Clinical trials: in Russia
Carcinoma，Non-Small-Cell Lung, Lung Carcinomas, Non-Small-Cell
Study of REGN 2810 Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC)
The primary objectives of the study are: To compare the overall survival (OS) of cemiplimab versus standard-of-care platinum-based chemotherapies in the first-line treatment of patients with advanced or metastatic non-small cell…
- Conditions
- Carcinoma，Non-Small-Cell Lung, Lung Carcinomas, Non-Small-Cell, Non-small-cell Lung Carcinoma, Nonsmall Cell Lung Cancer
- Trial name
- NCT03088540
- Testing
- Pemetrexed, Paclitaxel, Gemcitabine
- Where
- 192 sites in Australia, Belarus and 22 more
- Volunteers
- 712 people
- Sponsor
- Regeneron Pharmaceuticals
Migraine
A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine
The reason for this 12-month, open-label study is to see if the study drug lasmiditan is safe and effective for the intermittent acute treatment of migraine in children aged 6 to 17.
- Trial name
- PIONEER-PEDS2 (NCT04396574)
- Testing
- Lasmiditan
- Where
- 134 sites in United States, Belgium and 13 more
- Volunteers
- 558 people
- Sponsor
- Eli Lilly and Company
ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
The EPIVER Randomized Controlled Trial
The trial aims to estimate the efficacy and safety of the intracoronary administration of adrenalin, verapamil, as well as their combination compared to standard treatment in patients with STEMI and refractory coronary no-reflow…
- Conditions
- ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, No-Reflow Phenomenon
- Trial name
- EPIVER (NCT04573751)
- Testing
- Standard therapy, Epinephrine, Verapamil
- Where
- Russia
- Volunteers
- 104 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Chronic Heart Failure, Iron Deficiency, Latent
The Prevalence of Iron Deficiency and the Effectiveness of Ferinject® in Patients With HFpEF (ID-HFpEF)
Observational cohort randomized controlled study to study the influence of correction of ID by intravenous injection of ferric carboxymaltose (Ferinject®) on quality of life indicators, functional status in a cohort of patients…
- Trial name
- ID-HFpEF (NCT05793996)
- Testing
- Ferinject, Diet therapy
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Coronary Artery Disease
Effect of Digital Technologies on Risk Factor Modification
DigTech investigates the effect of a text message-based intervention to encourage lifestyle change on objective measures of cardiovascular risk in individuals with coronary heart disease (CHD) after percutaneous coronary…
- Trial name
- NCT03871907
- Testing
- Digital technology
- Where
- Russia
- Volunteers
- 700 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Primary Breast Cancer
Molecular Imaging of HER2 Expression in Breast Cancer Using 99mTc-HE3-G3
The study should evaluate distribution of 99mTc-HE3-G3 in patients with primary HER2-positive and HER2-negative breast cancer. The primary objective are: 1.
- Trial name
- HE3-G3 (NCT04277338)
- Testing
- SPECT
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Covid19, Cardiac Complication
One-year Cardiac Follow-up of Patients With COVID-19 Pneumonia
The primary objective of the study is to assess the cardiac status of COVID-19 pneumonia patients during 1 year after discharge
- Trial name
- NCT04501822
- Testing
- Evaluation of clinical, instrumental and laboratory diagnostics tests
- Where
- Russia
- Volunteers
- 380 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Failure With Preserved Ejection Fraction
Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
- Trial name
- NCT05839028
- Where
- Russia
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
ACS - Acute Coronary Syndrome
Telemedicine Follow-up for Post-ACS Patients
The aim is to compare the safety of using telemedicine and office visit follow-up in post-acute coronary syndrome patients
- Trial name
- NCT04485754
- Testing
- Telemedicine FU, Office FU
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Primary Breast Cancer
Molecular Imaging of HER2 Expression in Breast Cancer Using [123I] I-(HE)3-G3
The study should evaluate distribution of [123I] I-(HE)3-G3 in patients with primary HER2-positive and HER2-negative breast cancer
- Trial name
- NCT05923177
- Testing
- SPECT
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Myocardial Infarction, Acute
Registry of Acute Myocardial Infarction
The Registry of Acute Myocardial Infarction (RAMI) aims at regular and centralized acquiring and processing standard information about verified and suspected cases of acute myocardial infarction (AMI), monitoring of AMI cases…
- Trial name
- RAMI-Tomsk (NCT06252168)
- Where
- Russia
- Volunteers
- 97,500 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Prostate Cancer, Breast Cancer Female
Molecular Imaging of Gastrin Releasing Peptide Receptors Using Labeled Technetium-99m RM26
The study should evaluate the biological distribution of 99mTc-RM26 in patients with prostate cancer and breast cancer. The primary objective are: 1.
