Clinical trials: in India
Severe Hemophilia A
Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study
Recombinant factor VIII for the prevention of bleeding in patients with severe haemophilia A undergoing major surgery while receiving emicizumab prophylaxis
- Trial name
- NuPOWER (NCT05935358)
- Testing
- Nuwiq
- Where
- 18 sites in United States, Croatia and 9 more
- Volunteers
- 28 people
- Sponsor
- Octapharma
Vessel Puncture Site Reaction
A Randomized Controlled Trial Comparing Underwater Versus Conventional Preventive Coagulation for Intraprocedural Vessel Management During Peroral Endoscopic Myotomy
Peroral Endoscopic Myotomy (POEM) has become an established, minimally invasive therapy for achalasia and esophageal motility disorders.
- Trial name
- POEM (NCT07575295)
- Testing
- Under Water Preventive Coagulation
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Asian Institute of Gastroenterology, India
Ulcerative Colitis (UC), Crohns Disease
Prospective Evaluation of the Carbon Footprint and Clinical Utility of IBUS Compared to Colonoscopy and Enterography in UC and CD
Healthcare contributes approximately 4.4% of global GHG emissions, with diagnostic imaging and endoscopic services being substantial contributors.
- Trial name
- NCT07431983
- Where
- 2 sites in India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Relapsed Refractory Multiple Myeloma
Study to Evaluate Safety Tolerability & Efficacy of Kyprolis (Carfilzomib) in Relapsed or Refractory Multiple Myeloma
To characterize safety associated with the use of Kyprolis under the locally approved label.
- Trial name
- NCT03934684
- Testing
- Drug: Carfilzomib + Dexamethasone, Drug: Carfilzomib + Lenalidomide + Dexamethasone
- Where
- 17 sites in India
- Volunteers
- 101 people
- Sponsor
- Amgen
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial Pilot
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine.
- Trial name
- NCT03484507
- Testing
- Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate
- Where
- 2 sites in India
- Volunteers
- 49 people
- Sponsor
- University of California, San Francisco
Periodontitis, Bruxism
Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis
This study aims to explore the mechanisms by which periodontal disease affects the bruxers and to assess the impact of subgingival instrumentation on jaw symptoms of probable bruxers among patients with periodontitis .
- Trial name
- NCT06429917
- Testing
- Subgingival instrumentation
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Gingival Recession, Localized
Impact of Microneedling on Coverage of RT1 Gingival Recession in Thin Phenotype.
Gingival Recession (GR) is a common finding among adults, regardless of the oral hygiene levels. When it is associated with esthetic impairment, dentin hypersensitivity, root caries, surgical treatment is indicated.
- Trial name
- NCT06432439
- Testing
- microneedling followed by CAF procedures, CAF procedure
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
Trial Evaluating Hypo-fractionated Accelerated Versus Conventional Fractionated Adjuvant RT in Head & Neck Malignancies
Hypo-fractionated radiotherapy reduces the OTT (overall treatment time) which may in turn reduce rapid accelerated repopulation of clonogenic cells during waiting period after surgery.
- Trial name
- Radiotherapy (NCT07573956)
- Testing
- Standard conventionally fractionated PORT, hypo-fractionated PORT
- Where
- India
- Volunteers
- 369 people
- Sponsor
- All India Institute of Medical Sciences
Cardiac Arrhythmias, Symptoms and Signs
Confirm Rx Insertable Cardiac Monitor SMART Registry
The purpose of the Confirm Rx SMART Registry is to collect real world data to assess the safety and performance of the Confirm Rx Insertable Cardiac Monitor (ICM) and system over a 12 month period.
- Conditions
- Cardiac Arrhythmias, Symptoms and Signs, Atrial Fibrillation
- Trial name
- NCT03505801
- Testing
- Confirm Rx ICM insertion procedure
- Where
- 113 sites in United States, Algeria and 22 more
- Volunteers
- 1,826 people
- Sponsor
- Abbott Medical Devices
Diabetes Mellitus, Type 2, Gestational Diabetes
Community Health Worker-Led Postpartum Diabetes Screening
Women who experience gestational diabetes are at high risk of developing type 2 diabetes mellitus in the postpartum period-especially in low- and middle-income countries like India where the burden of diabetes is high and…
- Trial name
- NCT06209411
- Testing
- Home Based Testing, Clinic Based Screening, Food order nutritional intervention before meals
- Where
- India
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Head and Neck Cancer
A Trial Evaluating Omission of Radiotherapy to Regional Lymphatic's
The present study is a phase II/III prospective randomized trial designed to determine whether eliminating of post operative radiotherapy to regional lymphatics in pN0-N1oral cavity is associated with similar treatment outcomes.
