Clinical trials: suspended, in Italy
Acromegaly
Hypoproteic Diet in Acromegaly
Since protein and AAs are master regulator of GH and IGF-I secretion, we hypothesized that a low protein diet could reduce GH and IGF-I levels in acromegalic patients in addition to conventional therapy.
- Trial name
- IpoProAcro (NCT05298891)
- Testing
- Usual clinical practice + hypoproteic diet
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Solid Tumors
A Study to Test Different Doses of BI 1831169 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)
This study is open to adults with different types of advanced cancer (solid tumors) that are accessible for injection and/or biopsy.
- Trial name
- NCT05155332
- Testing
- BI 1831169, anti-PD-1 antibody
- Where
- 33 sites in United States, Australia and 8 more
- Volunteers
- 190 people
- Sponsor
- Boehringer Ingelheim
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Cardiac Surgery, Coronary Artery Bypass Graft
Micro- and Macro-Circulation in Cardiac Surgery Patients
The hypothesis under the study is that there could be a link between a dysfunction in peripheral microcirculation, sublingual microcirculation or cardiovascular control and the development of post cardiac surgery major…
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Graft, Surgical Aortic Valve Replacement
- Trial name
- MiMaC (NCT05706545)
- Testing
- Acquisition of cardiovascular signals and microcirculation sidestream darkfield images
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction…
- Trial name
- NCT04331769
- Testing
- AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
- Where
- 122 sites in United States, Belarus and 8 more
- Volunteers
- 400 people
- Sponsor
- Ancora Heart, Inc.
Progressive Multiple Sclerosis
Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis
To evaluate the efficacy and safety of oral masitinib versus placebo in the treatment of patients with primary progressive or secondary progressive multiple sclerosis without relapse.
- Trial name
- MAXIMS (NCT05441488)
- Testing
- Masitinib (4.5)
- Where
- 37 sites in France, Greece and 6 more
- Volunteers
- 800 people
- Sponsor
- AB Science
Pancreatitis
Time of Cannulation During Primary ERCP With Short Guide Wire Rapid Exchange or With Long Guide Wire
The aim of this study is to compare the cannulation time during primary wire guided ERCP (Endoscopic Retrograde Cholangio-Pancreatography) according to two different length of guide wire: long wire or short wire rapid exchange…
- Trial name
- RELG (NCT02290769)
- Testing
- Short guide wire rapid exchange, Long guide wire
- Where
- Italy
- Volunteers
- 292 people
- Sponsor
- Niguarda Hospital
Spinal Cord Injuries
Patient-centered Assessment of the Effects of Powered Exoskeleton Use in People With Spinal Cord Injury
The goal of this clinical trial is to assess the efficacy of the use of powered exoskeleton for ambulation on the quality of life in subjects with spinal cord injury. The main questions it aims to answer are: 1.
- Trial name
- NCT05811884
- Testing
- Rehabilitation
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Syndrome (hrMDS).
- Trial name
- NCT04278768
- Testing
- Emavusertib, Venetoclax
- Where
- 32 sites in United States, Czechia and 6 more
- Volunteers
- 366 people
- Sponsor
- Curis, Inc.
Anomic Aphasia
Virtual Reality Training for Aphasia Rehabilitation
Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language.
- Trial name
- Aphasia360 (NCT05793879)
- Testing
- Video 360, Standard videos
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Restless Legs Syndrome
A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo
Proof of concept, double-blind, randomized, placebo-controlled trial with d-methadone proposed for the first time for use in the treatment of patients diagnosed with primary, moderate to very severe Restless Legs Syndrome (RLS).
