Clinical trials: in Sweden
Atherosclerotic Cardiovascular Disease
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease
Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants with established cardiovascular disease (CVD).
- Trial name
- VICTORION-2P (NCT05030428)
- Testing
- Inclisiran sodium 300 mg
- Where
- 983 sites in United States, Argentina and 48 more
- Volunteers
- 17,004 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Myeloma
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer).
- Trial name
- NCT06152575
- Testing
- Elranatamab, Elotuzumab, Pomalidomide
- Where
- 270 sites in United States, Argentina and 25 more
- Volunteers
- 492 people
- Sponsor
- Pfizer
Drinking Excessive
Optimization of Guidance in a Digital Tool for Problematic Alcohol Use
The purpose of the study is to evaluate the effects on alcohol consumption, and the consumption of time spent by a qualified clinician, by adding different forms of guidance to a digital intervention based on an alcohol diary and…
- Trial name
- NCT05649982
- Testing
- ALVA
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Karolinska Institutet
Pancreatic Cancer Metastatic to Liver
Study-group on Palliative ERCP And RFA-ablation in Metastatic and Inoperable Pancreatic Tumors
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive cancer and may become the second leading cause of cancer death by 2030.
- Trial name
- Spearmint (NCT07191418)
- Testing
- Habib™ EndoHPB, ERCP
- Where
- Sweden
- Volunteers
- 178 people
- Sponsor
- Roberto Valente
Cardiometabolic Risk Factors, Microbiota
Health Effects of Ultra-processed Food Intake
Ultra-processed food (UPF) intake has been related to negative health effects and increased energy intake in previous intervention studies.
- Conditions
- Cardiometabolic Risk Factors, Microbiota, Diet Interventions
- Trial name
- UPFront (NCT07634159)
- Testing
- Diet high in UPF, Diet low in UPF
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Ice Hockey, Hand
Medical Team Perspectives on Hand and Wrist Injuries in Elite Male and Female Ice Hockey Players
This is a cross-sectional survey study investigating how medical team staff in elite Swedish ice hockey perceive hand and wrist injuries in male and female players.
- Conditions
- Ice Hockey, Hand, Wrist, Injuries
- Trial name
- NCT07586085
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Dalarna County Council, Sweden
Acute Myeloid Leukemia
Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)
A study to evaluate if the randomized addition of venetoclax to a chemotherapy backbone (fludarabine/cytarabine/gemtuzumab ozogamicin [GO]) improves survival of children/adolescents/young adults with acute myeloid leukemia (AML)…
- Trial name
- NCT05183035
- Testing
- Fludarabine, Cytarabine, Gemtuzumab Ozogamicin
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 130 people
- Sponsor
- PedAL BCU, LLC
Multiple Myeloma
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
The purpose of this clinical trial is to (1) learn whether the BCMA-CD3 bispecific antibody elranatamab can provide more benefit to people with multiple myeloma compared to a combination therapy including daratumumab…
- Trial name
- MAGNETISMM-5 (NCT05020236)
- Testing
- Elranatamab, Daratumumab, Pomalidomide
- Where
- 237 sites in United States, Argentina and 24 more
- Volunteers
- 893 people
- Sponsor
- Pfizer
Cardiovascular Disease
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established…
- Trial name
- AZURE-Outcomes (NCT07000357)
- Testing
- AZD0780
- Where
- 1,452 sites in United States, Argentina and 34 more
- Volunteers
- 15,100 people
- Sponsor
- AstraZeneca
Healthy Volunteers, Inflammatory Bowel Disease (IBD)
Fermented Vegan Optimized Diet in Health and Colitis
The diet is assumed to contribute to many of our present non-communicable diseases. Vegetarian products are instead considered to be health promoting, However, it is not verified that the modern vegetarian and vegan products are…
- Trial name
- FAVORIT (NCT06696222)
- Testing
- Vegetarian yogurt, Vegetarian meat alternative, Ordinary meat diet
- Where
- 2 sites in Sweden
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Region Skane
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter's…
- Conditions
- Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
- Trial name
- NCT05458297
- Testing
- Zilovertamab vedotin, Nemtabrutinib
- Where
