Clinical trials: active, in Tanzania
Postpartum Hemorrhage
Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women at Higher Risk
Heavy bleeding after childbirth, known as a postpartum haemorrhage (PPH), causes about 70,000 maternal deaths every year. Tranexamic acid (TXA) is a lifesaving treatment for women with PPH.
- Trial name
- I'M-WOMAN (NCT05562609)
- Testing
- Tranexamic acid
- Where
- Tanzania
- Volunteers
- 40,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV-1-infection
Investigating the Optimal Management of Dolutegravir Resistance
The goal of this study is to address the gap in published data on viral suppression among people meeting the criteria for virologic failure on dolutegravir (DTG)-based ART regimens without a change in regimen.
- Trial name
- NCT06762054
- Testing
- Continue DTG-based antiretroviral therapy, Enhanced adherence counselling
- Where
- 9 sites in Kenya, Lesotho and 2 more
- Volunteers
- 6,624 people
- Sponsor
- University of Nairobi
Acute Conditions
Massive Online Open Validation and Evaluation of Large Language Models for Resource Constrained Settings - a Study of Contextual Awareness, Safety, and Accuracy
Healthcare settings in low and middle income countries, clinicians are frequently required to manage a wide range of acute conditions under the constraints of time pressure, limited diagnostic resources, and variable availability…
- Trial name
- SilentMOOVE (NCT07914140)
- Testing
- Non interventional study
- Where
- 4 sites in Kenya, Malawi and 1 more
- Volunteers
- 3,000 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Tuberculosis, MDR
Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients
The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB) during 96 weeks of follow-up among…
- Trial name
- PHOENIx MDR-TB (NCT03568383)
- Testing
- Delamanid (DLM), Isoniazid (INH), Pyridoxine (vitamin B6)
- Where
- 31 sites in Botswana, Brazil and 11 more
- Volunteers
- 5,832 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis (TB)
A Study to Evaluate the Efficacy, Safety and Immunogenicity of MTBVAC in Adolescents and Adults Living in a TB Endemic Region.
A Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety and immunogenicity of a candidate tuberculosis (TB) vaccine, MTBVAC, against TB disease in adolescents and adults aged 14-45 years…
- Trial name
- NCT06272812
- Testing
- MTBVAC
- Where
- 16 sites in Kenya, South Africa and 1 more
- Volunteers
- 5,531 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV (Human Immunodeficiency Virus)
Testing a Multi-Level Approach to Reduce Stigma for Women Living With HIV
This study will test two approaches to reduce HIV-related stigma and improve quality of life and viral suppression among women living with HIV in Dar es Salaam, Tanzania. Twenty health facilities will take part.
- Trial name
- NCT07881575
- Testing
- Labda Siku Moja, Total Facility Approach
- Where
- Tanzania
- Volunteers
- 680 people
- Sponsor
- RTI International
Tuberculosis, Latent
Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB
A seamless, staged Phase II/III, open-label, multicenter, non-inferiority trial, to compare the efficacy and safety of 4 weeks of bedaquiline (BDQ) versus a a standard regimen for preventing regimen for preventing confirmed or…
- Trial name
- BREACH-TB (NCT06568484)
- Testing
- Bedaquiline, Isoniazid, rifapentine, Levofloxacin
- Where
- 8 sites in Mongolia, Peru and 2 more
- Volunteers
- 2,530 people
- Sponsor
- Johns Hopkins University
Sickle Cell Anemia in Children
Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)
This study will 1) Evaluate the prevalence of elevated (conditional or abnormal) transcranial Doppler (TCD) velocities in a cross-sectional analysis of children with Sickle Cell Anemia (SCA) living in Tanzania; 2) Obtain…
- Trial name
- NCT03948867
- Testing
- Hydroxyurea, Elevated Arm TCD Examination, Normal Arm TCD Examination
- Where
- 2 sites in United States, Tanzania
- Volunteers
- 202 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Breast Cancer Invasive
Fast and Accurate Breast Cancer Diagnosis Using Nanopore Sequencing in Tanzania (Fast-ABCD Sequencing)
This pilot study will test the feasibility of using nanopore sequencing for breast cancer diagnosis in Tanzania. It aims to show that nanopore sequencing is non-inferior to the current standard of care, with the potential for…
- Trial name
- NCT06633276
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- University of Bonn
Pulmonary Tuberculosis
Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB
The UNITE4TB consortium is a group of universities and pharmaceutical companies funded by the European Union. This consortium are carrying out a trial to find better and faster ways to treat tuberculosis (TB).
