Clinical trials: in India
Obesity, Morbid, Anesthesia
Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System
The pharmacokinetic profile of various drugs is altered in obese patients especially those administered by the intravenous route.
- Conditions
- Obesity, Morbid, Anesthesia, Propofol
- Trial name
- NCT05305313
- Testing
- Propofol
- Where
- India
- Volunteers
- 46 people
- Sponsor
- Sir Ganga Ram Hospital
Postoperative Delirium
Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
Postoperative delirium (POD) is the most common adverse neurologic complication that can occur in patients of any age. Its incidence varies across age groups and is substantially influenced by patient-related risk factors.
- Trial name
- NCT04707794
- Testing
- Sevoflurane, Desflurane
- Where
- 2 sites in India
- Volunteers
- 270 people
- Sponsor
- Sir Ganga Ram Hospital
Colitis Ulcerative
Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis
This is a randomized, double-blind, placebo controlled, dose-ranging Phase 2 study. The primary objective is to evaluate the efficacy and safety of SAR443122 compared to placebo in participants with moderate to severe UC.
- Trial name
- RESOLUTE (NCT05588843)
- Testing
- SAR443122
- Where
- 106 sites in United States, Argentina and 17 more
- Volunteers
- 187 people
- Sponsor
- Sanofi
Anesthesia
Performance Analysis of Hermetic Closed-loop Anesthesia Delivery System
Total intravenous anaesthesia (TIVA) is now a preferred technique for providing general anaesthesia (GA) because of its various inherent advantages like reduced postoperative nausea and vomiting (PONV), improved quality of…
- Trial name
- NCT05967403
- Testing
- Propofol
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Sir Ganga Ram Hospital
Postoperative Sore Throat
Effect of Inflated Versus Non-inflated Endotracheal Tube on Sore Throat
Postoperative sore throat (POST) is a common morbidity following upper airway access-control with direct laryngoscopy-intubation (DLI) technique.
- Trial name
- NCT06218836
- Testing
- Pre-inflated endotracheal tube, Non-inflated endotracheal tube
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Sir Ganga Ram Hospital
Intraoperative Awareness
Incidence of Intraoperative Awareness in Indian Patient Population
The profiling of bi-spectral index (BIS) monitored facilitation of general anesthesia (GA), including, anesthesia induction and maintenance of GA depth state, emergence characteristics, and postoperative recovery parameters, is…
- Trial name
- NCT03571945
- Testing
- Bi-spectral Index (BIS QUATRO REF #186-0106), End tidal anaesthesia gas concentration (ETAG)
- Where
- 5 sites in India
- Volunteers
- 2,000 people
- Sponsor
- Sir Ganga Ram Hospital
Breast Cancer
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
The purpose of this study is to evaluate the safety and efficacy of the study drug abemaciclib in participants with high risk, node positive, early stage, hormone receptor positive (HR+), human epidermal receptor 2 negative…
- Trial name
- monarchE (NCT03155997)
- Testing
- Abemaciclib, Standard Adjuvant Endocrine Therapy
- Where
- 619 sites in United States, Argentina and 36 more
- Volunteers
- 5,637 people
- Sponsor
- Eli Lilly and Company
Immunoglobulin A Nephropathy, Glomerular Disease
Safety and Efficacy Study of VIS649 for IgA Nephropathy
The purpose of this study is to evaluate the efficacy and safety of VIS649 in participants with immunoglobulin A (IgA) Nephropathy (IgAN)
- Conditions
- Immunoglobulin A Nephropathy, Glomerular Disease, IgAN
- Trial name
- NCT04287985
- Testing
- Low Dose-VIS649, Medium Dose-VIS649, High Dose-VIS649
- Where
- 93 sites in United States, Australia and 13 more
- Volunteers
- 155 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Body Weight Changes
Comparison of Once Daily 40 mg Torsemide With Twice-daily 40 mg Furosemide
To compare the effects of 40 mg once-daily Torsemide ER to 40 mg twice daily Furosemide on 24-hour sodium excretion.
- Trial name
- NCT03509545
- Testing
- CHF Patients: ER Torsemide 40 mg, CHF Patients: Furosemide 40 mg
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Dermatitis Atopic
Open Label, Long-term Study Evaluating Safety and Efficacy of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis
This is a single group, 1-arm, long-term safety study for treatment of participants with moderate to severe atopic dermatitis (AD).
