Clinical trials: in Russia
Ischemic Stroke, Upper Limb Motor Impairment
Neurophysiological Markers for Prediction of Rehabilitation Outcomes After Ischemic Stroke
The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke.
- Trial name
- NCT07520630
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Alopecia Areata
Long-Term PF-06651600 for the Treatment of Alopecia Areata
This is a global Phase 3 study to evaluate the safety and effectiveness of an investigational study drug (called PF-06651600) in adults and adolescents (12 years and older) who have alopecia areata.
- Trial name
- ALLEGRO-LT (NCT04006457)
- Testing
- PF-06651600, Tetanus and diphtheria toxoids and acellular pertussis (Tdap) vaccine, Meningococcal (groups A, C, W-135 and Y [ACWY]) oligosaccharide diphtheria CRM197 conjugate vaccine
- Where
- 144 sites in United States, Argentina and 15 more
- Volunteers
- 1,057 people
- Sponsor
- Pfizer
Acute Myeloid Leukemia (AML)
A Study of Oral Venetoclax Tablets and Oral Azacitidine as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy
This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in combination with azacitidine (AZA).
- Trial name
- VIALE-M (NCT04102020)
- Testing
- Venetoclax, Azacitidine
- Where
- 156 sites in United States, Australia and 17 more
- Volunteers
- 112 people
- Sponsor
- AbbVie
Pregnancy Related
Maternal and Fetal Electrocardiograms Separation Algorithm
Effective monitoring of fetal heart activity during the second and third trimesters remains a vital challenge in perinatal medicine.
- Trial name
- NCT07518550
- Testing
- Maternal and fetal electrocardiograms separation
- Where
- Russia
- Volunteers
- 350 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Atrial Fibrillation, Atrial Flutter
A Study to Select the Dose and Evaluate the Effectiveness and Safety of the Drug Refralon®, Tablets, 1 mg for Long-term Use to Prevent Recurrence of Atrial Fibrillation/Flutter After Terminating Its Persistent Form
Refralon® tablets in two different doses (1 or 2 tablets per day) will be evaluated vs. placebo in patients with persistent atrial fibrillation/flutter after synus rhythm restoration in order to prevent recurrence of arrhythmia.
- Trial name
- NCT06540352
- Testing
- 4-Nitro-N-[(1RS)-1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]benzamide hydrochloride, Mannitol
- Where
- Russia
- Volunteers
- 175 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Juvenile Idiopathic Arthritis
Pharmacokinetics, Efficacy and Safety of Olokizumab In Patients With Juvenile Idiopathic Arthritis
The primary objective of this study is to evaluate the pharmacokinetics (PK) of olokizumab (OKZ) in patients with polyarticular juvenile idiopathic arthritis aged >2 and <18 years in two doses (64 mg or 48 mg every 4 weeks)…
- Trial name
- NCT07517575
- Testing
- OKZ q4w
- Where
- 14 sites in Russia
- Volunteers
- 71 people
- Sponsor
- R-Pharm International, LLC
Pulmonary Arterial Hypertension
Evaluation of the Efficacy and Safety of Oxacom® in Patients With Pulmonary Arterial Hypertension
A multicenter, randomized, double-blind, placebo-controlled, phase II-III clinical trial to evaluate the efficacy and safety of the study drug in adult patients with pulmonary arterial hypertension (PAH).
- Trial name
- NCT06683040
- Testing
- Oxacom
- Where
- Russia
- Volunteers
- 260 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Prostatic Neoplasms, Genital Neoplasms
Moderately Hypofractionated Radiotherapy for Prostate Cancer.
Radiation therapy is one of the standard treatments for men with prostate cancer. Moderately hypofractionated radiotherapy has been established to be equivalent to standard fractionated radiotherapy in several large randomized…
- Trial name
- NCT03827616
- Testing
- Hypofractionated IMRT using helical Tomotherapy.
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Tatarstan Cancer Center
Advanced Epithelial Ovarian Cancer, Peritoneal Carcinomatosis
Intensification Treatment of Ovarian Cancer by PIPAC
The goal of this clinical trial is to learn whether repeated cisplatin-based PIPAC added to standard TC chemotherapy can improve outcomes in women aged 18-75 years with newly diagnosed FIGO IIIB-IIIC epithelial ovarian cancer and…
- Trial name
- PrimPIPAC (NCT07514494)
- Testing
- PIPAC
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Moscow Regional Oncological Dispensary
Peri-implantitis
Decontamination Methods in the Treatment of Peri-implantitis
The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis.
