Clinical trials: in Liberia
Lassa Fever, Lassa Virus Infection
A Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-LASV-GPC Vaccine in Adults in Good General Heath
A Phase 1 Randomized, Double-blinded, Placebo-controlled, Dose-escalation Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-LASV-GPC Vaccine in Adults in Good General Health
- Trial name
- NCT04794218
- Testing
- rVSV∆G-LASV-GPC
- Where
- 4 sites in United States, Liberia
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Ebola Virus Disease
Community Preparedness for Outbreak Response and Readiness for Ebola Vaccination in Liberia
This community-based mixed methods study intends to identify, explore, and assess the determinants of community preparedness for outbreak situations, including acceptance for Ebola vaccines.
- Trial name
- NCT05888649
- Testing
- Community Clusters
- Where
- Liberia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- UL-PIRE Africa Center
Ebola Virus Disease
Ebola Virus Disease Survivors: Clinical and Immunologic Follow-up
Background: Ebola is a lethal disease. A lot is still unknown about Ebola and its long-term effects. Researchers want to learn what ill health conditions Ebola survivors have.
- Trial name
- NCT02431923
- Where
- 4 sites in United States, Liberia
- Volunteers
- 4,043 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ebola Virus Disease
PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term Sequelae, Viral RNA Persistence, Humoral Immunity, and Ebola Vaccine Response
Background: Genes are instructions that tell the body how to work and grow. They can affect how the body responds to infection. Researchers want to learn more about genes that affect how the body responds to the Ebola virus.
- Trial name
- NCT03098862
- Where
- 4 sites in Liberia
- Volunteers
- 4,830 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ebola
GS-5734 to Assess the Antiviral Activity, Longer-Term Clearance of Ebola Virus, and Safety in Male Ebola Survivors With Evidence of Ebola Virus Persistence in Semen
Background: Some people have Ebola virus in their body for months after they recover from Ebola virus disease. Some may have health problems from the virus while others are fine.
- Trial name
- NCT02818582
- Testing
- GS-5734
- Where
- 2 sites in Guinea, Liberia
- Volunteers
- 38 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphatic Filariasis, Onchocerciasis
Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
Approximately 5,200 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- DOLF-LIBERIA (NCT01905436)
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
- Where
- Liberia
- Volunteers
- 21,862 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Malaria, Diarrhea
Liberia National Community Health Assistant (NCHA) Program and Under-five Mortality
Last Mile Health (LMH) has partnered with the Liberian Ministry of Health (MOH) to support the design and implementation of the National Community Health Assistant Program (NCHAP).
- Conditions
- Malaria, Diarrhea, Acute Respiratory Infection, Malnutrition, Child
- Trial name
- NCT05123378
- Testing
- Liberia National Community Health Assistant Program
- Where
- Liberia
- Volunteers
- 23,702 people, healthy volunteers welcome
- Sponsor
- Last Mile Health
Cataract
PREVAIL VII: Cataract Surgery in Ebola Survivors
Objective: Zaire ebolavirus is a single-stranded RNA virus associated with high morbidity and mortality. The most recent epidemic of Ebola virus disease (EVD) in West Africa resulted in over 11,000 deaths and disabling sequelae…
- Trial name
- NCT03309020
- Testing
- Cataract surgery
- Where
- Liberia
- Volunteers
- 37 people
- Sponsor
- National Eye Institute (NEI)
Ebola Virus
Partnership for Research on Ebola Vaccines in Liberia (PREVAIL)
Background: Ebola virus disease (EVD) affects many people in Liberia and other countries in West Africa. It is caused by the Ebola virus and makes people sick with fever, headache, vomiting, diarrhea, rash, and bleeding.
- Trial name
- NCT02344407
- Testing
- VSVG-ZEBOV, ChAd3-EBO Z
- Where
- Liberia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Severe Acute Malnutrition
Biomedical Investigations for Optimized Diagnosis and Monitoring of Severe Acute Malnutrition (SAM): Elucidating the Heterogeneous Diagnosis of SAM by Current Anthropometric Criteria and Moving Beyond
INTRODUCTION In 2014, 50 million children under 5 suffered from acute malnutrition, of which 16 million suffered from SAM, most of them living in sub-Saharan Africa and Southeast Asia.
