Clinical trials: in Panama
Molar, Third
A First-in-Human Study of a Novel 3rd Molar Tooth Bud Ablation Procedure
The goal of this single-arm prospective, non-randomized study is to demonstrate microwave ablation and agenesis of 3rd molar tooth buds using the Zero3 System in participants that have 3rd molar tooth bud(s) without the formation…
- Trial name
- Zero3 (NCT05374993)
- Testing
- Zero3 System
- Where
- Panama
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- TriAgenics Inc
Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease
Phase 2b Study of GSK4532990 in Adults With NASH
The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced fibrosis on biopsy (F3 or F4).
- Trial name
- HORIZON (NCT05583344)
- Testing
- GSK4532990
- Where
- 170 sites in United States, Argentina and 15 more
- Volunteers
- 284 people
- Sponsor
- GlaxoSmithKline
Non Squamous Non Small Cell Lung Cancer
A Study to Compare Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB12 (Proposed Pembrolizumab Biosimilar) to Keytruda® in Non-small Cell Lung Cancer (BENITO Study)
This is a randomized, multicenter, multinational, double-blind, integrated pharmacokinetics (PK) and efficacy similarity study to compare the PK, efficacy, safety, and immunogenicity of MB12 versus Keytruda® in combination with…
- Trial name
- NCT06687369
- Testing
- MB12 (Proposed Pembrolizumab Biosimilar), EU-sourced Keytruda®, US-sourced Keytruda®
- Where
- 173 sites in Armenia, Bosnia and Herzegovina and 22 more
- Volunteers
- 726 people
- Sponsor
- mAbxience Research S.L.
Pneumococcal Immunization
PCV21 Acceptance in Adults ≥50 Years and Caregivers in Panama
This study will look at what adults age 50 years and older in Panama know, think, and do about pneumococcal vaccination, including the 21-valent pneumococcal conjugate vaccine (PCV21).
- Trial name
- NCT07809113
- Where
- Panama
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Endpoints Site Network
Lung Diseases, Interstitial
A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease
Interstitial lung disease (ILD) is a lung condition resulting in inflammation and stiffening of the lung, often associated with connective tissue diseases (CTDs).
- Trial name
- BEconneCTD-ILD (NCT06572384)
- Testing
- Belimumab
- Where
- 132 sites in United States, Argentina and 16 more
- Volunteers
- 440 people
- Sponsor
- GlaxoSmithKline
Non-Small Cell Lung Cancer
A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
This is a phase 2/3, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in combination in participants with unresectable…
- Trial name
- B-FAST (NCT03178552)
- Testing
- Alectinib, Atezolizumab, Pemetrexed
- Where
- 161 sites in United States, Argentina and 25 more
- Volunteers
- 1,000 people
- Sponsor
- Hoffmann-La Roche
Cataract
Clinical Study of a Fluid Accommodating Intraocular Lens (IOL) Design
The purpose of this clinical study is to evaluate the surgical, refractive, and visual outcomes with implantation of an investigational intraocular lens (IOL).
- Trial name
- NCT05317728
- Testing
- BAL-FAIOL IOL, Monofocal IOL, Cataract surgery
- Where
- 6 sites in Costa Rica, Dominican Republic and 2 more
- Volunteers
- 175 people
- Sponsor
- Alcon Research
Neoplasm Metastasis
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
This is a global, multicenter, open-label safety extension study. Participants receiving single-agent trastuzumab emtansine or trastuzumab emtansine administered in combination with other anti-cancer therapies in a Genentech /…
- Trial name
- NCT00781612
- Testing
- Docetaxel, Paclitaxel, Pertuzumab
- Where
- 179 sites in United States, Australia and 33 more
- Volunteers
- 378 people
- Sponsor
- Genentech, Inc.
Knee Cartilage Lesions
Nanochon Chondrograft First in Human (FIH) Early Feasibility Study (EFS) - Panama
The goal of this First in Human study is to learn if the Nanochon Chondrograft Implant is a safe primary surgical treatment for participants with cartilage lesions in the knee.
- Trial name
- NCT07542184
- Testing
- Nanochon Chondrograft
- Where
- Panama
- Volunteers
- 5 people
- Sponsor
- Nanochon, Inc.
