Clinical trials: in Malta
Pneumoperitoneum
Evaluating the Novel Veress Plus Needle
18 participants (novices, intermediates and experts) performed in total 248 insertions in a systematic way on Thiel embalmed bodies with wide and small bore versions of the conventional VNc (conventional Veress Needle) and the…
- Trial name
- Veress+ (NCT05613959)
- Testing
- Veress +, Conventional Veress
- Where
- Malta
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Prof Jean Calleja-Agius
Mental Illness, Stigmatization
European Study on the Attitude of Psychiatrists Towards Their Patients
Background: Many people think that people with mental disorders might be dangerous or unpredictable. These patients face various sources of disadvantages and experience discrimination on job interviews, in education, and housing.
- Trial name
- Eustigma (NCT04644978)
- Testing
- anonymous online survey
- Where
- 31 sites in Albania, Austria and 29 more
- Volunteers
- 4,245 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Hemodynamic Monitoring, Monitoring, Physiologic
Non-Invasive Vital Signs Monitoring (NIVS) Project
This study is aimed at non-invasive extraction of cardiovascular and respiratory parameters from red-green-blue (RGB) and thermal imaging cameras from patients in the intensive care unit (ICU) setting.
- Trial name
- NIVS (NCT05202769)
- Testing
- Video filming
- Where
- Malta
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sciberras, Stephen M.D.
Arthroplasty, Replacement, Knee, Chronic Pain Post-Proceduraal
The Effect of Regional Anaesthesia and Genetic Factors in the Development of Chronic Pain Following Total Knee Arthroplasty
The study aims to assess the effect of spinal anaesthesia against a general anaesthesia with a femoral block, with respect to the incidence of chronic pain following a total knee replacement.
- Trial name
- NCT04206046
- Testing
- Spinal anaesthesia, General anaesthesia
- Where
- Malta
- Volunteers
- 200 people
- Sponsor
- Sciberras, Stephen M.D.
Acute Kidney Injury (AKI)
Observational Study to Evaluate the Epidemiology of Surgical-induced Acute Kidney Injury
The evaluation of an accurate occurrence rate for AKI is of great importance for health policy, quality initiatives as well as for designing clinical trials.
- Trial name
- Epis-AKI (NCT04165369)
- Where
- 82 sites in United States, Egypt and 12 more
- Volunteers
- 10,568 people
- Sponsor
- University Hospital Muenster
Breast Cancer
Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Anastrozole may be effective in preventing breast cancer.
- Trial name
- IBIS II (NCT00078832)
- Testing
- anastrozole
- Where
- 74 sites in Australia, Belgium and 12 more
- Volunteers
- 3,864 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Post Traumatic Stress Disorder, Depression
Impact of COVID-19 Pandemic in Perinatal Mental Health (RISEUP-PPD-COVID-19)
Introduction: Coronavirus disease 2019 (COVID-19) is a new pathology, declared a public health emergency by the World Health Organization, which can have negative consequences for pregnant women and their newborns.
- Conditions
- Post Traumatic Stress Disorder, Depression, Anxiety, Psychological Distress
- Trial name
- NCT04595123
- Where
- 13 sites in Albania, Brazil and 11 more
- Volunteers
- 7,642 people, healthy volunteers welcome
- Sponsor
- University of Minho
Breast Cancer
Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer
The purpose of this study is to investigate whether neratinib can further reduce the risk of recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment with trastuzumab.
- Trial name
- ExteNET (NCT00878709)
- Testing
- neratinib
- Where
- 494 sites in United States, Australia and 38 more
- Volunteers
- 2,840 people
- Sponsor
- Puma Biotechnology, Inc.
Physical Fitness, Lifestyle, Healthy
'The Actual and Perceived Levels of Physical Fitness and Lifestyle Habits in University of Malta Students'
The ultimate goal for every health-care system is to have a healthy population by maintaining good physical fitness levels and lifestyle habits, including regular physical activity, good sleep quality, smoking and alcohol…
- Trial name
- NCT04775433
- Where
- Malta
- Volunteers
- 384 people
- Sponsor
- University of Malta
Cerebrovascular Accident
Stroke in Young Fabry Patients (sifap1): Frequency of Fabry Disease in Young Stroke Patients
More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years.