- Trial name
- PARADIGM4TB (NCT06114628)
- Testing
- Ganfeborole, BTZ-043, Bedaquiline (B)
- Where
- 11 sites in Moldova, South Africa and 3 more
- Volunteers
- 2,500 people
- Sponsor
- University College, London
HIV - Human Immunodeficiency Virus, Suicide Prevention
IDEAS for Hope to Reduce Suicide Risk and Improve HIV Care Engagement in Tanzania
In this project, the investigators will conduct a clinical trial to test the effectiveness and implementation of IDEAS for Hope, a 3-session telehealth counseling intervention delivered by nurses, to reduce suicidality and…
- Trial name
- NCT07459218
- Testing
- IDEAS for Hope, Safety Planning Intervention
- Where
- Tanzania
- Volunteers
- 600 people
- Sponsor
- Duke University
Health Knowledge, Attitudes, Practice, Training
Evaluating the Effects of Reproductive Health Training on Provider Behavior
The goal of this randomized, controlled, single blinded trial is to evaluate the medium to long-term effects of an Afrocentric sexual health curriculum on health professional students' knowledge, attitudes, and clinical skills in…
- Trial name
- THP-2 (NCT06428058)
- Testing
- Comprehensive sexual health curriculum
- Where
- Tanzania
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Pneumonia, Pneumonia Childhood
Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia - ToolCAP
The ToolCAP study aims to see if using ultrasound to look at the lungs when children have symptoms of a lung infection will safely allow doctors to improve how they treat those infections.
- Conditions
- Pneumonia, Pneumonia Childhood, Pneumonia - Bacterial, Pediatrics
- Trial name
- ToolCAP (NCT06670833)
- Testing
- Lung ultrasound, Standard of Care (SOC)
- Where
- 9 sites in Senegal, South Africa and 1 more
- Volunteers
- 4,894 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Rift Valley Fever, Hemorrhagic Fevers, Viral
RVF and Other Emerging Infectious Diseases in East and Central Africa
Rift Valley fever (RVF), a disease transmitted from livestock (cattle, sheep, goats, camels) to humans more commonly occurs in the East and Central Africa (ECA) regions where more than 15 major epidemics affecting more than one…
- Trial name
- NCT05139524
- Testing
- Evidence of past or recent RVF exposure
- Where
- 10 sites in Democratic Republic of the Congo, Kenya and 2 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Washington State University
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
CAYA Cancer Retrospective Cohort Study
Despite advances in cancer treatment, significant disparities in outcomes persist between high-income countries (HICs) and low-and middle-income countries (LMICs).
- Conditions
- Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Young Adult Cancer, Adolescent Cancer
- Trial name
- NCT07246213
- Testing
- Retrospective Medical Record Review
- Where
- 7 sites in Armenia, Egypt and 4 more
- Volunteers
- 18,000 people
- Sponsor
- Resonance, Inc.
Anemia
Multiple Micronutrient Supplementation With Digital Layering Among Adolescents in Tanzania
This study is a three-arm, individually randomized controlled trial evaluating the impact of digitally delivered nutrition education, layered onto multiple micronutrient supplementation (MMS), on anemia and related health…
- Trial name
- MMSDigitalTZ (NCT07493772)
- Testing
- Behavioral: SMS Intervention (Intervention Arm I), Behavioral: In Person Digital Arm (Intervention Arm II)
- Where
- Tanzania
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Sexual and Reproductive Health, Disability
Evaluation of a Disability-Focused Sexual and Reproductive Health Curriculum for Health Students in Tanzania
This randomized controlled trial will evaluate the efficacy of a three-day sexual and reproductive health curriculum focused on persons with disabilities and tailored to the Tanzanian context.
- Conditions
- Sexual and Reproductive Health, Disability, Health Knowledge, Attitudes, Practice, Health Education
- Trial name
- NCT07772778
- Testing
- Disability-Focused Sexual and Reproductive Health Curriculum
- Where
- Tanzania
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sexual and Reproductive Health, Health Knowledge, Attitudes, Practice
Evaluating the Effects of Reproductive Health Training on Provider Behavior - Aim 3
This study will evaluate the real-world effectiveness of a four-day Afrocentric sexual and reproductive health curriculum for health professional students in Tanzania.
- Conditions
- Sexual and Reproductive Health, Health Knowledge, Attitudes, Practice, Provider Behavior, Health Education
- Trial name
- THP-2 Aim 3 (NCT07770438)
- Testing
- Afrocentric Sexual and Reproductive Health Curriculum
- Where
- 3 sites in Tanzania
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
HIV Prevention
Private-sector Access to Testing for Health Sustainability
New and innovative strategies are urgently needed to increase the uptake of HIV prevention and sexual and reproductive health services among adolescent girls and young women (AGYW) in sub-Saharan Africa.
- Trial name
- PATHS (NCT06820697)
- Testing
- Low HIVST kit subsidy, High HIVST kit subsidy
- Where
- Tanzania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco