Clinical trials: completed, in Rwanda
Male Circumcision
Safety Study of the PrePex Device for Non-Surgical Adult Male Circumcision During Phased in National Implementation in an Effort to Prevent the Spread of HIV
It is well known from a range of observational and epidemiological studies that the lifetime risk of acquiring HIV among males can be significantly reduced via circumcision.
- Trial name
- RMC-07 (NCT01921608)
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Faecal Contamination of Household Drinking Water (Environmental Outcome)
Evaluation of a Project to Distribute Water Filters and Cookstoves in Western Rwanda
DelAgua Health and Development, Manna Energy and the Rwanda Ministry of Health are collaborating on a project financed by carbon credits that will distribute household-based water filters and high-efficiency cook stoves to…
- Trial name
- NCT01882777
- Testing
- Household drinking water filters and cookstoves
- Where
- Rwanda
- Volunteers
- 566 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
Safety and Immunogenicity Study of Ad26-ENVA and Ad35-ENV HIV Vaccines in Healthy HIV-uninfected Adults
The purpose of this study is to evaluate the safety and tolerability of Ad26.ENVA.01 and Ad35-ENV in low-risk for HIV-uninfected healthy adults administered in heterologous and homologous prime-boost regimens at different time…
- Trial name
- NCT01215149
- Testing
- Ad35-ENV vaccine, Ad26.ENVA.01 vaccine
- Where
- 6 sites in United States, Kenya and 2 more
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Enrichment of Blood
Iron Absorption From Biofortified Beans With Different Levels of Phytic Acid
Iron deficiency and iron deficiency anemia are among the major health problems in the developing world. Women of childbearing age as well as children are the most vulnerable population groups.
- Trial name
- NCT01521273
- Testing
- Bean varieties
- Where
- Rwanda
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Contraception
Postpartum Family Planning Service Through Enhanced Family Planning in Immunization Services
The purpose of this study is to determine the effectiveness of an intervention, which is designed to increase contraceptive prevalence among postpartum women attending vaccination services who desire to either space or limit…
- Trial name
- PPFP-IZ (NCT01115361)
- Testing
- Family planning for postpartum women
- Where
- Rwanda
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV
Comparing the PrePex™ Device to Surgical Circumcision for Rapid Scale Up of Male Circumcision in Resource Limited Setting
The World Health Organization and UNAIDS cite that male circumcision can reduce the lifetime risk of HIV infection by 60% in high risk areas such as Sub Saharan Africa.
- Trial name
- NCT01284088
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Rwanda
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
HIV Infections, Acquired Immunodeficiency Syndrome
An Expanded Safety Study of Dapivirine Gel 4759 in Africa
The purpose of this study is to determine whether dapivirine gel 4759 is safe for daily use by healthy women in Kenya, Malawi, Rwanda, South Africa and Tanzania.
- Trial name
- NCT00917891
- Testing
- dapivirine
- Where
- 10 sites in Kenya, Malawi and 3 more
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Acquired Immunodeficiency Syndrome, Stress Disorders, Post-Traumatic
HIV Prevention and Care of Psychological Trauma in Vulnerable Rwandan Youth
The investigators propose a prospective single arm pilot cohort study of 100 youth (ages 15-25) to evaluate the feasibility of this project.
- Trial name
- NCT01401335
- Testing
- Questionnaires
- Where
- 2 sites in United States, Rwanda
- Volunteers
- 120 people
- Sponsor
- Stanford University
Male Circumcision, HIV Prevention
A Pivotal Study to Assess the Safety and Efficacy of The PrePex System, a Male Circumcision Device and Methodology for Rapid Scale up of Painless and Bloodless National Circumcision Programs, in Urban and Remote Rural Settings
The protocol, approved by the Rwanda National Ethical Committee, was issued to assess the safety and efficacy of the circumcision device for applying it to the national scale up of adult male circumcision in Rwanda
- Conditions
- Male Circumcision, HIV Prevention, HIV Infections
- Trial name
- NCT01150370
- Testing
- The PrePex a novel device for adult male circumcision
- Where
- Rwanda
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Vernal Keratoconjunctivitis
Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda
Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, external ocular inflammatory disease of unknown cause. It is a fairly common disease in hot, dry environments, representing as much as 3% of severe ophthalmic diseases…
- Trial name
- NCT01211327
- Testing
- Cyclosporine A, Dexamethasone
- Where
- Rwanda
- Volunteers
- 366 people
- Sponsor
- University Hospital, Ghent
Non HIV Infected Pregnant Women
IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda
The present study will address the question whether the use of IPT using SP in pregnancy is efficacious in Rwanda, where it is going to be used for the first time, in areas with high levels of SP resistance.
- Trial name
- NCT00372632
- Testing
- Sulfadoxine-Pyrimethamine
- Where
- Rwanda
- Volunteers
- 1,717 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Investigation of the Efficacy of Quinine Sulphate Administered Via Taste-Masked Pellets to Children With Falciparum Malaria
No pediatric formulations of quinine exist. Therefore, quinine tablets are broken into 2 or 4 parts, according to the body weight. Based on the body weight, 1/2 or 1/4 a tablet is administered to the child.
- Trial name
- NCT00329134
- Testing
- Administration of quinine sulphate taste-masked pellets
- Where
- Rwanda
- Volunteers
- 56 people
- Sponsor
- University Ghent
Plasmodium Falciparum Malaria
Multi-Centre Trial Comparing Three Artemisinin-Based Combination Treatments on P. Falciparum Malaria
The purpose of this open randomised multi-centre clinical trial is to test the hypothesis that three pills of the fixed dose combination artesunate/sulfamethoxypyrazine/pyrimethamine, administered over 24 hours is not inferior in…
- Trial name
- NCT00484900
- Testing
- Co-Arinate FDC, Coartem
- Where
- 4 sites in Cameroon, Mali and 2 more
- Volunteers
- 1,390 people
- Sponsor
- Dafra Pharma
Malaria
Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children
In 2005-2006, a clinical trial was carried out to test safety, tolerability and efficacy of the combination chlorproguanil-dapsone+artesunate (CD+A): 800 children aged 12-59 months with uncomplicated P.
- Trial name
- NCT00461578
- Testing
- Chlorproguanil-dapsone + artesunate
- Where
- Rwanda
- Volunteers
- 800 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
A Safety and Tolerability Study of Dapivirine (TMC120) Vaginal Microbicide Gel
Approximately 112 HIV-negative women, aged 18 to 50, will be enrolled in this multicenter study at four sites. Volunteers will be randomized to dapivirine (TMC120) vaginal gel or matching placebo gel.
- Trial name
- NCT00303576
- Testing
- dapivirine (TMC120) vaginal gel
- Where
- 4 sites in Rwanda, South Africa and 1 more
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.