- Trial name
- OptiDiag (NCT03400930)
- Testing
- Severe Acute Malnutrition
- Where
- 3 sites in Bangladesh, Burkina Faso and 1 more
- Volunteers
- 473 people
- Sponsor
- Action Contre la Faim
Ebola Virus Infection
Putative Investigational Therapeutics in the Treatment of Patients With Known Ebola Infection
Background: Ebola is a viral infection that can spread quickly and causes life-threatening disease. Right now there is an Ebola outbreak in many countries in West Africa. There are no approved treatments for Ebola.
- Trial name
- NCT02363322
- Testing
- B/Current Standard of Care Plus ZMapp, A/Current Standard of Care Alone
- Where
- 11 sites in United States, Guinea and 2 more
- Volunteers
- 72 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adolescent Behavior, Sexual Violence
Girl Empower: Studying the Impact of Mentorship, Asset Building, Caregiver Discussion Groups, and Cash Transfers on Reducing Girl's Vulnerability to Sexual Exploitation and Abuse
Girl Empower (GE) is a program designed to equip girls with the skills and experiences necessary to make healthy, strategic life choices and to stay safe from sexual exploitation and abuse.
- Trial name
- NCT03756467
- Testing
- Girl Empower Program
- Where
- Liberia
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Population Council
Malaria, Falciparum, Anemia
Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)
A cluster-randomized control trial will study the effect of insecticide-treated wall lining on malaria transmission in Bomi County, Liberia.
- Trial name
- NCT02448745
- Testing
- Insecticide treated wall lining
- Where
- Liberia
- Volunteers
- 6,317 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Onchocerciasis
Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection
This is a Phase 3 study comparing the efficacy, safety and tolerability of moxidectin and ivermectin in subjects infected with Onchocerca volvulus, which is the parasite that causes river blindness.
- Trial name
- NCT00790998
- Testing
- Moxidectin, Ivermectin
- Where
- 4 sites in Democratic Republic of the Congo, Ghana and 1 more
- Volunteers
- 1,497 people
- Sponsor
- Medicines Development for Global Health
Parenting Behavior, Pre-academic and Developmental Skills
Impact of a Parenting Program in Liberia to Improve Parenting, Education, and Health Outcomes for Children in Liberia
The aim of this study is to assess the impact of an intervention to improve parenting practices, pre-academic and developmental skills, and use of mosquito nets for children in kindergarten in Liberia.
- Conditions
- Parenting Behavior, Pre-academic and Developmental Skills, Malaria Prevention
- Trial name
- NCT01829815
- Testing
- Parents Make the Difference
- Where
- Liberia
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- International Rescue Committee
Ebola Virus Disease
Clinical Trial to Evaluate the Efficacy and Safety of Convalescent Plasma for Ebola Treatment
A Phase I/II Pilot Clinical Trial to Evaluate the Efficacy and Safety of Ebola Virus Disease (EVD) Convalescent Plasma (ECP) for treatment of EVD.
- Trial name
- EVD001 (NCT02333578)
- Testing
- Convalescent Plasma Treatment
- Where
- Liberia
- Volunteers
- 70 people
- Sponsor
- Clinical Research Management, Inc.
HIV Infections
A School-Based HIV/STD Prevention Program to Reduce Risky Sexual Behaviors Among Adolescents in Liberia
This study will evaluate the effectiveness of a school-based HIV/sexually transmitted disease prevention program in reducing sexual risk behaviors of youth attending school in Liberia.
- Trial name
- NCT00698321
- Testing
- HIV/STD prevention curriculum, General health promotion curriculum
- Where
- Liberia
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Poverty, Social Instability
Ex-combatant Reintegration in Liberia
This project is an evaluation of an agricultural training and resettlement program for high-risk young adults in Liberia, especially poorly integrated male ex-combatants.
- Trial name
- NCT01703936
- Testing
- Agricultural and life skills training program
- Where
- 2 sites in Liberia
- Volunteers
- 1,330 people, healthy volunteers welcome
- Sponsor
- Columbia University