Clinical trials: in Sweden
Healthy Tissue, Muscles
Deep Optical Imaging of Tissue (DOIT)
In medical imaging, X-ray-based methods are widely used, which means that patients are exposed to ionizing radiation. In addition, invasive tissue samples often need to be taken with biopsy needles to, for example, safely…
- Conditions
- Healthy Tissue, Muscles, Extremity, Breast
- Trial name
- DOIT (NCT07754500)
- Testing
- Mk1
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Thumb Osteoarthritis
Trapeziectomy vs. Trapeziometacarpal Limited Excision for Thumb Base Osteoarthritis
A randomized comparison between trapeziectomy and trapeziometacarpal limited excision for thumb base osteoarthritis in 90 patients.
- Trial name
- NCT04210687
- Testing
- trapeziometacarpal limited excision, Trapeziectomy
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Breast Neoplasms
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physician's choice (TPC)…
- Trial name
- NCT06926868
- Testing
- Iza-bren, Nab-paclitaxel, Paclitaxel
- Where
- 295 sites in United States, Argentina and 26 more
- Volunteers
- 600 people
- Sponsor
- Bristol-Myers Squibb
Temporomandibular Disorders (TMD), Temporomandibular Joint Disc Displacement, With Reduction
Long-term Follow up of TMJ Surgery and Evaluation of the 6-month Control as a Prognostic Marker.
The goal of this clinical trial is to evaluate the long-term outcome of surgical intervention (arthroscopy or discectomy) due to the diagnoses temporomandibular joint disc displacement with or without displacement.
- Conditions
- Temporomandibular Disorders (TMD), Temporomandibular Joint Disc Displacement, With Reduction, Temporomandibular Joint Disc Displacement, Without Reduction
- Trial name
- NCT06782165
- Testing
- Arthroscopy & saline irrigation alone, Discectomy
- Where
- Sweden
- Volunteers
- 91 people
- Sponsor
- Karolinska Institutet
Prostate Cancer
Prostate Cancer IRE Study (PRIS)
The aim of this study is to evaluate the feasibility to treat localized prostate cancer diagnosed with MRI and targeted/systematic biopsies, with IRE in comparison with conventional radical treatments with the primary objective…
- Trial name
- PRIS (NCT05513443)
- Testing
- Irreversible electroporation, IRE, Radical prostatectomy, Radiation therapy
- Where
- Sweden
- Volunteers
- 184 people
- Sponsor
- Karolinska Institutet
Cholecystolithiasis, Common Bile Duct Gall Stones
ChOlanGiography Performed Routinely Versus Selectively During Cholecystectomy: A NAtional Registry-based Randomized Controlled Trial
Common bile duct stones (CBDS) may be asymptomatic but can cause pancreatitis, obstructive jaundice, and/or cholangitis. In Sweden, intraoperative cholangiography (IOC) is usually performed during gallstone surgery in order to…
- Trial name
- COGNAC (NCT07002619)
- Testing
- Routine cholangiography, Selective cholangiograpy
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Karolinska Institutet
Fontan Circulation
Muscle Function in Patients With Single-chamber Heart
Groundbreaking cardiac surgery has significantly improved survival rates for patients with single-chamber hearts. However, despite these life-saving interventions, the long-term prognosis remains concerning, with an increased…
- Trial name
- Muscle in TCPC (NCT07420660)
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska Institutet
PTSD - Post Traumatic Stress Disorder, Sexual Abuse
Evaluation of Restory - an Online Trauma Treatment for Victims of Sexual Abuse
This project aims to evaluate Restory - a newly developed anonymous, iCBT prolonged exposure therapy program specifically tailored for victims of sexual abuse - using a pre-registered randomized controlled trial with waitlist…
- Trial name
- NCT07610187
- Testing
- Restory
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Karolinska Institutet
Malocclusion, Angle Class II, Overbite (Excessive) Horizontal
Long-term Stability of Treatment With the Twin Block Appliance
The objective of this observational study is to investigate the long-term stability of treatment with the Twin block appliance in a patient group previously treated with a Twin block appliance.
- Conditions
- Malocclusion, Angle Class II, Overbite (Excessive) Horizontal, Overbite (Excessive) Deep, Treatment Outcome
- Trial name
- NCT07752498
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Region Jönköping County
ADHD
Internet-based Cognitive Behavioral Therapy for Adult Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is a disorder characterized by lack of attention, hyperactivity, and impulsivity.
