Clinical trials: in Sweden
Dental Caries, Dental Cavities
Evaluation of Selective and Stepwise Excavation in Young Permanent Teeth With Deep Caries Lesions.
The purpose of this clinical trial is to evaluate and compare the outcomes of selective carious tissue removal versus stepwise carious tissue removal in young permanent teeth with deep carious lesions.
- Trial name
- SELECT (NCT06944028)
- Testing
- Selective excavation, Stepwise excavation
- Where
- Sweden
- Volunteers
- 666 people
- Sponsor
- Karolinska Institutet
Vulvodynia (Chronic Vulvar Pain)
Vulvodynia Intervention: the Effect of Multimodal Treatment for Provoked Vulvodynia
The purpose of this project is to develop and evaluate a multimodal treatment for provoked vulvodynia, by addressing the following specific research questions: 1.
- Trial name
- NCT06981611
- Testing
- Vulvodynia Intervention: a multimodal treatment for provoked vulvodynia
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karlstad University
Cesarean Birth
The Cesarean Study: Optimizing Cesarean Sections and Improving Patient-Healthcare Provider Trust Using Evidence Informed Recommendations
Cesarean section (CS) rates have rapidly increased worldwide, with projections suggesting that by 2030, one in every three births will be by CS (1).
- Trial name
- CS (NCT07759622)
- Testing
- Cesarean Bundle
- Where
- Sweden
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Lund University
Domestic Violence, Child Development
Musical Group Intervention for Children in Shelters
The aim of the study is to augment knowledge on interventions for children who live, or have lived, in shelters after exposure to domestic violence.
- Conditions
- Domestic Violence, Child Development, Psychological Distress, Music Therapy
- Trial name
- NCT05755178
- Testing
- Music, feelings and relationships - music group for children at shelters
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Kronoberg County Council
Primary Health Care Providers, Early Childhood Behavior
Young Children and Screens: Parents' Perspectives and Child Health Nurses' Approaches in a Digital Age
The overall aim of the research project is to investigate screen habits among children (0-5 years) and their parents including nurses' perspective, and further parents' and nurses' experiences of using web-based healthcare…
- Conditions
- Primary Health Care Providers, Early Childhood Behavior, Child Health Services, Parenting Practices
- Trial name
- NCT07168057
- Where
- Sweden
- Volunteers
- 320 people
- Sponsor
- Karolinska Institutet
Hearing Loss, Hearing Impairment
Follow Up of an Online Hearing Support for First-time Hearing Aid Users
The main questions the research aims to answer are short- and long-term effects on consequences of hearing loss depending on which type of follow-up the participant chooses.
- Conditions
- Hearing Loss, Hearing Impairment, Hearing Disorders
- Trial name
- NCT06468137
- Testing
- Swedish I-ACE, Clinical visit, No follow-up
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Student Education
Systematic Evaluation of Psychotherapy Training: Supervision, Student Learning, and Patient Outcomes
The project is a longitudinal observation study that aims to systematically evaluate selected parts of the material collected within the framework of the psychotherapy training conducted at the Center of Psychotherapy Education…
- Trial name
- NCT06105502
- Testing
- Psychotherapy education
- Where
- Sweden
- Volunteers
- 417 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Patients with a suspected myocardial infarction are subdivided into ST-elevation and non-ST-elevation myocardial infarctions (STEMI and NSTEMI, respectively) using ECG.
- Trial name
- KaPSICA-CMR (NCT06566625)
- Testing
- Cardiac MRI (CMR) examination
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Generalized Anxiety Disorder
Effects and Mechanisms of Change of Internet Delivered Cognitive Behavior Therapy for Generalized Anxiety Disorder
The goal of this clinical trial is to compare two psychological treatments for Generalized Anxiety Disorder. The main questions it aims to answer are: How well do these treatments work compared to earlier studies? Is one of the…
- Trial name
- ORIGAMI (NCT05849493)
- Testing
- Metacognitive Internet delivered Cognitive Behavior Therapy, Intolerance of uncertainty based Internet delivered Cognitive Behavior Therapy
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Alpha 1-Antitrypsin Deficiency
Phase III, Efficacy and Safety of "Kamada-AAT for Inhalation"
The goal of this clinical trial is to learn if AAT for inhalation, at a dose of 80 mg/day can slow the progression of lung disease in people who have lung disease caused by severe genetic deficiency in Alpha 1 Antitrypsin (AATD).
