Clinical trials: in Russia
Breast Cancer, Ovarian Cancer
Phenotypic Spectrum of CTCs in Tumors of the Female Reproductive System
The study evaluates the level and molecular profiles of different CTC populations as markers for predicting the risk of developing hematogenous metastases and the effectiveness of treatment in patients with tumors of the female…
- Conditions
- Breast Cancer, Ovarian Cancer, Endometrial Cancer
- Trial name
- CTCs (NCT04817501)
- Testing
- Taking 5 ml of venous blood at different time intervals, Taking 5 ml EDTA-stabilized ascitic fluid sampled during laparoscopy if any
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Solid Tumor, Adult
Molecular Imaging of EpCAM Receptors Using [99mTc]Tc(CO)3-(HE)3-Ec1
The study should evaluate the biological distribution of [99mTc]Tc(CO)3-(HE)3-Ec1 in patients with solid tumor The primary objective are: 1.
- Trial name
- NCT05620472
- Testing
- Diagnostic Test: whole body study and SPECT with [99mTc]Tc(CO)3-(HE)3-Ec1
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Lung Cancer, Ovarian Cancer
Molecular Imaging of EpCAM Receptors Using [123I]I-DARPIN-Ec1
The study should evaluate the biological distribution of [123I]I-DARPIN-Ec1 in patients with lung and ovarian cancer The primary objective are: 1.
- Trial name
- NCT06386653
- Testing
- Diagnostic injection of [123I]I-DARPIN-Ec1, Whole-body planar scintigraphy with [123I]I-DARPIN-Ec1, Whole-body SPECT with [123I]I-DARPIN-Ec1
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
The primary aim of this single-center, prospective, randomized, controlled, study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac surgery…
- Trial name
- NCT06261827
- Testing
- 200-ppm NO
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Breast Cancer Female
99mTc-DARPinG3 SPECT/CT for Non-invasive HER2-AX in Breast Cancer With Metastatic Lymph Nodes Before Targeted Therapy
An open-label, single center study with 99mTc-DARPinG3 SPECT/CT and biopsies of primary tumour and metastatic lymph nodes in breast cancer patients, where the primary endpoint of the study is to find out the correlation between…
- Trial name
- NCT05695859
- Testing
- 99mTc-DARPinG3 SPECT/CT
- Where
- Russia
- Volunteers
- 24 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Myocardial Infarction (MI), Delirium, Intensive Care Unit, Randomised Controlled Trial
Mannitol Administration for Delerium Prevention
The aim of the study is to evaluate the efficacy of adjuvant administration of mannitol for the prevention of delirium in patients with myocardial infarction.
- Trial name
- MAD (NCT06759259)
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Chronic Heart Failure
SPECT-based Prediction and Evaluation of CRT Efficacy in CHF
This study evaluates the state of the cardiac sympathetic activity and the severity of ventricular dyssynchrony in chronic heart failure patients and assesses the capabilities of radionuclide indication methods in determining the…
- Trial name
- MIBGinCRT (NCT03667989)
- Testing
- Assessment of cardiac sympathetic innervation by 123I-MIBG
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Coronary Heart Disease, Stable Angina Pectoris
Heterogeneity of Neointimal Healing Following Biodegradable-polymer Drug-Eluting Coronary Stent Implantation
The objective of this study is a comparative evaluation of Orsiro stent and of Resolute Integrity stent in terms of the extent of neointima formation at 4 months after implantation using optical coherence tomography (OCT).
- Conditions
- Coronary Heart Disease, Stable Angina Pectoris, Silent Myocardial Ischemia
- Trial name
- Healing (NCT04465669)
- Testing
- Orsiro stents, Resolute Integrity® stents
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Primary Breast Cancer
Evaluation of Different Types of HER2 Expression in Breast Cancer Using [99mTc]Tc -ZHER2:4107
The study should evaluate the [99mTc]Tc -ZHER2:4107 accumulation in primary tumour of breast cancer patients with different HER2 expression
- Trial name
- NCT07292571
- Testing
- Injection of [99mTc]Tc-ZHER2:4107, SPECT/CT
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Degenerative Mitral Valve Disease
Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae
The study compares the efficacies of two surgical procedures for the treatment of mitral valve prolapse due to myxomatous degeneration of the mitral valve: the chordae replacement and the translocation of secondary mitral valve…
- Trial name
- NCT03674593
- Testing
- Mitral valve chordae prosthesis, Mitral valve chordae translocation
- Where
- Russia
- Volunteers
- 64 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Coronary Artery Disease
Effect of Introducer Length on the Rate of Radial Artery Occlusion During Endovascular Coronary Procedures
This study evaluates estimate impact of introducers length during endovascular coronary procedures on rate of a radial artery occlusion.