- Trial name
- NCT05700539
- Testing
- Internet-based cognitive behavioral therapy
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cervical Cancer
Robot-assisted Approach to Cervical Cancer
The purpose of the RACC trial is to compare the oncologic outcome defined as recurrence-free survival (RFS) between robot-assisted and open radical hysterectomy for the treatment of early stage cervical cancer.
- Trial name
- RACC (NCT03719547)
- Testing
- Abdominal radical hysterectomy, Robot-assisted radical hysterectomy, Sentinel lymph node biopsy
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Karolinska Institutet
Melanoma
Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
The purpose of this study is to determine the effectiveness of nivolumab adjuvant immunotherapy compared to placebo in adults and pediatric participants after complete resection of Stage IIB/C melanoma with no evidence of disease…
- Trial name
- CheckMate76K (NCT04099251)
- Testing
- Nivolumab
- Where
- 130 sites in United States, Australia and 18 more
- Volunteers
- 790 people
- Sponsor
- Bristol-Myers Squibb
Borderline Personality Disorder, Self-harm
Effects of Psychiatric Admissions on Self-harm and Suicide in People With Borderline Personality Disorder
The current study aims to evaluate the impact of long (>5 days) and/or compulsory psychiatric inpatient care on subsequent healthcare utilization for self-harm and suicide in people with borderline personality disorder, a…
- Conditions
- Borderline Personality Disorder, Self-harm, Non-suicidal Self-injury, Suicide
- Trial name
- NCT06424509
- Testing
- High degree of long (>5 days) and/or compulsory psychiatric inpatient care
- Where
- Sweden
- Volunteers
- 390 people
- Sponsor
- Lund University
Peri-Implantitis, Plaque, Dental
Antibacterial Photodynamic Therapy in the Management of Peri-implantitis
This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term.
- Trial name
- NCT06017817
- Testing
- Lumoral Treatment, Standard oral hygiene instructions, Scaling and root planing (SRP
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Koite Health Oy
Asthma (Part 1), COPD
APP-based Medical Device for Education and Training of Inhalation Technique
Primary aim: To investigate if app-based education and training of inhalation technique improves the rate of successful inhalation techniques compared with control group at 6-12 weeks follow-up visit.
- Trial name
- APPETITE (NCT07145632)
- Testing
- App-based education and training of inhalation technique
- Where
- 3 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Hospitalization, Older Adults
The Preventing Functional Decline in Acutely Hospitalized Older Patients (PREV_FUNC) Study
This study aims to examine 1) if multicomponent exercise interventions (including both mobility and strengthening exercises) have effects on physical function compared to usual care in older adults, and 2) if a comprehensive…
- Trial name
- PREV_FUNC (NCT05366075)
- Testing
- Intervention 1 (simple exercise program), Intervention 2 (comprehensive exercise program)
- Where
- Sweden
- Volunteers
- 324 people
- Sponsor
- Karolinska Institutet
Anorexia Nervosa
Patient-derived Stem Cell Models of Anorexia Nervosa
Experimental and genetic data, as well as brain imaging, support a role of the hypothalamic Arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been…
- Trial name
- ANSTEM (NCT06259500)
- Testing
- observational
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Leukemia
A Study in Leukemia Patients With Karonudib
The primary objective of this study is to determine safety and tolerability of Karonudib for the treatment of hematological malignancies.
- Trial name
- MAATEO (NCT04077307)
- Testing
- Karonudib
- Where
- 7 sites in Denmark, Serbia and 1 more
- Volunteers
- 50 people
- Sponsor
- Thomas Helleday Foundation
Non Small Cell Lung Carcinoma NSCLC
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy versus platinum-based SoC chemotherapy in the first-line treatment of…
- Trial name
- NEPTUNE (NCT02542293)
- Testing
- Durvalumab +Tremelimumab, Paclitaxel + carboplatin, Gemcitabine + cisplatin
- Where
- 210 sites in United States, Argentina and 27 more
- Volunteers
- 953 people
- Sponsor
- AstraZeneca
Obesity, Diabetes Mellitus, Type 2
A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
This study is open to adults who are at least 18 years old and have a body mass index of 27 kg/m² or more. People can take part if they have type 2 diabetes and if they are currently being treated only with diet and exercise or…
- Trial name
- SYNCHRONIZE™-2 (NCT06066528)
- Testing
- Survodutide
- Where
- 143 sites in United States, Australia and 17 more
- Volunteers
- 755 people
- Sponsor
- Boehringer Ingelheim
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