Clinical trials: in Kenya
The Study Goal is to Assess the Introduction of Sustainable Family Planning/Reproductive Health Information and Services Through, Land O' Lakes-supported Dairy Cooperatives
Family Planning Through Dairy Cooperatives
This observational study will assess a model for providing family planning through quarterly events organized by dairy cooperatives supported by Land O'Lakes in Kenya.
- Trial name
- NCT01226433
- Where
- Kenya
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Safety and Immunogenicity Study of 2 Investigational Preventive HIV Vaccines
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of an adjuvanted GSK investigational HIV vaccine and Ad35-GRIN in 4 different regimens at months 1, 2, 3, and 4.
- Trial name
- NCT01264445
- Testing
- Adjuvanted GSK investigational HIV vaccine formulation 1, Adjuvanted GSK investigational HIV vaccine formulation 2, Ad35 investigational HIV vaccine
- Where
- 4 sites in Kenya, Uganda and 1 more
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections
Safety and Immunogenicity Study of Ad26-ENVA and Ad35-ENV HIV Vaccines in Healthy HIV-uninfected Adults
The purpose of this study is to evaluate the safety and tolerability of Ad26.ENVA.01 and Ad35-ENV in low-risk for HIV-uninfected healthy adults administered in heterologous and homologous prime-boost regimens at different time…
- Trial name
- NCT01215149
- Testing
- Ad35-ENV vaccine, Ad26.ENVA.01 vaccine
- Where
- 6 sites in United States, Kenya and 2 more
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Malaria
Anti-parasitic Activity and Safety Assessment of SAR97276A in Children With Uncomplicated Malaria
Primary Objective: To assess the antiparasitic activity of intramuscular (IM) SAR97276A based on parasite reduction ratio at 72 hours in pediatric patients with uncomplicated malaria Secondary Objectives: To assess the evolution…
- Trial name
- NCT01445938
- Testing
- SAR97276A, arthemeter + lumefantrine (ACTs)
- Where
- 4 sites in Benin, Burkina Faso and 2 more
- Volunteers
- 20 people
- Sponsor
- Sanofi
Malaria
Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission
In this study, the investigators propose to determine the value of rolling out four targeted malaria control efforts in reducing overall malaria transmission.
- Trial name
- REDHOT (NCT01575613)
- Testing
- Artemether-lumefantrine combination, Bacillus thuringiensis, Long lasting insecticide treated net (LLINs)
- Where
- Kenya
- Volunteers
- 17,506 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria
Safety and Immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP Vaccines in Malaria Endemic Areas
The purpose of this trial is to assess the safety and immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP candidate vaccines in healthy adult volunteers in a malaria endemic region.
- Trial name
- NCT01379430
- Testing
- AdCh63 ME-TRAP followed by MVA ME-TRAP
- Where
- Kenya
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Anemia
Intermittent Preventive Treatment With Antimalarials in Kenyan Infants
The purpose of the study is to see whether antimalarial drugs administered at the time of routine infant vaccinations prevents malaria and anemia in the first year of life.
- Trial name
- NCT00111163
- Testing
- sulfadoxine-pyrimethamine with artesunate, amodiaquine with artesunate, chlorproguanil-dapsone
- Where
- Kenya
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria
The Effect of Folic Acid on Efficacy of Sulfadoxine-pyrimethamine in Pregnant Women in Western Kenya
The purpose of this study is to determine whether folic acid, which is often routinely given to pregnant women to prevent birth defects and anemia, affects the efficacy of sulfadoxine-pyrimethamine, another drug that is routinely…
- Trial name
- NCT00130065
- Testing
- Sulfadoxine-pyrimethamine/folic acid
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Centers for Disease Control and Prevention
Male Circumcision
A Prospective Field Study: Introducing the Shang Ring in Routine Clinical Settings
Male Circumcision (MC) is the only new biomedical method to demonstrate consistent efficacy as an HIV prevention intervention in randomized controlled trials (WHO and UNAIDS, 2007), based on three randomized controlled trials in…
- Trial name
- NCT01567436
- Testing
- Shang Ring
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- FHI 360
Rotavirus
Molecular Epidemiology of Rotavirus Diarrhea Among Infants and Young Children Attending Maua Methodist Hospital, Kenya
Rotavirus is the most common cause of severe infantile diarrhoea disease in infants and young children below five years worldwide.