- Trial name
- Glu-REST (NCT04145674)
- Testing
- D-methadone
- Where
- 4 sites in Italy, Switzerland
- Volunteers
- 50 people
- Sponsor
- Mauro Manconi
Stage II Colon Cancer, Stage III Colon Cancer
Exploiting Circulating Tumour DNA to Intensify the Postoperative Treatment Resected Colon Cancer Patients
The aims of this study are to evaluate if an intensified adjuvant treatment with FOLFOXIRI could increase the rate of cases with undetectable ct-DNA after chemotherapy and to evaluate if a further adjuvant treatment with…
- Conditions
- Stage II Colon Cancer, Stage III Colon Cancer, HER2-positive Colon Cancer, RAS Wild-type Colon Cancer
- Trial name
- ERASE-CRC (NCT05062889)
- Testing
- 5-Fluorouracil continuous infusion FOLFOXIRI schedule, 5-Fluorouracil bolus FOLFOX schedule, 5-Fluorouracil continuous infusion FOLFOX schedule
- Where
- 28 sites in Italy
- Volunteers
- 477 people
- Sponsor
- Gruppo Oncologico del Nord-Ovest
Metabolic Syndrome, Cardiac Fibrosis
The Effects of Inositol on Glucose Metabolism in Patients With Metabolic Syndrome at Risk of Cardiac Fibrosis
The study aims to evaluate the effects of an oral supplementation based on inositols and alpha-lactalbumin on principals metabolic parameters in patients with metabolic syndrome at risk of cardiac fibrosis
- Trial name
- NCT05689710
- Testing
- Inositol and alpha-lactalbumin
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Lo.Li.Pharma s.r.l
Type 2 Diabetes
Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes
The Revita® system is being investigated to assess the efficacy of DMR versus Sham on improvement in Glycemic, Hepatic and Cardiovascular endpoints for patients with Type 2 Diabetes who are inadequately controlled on one or more…
- Trial name
- REVITALIZE 1 (NCT04419779)
- Testing
- Duodenal Mucosal Resurfacing (DMR)
- Where
- 58 sites in United States, Belgium and 5 more
- Volunteers
- 320 people
- Sponsor
- Fractyl Health Inc.
Sleep Bruxism, Masseter Muscle Hypertrophy
Changes in Electromyographic Activity in Aligner Treatment of Adult Patients With and Without Nocturnal Bruxism
The purpose of the study is to evaluate the effectiveness of clear aligners on the symptoms and signs reported by bruxism patients.
- Conditions
- Sleep Bruxism, Masseter Muscle Hypertrophy, Grinding Teeth
- Trial name
- EMG_BRUX (NCT06343194)
- Testing
- Bruxoff ®
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intestinal GVHD
Multiparametric Ultrasound Study in Diagnosing GvHD
The study evaluate the role of the use of bed-side multiparametric ultrasound study in the diagnosis of gastrointestinal acute graft-versus host disease (aGvHD) in patients underwent allogenic stem cell transplantation
- Trial name
- ECO-STEM (NCT05790135)
- Testing
- shear wave elastography
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Aneurysm
Cryoablation of Intercostal Nerves for Better Control of Postoperative Pain After Thoracic and Thoracoabdominal Open Surgery
The purpose of the registry is to evaluate the peri-operative and short- term outcomes of intercostal nerves cryoablation for post-operative pain control after open thoracic and thoracoabdominal aortic aneurysms repair.
- Trial name
- NCT05153083
- Testing
- Open thoracic (TAA) and thoracoabdominal aortic aneurysms repair (TAAA)
- Where
- 13 sites in Austria, France and 6 more
- Volunteers
- 200 people
- Sponsor
- Germano Melissano
Rectovaginal Fistula, Crohn Disease
Treatment of Rectovaginal Crohn's Fistula by Combination of TAAM Injection and Biological Plug Placement
Interventional, prospective, randomized, controlled, double blind, parallel groups, nonprofit, single center trial
- Trial name
- LIPOPLUG (NCT06813768)
- Testing
- Microfractured adipose tissue injection and plug placement
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cow's Milk Allergy
Hypoallergenicity of a Hydrolyzed Protein Infant Formula
Study to demonstrate hypoallergenicity of a hydrolysed protein infant formula in a population of children with confirmed cow's milk allergy.
- Trial name
- HYPO STORY (NCT05731206)
- Testing
- Hydrolyzed protein infant formula, commercially available hypoallergenic infant formula
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- Nutricia Research
Borderline Resectable Pancreatic Cancer
IORT on Borderline Resectable Pancreatic Cancer
This phase II study investigates the efficacy of IORT for patients with borderline resectable pancreatic cancer. The purpose of the study is to investigate whether the addition of IORT, after FOLOFIRINOX-base chemotherapy, and…
- Trial name
- PancFORT (NCT04090463)
- Testing
- Intraoperative radiotherapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Universita di Verona