- Trial name
- Eliminate (NCT07528495)
- Testing
- IMRT - adjuvant concurrent CRT/ RT, ommission of IMRT - adjuvant concurrent CRT/ RT for regional lymphatics, Cisplatin
- Where
- India
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Tuberculosis
Rapid Research in Diagnostics Development for TB Network
To reduce the burden of TB worldwide through more accurate, faster, simpler, and less expensive diagnosis of TB Every year, more than 3 million people with TB remain undiagnosed and 1 million die.
- Trial name
- R2D2TB Network (NCT04923958)
- Testing
- Novel mycobacterial culture techniques, Novel sputum smear microscopy techniques, Sputum-based molecular assays
- Where
- 16 sites in Georgia, India and 6 more
- Volunteers
- 26,436 people
- Sponsor
- University of California, San Francisco
Acute Respiratory Distress Syndrome in Children
PROSpect: Prone and Oscillation Pediatric Clinical Trial
Severe pediatric acute respiratory distress syndrome (PARDS) is a life-threatening and frequent problem experienced by thousands of children each year.
- Trial name
- NCT03896763
- Testing
- Either supine or prone positioning and either CMV or HFOV
- Where
- 49 sites in United States, Argentina and 13 more
- Volunteers
- 600 people
- Sponsor
- University of Pennsylvania
Quality Improvement, Appointments and Schedules
Enhancing Operational Efficiency in Eye Care Services
Pushpagiri Vitreo Retina Institute (PVRI) based in Secunderabad is a tertiary care eye hospital providing specialty eye care services since 2007.
- Conditions
- Quality Improvement, Appointments and Schedules, Operations Research Workflow
- Trial name
- NCT07416864
- Testing
- Health service Optimization
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Seva Canada Society
Partially Edentulous Patients, Implant Stability
Comparative Clinical Study of Implant Stability and Peri-implant Bone Loss in Two Implant Designs
This clinical study was conducted to evaluate the effect of different dental implant designs on implant stability and peri-implant bone levels during the early healing phase.
- Conditions
- Partially Edentulous Patients, Implant Stability, Peri-implant Marginal Bone Loss
- Trial name
- NCT07557836
- Testing
- Double-threaded straight-body dental implant, Triple-threaded conical-body dental implant
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Career Postgraduate Institute of Dental Science and Hospital Lucknow
Acute Necrotizing Pancreatitis, Pancreatic Exocrine Insufficiency
Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis
In this multicenter, double blinded, placebo-controlled, 1:1 parallel group RCT, the investigators propose to evaluate the impact of pancreatic exocrine replacement therapy on patients with acute necrotizing pancreatitis (ANP).
- Trial name
- PERiANP (NCT07441824)
- Testing
- Pancreatic enzyme capsules
- Where
- 4 sites in India
- Volunteers
- 140 people
- Sponsor
- Asian Institute of Gastroenterology, India
Immunoglobulin A Nephropathy
Trial of Sibeprenlimab in the Treatment of Immunoglobulin A Nephropathy (IgAN)
To evaluate the long-term safety and tolerability of sibeprenlimab in subjects with IgAN
- Trial name
- NCT05248659
- Testing
- Sibeprenlimab 400 mg s.c. Q4weeks
- Where
- 158 sites in United States, Argentina and 29 more
- Volunteers
- 600 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Breastfeeding, Exclusive, Infant Development
Breastfeeding Education Support Tool
The proposed project seeks to evaluate the effectiveness and implementation of the Breastfeeding Education Support Tool for Baby (BEST4Baby) intervention, an mHealth-supported community-based peer counselor breastfeeding…
- Conditions
- Breastfeeding, Exclusive, Infant Development, Infant Growth, Breast Feeding
- Trial name
- BEST4Baby (NCT06797063)
- Testing
- BEST4Baby, Usual Care
- Where
- India
- Volunteers
- 336 people
- Sponsor
- Thomas Jefferson University
Diabetic Macular Edema
A Pivotal Safety and Efficacy Study of OCS-01 Eye Drops in Participants With Diabetic Macular Edema (DIAMOND 1)
The primary objective of this study is to evaluate the efficacy and safety of the topical ophthalmic administration of OCS- 01 as compared to Vehicle in participants with Diabetic Macular Edema (DME).
- Trial name
- NCT05066997
- Testing
- Dexamethasone ophthalmic suspension (OCS-01), Vehicle
- Where
- 52 sites in United States, Hong Kong and 2 more
- Volunteers
- 552 people
- Sponsor
- Oculis
Schizophrenia
A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia
This is a Phase 3, 6-week, randomized, double-blind, placebo-controlled, multicenter, outpatient study in subjects with schizophrenia with an inadequate response to their current atypical antipsychotic treatment.
- Trial name
- ARISE (NCT05145413)
- Testing
- Xanomeline and Trospium Chloride Capsules
- Where
- 166 sites in United States, Bulgaria and 6 more
- Volunteers
- 396 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
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