Clinical trials: in Martinique
Weight Gain, Weight Loss
Weight Changes Among Martinican Prisoners
Assessment of body weight change among prisoners in Martinique between admission in jail and 3 months later expressed as a percentage of admission weight.
- Trial name
- NUTRI-LAJÔL (NCT05982132)
- Testing
- anthropometric measurement
- Where
- Martinique
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Dengue, Vaccination
Dengue Vaccine Strategy in Children Aged 9 to 17 Years in the French Caribbean
Dengue fever, an arbovirus transmitted by the Aedes mosquito, is a public health problem in all tropical and subtropical regions of the world. There is currently no antiviral treatment and vector control has shown its limits.
- Conditions
- Dengue, Vaccination, Seroprevalence, Infectious Disease
- Trial name
- DengueSEA (NCT04839757)
- Where
- Martinique
- Volunteers
- 590 people
- Sponsor
- University Hospital Center of Martinique
Schatzker Type 2 or 3 Tibial Plateau Fracture
Comparative Evaluation of Minimally Invasive "tibial Tuberoplasty" Surgical Technique Versus Conventional Open Surgery for Tibial Plateau Fractures
PMSI (French Medico-Administrative Database) data shows more than 10000 proximal tibial fractures diagnosed in 2014 and 4055 lateral tibial plateau fractures operated in 2013 in France.
- Trial name
- TUBERIMPACT (NCT03444779)
- Testing
- Tibial Tuberoplasty, Open technique
- Where
- 12 sites in France, Martinique
- Volunteers
- 137 people
- Sponsor
- Poitiers University Hospital
Suicide, Mental Disorders
Contribution of Psychological Autopsy to the Understanding of Suicidal Behaviors in French Overseas Territories
The mains objectives of our project are to coordinate the monitoring of suicides and to identify common or specific suicide risk factors in four overseas DROM-COM (French Polynesia, La Reunion, French Guiana and Martinique) by…
- Conditions
- Suicide, Mental Disorders, Prognostic Factors
- Trial name
- AUTOPSOM (NCT05773898)
- Testing
- other
- Where
- Martinique
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Snake Envenomation, Thrombi
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
In 2017, the World Health Organization placed snakebites at the top of its list of neglected tropical diseases in an effort to facilitate funding for prevention programs, improve access to anti-venom, and stimulate new research…
- Conditions
- Snake Envenomation, Thrombi, Coagulopathy, Hemorrhage
- Trial name
- WBOTHROPS (NCT06304714)
- Testing
- Patients suffering from envenomation by Bothrops
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Sickle Cell Disease
ESCORT-HU Extension: European Sickle Cell Disease Cohort - Hydroxyurea - Extension Study
As safety information pertaining to the long-term use of HU remains incomplete in spite of the first safety study (ESCORT-HU), an extension of the latter is proposed.
- Trial name
- NCT04707235
- Testing
- Hydroxycarbamide
- Where
- 87 sites in France, French Guiana and 6 more
- Volunteers
- 2,093 people
- Sponsor
- Theravia
Endometrial Neoplasms
Characterization of the Genetic Profile of Type 2 Endometrial Carcinoma in Martinique
In Martinique, about 33 new cases are diagnosed per year, with a high incidence rate of type 2 endometrial carcinoma which has a poor prognosis with few therapeutic options.
- Trial name
- ENDO-NGS-MQ (NCT03766672)
- Testing
- Intervention Arm
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Cancer
Prioritising Prevention of COVID-19 in Persons With Cancer in the French West Indies
The public health council (Haut Conseil de Santé Publique) published a statement on 14 March 2020 relating to the management of patients with severe forms of COVID-19, stipulating specific recommendations for patients with…
- Trial name
- RESILIENCE (NCT04768153)
- Testing
- Serology
- Where
- Martinique
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Lupus Erythematosus, Systemic
Validation of Patient E-tool to Measure Systemic Lupus Activity
Validation of a self-questionnaire (SLEDAI-P/LUPIN) completed by the patient to measure the activity of the systemic lupus, in order to improve the patient's empowerment.
- Trial name
- OPTIMISE (NCT05763225)
- Where
- 31 sites in France, Guadeloupe and 1 more
- Volunteers
- 450 people
- Sponsor
- Association Francaise du Lupus et Autres Maladies Auto-immunes (AFL+)
Mild Leptospirosis
Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte)
Leptospirosis is a globally distributed neglected tropical disease affecting subtropical and tropical areas, such as the Caribbean and the Indian Ocean, with favorable climatic conditions for disease transmission.
- Trial name
- LEPTO3 (NCT04211649)
- Testing
- 3 days of antibiotherapy
- Where
- 5 sites in French Guiana, Guadeloupe and 3 more
- Volunteers
- 220 people
- Sponsor
- University Hospital Center of Martinique
Crohn Disease, Ulcerative Colitis
SAPHIR : Assessment of Predictive Factors for Persistence of Treatment After Initiation of Adalimumab With a Biosimilar (Adalimumab Fresenius KaBI or Substitution of Reference Adalimumab With the Fresenius Kabi Adalimumab Biosimilar in Patients With Chronic Inflammatory Diseases
A prospective, longitudinal, multicentre, observational cohort follow-up study conducted in France.