- Trial name
- ATLANTIS (NCT05769777)
- Testing
- Amlitelimab
- Where
- 174 sites in United States, Argentina and 23 more
- Volunteers
- 999 people
- Sponsor
- Sanofi
Carcinoma
Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib
This study (the SAVANNAH study) will investigate the efficacy of osimertinib in combination with savolitinib in patients with EGFRm+ and MET+, locally advanced or metastatic NSCLC who have progressed following treatment with…
- Trial name
- SAVANNAH (NCT03778229)
- Testing
- osimertinib, savolitinib
- Where
- 90 sites in United States, Brazil and 11 more
- Volunteers
- 367 people
- Sponsor
- AstraZeneca
Progressive Pulmonary Fibrosis
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis.
- Trial name
- NCT06025578
- Testing
- BMS-986278
- Where
- 459 sites in United States, Argentina and 33 more
- Volunteers
- 1,057 people
- Sponsor
- Bristol-Myers Squibb
Hernia, Ventral Hernia
Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios
This prospective, single-arm clinical study evaluates the safety, feasibility, and early clinical outcomes of High-Purity Type I Collagen (HPTC; Surgicoll-Mesh®) when used as a biologic reinforcement in selected hernia repair…
- Conditions
- Hernia, Ventral Hernia, Incisional Hernia, İnguinal Hernia
- Trial name
- NCT07360691
- Testing
- High-Purity Type I Collagen Mesh
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Congenital Disorders, Cerebral Desaturation
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1.
- Conditions
- Congenital Disorders, Cerebral Desaturation, Neonatal Surgery
- Trial name
- NCT05673499
- Testing
- NIRS/EEG monitoring
- Where
- 15 sites in United States, Australia and 5 more
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Philadelphia
Giant Cell Tumor of Bone
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location.
- Trial name
- NCT03295981
- Testing
- Zoledronic Acid
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Moderate to Severe Vernal Keratoconjunctivitis
A Study to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants With Moderate to Severe Vernal Keratoconjunctivitis
The aim of the study is to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants with Moderate to Severe Vernal Keratoconjunctivitis
- Trial name
- NCT07169695
- Testing
- Slit Lamp Examination, Far Best Corrected Visual Acuity (BCVA), T1695
- Where
- 11 sites in India
- Volunteers
- 120 people
- Sponsor
- Laboratoires Thea
Anaesthesia Complication
Patients Gender Influence on Communication of Anaesthesia Risk
In Anaesthesia Practice, an Informed consent involves discussing the risks and benefits involved with a certain procedure and its alternatives.
- Trial name
- NCT06814236
- Testing
- Three-Stage Informed Consent Conversation Model for Anaesthesia Risk profiling
- Where
- 2 sites in India
- Volunteers
- 100 people
- Sponsor
- Sir Ganga Ram Hospital
Multiple Myeloma, Newly Diagnosed Multiple Myeloma
A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
The purpose of this Phase 3 study is to evaluate if BRd prolongs progression free survival (PFS) and/or improves minimal residual disease (MRD) negative status compared with DRd in participants with TI-NDMM.
- Trial name
- DREAMM-10 (NCT06679101)
- Testing
- Belantamab mafodotin, Lenalidomide, Dexamethasone
- Where
- 181 sites in United States, Argentina and 22 more
- Volunteers
- 520 people
- Sponsor
- GlaxoSmithKline
Chronic Periodontitis
Evaluation of Indian Gooseberry/ Amla in the Management of Chronic Periodontitis
This study aimed to evaluate the influence of amla (Emblica officinalis) on patients with chronic generalized periodontitis, using a single-blind, randomized controlled study design. 1.
- Trial name
- NCT07531823
- Testing
- Scaling and root planing + Amla, Scaling and root planing
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Mahatma Gandhi Postgraduate Institute of Dental Sciences
Uncontrolled Hypertension, Resistant Hypertension
A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
The purpose of this study is to measure the efficacy and safety of baxdrostat in participants with uHTN or rHTN. The main objective is to compare the difference in SBP change from baseline at Week 12 of treatment between…
- Trial name
- BaxAsia (NCT06344104)
- Testing
- Baxdrostat
- Where
- 93 sites in Argentina, Australia and 9 more
- Volunteers
- 326 people
- Sponsor
- AstraZeneca
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