Clinical trials: in Nepal
Problematic Internet Use, Internet Addiction
Group Cognitive-Behavioral Intervention for Problematic Internet Use in Nepalese University Students
Problematic internet use, using the internet in ways that interfere with daily life, is a growing concern among university students in Nepal, where studies report prevalence rates between 21.5% and 35.4%.
- Trial name
- NCT07806344
- Testing
- Group Cognitive-Behavioral Intervention for Problematic Internet Use
- Where
- Nepal
- Volunteers
- 59 people
- Sponsor
- Tribhuvan University, Nepal
Acute Coronary Syndromes (ACS), Adherence
Adherence to Secondary Prevention Drugs and Influencing Factors After Acute Coronary Syndrome in Patients at a Tertiary Center in Nepal
This study aimed to assess adherence to secondary prevention medications among patients in Nepal following an Acute Coronary Syndrome (ACS) event and to identify factors affecting adherence.
- Trial name
- NCT07288502
- Testing
- My Experience of Taking Medicines (MYMEDS) questionnaire
- Where
- Nepal
- Volunteers
- 109 people
- Sponsor
- Institute of medicine, Maharagjung medical campus
Intracranial Hemorrhages, Atrial Fibrillation
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
To assess whether edoxaban (60/30 mg daily) compared to non-antithrombotic medical therapy (either no antithrombotic therapy or antiplatelet monotherapy) reduces the risk of stroke (composite of ischemic, hemorrhagic and…
- Trial name
- ENRICH-AF (NCT03950076)
- Testing
- Edoxaban, Non-anticoagulant medical therapy
- Where
- 152 sites in United States, Argentina and 13 more
- Volunteers
- 948 people
- Sponsor
- Population Health Research Institute
Hypertension, Diabetes
Group-Care for Hypertension and Diabetes Management in Nepal
Hypertension and diabetes represent significant and growing public health challenges in Nepal, particularly in underserved communities.
- Trial name
- GCHD- Nepal (NCT07439380)
- Testing
- Low Intensity Community-Based Group NCD Care, High Intensity Community-Based Group NCD Care
- Where
- Nepal
- Volunteers
- 1,110 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mental Health
Stress Management Training for Nursing Professionals in a Tertiary Care Center in Nepal
The goal of this clinical trial is to learn if stress management programs can help alleviate existing and prevent future symptoms of stress in nursing professionals working in a tertiary care center in Nepal.
- Trial name
- NCT06438016
- Testing
- Stress Management Training
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Dhulikhel Hospital
Hip Fractures, Myocardial Injury
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
The HIP ATTACK-2 trial is a multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is superior to standard care in…
- Trial name
- HIP ATTACK-2 (NCT04743765)
- Testing
- Accelerated medical clearance and surgery
- Where
- 77 sites in United States, Australia and 18 more
- Volunteers
- 1,100 people
- Sponsor
- Population Health Research Institute
Spinal Anesthesia
Comparison of Efficacy of 0.5% Hyperbaric Bupivacaine and 0.75%Isobaric Ropivacaine for Spinal Anaeshesia
Spinal anaesthesia is a preferred technique used for lower abdominal and lower limb surgeries as it provides faster and profound sensory and motor blockade.
- Trial name
- NCT07777055
- Testing
- spinal anesthesia
- Where
- Nepal
- Volunteers
- 64 people
- Sponsor
- Tribhuvan University, Nepal
ICU Mortality
Comparison of Simplified Acute Physiology Score (SAPS II) , Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation) APACHE II Scoring Systems for Predicting Mortality of Critically Ill Patients Admitted in a Tertiary Hospital Intensive Care Unit.
This is a descriptive analytical prospective study to compare the performance of SOFA score, SAPSII score and APACHE II score in ICU mortality prediction.
- Trial name
- SAPS II SOFA (NCT07780617)
- Where
- Nepal
- Volunteers
- 201 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Postnatal Care
Use of mHealth Intervention in Improving Utilization of Postpartum Care
Despite implementation of many activities related to maternal health, maternal mortality ratio is still unacceptably high in Nepal, 239/100,000 in live births.
- Trial name
- mHealth (NCT06409208)
- Testing
- mHealth intervention (video and reminder SMSs)
- Where
- Nepal
- Volunteers
- 300 people
- Sponsor
- Dhulikhel Hospital
Gestational Diabetes, Hypertensive Disorder of Pregnancy
Mobile-based Obstetric Monitoring for Pregnancies Complicated by Hypertension and/or Diabetes (MOM-HD)
Hypertensive disorders during pregnancy (HDP) and gestational diabetes (GDM) are among the leading complications in pregnancy, significantly contributing to global maternal and fetal morbidity and mortality.