- Trial name
- NCT07500844
- Testing
- Miramistin, Sodium Bicarbonate Powder, Chlorhexidine
- Where
- Russia
- Volunteers
- 64 people
- Sponsor
- Research Centre for Medical Genetics, Russian Federation
Small Cell Lung Cancer
A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer
This study will evaluate the efficacy of tiragolumab plus atezolizumab and carboplatin and etoposide (CE) compared with placebo plus atezolizumab and CE in participants with chemotherapy-naive extensive-stage small cell lung…
- Trial name
- SKYSCRAPER-02 (NCT04256421)
- Testing
- Tiragolumab, Atezolizumab, Carboplatin
- Where
- 121 sites in United States, Australia and 21 more
- Volunteers
- 490 people
- Sponsor
- Hoffmann-La Roche
Hypertriglyceridemia
Russian Extreme Hypertriglyceridemia Registry
The REGGI registry is a prospective, multicenter observational registry in Russia designed to collect data on patients with extreme hypertriglyceridemia (triglyceride levels ≥10 mmol/L).
- Trial name
- REGGI (NCT07508930)
- Where
- 6 sites in Russia
- Volunteers
- 500 people
- Sponsor
- Russian Cardiology Research and Production Center
Hodgkin Lymphoma
Comparison of AVD + Low-Dose Nivolumab vs. PET-Adapted BEACOPP-like in Advanced cHL
Patients in this prospective multicenter phase II study will be randomized between two first-line therapy strategies for advanced stages of cHL.
- Trial name
- NCT07234487
- Testing
- Nivo-AVD, BEACOPP-like
- Where
- 3 sites in Russia
- Volunteers
- 178 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Heart Diseases, Coronary Artery Disease
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grafting (SAG).
- Conditions
- Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
- Trial name
- ROMA:Women (NCT04124120)
- Testing
- Single arterial graft, Multiple arterial grafting
- Where
- 146 sites in United States, Australia and 24 more
- Volunteers
- 2,300 people
- Sponsor
- Weill Medical College of Cornell University
HR+HER2- Advanced Breast Cancer
A Prospective Non-interventional Study to Evaluate Clinical Outcomes of Ribociclib Combined With Endocrine Therapy in Elderly Patients With HR+HER2 - Advanced Breast Cancer in Routine Clinical Practice in Russian Federation
This is а prospective, non-interventional, primary data collection study to evaluate the effectiveness, safety and quality of life in older patients (≥65 years) with HR+HER2- advanced breast cancer receiving ribociclib with ET in…
- Trial name
- PARFENOPA (NCT06625333)
- Where
- 20 sites in Russia
- Volunteers
- 329 people
- Sponsor
- Novartis Pharmaceuticals
Diffuse Large B-cell Lymphoma
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
This is a phase 3, multicenter, randomized, double-blind, placebo-controlled trial designed to compare the efficacy and safety of the humanized monoclonal anti CD19 antibody tafasitamab plus lenalidomide in addition to R-CHOP…
- Trial name
- frontMIND (NCT04824092)
- Testing
- Tafasitamab, Lenalidomide, Rituximab
- Where
- 307 sites in United States, Argentina and 27 more
- Volunteers
- 899 people
- Sponsor
- Incyte Corporation
NSCLC, ALCL
Crizotinib Continuation Clinical Study
The purpose of this continuation study is to provide continued access to crizotinib treatment for eligible participants from a current Pfizer sponsored crizotinib clinical study that is planned to close.
- Conditions
- NSCLC, ALCL, IMT
- Trial name
- NCT05160922
- Testing
- crizotinib
- Where
- 13 sites in China, Italy and 3 more
- Volunteers
- 27 people
- Sponsor
- Pfizer
Activated PI3Kdelta Syndrome (APDS); PASLI Disease
Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI
This study is designed to provide long-term CDZ173 treatment, a selective PI3Kδ inhibitor, to the patients with genetically activated PI3Kδ, i.e., patients with APDS/PASLI who participated in the CCDZ173X2201 study or who were…
- Trial name
- NCT02859727
- Testing
- CDZ173
- Where
- 8 sites in United States, Belarus and 5 more
- Volunteers
- 37 people
- Sponsor
- Pharming Technologies B.V.
Periapical Periodontitis
Hyaluronic Acid in Endodontic Microsurgery
This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first…
- Trial name
- NCT07501585
- Testing
- Hyaluronic Acid, Endodontic microsurgery
- Where
- Russia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Bern
Metabolic Syndrome
Assessing the Association Between H. Pylori Persistence and the Severity of Insulin Resistance in Patients With Metabolic Syndrome
This retrospective cohort study evaluates the association between H. pylori persistence and insulin resistance severity (HOMA-IR) in 100 patients with metabolic syndrome at Novosibirsk's Center for New Medical Technologies…
- Trial name
- NCT07501858
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Center of New Medical Technologies
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