Clinical trials: in Mozambique
Falciparum Malaria
Biological Mechanisms in Afebrile P. Falciparum Malaria
This project aims to disentangle the role of host immune resistance and disease tolerance in afebrile malaria infections, with the goal of guiding context-adapted tactics to target this hidden reservoir, as well as to develop new…
- Trial name
- AsintMal (NCT04422015)
- Testing
- No intervention
- Where
- Mozambique
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Alfredo Mayor
COVID-19
COVID-19 Surveillance in Rural Mozambique for Prompt and Effective Response
Extraordinary times require extraordinary measures. The current COVID-19 pandemic is the paradigmatic example of how infectious diseases may menace the world's health and economy, and particularly contribute to enhancing current…
- Trial name
- MozCOVID (NCT05228639)
- Where
- Mozambique
- Volunteers
- 6,494 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
Human Immunodeficiency Virus
Partners-based HIV Treatment for Couples Attending Antenatal Care
The purpose of this R01 proposal is to evaluate the clinical impact, hypothesized mechanisms of behavior change, and cost-effectiveness of a partners-focused integrated elimination of mother-to-child transmission of HIV (EMTCT)…
- Trial name
- NCT03149237
- Testing
- Couples-based services
- Where
- Mozambique
- Volunteers
- 2,160 people
- Sponsor
- Vanderbilt University Medical Center
Malaria in Pregnancy
TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study
The main objective of this study is to monitor SP resistance via molecular markers in the context of the TIPTOP project implementation of community distributed SP for women during pregnancy.
- Trial name
- TIPTOP-DRS (NCT03998839)
- Testing
- Community distribution of Sulfadoxine-pyrimethamine (SP)
- Where
- 4 sites in Democratic Republic of the Congo, Madagascar and 2 more
- Volunteers
- 7,200 people
- Sponsor
- Jhpiego
HIV
Early ART Initiation Among HIV-positive Pregnant Women in Central Mozambique
The overall objective of the study is to develop and test a pilot intervention in central Mozambique to implement the new WHO "Option B+" guidelines that seek to increase the proportion of HIV-positive pregnant women in six…
- Trial name
- NCT02371265
- Testing
- Adherence and retention package
- Where
- Mozambique
- Volunteers
- 761 people
- Sponsor
- University of Washington
Tuberculosis, Diagnoses Disease
Rapid and Accurate Diagnosis of Paediatric TB (RaPaed-AIDA-TB)
This study will serve as a platform to evaluate new diagnostics in children suspected to have TB, establish diagnostic performance (sensitivity and specificity) and calculate positive and negative predictive values in a real-life…
- Trial name
- RaPaed (NCT03734172)
- Testing
- Sample collection
- Where
- 5 sites in India, Malawi and 3 more
- Volunteers
- 974 people
- Sponsor
- Michael Hoelscher
Sars-CoV-2 Infection
Effectiveness Evaluation of the Sinopharm Vaccine in the Dondo District in Mozambique
Three complementary activities will be implemented:1) Baseline and repeat census of the catchment population; described in a separate protocol (IVI-ECOVA-03-WS1); 2) Enhanced surveillance for COVID-19 disease, and 3)…
- Trial name
- NCT05362682
- Testing
- Sinopharm Vaccine
- Where
- Mozambique
- Volunteers
- 3,000 people
- Sponsor
- International Vaccine Institute
Covid19
Mix and Match Heterologous Prime-Boost Study Using Approved COVID-19 Vaccines
This is an observer-blind, randomized study which aims to assess the immune response and the safety of two different approved vaccines for first and second dose in healthy adults.
- Trial name
- NCT04998240
- Testing
- BBIBP-CorV - Inactivated SARS-CoV-2 vaccine (Vero cell), Ad26.COV2.S (Recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike protein),
- Where
- 2 sites in Madagascar, Mozambique
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
HIV-1
A Study to Assess the Efficacy of a Heterologous Prime/Boost Vaccine Regimen of Ad26.Mos4.HIV and Aluminum Phosphate-Adjuvanted Clade C gp140 in Preventing Human Immunodeficiency Virus (HIV) -1 Infection in Women in Sub-Saharan Africa
The primary purpose of this study is to assess the preventive vaccine efficacy (VE), safety and tolerability of a heterologous prime/boost regimen utilizing Ad26.Mos4.HIV and aluminum-phosphate adjuvanted Clade C gp 140 for the…
- Trial name
- NCT03060629
- Testing
- Ad26.Mos4.HIV, Clade C gp140
- Where
- 23 sites in Malawi, Mozambique and 3 more
- Volunteers
- 2,636 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Suicide, Adolescent Behavior
Adapting the Suicide Safety Planning Intervention for Delivery to Adolescents in Mozambican Primary Care Settings
Globally, suicide is ranked as the second leading cause of death for youth ages 10-24 years, and more than 75% of all deaths by suicide occur in low- and middle-income countries (LMIC).