- Trial name
- MOM-HD (NCT07243886)
- Testing
- MOM-HD, Standard Care
- Where
- 3 sites in Nepal
- Volunteers
- 864 people
- Sponsor
- Rutgers, The State University of New Jersey
Nurse Led Interventions, Patients on Hemodialysis
Nurse Led Intervention on Self Care Adherence and Quality of Life
Background: Hemodialysis is the most common treatment modality in patients with chronic kidney disease. The majority of people with dialysis have a below-average quality of life.
- Conditions
- Nurse Led Interventions, Patients on Hemodialysis, Self Care, Quality of Life
- Trial name
- Selfcare (NCT07506980)
- Testing
- laptop based education and counselling, Reminder call, distribution of self care booklet having all the content covered in discussion
- Where
- 2 sites in Nepal
- Volunteers
- 112 people
- Sponsor
- Kathmandu University School of Medical Sciences
Mental Disorders
Reducing Stigma Among Healthcare Providers to Improve Mental Health Services
A growing number of trials have demonstrated treatment effectiveness for people with mental illness (PWMI) by non-specialist providers, such as primary care and community health workers, in low-resource settings.
- Trial name
- RESHAPE-mh (NCT02793271)
- Testing
- RESHAPE, PRIME/mhGAP
- Where
- Nepal
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Brandon A Kohrt, MD, PhD
High Risk Pregnancy
Antenatal High-Risk Pregnancy Intervention Bundle in Rural Nepal
The proposed study will assess and implement a comprehensive antenatal HRP screening and telehealth follow-up program in rural Nepal. The main questions it aims to answer are: 1.
- Trial name
- NCT07717619
- Testing
- High Risk Pregnancy Bundle
- Where
- Nepal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postpartum Preeclampsia
Postpartum Preeclampsia Early Detection and Treatment: Nepal Pilot Study
The goal of this study is to address the significant morbidity associated with preeclampsia diagnosed after delivery. All participants will undergo biomarker evaluation with soluble fms-like tyrosine kinase-1 and placental growth…
- Trial name
- PREDiCT-NPL (NCT07185204)
- Testing
- Early detection and management of postpartum preeclampsia bundle
- Where
- 2 sites in United States, Nepal
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Antimicrobial Resistance
Optimizing Antibiotics Prescription
Interventions that are low-cost, do not add substantially to the physician workload, are consistent with good physician practices and WHO guidelines, and serve as a reminder on the risks of overprescribing antibiotics are…
- Trial name
- NCT06436690
- Testing
- Diagnosis Mandate, Individualized Feedback
- Where
- 2 sites in United States, Nepal
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypertension, Medication Adherence
Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal
Despite evidence of preventing cardiovascular disease (CVD) risk through lifestyle changes, many patients with hypertension (HTN) do not comply with this and suffer from CVD and other complications.
- Conditions
- Hypertension, Medication Adherence, Blood Pressure, Cardiovascular Diseases
- Trial name
- TelTex4BP (NCT05979168)
- Testing
- Phone call and text Messages
- Where
- 2 sites in Nepal
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Central Department of Public Health
Health Informatics Education
Health Informatics Education Effectiveness in Nepal
This study evaluates the effectiveness of a blended Health Informatics (HI) course (HI471) on knowledge retention and technology awareness among health science students in Nepal.
- Trial name
- HI-EDU (NCT07690241)
- Testing
- Health Informatics-471 Blended Course
- Where
- Nepal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Axon Infotech Research Academy Pvt. Ltd.
Post Partum Depression
Sensing Technologies for Maternal Depression Treatment in Low-Resource Settings
In certain low- and middle- income country settings, there is a disproportionate level of untreated postpartum depression that presents both acute and long-term risks to a mother's well-being.
- Trial name
- StandStrong (NCT06253676)
- Testing
- Problem Management Plus (PM+)
- Where
- Nepal
- Volunteers
- 121 people
- Sponsor
- George Washington University
Anemia
How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent
This study aims to evaluate whether a food-based nutrition intervention using goat liver can improve anemia among adolescent girls in Kathmandu, Nepal, and compare its effectiveness with the current standard iron and folic acid…
- Trial name
- NCT07661602
- Testing
- Iron folic acid supplement, Goat liver supplementation, Nutrition education on anemia prevention and control
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- Southern Medical University, China
Birth Outcomes
Effect of a Mobile Health Intervention on Birth Outcomes
Globally, neonatal and infant mortality persist as challenging concerns, paralleled by a notable prevalence of low birth weight and preterm birth.
- Trial name
- NCT06431581
- Testing
- mHealth intervention (educational video, SMS and reminder phone call)
- Where
- Nepal
- Volunteers
- 494 people
- Sponsor
- Kathmandu University School of Medical Sciences