- 109 sites in United States, Brazil and 19 more
- Volunteers
- 189 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Disease, Chronic Obstructive
Mepolizumab as Add-on Treatment IN Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level
This is a multi-center, randomized, placebo-controlled, double-blind, parallel group study designed to confirm the benefits of mepolizumab treatment on moderate or severe exacerbations in chronic obstructive pulmonary disease…
- Trial name
- MATINEE (NCT04133909)
- Testing
- Mepolizumab
- Where
- 339 sites in United States, Argentina and 24 more
- Volunteers
- 806 people
- Sponsor
- GlaxoSmithKline
Kidney Transplant, DCD Kidney
NRP + ex Situ HMPO2 vs NRP Alone in DCD Kidney Transplantation
The goal of this clinical trial is to learn if the combination of Normothermic Regional Perfusion (NRP) at the time of organ procurement with ex situ Hypothermic Oxygenated Perfusion (HMPO2) of kidneys recovered from donors after…
- Trial name
- OxyPerf (NCT07779187)
- Testing
- Ex situ hypothermic oxygenated machine preservation
- Where
- 3 sites in Sweden
- Volunteers
- 214 people
- Sponsor
- Karolinska University Hospital
Chronic Pain
BurstDR Spinal Cord Stimulation Versus Sham in Established Responders
This study aims to determine whether ongoing BurstDR spinal cord stimulation (SCS) provides pain relief beyond sham stimulation in patients with chronic pain who are established responders to BurstDR therapy.
- Trial name
- NCT07779733
- Testing
- BurstDR Spinal Cord Stimulation
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Umeå University
Colon Cancer
Neoadjuvant Chemotherapy Versus Standard Treatment in Patients With Locally Advanced Colon Cancer
The purpose of this study is to compare 3 cycles of neoadjuvant (preoperative) chemotherapy + operation with the standard treatment of locally advanced colon cancer, which is operation + 8 cycles of (adjuvant) chemotherapy.
- Trial name
- NCT01918527
- Testing
- Capecitabine, Oxaliplatin
- Where
- 9 sites in Denmark, Norway and 1 more
- Volunteers
- 250 people
- Sponsor
- Vejle Hospital
Parental Support, Emotion Regulation
Little ACF (Lilla ABC): Evaluation of a Parental Support Program for Parents of Children Aged 1-2 Years
Society can promote children's mental health at an early stage by creating good conditions with, for example, general parental support programs that are offered to all parents.
- Conditions
- Parental Support, Emotion Regulation, Coping Behavior, Stress, Emotional
- Trial name
- NCT05445141
- Testing
- Little ACF [in Swedish: Lilla ABC], Lectures
- Where
- Sweden
- Volunteers
- 732 people
- Sponsor
- Karolinska Institutet
Transplant Rejection
BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)
Primary Objectives: Cohort A: To evaluate the efficacy of BIVV020 in prevention of AMR Cohort B: To evaluate the efficacy of BIVV020 in treatment of active AMR Secondary Objectives: To assess the overall efficacy of BIVV020 in…
- Trial name
- NCT05156710
- Testing
- BIVV020 (SAR445088), Intravenous immunoglobulin (IVIg), Rituximab or biosimilar
- Where
- 27 sites in United States, Canada and 5 more
- Volunteers
- 48 people
- Sponsor
- Sanofi
Cardiac Arrest
Biomarkers After Out-of-hospital Cardiac Arrest- a STEPCARE Substudy
A prospective multicenter biomarker study with adult patients treated on intensive care units after out-of-hospital cardiac arrest.
- Trial name
- NCT06471972
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 1,500 people
- Sponsor
- Region Skane
COPD (Chronic Obstructive Pulmonary Disease)
Internet-Based Cognitive Behavioral Therapy and Educational Program for People Living With Chronic Obstructive Pulmonary Disease (COPD)
The goal of this clinical trial is to learn if an internet-based cognitive behavioral therapy (CBT) and education program can help improve mental health, disease knowledge, and quality of life in adults with chronic obstructive…
- Trial name
- COPD BALANCE (NCT06891677)
- Testing
- Internet-Based Cognitive Behavioral Therapy (CBT) with ACT and COPD Education
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Jonas Agholme
Cardiac Arrest, Out-Of-Hospital
Late Biomarkers in Adult Survivors After Out-of-hospital Cardiac Arrest
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by…
- Trial name
- NCT06587763
- Where
- 3 sites in Sweden
- Sponsor
- Region Skane
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