- Trial name
- sifap1 (NCT00414583)
- Testing
- No intervention
- Where
- 45 sites in Austria, Belgium and 12 more
- Volunteers
- 5,000 people
- Sponsor
- CENTOGENE GmbH Rostock
Chronic Heart Failure (CHF)
A Prospective Evaluation of Natriuretic Peptide Based Referral of CHF Patients in Primary Care
This low interventional study, whose unique intervention was to measure the blood level of a biomarker called NT-proBNP in chronic heart failure patients daily followed-up by Primary Care Physicians (PCPs) in Europe, assessed if…
- Trial name
- PREFER (NCT02807857)
- Testing
- Standard care
- Where
- 191 sites in Belgium, Croatia and 16 more
- Volunteers
- 1,415 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure With Reduced Ejection Fraction (HF-rEF)
Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)
Novartis has set up this global Multiple Patient Program (MPP) treatment plan to provide access to life-saving treatment with LCZ696 for patients that were not previously exposed to LCZ696 but have no other option to receive…
- Trial name
- NCT02389933
- Testing
- LCZ696
- Where
- 286 sites in United States, Australia and 16 more
- Sponsor
- Novartis Pharmaceuticals
Menopause, Menopause Ovarian Failure
Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation
SEGOVA procedure includes - Stem cell therapy, G - Growth factor Platelet Plasma Rich therapy and in Vitro Activation of the ovaries.
- Conditions
- Menopause, Menopause Ovarian Failure, Ovarian Failure, Premature Ovarian Failure
- Trial name
- SEGOVA (NCT04009473)
- Testing
- SEGOVA procedure
- Where
- 3 sites in Malta, North Macedonia and 1 more
- Volunteers
- 100 people
- Sponsor
- Forever Young d.o.o.
Coronary Artery Disease
e-NOBORI Observational Registry of Nobori DES
Title Prospective, single-arm, multi-centre, observational registry to further validate safety and efficacy of the Nobori® DES in real-world patients.
- Trial name
- e-NOBORI (NCT01261273)
- Where
- 257 sites in Austria, Bangladesh and 30 more
- Volunteers
- 18,000 people
- Sponsor
- Terumo Europe N.V.
Low Anterior Resection Syndrome, Cancer
Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study
This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.
- Conditions
- Low Anterior Resection Syndrome, Cancer, Quality of Life
- Trial name
- NCT04114591
- Testing
- anterior resection
- Where
- Malta
- Volunteers
- 179 people
- Sponsor
- University of Malta
Gastric Cancer, Adenocarcinoma
Study of IMC-1121B (Ramucirumab) With Best Supportive Care in Participants With Gastric Cancer and Adenocarcinoma
The purpose of this study is to gather information about the use of an investigational drug called Ramucirumab in adenocarcinomas of the stomach or gastroesophageal junction.
- Trial name
- NCT00917384
- Testing
- ramucirumab, Best Supportive Care (BSC)
- Where
- 161 sites in United States, Argentina and 28 more
- Volunteers
- 355 people
- Sponsor
- Eli Lilly and Company
Interstitial Lung Disease
The Effects of Breathing Retraining in Patients With Interstitial Lung Diseases
Breathing retraining has been reported to lead to improvements in dyspnoea and walking distance in chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT03729583
- Testing
- Pulmonary Rehabilitation
- Where
- Malta
- Volunteers
- 30 people
- Sponsor
- University of Malta
Breast Cancer
Study Evaluating Neratinib Plus Paclitaxel VS Trastuzumab Plus Paclitaxel In ErbB-2 Positive Advanced Breast Cancer
This study is investigating the effects of an experimental drug (neratinib) in combination with paclitaxel versus trastuzumab in combination with paclitaxel for the treatment of women who have not received previous treatment for…
- Trial name
- NEFERTT (NCT00915018)
- Testing
- Neratinib, Trastuzumab, Paclitaxel
- Where
- 195 sites in United States, Australia and 33 more
- Volunteers
- 479 people
- Sponsor
- Puma Biotechnology, Inc.
Pulmonary Fibrosis
Effects of Pulmonary Rehabilitation on Functional and Health Status Measures in Pulmonary Fibrosis
The inclusion of Pulmonary Rehabilitation (PR) as part of the management of pulmonary fibrosis although being highly recommended and recommended in guidelines still sees studies exploring the outcomes from such an intervention…
- Trial name
- NCT03542318
- Testing
- Pulmonary Rehabilitation
- Where
- Malta
- Volunteers
- 120 people
- Sponsor
- University of Malta
Colorectal Cancer
First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX
The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab) in combination with FOLFOX.
- Trial name
- HORIZON III (NCT00384176)
- Testing
- Cediranib, Bevacizumab, 5-fluorouracil ( in FOLFOX)
- Where
- 280 sites in United States, Australia and 26 more
- Volunteers
- 1,814 people
- Sponsor
- AstraZeneca