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- SAPHIR (NCT05598684)
- Where
- 96 sites in France, Guadeloupe and 1 more
- Volunteers
- 600 people
- Sponsor
- Fresenius Kabi, France
Cocaine Use Disorder
Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder
Cocaine is the 2nd most used illicit substance in Europe and its use implies numerous health complications as well as an annual social cost of 8.7 G d'€.
- Trial name
- PICOC (NCT05833529)
- Testing
- Virtual Reality Cue Exposure (VRCE) Therapy for Cocaine Craving - 2 weeks, Memory Focused Cognitive Therapy (MFCT) - 1 week, Pictures-based Cue Exposure (PCE) Therapy for Cocaine Craving - 3 weeks
- Where
- 2 sites in Martinique
- Volunteers
- 54 people
- Sponsor
- Thomas Lehoux
COVID-19
Responses to CPET in Subjects With Persistent Exercise Intolerance After COVID-19: an Open-Source Exercise Network
This retrospective collaborative study on persistent exercise intolerance after COVID-19 offers to perform a large descriptive analysis of CPET performed in real-life by pulmonologists, cardiologists and physiologists.
- Trial name
- NCT05532995
- Where
- 29 sites in Canada, France and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Association pour la Complementarite des Connaissances et des Pratiques de la Pneumologie
Chlordecone (Kepone) Toxicity
Effects of Probiotic Oral Intake on Plasma Chlordecone (Kepone) Concentrations in Individuals Environmentally Exposed to Pesticide in Martinique.
The CHLOR-DETOX study is a single-centre, double-blind, prospective, interventional, controlled, exploratory pilot study on subjects environmentally exposed to the organochlorine pesticide (kepone or chlordecone, CLD) in the…
- Trial name
- CHLOR-DETOX (NCT06026228)
- Testing
- Limosilactobacillus reuteri
- Where
- Martinique
- Volunteers
- 100 people
- Sponsor
- University Hospital Center of Martinique
Parkinson Disease, Physical Medicine
Assessment of a Special Modality of Back Muscles Strengthening for Postural Deformations in Parkinsonian Patient
Parkinson's patients have postural disorders. These disorders are frequent in Martinique. Physiotherapeutic rehabilitation is essential because these disorders are generally non dopa-sensitive.
- Conditions
- Parkinson Disease, Physical Medicine, Rehabilitation
- Trial name
- ISOPARK (NCT04492345)
- Testing
- Isokinetic reeducation, Conventional reeducation
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Sickle Cell Disease
Algorithm for Apherisis Monitoring and Prescription Assistance in Sickle Cell Patients (ALGODREP)
The main objective of this study is to prove the superiority of a procedure which calculates the volume of RBCs to transfuse and the time between apheresis based on this algorithm, compared to the current procedure.
- Trial name
- ALGODREP (NCT04076683)
- Testing
- Algodrep
- Where
- 8 sites in France, Martinique
- Volunteers
- 65 people
- Sponsor
- Etablissement Français du Sang
Multiple Sclerosis
Safety of Exposure to Natalizumab During Pregnancy
Multiple sclerosis (MS) preferentially affects young adults with a female predominance. MS is not associated with an increased risk of complications or abnormal pregnancy outcomes.
- Trial name
- BABYZUMAB-2 (NCT05209815)
- Testing
- Questionnaire
- Where
- 27 sites in France, Martinique
- Volunteers
- 68 people
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Efficacy of Cholecalciferol (Vitamin D3) for Delaying the Diagnosis of MS After a Clinically Isolated Syndrome
The main objective of this study is to evaluate the efficacy and tolerance of 2 years of treatment with cholecalciferol (vitamin D3) in patients with a clinically isolated syndrome at high risk for MS (CIS).
- Trial name
- D-Lay-MS (NCT01817166)
- Testing
- Vitamin D, Imaging, Lumbar puncture
- Where
- 33 sites in France, Martinique
- Volunteers
- 316 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cardiac Amyloidosis
Mitochondrial Function in Transthyretin Amyloidosis
Hereditary (familial) amyloidosis arising from the misfolding of a mutated or variant transthyretin, is the most frequent form of amyloid cardiomyopathy in the Caribbean basin.
- Trial name
- MIT-Amylose (NCT03328338)
- Where
- Martinique
- Volunteers
- 12 people
- Sponsor
- University Hospital Center of Martinique
Obesity Morbid, Obesity-Associated Insulin Resistance
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients
Epidemiological studies show a very rapid increase in the epidemic of obesity in the Caribbean population. 6 out of 10 adults are overweight and 1 out of 4 is obese. Most are women.
- Trial name
- BARIAMITRI (NCT04814147)
- Testing
- Sleeve gastrectomy
- Where
- Martinique
- Volunteers
- 20 people
- Sponsor
- University Hospital Center of Martinique