- Trial name
- InnovAATe (NCT04204252)
- Testing
- Alpha 1-Antitrypsin
- Where
- 9 sites in Belgium, Finland and 4 more
- Volunteers
- 98 people
- Sponsor
- Kamada, Ltd.
Anesthesia, Surgery
Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality
Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.
- Conditions
- Anesthesia, Surgery, Surgery Complications
- Trial name
- PeriopPrePA (NCT07603622)
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska Institutet
Infratentorial Neoplasms, Mutism
Cerebellar Mutism Syndrome Study
The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS).
- Trial name
- NCT02300766
- Where
- 32 sites in Austria, Belgium and 12 more
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Homozygous Familial Hypercholesterolemia
A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)
This multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of zodasiran subcutaneous (SC) injection in subjects 12 years of age and older with genetically or clinically diagnosed Homozygous…
- Trial name
- NCT07037771
- Testing
- zodasiran Injection
- Where
- 43 sites in United States, Australia and 16 more
- Volunteers
- 70 people
- Sponsor
- Arrowhead Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease
Background: In patients with chronic obstructive pulmonary disease (COPD) and concomitant cardiovascular conditions cardio-selective beta-blockers reduce mortality and can be used without significant negative effects on lung…
- Trial name
- NCT03566667
- Testing
- Metoprolol, Standard care
- Where
- Sweden
- Volunteers
- 1,713 people
- Sponsor
- Ole Frobert, MD, PhD
Leukemia, Acute Lymphoblastic
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system…
- Trial name
- NCT04307576
- Testing
- Omitted Doxorubicin, Omitted Vincristine+Dexamethasone pulses, Inotuzumab Ozogamicin+Standard Maintenance Therapy
- Where
- 137 sites in Belgium, Denmark and 13 more
- Volunteers
- 6,430 people
- Sponsor
- Mats Heyman
Vulvodynia
Young Vulvodynia: Effect and Efficacy of Multimodal Treatment.
The aim of this SCED-study is to evaluate a multimodal treatment for vulvodynia in young women. The main questions it aims to answer are: Is multimodal treatment effective for provoked vulvodynia in young women? How is multimodal…
- Trial name
- UV (NCT07092332)
- Testing
- Multimodal treatment
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Region Örebro County
Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders
Exposure Therapy for Reactivity to Symptoms
It is unclear to what degree systematic exposure exercises contribute to the overall effects of exposure therapy (exposure and response prevention).
- Conditions
- Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders, Bodily Distress Disorder
- Trial name
- SOMEX2 (NCT07757854)
- Testing
- Planned, systematic, exposure exercises, Response prevention
- Where
- Sweden
- Volunteers
- 360 people
- Sponsor
- Region Stockholm
Breast Cancer
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
This is open-label, multicenter, international study, assessing the efficacy and safety of Trastuzumab deruxtecan (T-DXd) in participants with or without brain metastasis (BMs), with previously-treated advanced/metastatic…
- Trial name
- DESTINY-B12 (NCT04739761)
- Testing
- Trastuzumab Deruxtecan
- Where
- 81 sites in United States, Australia and 16 more
- Volunteers
- 506 people
- Sponsor
- AstraZeneca
Hematopoietic Neoplasm
Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis
Primary Objective: To evaluate the efficacy of daily oral doses of 400 mg or 500 mg of SAR302503 (Investigational Medicinal Product, IMP) compared to placebo in the reduction of spleen volume as determined by magnetic resonance…
- Trial name
- JAKARTA (NCT01437787)
- Testing
- SAR302503
- Where
- 101 sites in United States, Australia and 23 more
- Volunteers
- 289 people
- Sponsor
- Bristol-Myers Squibb
Chronic Inflammatory Demyelinating Polyneuropathy
To Assess Efficacy and Safety of Batoclimab in Adult Participants With Active CIDP
This is a multi-center, randomized, quadruple-blind, placebo-controlled study to evaluate the efficacy and safety of batoclimab in adult participants with active CIDP.
- Trial name
- NCT05581199
- Testing
- Batoclimab 680 milligrams (mg) subcutaneous (SC) weekly, Batoclimab 340 mg SC weekly
- Where
- 98 sites in United States, Argentina and 19 more
- Volunteers
- 94 people
- Sponsor
- Immunovant Sciences GmbH
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