- Trial name
- NCT04746638
- Testing
- whole body study and SPECT with 99mTc-RM26
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Breast Cancer
99mTc-ADAPT6-based HER2 Imaging in Breast Cancer
The study should evaluate distribution of 99mTc- ADAPT6 in patients with primary HER2-positive and HER2-negative breast cancer. The primary objective are: 1.
- Trial name
- 99mTc-ADAPT6 (NCT03991260)
- Testing
- SPECT
- Where
- Russia
- Volunteers
- 16 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Primary Breast Cancer
[99mTc]Tc-DB8 Accumulation in Primary Tumor in Breast Cancer With Positive and Negative Estrogen Receptor Expression
The study should evaluate the [99mTc]Tc-DB8 accumulation in primary tumour of breast cancer patients with positive and negative estrogen receptor expression.
- Trial name
- NCT07275463
- Testing
- [99mTc]Tc-DB8
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Hepatitis B
Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
This is a global multi-center, long-term follow-up study to assess durability of efficacy, as measured by maintenance of treatment response from the parent study, in participants who participated in a previous bepirovirsen study…
- Trial name
- B-Sure (NCT04954859)
- Testing
- Bepirovirsen
- Where
- 163 sites in United States, Argentina and 27 more
- Volunteers
- 360 people
- Sponsor
- GlaxoSmithKline
Breast Cancer Female
Molecular Imaging of HER2 Expression in Breast Cancer Using [99mTc]Tc-G3-(G3S)3C Before Chemo/Targeted Therapy
The study should evaluate distribution of [99mTc]Tc-G3-(G3S)3C in patients with primary HER2-positive and HER2-negative breast cancer
- Trial name
- NCT05923268
- Testing
- [99mTc]Tc-G3-(G3S)3C
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Breast Cancer, Female
99mTc-ADAPT6 SPECT-based Non-invasive Quantification of HER2-expression in Breast Cancer With Metastatic Lymph Nodes
An open-label, single center study with 99mTc-ADAPT6 SPECT and biopsies of primary tumour and metastatic lymph nodes in breast cancer patients, where the primary endpoint of the study is to find out the correlation between the…
- Trial name
- 99mTc-ADAPT6 (NCT05412446)
- Testing
- ADAPT6-SPECT
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Prostate Cancer
Molecular Imaging of Prostate-Specific Membrane Antigen Using Labeled Technetium-99m BQ0413
The study should evaluate the biological distribution of [99mTc]Tc-BQ0413 in patients with prostate cancer. The primary objective are: 1.
- Trial name
- NCT06101927
- Testing
- Whole body study and SPECT with [99mTc]Tc-BQ0413
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
HER2-positive Breast Cancer, Female
99mTc-DARPinG3-based HER2 Expression Molecular Imaging in HER2-positive Breast Cancer During Chemo+Targeted Therapy
An open-label, single center study with 99mTc-DARPinG3 SPECT and biopsies of primary tumour in HER2-positive Breast Cancer in dynamic of chemo+targeted therapy, where the primary endpoint of the study is to find out the…
- Trial name
- NCT05412459
- Testing
- 99mTc-DARPinG3
- Where
- 2 sites in Russia
- Volunteers
- 15 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Chronic Ischemic Heart Disease, Obesity
Results of Coronary Artery Bypass Grafting in Obese Patients
This study is planned to assess the effect of obesity (BMI over 30 kg / m2) on hospital outcomes of isolated coronary artery bypass grafting in patients with chronic ischemic heart disease.
- Trial name
- NCT04916912
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
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