- Trial name
- Rotavirus (NCT00820261)
- Testing
- oral rehydration therapy for diarrhea cases
- Where
- Kenya
- Volunteers
- 630 people
- Sponsor
- Institute of Primate Research
HIV Infections
Highly Active Antiretroviral Therapy (HAART) Adherence Interventions
This study proposes a 4-armed factorial randomized clinical trial in Nairobi, Kenya to determine the effect of cognitive and behavioral interventions on HAART adherence.
- Trial name
- NCT00273780
- Testing
- Adherence counseling, Alarm device
- Where
- Kenya
- Volunteers
- 400 people
- Sponsor
- University of Washington
Postoperative Wound Infection
Study of the Efficacy of Plain Soap and Water Versus Alcohol-based Rubs for Surgical Hand Preparation
Surgical site infections (SSI) constitute a significant health-economic and clinical challenge. The investigators conducted a cluster-randomized, cross-over study to compare the efficacy of plain soap and water (PSW), used…
- Trial name
- NCT00987402
- Testing
- Plain soap and water (PSW), Alcohol-based hand rub (ABHR)
- Where
- Kenya
- Volunteers
- 3,317 people
- Sponsor
- University Hospital, Geneva
HIV Infections
Effect of Medication Diaries on Adherence to Highly Active Antiretroviral Drugs Among HIV-1 Infected Kenyan Children
Following significant reduction in antiretroviral drug prices over the past two years, more HIV-1 infected African adults and children are gaining access to treatment.
- Trial name
- NCT00194545
- Testing
- Medication diaries
- Where
- Kenya
- Volunteers
- 100 people
- Sponsor
- University of Washington
HIV
Evaluation of Use of Clinical Decision Support System in HIV Care in Resource Constrained Settings
The purpose of this study is to determine whether the use of a Computerized Decision Support System (CDSS) in form of alerts to clinicians enhances early detection of immunological treatment failure in HIV patients.
- Trial name
- CDSS (NCT01634802)
- Testing
- EMR Only, EMR+CDSS
- Where
- Kenya
- Volunteers
- 1,460 people
- Sponsor
- Kenya Medical Research Institute
HIV Infections
A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa
This is a double-blind, randomized, placebo-controlled Phase III study to asses the safety and efficacy of a silicone elastomer vaginal ring containing 25mg of dapivirine.
- Trial name
- NCT01337583
- Testing
- Dapivirine
- Where
- 5 sites in Kenya, Malawi and 1 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Malaria
Assessment of Safety and Pharmacokinetics of a Low Dose of Methotrexate in Healthy Adult Male Kenyan Volunteers
Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. This is a phase I evaluation to assess the safety and pharmacokinetic profile of this drug in healthy adult…
- Trial name
- NCT00791531
- Testing
- Methotrexate
- Where
- Kenya
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
HIV Infections
Integration of HIV Care and Treatment Into Antenatal Care in Migori District, Kenya
This study seeks to determine the most effective way to reach and provide pregnant women with accessible, comprehensive, and high quality HIV care and treatment.
- Trial name
- NCT00931216
- Testing
- Integrated ANC, PMTCT, HIV services
- Where
- Kenya
- Volunteers
- 1,172 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Efficacy of Amodiaquine-artesunate in Children Aged 6-59 Months With Uncomplicated P. Falciparum Malaria
We will be studying the clinical efficacy of amodiaquine-artesunate currently being studied in an intermittent preventive therapy in infants (IPTi)trial in the same area in order to correlate preventive efficacy seen in IPTi with…
- Trial name
- IPTi DRWG (NCT00425763)
- Testing
- AQAS
- Where
- Kenya
- Volunteers
- 110 people
- Sponsor
- Centers for Disease Control and Prevention
Circumcision, Male
Comparison of the Shang Ring With Conventional Surgical Methods
This is a randomized control trial of 400 adult male circumcision procedures with a one to one ratio between Shang Ring and the in-country standard surgical technique (forceps guided in Kenya and dorsal slit in Zambia).
- Trial name
- NCT01300910
- Testing
- Shang Ring, Male circumcision
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- FHI 360
Contraception
Effects of Counseling on the Continuation Rates and Compliance for Newly Prescribed Oral Contraceptives (Yasmin® or Any Other Oral Contraceptives (OC)
This study is a prospective, company-sponsored, non-interventional cohort study of up to 5000 patients in European countries and countries in Middle East who are newly prescribed any available OC.
- Trial name
- NCT00905684
- Testing
- EE30/DRSP (Yasmin, BAY86-5131), Any other OC
- Where
- 13 sites in Albania, Bahrain and 11 more
- Volunteers
- 5,446 people
- Sponsor
- Bayer