- Trial name
- IntroLength (NCT03854253)
- Testing
- Long introducer sheath, Short introducer sheath
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Mediastinitis
Combined Air-plasma Flow and Nitric Oxide Therapy in Cardiac Surgery
In cardiovascular surgery, the most common and serious complication is postoperative wound infection. The most formidable wound complication is mediastinitis, the frequency of which varies from 1 to 3%.
- Trial name
- NCT04617353
- Testing
- NO-based treatment of sterno-mediastinitis, Treatment of sterno-mediastinitis
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Potentially Inappropriate Medications
PIM Incidence in Older Cardiovascular Patients During COVID-19 Pandemics
The aim of the study is to assess the incidence of potentially inappropriate medication (PIM) administration, polypharmacy, and potential drug-drug-interactions (PDDIs) in cardiovascular patients enrolled in the reimbursement…
- Trial name
- PIM-BARS (NCT05336565)
- Testing
- Electronic medical record analysis
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Rheumatoid Arthritis
A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis
This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis.
- Trial name
- RA-BRIDGE (NCT03915964)
- Testing
- Baricitinib, TNF Inhibitor
- Where
- 261 sites in United States, Australia and 22 more
- Volunteers
- 2,659 people
- Sponsor
- Eli Lilly and Company
Ascending Aortic Aneurysm
Biomechanical Properties of the Human Ascending Aortic Wall in Aneurysm
The aim of the study is to analyze the efficacy of the surgical tretment in patients with ascending aortic aneurysm and dilatation.
- Trial name
- NCT05839990
- Testing
- Surgery
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Ascending Aortic Aneurysm
The Gender Specific Effect on the Results of Ascending Aortic Replacement
The aim of our study is to analyze the early and late results in men and women who underwent ascending aortic replacement in antegrade cerebral perfusion (ACP) with mild-to-moderate hypothermic circulatory arrest.
- Trial name
- NCT04905225
- Testing
- Ascending aortic replacement
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Brain, Neoplasms
Molecular Imaging of Brain Tumors Using Labeled Technetium-99m 1-Thio-D-Glucose.
The study should evaluate the biological distribution of 99mTc-1-thio-D-glucose in patients with primary brain tumors and recurrence of brain tumors. The primary objective are: 1.
- Trial name
- NCT04288518
- Testing
- SPECT or SPECT-CT with 99mTc-1-thio-D-glucose
- Where
- Russia
- Volunteers
- 16 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Glioma (Any Grade) in the Brain
99mTc-1-thio-D-glucose SPECT/CT Versus 18F-Fluoroethyl-l-tyrosine PET/CT in Brain Tumor Imaging
An open-label, single-center study with 99mTc-1-thio-D-glucose single photon emission computed tomography / computed tomography (SPECT/CT) and 18F-fluoroethyl-l-tyrosine (18F-FET) positron emission tomography / computed…
- Trial name
- NCT07475390
- Testing
- 99mTc-1-thio-D-glucose, 18F-FET
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency
Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency
This is a 2-year open-label, multicenter extension of the double-blind, placebo-controlled GTi1201 study. The purpose of this study is to obtain an additional 2 years of safety data for intravenously administered Alpha1-MP 60…
- Trial name
- SPARTA-OLE (NCT02796937)
- Testing
- Alpha-1 MP
- Where
- 28 sites in United States, Australia and 10 more
- Volunteers
- 290 people
- Sponsor
- Grifols Therapeutics LLC
Crohn's Disease, IBD
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease
This study seeks to evaluate the safety and efficacy of brazikumab versus placebo (Stage I) and versus an active comparator (Stage 2) in participants with moderately to severely active CD and will include assessments of clinical…
- Trial name
- INTREPID (NCT03759288)
- Testing
- Brazikumab low dose, Brazikumab high dose, Humira®
- Where
- 102 sites in United States, Canada and 15 more
- Volunteers
- 89 people
- Sponsor
- AstraZeneca
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.