- Trial name
- NCT05346133
- Testing
- Suicide Prevention Intervention for Adolescents
- Where
- 2 sites in Mozambique
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Columbia University
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique
The use of insecticide-treated bed nets (ITNs) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance to commonly used insecticides in important mosquito…
- Trial name
- NCT04716387
- Testing
- Standard LLIN, Piperonyl butoxide ITN, Pyriproxyfen ITN
- Where
- Mozambique
- Volunteers
- 8,726 people
- Sponsor
- PATH
Malaria
Antenatal Care as a Platform for Malaria Surveillance: Utilizing Community Prevalence Measures From the New Nets Project to Validate ANC Surveillance of Malaria in Mozambique
This study outlines a plan for conducting a routine assessment of malaria infection prevalence and intervention coverage using antenatal care (ANC) attendees.
- Trial name
- NCT04724161
- Testing
- ANC surveillance
- Where
- Mozambique
- Volunteers
- 19,215 people
- Sponsor
- PATH
Covid19, Morbidity
BCG to Reduce Absenteeism Among Health Care Workers During the COVID-19 Pandemic
The COVID-19 pandemic challenges available hospital capacity. Strategies to protect health care workers (HCW) are desperately needed.
- Conditions
- Covid19, Morbidity, Absenteeism
- Trial name
- EDCTP (NCT04641858)
- Testing
- BCG-Denmark, Saline
- Where
- 2 sites in Guinea-Bissau, Mozambique
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Rheumatic Heart Disease
INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority
This program is a comprehensive evaluation of rheumatic valvular heart disease (RVHD), Atrial fibrillation (AF)/flutter and stroke.
- Trial name
- INVICTUS-VKA (NCT02832544)
- Testing
- Rivaroxaban (20 mg), Vitamin K antagonists (VKA)
- Where
- 139 sites in Botswana, Brazil and 23 more
- Volunteers
- 4,565 people
- Sponsor
- Population Health Research Institute
HIV
Systems Analysis and Improvement Approach for Prevention of MTC HIV Transmission
Optimizing the prevention of mother-to-child HIV transmission cascade minimizes drop offs from one step to the next to maximize the benefits of antiretroviral therapy on maternal health and pediatric survival, growth, and…
- Trial name
- SAIA-SCALE (NCT03425136)
- Testing
- Systems Analysis and Improvement Approach (SAIA)
- Where
- Mozambique
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Washington
Malaria in Pregnancy
Evaluating the Effects of Community Delivery of Malaria Intermittent Preventive Treatment on Pregnant Women and Babies
This study evaluates the effectiveness of community delivery of sulfadoxine-pyrimetamine (SP) for intermittent preventive treatment of malaria in pregnancy (IPTp) in increasing the coverage of IPTp among pregnant women in…
- Trial name
- TIPTOP (NCT03600844)
- Testing
- Community distribution of SP for IPTp
- Where
- 12 sites in Democratic Republic of the Congo, Madagascar and 2 more
- Volunteers
- 10,602 people, healthy volunteers welcome
- Sponsor
- Jhpiego
Plasmodium Falciparum Infection
To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
Primary Objective: To determine whether a single dose combination of OZ439 (Artefenomel)/FQ (Ferroquine) was an efficacious treatment for uncomplicated Plasmodium falciparum malaria in adults and children.
- Trial name
- FALCI (NCT02497612)
- Testing
- Ferroquine SSR97193, Artefenomel
- Where
- 12 sites in Benin, Burkina Faso and 5 more
- Volunteers
- 377 people
- Sponsor
- Sanofi
HIV Infections
Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in Women
This study will evaluate the safety and efficacy of the human monoclonal antibody (mAb) VRC-HIVMAB060-00-AB (VRC01) in preventing HIV-1 infection in high-risk, HIV-uninfected women.
- Trial name
- NCT02568215
- Testing
- VRC01
- Where
- 21 sites in Botswana, Kenya and 5 more
- Volunteers
- 1,924 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Uncomplicated Plasmodium Falciparum Malaria
Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
This study was designed to determine the most effective and tolerable dose at the shortest dosing regimen of the investigational drug KAF156 in combination with a solid dispersion formulation of lumefantrine (LUM-SDF) in…
- Trial name
- NCT03167242
- Testing
- KAF156, Coartem, Lumefantrine Solid Dispersion Formulation
- Where
- 11 sites in Burkina Faso, Gabon and 7 more
- Volunteers
- 524 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients
The primary objective of this Phase III clinical study is to demonstrate the efficacy of the fixed combination of pyronaridine artesunate (PA) granule formulation (60:20 mg; pediatric PYRAMAX®) by showing a PCR-corrected adequate…
- Trial name
- NCT00541385
- Testing
- pyronaridine artesunate, arthemeter lumefantrine
- Where
- 8 sites in Burkina Faso, Côte d’Ivoire and 6 more
- Volunteers
- 535 people
- Sponsor
- Medicines for Malaria Venture