Respiratory Syncytial Virus
A Study of mRNA-1345, an mRNA Vaccine Targeting Respiratory Syncytial Virus, in Children 2 to <18 Years of Age at High Risk of Respiratory Syncytial Virus
Part A: The purpose is to evaluate the safety, reactogenicity, and immunogenicity of mRNA-1345 in children aged 2 to <5 years (Cohort 1) and in children at high risk of respiratory syncytial virus (RSV) disease 5 to <18 years of…
- Trial name
- NCT06097299
- Testing
- mRNA-1345
- Where
- 50 sites in United States, Panama
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Anemia, Sickle Cell
A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD)
This is a multi-center, open label Phase 2a clinical trial in subjects with sickle cell disease to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of HBI-002, an orally administered liquid containing carbon…
- Trial name
- NCT06144749
- Testing
- HBI-002
- Where
- 2 sites in Panama
- Volunteers
- 13 people
- Sponsor
- Hillhurst Biopharmaceuticals, Inc.
Ovarian Cancer
Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer
To compare the efficacy of olaparib in combination with paclitaxel and carboplatin (AUC4) when compared with carboplatin (AUC6) and paclitaxel alone in patients with advanced ovarian cancer.
- Trial name
- NCT01081951
- Testing
- olaparib, paclitaxel, carboplatin
- Where
- 53 sites in United States, Australia and 11 more
- Volunteers
- 162 people
- Sponsor
- AstraZeneca
Benign Prostatic Hyperplasia
Vivifi Device Safety Evaluation for the Treatment of Benign Prostatic Hyperplasia
The study objective is to evaluate the safety and feasibility of the Vivifi device to treat symptomatic, benign prostatic hyperplasia (BPH).
- Trial name
- BPH (NCT07745621)
- Testing
- Minimally invasive percutaneous ablation
- Where
- Panama
- Volunteers
- 20 people
- Sponsor
- Vivifi Medical
Glaucoma, Ocular Hypertension
Safety and Efficacy of TimoD Sustained-Release Implant in Participants With Glaucoma or Ocular Hypertension Undergoing Cataract Surgery
The goal of this clinical trial is to test a new method to deliver an approved medicine called Timolol in the eye of participants with glaucoma or ocular hypertension and requiring cataract surgery.
- Trial name
- NCT07036510
- Testing
- TimoD implant, Injector system, Timolol eye drops 0.5%
- Where
- Panama
- Volunteers
- 42 people
- Sponsor
- EyeD Pharma
Suicide Risk
Suicidal Risk in Adults in Panama: Validation of a Clinical Intervention Protocol
This study aims to validate MBT as an effective and viable intervention for implementation in public health services, with the potential to directly impact suicide prevention policies in the region.
- Trial name
- NCT07717320
- Testing
- Mentalization-Based Therapy (MBT), Treatment as Usual (TAU)
- Where
- 2 sites in Panama
- Volunteers
- 300 people
- Sponsor
- Fundación Judío Panameña (JUPA)
Degenerative Disc Disease, Chronic Low-back Pain
"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)
This study will be a prospective, open-label, multi-center study including 72 patients that will collect additional safety and efficacy data for the Spinal Stabilization Technologies PerQdisc Nucleus Replacement System.
- Trial name
- LOPAIN2 (NCT05508360)
- Testing
- PerQdisc Nucleus Replacement System
- Where
- 11 sites in Colombia, Costa Rica and 3 more
- Volunteers
- 72 people
- Sponsor
- Spinal Stabilization Technologies
Progressive Multiple Sclerosis (PMS)
A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis
This study is a prospective, multicenter, open-label, single-arm effectiveness and safety study in participants with progressive multiple sclerosis (PMS).
- Trial name
- CONSONANCE (NCT03523858)
- Testing
- Ocrelizumab
- Where
- 120 sites in United States, Bosnia and Herzegovina and 22 more
- Volunteers
- 927 people
- Sponsor
- Hoffmann-La Roche
Open Angle Glaucoma
Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes
This observational study will enroll adults with open angle glaucoma (OAG) who had surgery to reduce intraocular pressure (IOP) using the CycloPen Micro-Interventional System.
- Trial name
- CREST (NCT05506423)
- Testing
- CycloPen Cyclodialysis System
- Where
- 16 sites in United States, Panama
- Volunteers
- 300 people
- Sponsor
- Iantrek, Inc.
Lung Cancer, Non-Small Cell
A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)
The goal of this clinical trial is to evaluate the safety and tolerability profile of dostarlimab in combination with belrestotug when compared with pembrolizumab and placebo in participants with previously untreated…
- Trial name
- NCT06472076
- Testing
- Dostarlimab, Belrestotug, Pembrolizumab
- Where
- 108 sites in United States, Argentina and 19 more
- Volunteers
- 88 people
- Sponsor
- GlaxoSmithKline
Pre-Eclampsia
Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia.
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries.
- Trial name
- NCT06122220
- Testing
- ONSD+AF
- Where
- Panama
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Saint Thomas Hospital, Panama