is a prospective randomised parallel mouth study to evaluate the effect of Fucoidan gel around immediate implant to assess the wound healing and bone regeneration in comparison to regular implant placement…
- Trial name
- NCT07736287
- Testing
- Fucoidan extracted from F. Vesiculosus, immediate implant placement
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Bradycardia
Conduction System Pacing Display Research System for SmartSync Pacing System Analyzer
The purpose of this study is to collect and compare the heart's electrical activity data measured by the novel Conduction System Pacing (CSP) Display Research System with data measured via 12 lead electrocardiogram (ECG) from a…
- Trial name
- CSP Display (NCT07733960)
- Testing
- CSP Display research system
- Where
- 2 sites in India
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Cerebral Adrenoleukodystrophy (cALD)
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male Subjects with Cerebral Adrenoleukodystrophy.
- Trial name
- CALYX (NCT05819866)
- Testing
- Leriglitazone
- Where
- 11 sites in United States, Argentina and 6 more
- Volunteers
- 40 people
- Sponsor
- Minoryx Therapeutics, S.L.
Norm, Social, Autonomy
Gender-Transformative Interventions and Normative Beliefs About Reproductive Decision-Making
The ECOVI trial is a two-arm cluster randomized controlled trial (cRCT) conducted in rural and urban communities across Maharashtra, Andhra Pradesh, and Rajasthan, India, and funded by the European Research Council (ERC).
- Conditions
- Norm, Social, Autonomy, Relation, Family
- Trial name
- Beyond (NCT07734961)
- Testing
- Let Us Grow Together: Economic Wellbeing for Families
- Where
- India
- Volunteers
- 2,276 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Acute Kidney Injury Due to Sepsis
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)
The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting…
- Trial name
- CLEAR-AKI (NCT05996835)
- Testing
- TIN816 70 mg lyophilisate powder
- Where
- 79 sites in United States, Argentina and 15 more
- Volunteers
- 316 people
- Sponsor
- Novartis Pharmaceuticals
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